Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins GTF2E2 (from a repository: Tue Nov 15 15:25:28 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 35 The number (and %) of the onco-proteins 17 (48.57 %) The number (and %) of the tumor suppressors 2 (5.71 %) Total number of binary PPIs (saturation %) 128 (21.51 %) The number (and %) of affected PPIs 35 (27.34 %) The number of possible different fusions 9 PPI diameter 2 PPI radius 1 The average degree of PPI 6.514 Assortativity coefficient -0.3219 The network average Clustering coefficient 0.606 The number (and %) of a zero Clustering coefficients 2 (5.71 %) The number (and %) of a zero Betweenness Centrality 10 (28.57 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: GTF2E2	All fusions : BG024711; BE005000;
Proteins found in more fusions	FOS (see 4 fusions); POLR2A (see 2 fusions); SART3 (see 2 fusions); APP (see 4 fusions); HSP90AB1 (see 1 fusions); EEF1G (see 1 fusions); UBR5 (see 4 fusions); GTF2E2 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GTF2E2	parental protein	35	0.143	711.467	TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain VCX_VCY (PF15231, IPR026653): Variable charge X/Y family
2	APP	protein found in more fusions	12	0.273	33.967	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3	ATF7IP	oncoprotein	4	1.000	0	TCP (PF03634, IPR005333): TCP family transcription factor DUF2951 (PF11166, IPR021337): Protein of unknown function (DUF2951) ALMT (PF11744, IPR020966): Aluminium activated malate transporter ATF7IP_BD (PF16788, IPR031870): ATF-interacting protein binding domain fn3_4 (PF16794, IPR003961): Fibronectin-III type domain
4	CDK7	oncoprotein	7	0.600	4.000	Pkinase (PF00069, IPR000719): Protein kinase domain
5	DNM2	interactor	2	1.000	0	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
6	EEF1G	protein found in more fusions	4	0.667	0.400	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
7	ERCC3	oncoprotein	7	0.571	6.500	ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit DUF2748 (PF10871, IPR020183): Protein of unknown function (DUF2748) Helicase_C_3 (PF13625, IPR032830): Helicase conserved C-terminal domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
8	EXOC4	oncoprotein	1	0	0	DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain Vps51 (PF08700): Vps51/Vps67
9	FOS	oncoprotein	7	0.800	1.300	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
10	GTF2A1	oncoprotein	6	0.600	4.400	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
11	GTF2B	interactor	9	0.694	6.300	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
12	GTF2E1	interactor	13	0.410	32.633	DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980) TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
13	GTF2F1	interactor	11	0.527	17.767	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
14	GTF2F2	interactor	10	0.622	11.933	TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
15	HNRNPA1	interactor	9	0.321	15.233	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
16	HSP90AB1	oncoprotein	6	0.500	3.167	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
17	JUN	oncoprotein	10	0.639	7.433	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
18	KLF5	suppressor	5	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
19	MCC	suppressor	2	1.000	0	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair FAM76 (PF16046, IPR032017): FAM76 protein
20	MDM2	oncoprotein	8	0.429	9.733	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
21	MMS19	interactor	3	0.667	0.500	DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
22	MOV10	interactor	3	0.667	0.500	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
23	MTA2	interactor	3	0.667	0.500	BAH (PF01426, IPR001025, SM00439): BAH domain ELM2 (PF01448, IPR000949): ELM2 domain Resolvase (PF00239, IPR006119, SM00857): Resolvase, N terminal domain DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain GATA (PF00320, IPR000679, SM00401): GATA zinc finger
24	NXF1	interactor	9	0.357	14.833	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
25	PBDC1	interactor	1	0	0	Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
26	POLR2A	protein found in more fusions	15	0.341	48.500	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
27	SART3	protein found in more fusions	3	1.000	0	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866) DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993) Lsm_interact (PF05391, IPR008669): Lsm interaction motif Phage_GPD (PF05954): Phage late control gene D protein (GPD) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Suf (PF05843, IPR008847): Suppressor of forked protein (Suf) TPR_14 (PF13428): Tetratricopeptide repeat MRI (PF15325, IPR028278): Modulator of retrovirus infection LSM_int_assoc (PF16605): LSM-interacting associated unstructured
28	SEC24D	interactor	2	1.000	0	Gelsolin (PF00626, IPR007123): Gelsolin repeat Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain Transp_Tc5_C (PF04236, IPR007350): Tc5 transposase C-terminal domain zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
29	SHMT2	interactor	4	0.500	2.500	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
30	SIN3A	oncoprotein	4	0.500	1.833	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
31	SND1	interactor	5	0.700	1.667	TUDOR (PF00567, IPR002999, SM00333): Tudor domain SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
32	TBP	interactor	13	0.500	22.267	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
33	TPR	oncoprotein	4	0.500	2.667	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373) DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
34	UBR5	protein found in more fusions	3	1.000	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
35	XPA	oncoprotein	2	1.000	0	XPA_C (PF05181, IPR022656): XPA protein C-terminus XPA_N (PF01286, IPR022652): XPA protein N-terminal MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1 zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain

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List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	FOS	oncoprotein	bZIP_1 (PF00170, IPR004827): bZIP transcription factor	BG024711
2	GTF2E2	parental protein	TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain VCX_VCY (PF15231, IPR026653): Variable charge X/Y family	BG024711

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