Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins GSS (from a repository: Thu Nov 17 15:35:05 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 27 The number (and %) of the onco-proteins 10 (37.04 %) The number (and %) of the tumor suppressors 1 (3.70 %) Total number of binary PPIs (saturation %) 106 (30.20 %) The number (and %) of affected PPIs 27 (25.47 %) The number of possible different fusions 7 PPI diameter 2 PPI radius 1 The average degree of PPI 7.111 Assortativity coefficient -0.2794 The network average Clustering coefficient 0.667 The number (and %) of a zero Clustering coefficients 2 (7.41 %) The number (and %) of a zero Betweenness Centrality 8 (29.63 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: GSS	All fusions : AW894712;
Proteins found in more fusions	VCL (see 2 fusions); ECHS1 (see 1 fusions); YWHAH (see 2 fusions); YWHAG (see 1 fusions); GSS (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GSS	parental protein	27	0.215	363.217	GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
2	ABHD14A	interactor	6	0.867	0.833	Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
3	ASNS	oncoprotein	10	0.556	14.800	Asn_synthase (PF00733, IPR001962): Asparagine synthase GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
4	ASS1	suppressor	4	0.667	0.667	Arginosuc_synth (PF00764, IPR001518): Arginosuccinate synthase
5	CDK9	protein found in more fusions	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
6	DCPS	interactor	8	0.786	2.467	DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
7	ECHS1	protein found in more fusions	8	0.714	3.467	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
8	GBE1	interactor	1	0	0	Alpha-amylase (PF00128, IPR006047): Alpha amylase, catalytic domain CBM_48 (PF02922, IPR004193): Carbohydrate-binding module 48 (Isoamylase N-terminal domain) Alpha-amylase_C (PF02806, IPR006048, SM00632): Alpha amylase, C-terminal all-beta domain
9	GINS3	interactor	9	0.750	3.517	Sld5 (PF05916, IPR021151): GINS complex protein
10	HMGB3	interactor	3	1.000	0	HMG_box_2 (PF09011, IPR009071): HMG-box domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
11	MSN	oncoprotein	10	0.639	8.250	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
12	MVK	interactor	3	1.000	0	GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain GalKase_gal_bdg (PF10509, IPR019539): Galactokinase galactose-binding signature
13	OLA1	interactor	3	1.000	0	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
14	PAFAH1B2	oncoprotein	10	0.533	13.300	Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
15	PDIA4	interactor	10	0.622	10.517	Calsequestrin (PF01216, IPR001393): Calsequestrin Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain FAM176 (PF14851): FAM176 family
16	PPP5C	interactor	7	0.810	1.450	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PPP5 (PF08321, IPR013235): PPP5 TPR repeat region TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat
17	RAP1GDS1	oncoprotein	14	0.495	30.117	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1 V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H HEAT_2 (PF13646): HEAT repeats Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
18	RRAGB	interactor	2	1.000	0	Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
19	TBCB	interactor	6	0.933	0.400	CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
20	TERF1	interactor	7	0.333	9.167	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
21	USP14	interactor	3	1.000	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
22	VCL	oncoprotein	14	0.526	22.967	Vinculin (PF01044, IPR006077): Vinculin family
23	YWHAB	interactor	6	0.667	4.400	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
24	YWHAE	oncoprotein	10	0.644	8.417	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
25	YWHAG	protein found in more fusions	8	0.619	5.483	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
26	YWHAH	protein found in more fusions	9	0.643	6.567	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
27	ZFAND6	interactor	1	0	0	zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger zf-AN1 (PF01428, IPR000058, SM00154): AN1-like Zinc finger

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