Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins GSK3B (from a repository: Sun Dec 4 13:06:33 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 255 The number (and %) of the onco-proteins 73 (28.63 %) The number (and %) of the tumor suppressors 36 (14.12 %) Total number of binary PPIs (saturation %) 1327 (4.10 %) The number (and %) of affected PPIs 255 (19.22 %) The number of possible different fusions 39 PPI diameter 2 PPI radius 1 The average degree of PPI 9.671 Assortativity coefficient -0.3176 The network average Clustering coefficient 0.475 The number (and %) of a zero Clustering coefficients 29 (11.37 %) The number (and %) of a zero Betweenness Centrality 64 (25.10 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: GSK3B	All fusions
Proteins found in more fusions	EEF1G (see 1 fusions); MAP3K2 (see 2 fusions); MAPK1 (see 1 fusions); EEF1A1 (see 1 fusions); GSK3B (see 1 fusions); MAP3K1 (see 1 fusions); MYC (see 1 fusions); PRKAR1A (see 2 fusions); CDH1 (see 3 fusions); EWSR1 (see 2 fusions); PRKDC (see 3 fusions); SMURF2 (see 1 fusions); PIAS1 (see 2 fusions); SNCAIP (see 1 fusions); PDE4D (see 2 fusions); APC (see 1 fusions); RXRA (see 2 fusions); COPS5 (see 1 fusions); MTOR (see 1 fusions); CCND1 (see 1 fusions); STRAP (see 2 fusions); TP53 (see 3 fusions); PTPN11 (see 1 fusions); APP (see 4 fusions); LUC7L2 (see 2 fusions); FOXO1 (see 1 fusions); HSP90AA1 (see 2 fusions); NIN (see 1 fusions); HDAC4 (see 1 fusions); NFKB1 (see 2 fusions); CREB1 (see 2 fusions); MAPT (see 1 fusions); NFE2L1 (see 1 fusions); UBR5 (see 4 fusions); CHD3 (see 1 fusions); PTK2 (see 2 fusions); SMAD3 (see 3 fusions); GAPDH (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GSK3B	parental protein	255	0.030	51887.088	Pkinase (PF00069, IPR000719): Protein kinase domain
2	ACLY	interactor	3	0.667	0.182	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain Ligase_CoA (PF00549, IPR005811): CoA-ligase Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
3	ACSBG1	interactor	2	1.000	0	AMP-binding (PF00501, IPR000873): AMP-binding enzyme IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
4	ACTL6B	interactor	3	0.667	0.400	Actin (PF00022, IPR004000, SM00268): Actin
5	ADAP1	interactor	2	1.000	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf PH (PF00169, IPR001849, SM00233): PH domain
6	ADIRF	interactor	1	0	0	Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
7	AKAP11	interactor	6	0.533	4.633	E_raikovi_mat (PF06360, IPR009064): Euplotes raikovi mating pheromone RNA_lig_T4_1 (PF09511, IPR019039): RNA ligase
8	AKT1	oncoprotein	38	0.174	362.262	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
9	AKT2	oncoprotein	9	0.361	10.872	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
10	AKT3	oncoprotein	3	0.667	0.500	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
11	ANKRD6	interactor	2	1.000	0	DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) Swi5 (PF07061, IPR010760): Swi5 Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
12	APC	suppressor	13	0.424	20.061	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
13	APP	protein found in more fusions	51	0.104	901.146	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
14	AR	oncoprotein	25	0.341	86.831	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
15	ARHGEF11	interactor	2	1.000	0	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) RGS-like (PF09128, IPR015212): Regulator of G protein signalling-like domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain PH_13 (PF16652, IPR001849): Pleckstrin homology domain
16	ARRB1	interactor	14	0.374	25.382	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
17	ASRGL1	interactor	1	0	0	Asparaginase_2 (PF01112, IPR000246): Asparaginase
18	ATF3	suppressor	14	0.436	23.377	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
19	ATPIF1	interactor	2	1.000	0	DivIC (PF04977, IPR007060): Septum formation initiator IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
20	ATXN3	interactor	11	0.267	19.621	Josephin (PF02099, IPR006155): Josephin UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
21	AURKA	oncoprotein	19	0.386	38.009	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
22	AXIN1	suppressor	22	0.243	108.372	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
23	AXIN2	suppressor	7	0.667	5.733	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain THP2 (PF09432, IPR018557): Tho complex subunit THP2 DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
24	BAG6	interactor	11	0.244	28.033	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
25	BCL3	oncoprotein	9	0.556	6.257	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
26	BEX1	interactor	2	1.000	0	BEX (PF04538, IPR021156): Brain expressed X-linked like family
27	BHLHE41	suppressor	7	0.467	5.200	Adeno_PIX (PF03955, IPR005641): Adenovirus hexon-associated protein (IX) Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
28	BIRC2	oncoprotein	11	0.489	13.419	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
29	BIRC3	oncoprotein	10	0.583	7.652	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
30	BRIX1	interactor	1	0	0	Brix (PF04427, IPR007109, SM00879): Brix domain
31	BTRC	oncoprotein	38	0.185	377.504	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
32	BZW2	interactor	2	1.000	0	W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
33	C14orf1	interactor	4	0.500	2.500	Erg28 (PF03694, IPR005352): Erg28 like protein
34	CAMSAP3	interactor	2	1.000	0	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
35	CCDC6	oncoprotein	6	0.533	2.475	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046) FAM199X (PF15814, IPR029672): Protein family FAM199X
36	CCND1	oncoprotein	13	0.515	16.614	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
37	CCNE1	oncoprotein	8	0.429	8.190	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
38	CDH1	suppressor	8	0.476	4.719	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
39	CEBPB	oncoprotein	15	0.418	23.903	RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
40	CEBPZ	interactor	5	0.500	2.265	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
41	CENPB	interactor	3	0.667	0.400	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain DDE_1 (PF03184, IPR004875): DDE superfamily endonuclease K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
42	CHD3	oncoprotein	10	0.444	15.933	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
43	CIITA	oncoprotein	4	0.667	0.582	NACHT (PF05729): NACHT domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_6 (PF13516, IPR001611): Leucine Rich repeat
44	CLASP2	interactor	5	0.400	3.315	HEAT (PF02985, IPR000357): HEAT repeat TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal HEAT_EZ (PF13513): HEAT-like repeat
45	CLEC3B	interactor	2	1.000	0	Chordopox_A33R (PF05966, IPR009238): Chordopoxvirus A33R protein Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
46	COPS5	protein found in more fusions	39	0.179	407.424	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
47	CREB1	oncoprotein	20	0.234	92.507	bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF4988 (PF16378, IPR032149): Domain of unknown function
48	CREB3L3	interactor	4	0.667	0.400	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
49	CSAD	interactor	1	0	0	GLE1 (PF07817, IPR012476): GLE1-like protein Pyridoxal_deC (PF00282, IPR002129): Pyridoxal-dependent decarboxylase conserved domain
50	CSF3R	oncoprotein	4	0.500	3.000	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
51	CSNK2B	interactor	29	0.106	301.500	CK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
52	CST6	suppressor	2	1.000	0	Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
53	CTNNB1	oncoprotein	37	0.168	390.083	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
54	DBI	interactor	2	1.000	0	ACBP (PF00887, IPR000582): Acyl CoA binding protein JmjN (PF02375, IPR003349, SM00545): jmjN domain
55	DCTN3	interactor	1	0	0	Dynactin_p22 (PF07426, IPR009991): Dynactin subunit p22
56	DDIT4	interactor	3	0.667	0.222	RTP801_C (PF07809, IPR012918): RTP801 C-terminal region
57	DDX20	interactor	8	0.476	7.467	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
58	DEAF1	interactor	4	0.667	1.667	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAND (PF01342, IPR000770, SM00258): SAND domain zf-MYND (PF01753, IPR002893): MYND finger
59	DEC1	suppressor	6	0.700	2.000	DEC1 (PF15859, IPR031718): Deleted in esophageal cancer 1 family
60	DEFA1	interactor	1	0	0	Defensin_1 (PF00323, IPR006081): Mammalian defensin Defensin_propep (PF00879, IPR002366): Defensin propeptide
61	DHX34	interactor	1	0	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
62	DHX36	interactor	4	0.500	1.667	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
63	DNAJC13	interactor	1	0	0	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DnaJ (PF00226, IPR001623, SM00271): DnaJ domain Arm_2 (PF04826, IPR006911): Armadillo-like DUF4339 (PF14237, IPR025640): Domain of unknown function (DUF4339)
64	DNM1L	interactor	5	0.500	2.067	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family AAA_16 (PF13191): AAA ATPase domain
65	DNMT1	suppressor	9	0.357	10.084	BAH (PF01426, IPR001025, SM00439): BAH domain DMAP_binding (PF06464, IPR010506, SM01137): DMAP1-binding Domain DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain DNMT1-RFD (PF12047, IPR022702): Cytosine specific DNA methyltransferase replication foci domain
66	DNMT3L	interactor	10	0.556	7.295	CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
67	DUSP9	suppressor	1	0	0	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
68	DYNLL1	interactor	13	0.212	41.067	Dynein_light (PF01221, IPR001372): Dynein light chain type 1
69	E2F1	suppressor	12	0.364	25.491	Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
70	EEF1A1	suppressor	18	0.368	46.344	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
71	EEF1G	protein found in more fusions	8	0.333	5.708	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
72	EFTUD2	interactor	10	0.639	4.655	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
73	EIF4EBP1	oncoprotein	8	0.393	11.125	eIF_4EBP (PF05456, IPR008606): Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
74	ELAVL1	oncoprotein	54	0.087	1061.538	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
75	ENTPD6	interactor	1	0	0	GDA1_CD39 (PF01150, IPR000407): GDA1/CD39 (nucleoside phosphatase) family
76	EPB41L3	suppressor	6	0.333	7.233	4_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD) FA (PF08736, IPR014847): FERM adjacent (FA) FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SAB (PF04382, IPR007477): SAB domain
77	EPM2A	interactor	2	0	0	CBM_20 (PF00686, IPR002044): Starch binding domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
78	EWSR1	oncoprotein	21	0.205	115.055	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
79	EYA1	interactor	2	1.000	0	NA
80	FAM193B	interactor	3	1.000	0	SPX (PF03105, IPR004331): SPX domain FAM193_C (PF15914, IPR031802): FAM193 family C-terminal
81	FAM83D	interactor	4	0.500	2.667	DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
82	FBN3	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain TB (PF00683, IPR017878): TB domain hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
83	FBXW11	interactor	24	0.281	105.213	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
84	FBXW7	suppressor	31	0.108	309.133	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
85	FEN1	oncoprotein	4	0.500	2.333	5_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold XPG_I (PF00867, IPR006086, SM00484): XPG I-region XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
86	FIBP	interactor	3	0.667	0.500	FIBP (PF05427, IPR008614): Acidic fibroblast growth factor binding (FIBP)
87	FKBP14	interactor	2	1.000	0	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
88	FOXO1	suppressor	9	0.607	3.483	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
89	FRAT1	oncoprotein	3	0.667	0.500	GSK-3_bind (PF05350, IPR008014): Glycogen synthase kinase-3 binding
90	FRAT2	interactor	2	1.000	0	GSK-3_bind (PF05350, IPR008014): Glycogen synthase kinase-3 binding
91	FZD1	interactor	1	0	0	Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region Fz (PF01392, IPR020067, SM00063): Fz domain
92	FZD5	interactor	2	1.000	0	Frizzled (PF01534, IPR000539): Frizzled/Smoothened family membrane region Fz (PF01392, IPR020067, SM00063): Fz domain
93	GAPDH	oncoprotein	16	0.476	21.278	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
94	GBP2	interactor	3	1.000	0	GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
95	GEMIN4	interactor	7	0.467	6.833	NA
96	GIPC1	interactor	4	0.500	2.500	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
97	GJB5	interactor	1	0	0	Connexin (PF00029, IPR013092, SM00037): Connexin
98	GNB2	interactor	4	0.833	0.087	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CALM_bind (PF16025): Calcium-dependent calmodulin binding WD40_like (PF17005, IPR031544): WD40-like domain
99	GPR39	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) 7tm_4 (PF13853): Olfactory receptor
100	GSKIP	interactor	1	0	0	DUF727 (PF05303, IPR007967): Protein of unknown function (DUF727)
101	GYS1	interactor	5	0.600	0.958	Glycogen_syn (PF05693, IPR008631): Glycogen synthase
102	HAX1	interactor	9	0.306	17.486	Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
103	HDAC4	oncoprotein	12	0.436	12.615	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
104	HDAC6	oncoprotein	19	0.275	60.370	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
105	HECW2	interactor	8	0.333	11.286	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
106	HSP90AA1	oncoprotein	43	0.193	437.021	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
107	HSPA4	interactor	24	0.293	107.785	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
108	IGF2BP1	oncoprotein	10	0.511	9.166	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain MOEP19 (PF16005, IPR031952): KH-like RNA-binding domain
109	IGHM	interactor	4	0.500	0.986	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
110	IGSF21	interactor	2	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
111	IKBKG	interactor	22	0.257	98.269	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
112	ILKAP	interactor	4	0.833	0.500	PP2C (PF00481, IPR001932): Protein phosphatase 2C
113	IQCG	interactor	2	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif TMPIT (PF07851, IPR012926): TMPIT-like protein DUF4936 (PF16290, IPR032556): Domain of unknown function (DUF4936)
114	ITLN1	interactor	2	1.000	0	Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
115	JUN	oncoprotein	32	0.217	219.403	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
116	KHSRP	interactor	4	0.833	0.200	DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain
117	KIAA1191	interactor	4	0.667	0.554	P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
118	KIF5B	interactor	6	0.400	7.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3 DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
119	KLF2	interactor	3	0.667	0.286	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
120	KLF5	suppressor	14	0.363	23.680	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
121	KRBA1	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box DUF3678 (PF12435, IPR022146): Protein of unknown function (DUF3678) KRBA1 (PF15287, IPR029317): KRBA1 family repeat
122	LMO4	interactor	3	0.667	0.667	LIM (PF00412, IPR001781, SM00132): LIM domain zf-dskA_traR (PF01258, IPR000962): Prokaryotic dksA/traR C4-type zinc finger
123	LPCAT1	interactor	3	1.000	0	JmjN (PF02375, IPR003349, SM00545): jmjN domain Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
124	LRP6	interactor	6	0.400	6.733	Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
125	LUC7L2	protein found in more fusions	10	0.361	16.038	LUC7 (PF03194, IPR004882): LUC7 N_terminus Paramyxo_ncap (PF00973, IPR002021): Paramyxovirus nucleocapsid protein Methyltransf_32 (PF13679, IPR025714): Methyltransferase domain
126	MAP2K7	interactor	12	0.394	25.305	Pkinase (PF00069, IPR000719): Protein kinase domain
127	MAP3K1	oncoprotein	13	0.348	25.008	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
128	MAP3K11	interactor	9	0.643	4.233	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH3_9 (PF14604, IPR001452): Variant SH3 domain
129	MAP3K2	protein found in more fusions	11	0.444	14.381	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain
130	MAP3K4	suppressor	5	0.500	2.333	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pkinase (PF00069, IPR000719): Protein kinase domain PLU-1 (PF08429, IPR013637): PLU-1-like protein Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
131	MAP4	oncoprotein	1	0	0	SdiA-regulated (PF06977, IPR009722): SdiA-regulated Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
132	MAPK1	oncoprotein	32	0.183	253.598	Pkinase (PF00069, IPR000719): Protein kinase domain
133	MAPT	protein found in more fusions	18	0.228	72.374	Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
134	MASP1	interactor	1	0	0	CUB (PF00431, IPR000859, SM00042): CUB domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Trypsin (PF00089, IPR001254, SM00020): Trypsin FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
135	MDM2	oncoprotein	35	0.267	223.581	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
136	MED24	interactor	8	0.500	5.541	Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
137	MGEA5	oncoprotein	4	0.500	0.773	NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
138	MICAL1	interactor	2	1.000	0	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DAO (PF01266, IPR006076): FAD dependent oxidoreductase FAD_binding_3 (PF01494, IPR002938): FAD binding domain LIM (PF00412, IPR001781, SM00132): LIM domain DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585) NAD_binding_7 (PF13241, IPR006367): Putative NAD(P)-binding
139	MID1IP1	interactor	1	0	0	Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
140	MKL1	oncoprotein	5	0.600	1.582	RPEL (PF02755, IPR004018, SM00707): RPEL repeat SAP (PF02037, IPR003034, SM00513): SAP domain Troponin-I_N (PF11636, IPR021666): Troponin I residues 1-32
141	MPP1	oncoprotein	2	1.000	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase P33MONOX (PF15302, IPR026759): P33 mono-oxygenase
142	MTF2	interactor	4	0.500	0.736	PHD (PF00628, IPR019787, SM00249): PHD-finger FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Mtf2_C (PF14061, IPR025894): Polycomb-like MTF2 factor 2 DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
143	MTOR	oncoprotein	15	0.308	36.892	DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat
144	MUC1	oncoprotein	6	0.400	2.827	SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter
145	MYC	oncoprotein	33	0.224	231.494	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
146	NAT9	interactor	4	0.667	1.000	Acetyltransf_3 (PF13302, IPR000182): Acetyltransferase (GNAT) domain
147	NBR1	oncoprotein	4	0.667	0.667	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681) N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
148	NCOA3	oncoprotein	18	0.333	48.338	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
149	NFE2L1	protein found in more fusions	7	0.533	3.119	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
150	NFE2L2	oncoprotein	8	0.357	7.957	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
151	NFE2L3	interactor	5	0.667	0.900	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
152	NFKB1	suppressor	23	0.299	80.125	Death (PF00531, IPR000488, SM00005): Death domain GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
153	NIN	oncoprotein	7	0.467	3.888	BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase bZIP_1 (PF00170, IPR004827): bZIP transcription factor DivIC (PF04977, IPR007060): Septum formation initiator DivIVA (PF05103, IPR007793): DivIVA protein DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) ZapB (PF06005, IPR009252): Cell division protein ZapB FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Rho_Binding (PF08912, IPR015008): Rho Binding TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF2205 (PF10224, IPR019357): Predicted coiled-coil protein (DUF2205) Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89 FlxA (PF14282, IPR025577): FlxA-like protein DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
154	NOTCH1	suppressor	19	0.301	61.458	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
155	NOTCH2	suppressor	5	0.500	3.900	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
156	NOTCH3	suppressor	6	0.467	4.508	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
157	NRBP1	suppressor	3	0.667	0.400	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
158	NSFL1C	interactor	7	0.333	12.667	SEP (PF08059, IPR012989, SM00553): SEP domain UBX (PF00789, IPR001012, SM00166): UBX domain UBA_4 (PF14555): UBA-like domain
159	NUB1	interactor	5	0.600	2.167	Glyphos_transf (PF04464, IPR007554): CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain TPR_12 (PF13424): Tetratricopeptide repeat HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
160	NUFIP1	interactor	5	0.500	2.686	NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395) zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
161	PDE4D	oncoprotein	7	0.533	2.997	Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase
162	PFKFB4	interactor	2	1.000	0	6PF2K (PF01591, IPR013079): 6-phosphofructo-2-kinase His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
163	PHLPP1	suppressor	4	0.667	0.508	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat PRIMA1 (PF16101): Proline-rich membrane anchor 1
164	PIAS1	suppressor	14	0.449	23.409	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
165	PIM2	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
166	PMAIP1	interactor	2	1.000	0	PMAIP1 (PF15150, IPR024140): Phorbol-12-myristate-13-acetate-induced
167	PPARGC1A	interactor	9	0.389	11.849	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
168	PPP1CA	suppressor	26	0.206	187.079	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
169	PPP1R2	interactor	5	0.500	3.389	IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
170	PPP2R5D	interactor	5	0.500	5.000	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
171	PPP3CC	suppressor	5	0.400	4.567	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
172	PRKACA	interactor	14	0.297	40.806	Pkinase (PF00069, IPR000719): Protein kinase domain
173	PRKAR1A	suppressor	11	0.422	13.874	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
174	PRKAR2A	interactor	6	0.600	2.819	RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
175	PRKCA	interactor	12	0.364	16.673	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
176	PRKCB	suppressor	8	0.667	2.971	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
177	PRKCZ	interactor	11	0.267	23.646	PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
178	PRKDC	protein found in more fusions	18	0.360	42.375	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
179	PRUNE1	interactor	2	1.000	0	DHH (PF01368, IPR001667): DHH family DHHA2 (PF02833, IPR004097, SM01131): DHHA2 domain
180	PSEN1	oncoprotein	10	0.417	13.106	Presenilin (PF01080, IPR001108): Presenilin LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
181	PTK2	protein found in more fusions	15	0.330	33.209	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
182	PTN	oncoprotein	8	0.333	12.400	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
183	PTPN1	suppressor	3	0.667	0.400	Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
184	PTPN11	suppressor	6	0.600	3.400	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
185	QARS	interactor	3	0.667	0.400	tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
186	RAI1	interactor	2	1.000	0	Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
187	RASSF1	suppressor	10	0.417	12.268	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Nore1-SARAH (PF16517, IPR011524): Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
188	RBPJ	interactor	8	0.536	6.676	BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding TIG (PF01833, IPR002909): IPT/TIG domain
189	RCAN2	interactor	2	1.000	0	Calcipressin (PF04847, IPR006931): Calcipressin
190	RELA	oncoprotein	31	0.271	169.400	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
191	RELB	oncoprotein	7	0.571	4.186	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
192	RICTOR	interactor	10	0.378	13.798	RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
193	RNF220	oncoprotein	2	1.000	0	Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat zf-ribbon_3 (PF13248): zinc-ribbon domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220
194	RPF2	interactor	3	0.667	0.667	Brix (PF04427, IPR007109, SM00879): Brix domain
195	RPL36AL	interactor	1	0	0	NOB1_Zn_bind (PF08772, IPR014881): Nin one binding (NOB1) Zn-ribbon like Ribosomal_L44 (PF00935, IPR000552): Ribosomal protein L44
196	RPLP1	interactor	6	0.700	2.500	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
197	RPS2	interactor	11	0.418	19.254	Ribosomal_S5 (PF00333, IPR013810): Ribosomal protein S5, N-terminal domain Ribosomal_S5_C (PF03719, IPR005324): Ribosomal protein S5, C-terminal domain
198	RPS6KA1	oncoprotein	13	0.244	43.395	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
199	RSU1	interactor	3	0.667	0.167	LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
200	RXRA	oncoprotein	16	0.295	40.692	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
201	SAP30BP	interactor	3	0.667	0.400	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HCNGP (PF07818, IPR012479): HCNGP-like protein Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
202	SF3B1	oncoprotein	9	0.417	10.152	Dopey_N (PF04118, IPR007249): Dopey, N-terminal HEAT (PF02985, IPR000357): HEAT repeat SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1 UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
203	SGK3	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain PX (PF00787, IPR001683, SM00312): PX domain
204	SLA	interactor	1	0	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
205	SMAD1	interactor	15	0.352	33.062	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
206	SMAD3	oncoprotein	30	0.273	167.938	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
207	SMN2	interactor	6	0.600	2.833	SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
208	SMURF2	protein found in more fusions	11	0.400	13.352	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
209	SMYD2	interactor	8	0.357	12.450	Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family) SET (PF00856, IPR001214, SM00317): SET domain TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat
210	SNAI1	oncoprotein	9	0.500	9.700	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
211	SNAI2	oncoprotein	4	0.833	0.133	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain KCNQ2_u3 (PF16642): Unstructured region on Potassium channel subunit alpha KvLQT2
212	SNCA	interactor	19	0.275	77.977	Synuclein (PF01387, IPR001058): Synuclein
213	SNCAIP	protein found in more fusions	6	0.400	4.500	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) SNCAIP_SNCA_bd (PF16700, IPR032027): Synphilin-1 alpha-Synuclein-binding domain
214	SNRNP70	interactor	12	0.470	13.464	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
215	SOX10	oncoprotein	2	1.000	0	Beta-lactamase (PF00144, IPR001466): Beta-lactamase HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
216	SP7	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
217	SPICE1	interactor	6	0.400	5.773	SPICE (PF15678, IPR031387): Centriole duplication and mitotic chromosome congression ANXA2R (PF15721, IPR031449): Annexin-2 receptor JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
218	SPTBN4	interactor	1	0	0	Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Laminin_II (PF06009, IPR010307): Laminin Domain II Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
219	SREBF1	interactor	8	0.571	2.665	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
220	STK11	suppressor	5	0.800	0.383	Pkinase (PF00069, IPR000719): Protein kinase domain
221	STRAP	protein found in more fusions	7	0.400	4.332	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
222	SYNE4	interactor	3	0.667	0.667	KASH (PF10541, IPR012315): Nuclear envelope localisation domain
223	TAZ	interactor	3	0.667	0.400	Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
224	TLE1	interactor	5	0.500	0.753	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
225	TMEM44	interactor	1	0	0	DUF2568 (PF10823, IPR021214): Protein of unknown function (DUF2568) DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
226	TONSL	interactor	4	0.667	0.333	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 (PF13424): Tetratricopeptide repeat LRR_6 (PF13516, IPR001611): Leucine Rich repeat Ank_4 (PF13637): Ankyrin repeats (many copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat Ank_5 (PF13857): Ankyrin repeats (many copies) UPF0697 (PF15117, IPR029368): Uncharacterised protein family UPF0697
227	TOP2A	oncoprotein	12	0.364	21.729	DNA_gyraseB (PF00204, IPR013506): DNA gyrase B DTHCT (PF08070, IPR012542): DTHCT (NUC029) region HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sec62 (PF03839, IPR004728): Translocation protein Sec62 Toprim (PF01751, IPR006171, SM00493): Toprim domain DNA_topoisoIV (PF00521, IPR002205, SM00434): DNA gyrase/topoisomerase IV, subunit A PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2 TOPRIM_C (PF16898, IPR031660): C-terminal associated domain of TOPRIM
228	TP53	suppressor	55	0.154	802.749	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
229	TRAF2	interactor	18	0.257	72.262	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
230	TRAK2	interactor	5	0.500	4.333	ZapB (PF06005, IPR009252): Cell division protein ZapB HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region Milton (PF12448, IPR022154): Kinesin associated protein
231	TSC1	suppressor	7	0.600	2.319	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
232	TSC2	suppressor	11	0.364	20.119	Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
233	TUBA1A	oncoprotein	12	0.333	23.495	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
234	UBE2D1	interactor	16	0.286	46.998	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
235	UBR1	interactor	4	0.500	1.917	ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
236	UBR5	protein found in more fusions	9	0.393	7.839	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain SDA1 (PF05285, IPR007949): SDA1 HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain E3_UbLigase_EDD (PF11547, IPR024725): E3 ubiquitin ligase EDD PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
237	UBXN2B	interactor	3	0.667	1.000	SEP (PF08059, IPR012989, SM00553): SEP domain UBX (PF00789, IPR001012, SM00166): UBX domain
238	UBXN6	interactor	6	0.400	6.222	PUB (PF09409, IPR018997): PUB domain UBX (PF00789, IPR001012, SM00166): UBX domain
239	UFM1	interactor	3	0.667	0.286	Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
240	UPF3A	interactor	3	0.667	0.154	Smg4_UPF3 (PF03467, IPR005120): Smg-4/UPF3 family DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
241	VIM	suppressor	13	0.364	24.463	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
242	VPS51	interactor	1	0	0	DUF1736 (PF08409, IPR013618): Domain of unknown function (DUF1736) Vps51 (PF08700): Vps51/Vps67 KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term Sec5 (PF15469): Exocyst complex component Sec5
243	VTA1	interactor	5	0.400	4.833	Vta1 (PF04652): Vta1 like
244	WSB1	interactor	2	1.000	0	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain SOCS_box (PF07525, IPR001496): SOCS box
245	XIAP	interactor	15	0.341	34.066	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
246	XPNPEP1	interactor	2	1.000	0	Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24 Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
247	XPO1	interactor	51	0.100	866.497	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
248	XPO6	interactor	6	0.400	8.000	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
249	YBX1	oncoprotein	18	0.301	50.100	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
250	YBX3	interactor	4	0.667	0.486	CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
251	ZFPM1	interactor	1	0	0	FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP) zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type GATA (PF00320, IPR000679, SM00401): GATA zinc finger zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger LELP1 (PF15042, IPR026076): Late cornified envelope-like proline-rich protein 1
252	ZHX1	interactor	9	0.571	5.989	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Homeobox (PF00046, IPR001356, SM00389): Homeobox domain Homez (PF11569, IPR024578): Homeodomain leucine-zipper encoding, Homez zf-C2H2_4 (PF13894): C2H2-type zinc finger TerB_C (PF15615, IPR028932): TerB-C domain
253	ZNF135	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
254	ZNF227	interactor	1	0	0	KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_11 (PF16622, IPR007087): zinc-finger C2H2-type
255	ZNF746	interactor	2	1.000	0	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein KRAB (PF01352, IPR001909, SM00349): KRAB box zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3669 (PF12417, IPR022137): Zinc finger protein zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain PRIMA1 (PF16101): Proline-rich membrane anchor 1

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