Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	170
The number (and %) of the onco-proteins	43 (25.29 %)
The number (and %) of the tumor suppressors	18 (10.59 %)
Total number of binary PPIs (saturation %)	745 (5.19 %)
The number (and %) of affected PPIs	170 (22.82 %)
The number of possible different fusions	22
PPI diameter	2
PPI radius	1
The average degree of PPI	8.259
Assortativity coefficient	-0.3165
The network average Clustering coefficient	0.494
The number (and %) of a zero Clustering coefficients	24 (14.12 %)
The number (and %) of a zero Betweenness Centrality	54 (31.76 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: GRK5	All fusions
Proteins found in more fusions	PSMC2 (see 1 fusions); UBE2O (see 1 fusions); GRK5 (see 3 fusions); PPFIBP1 (see 1 fusions); CUL4A (see 4 fusions); YWHAG (see 1 fusions); HSP90AA1 (see 2 fusions); KPNB1 (see 2 fusions); HSP90AB1 (see 1 fusions); RHO (see 1 fusions); CALR (see 6 fusions); ARF1 (see 2 fusions); PRKDC (see 3 fusions); RANBP9 (see 2 fusions); YWHAZ (see 1 fusions); SRSF1 (see 1 fusions); CDC37 (see 2 fusions); DDB1 (see 2 fusions); KCMF1 (see 3 fusions); NCL (see 3 fusions); JUP/MYH9 (see 1 fusions);

List of the fusions

PPI for parental proteins: GRK5

All fusions

Proteins found in more fusions

PSMC2 (see 1 fusions); UBE2O (see 1 fusions); GRK5 (see 3 fusions); PPFIBP1 (see 1 fusions); CUL4A (see 4 fusions); YWHAG (see 1 fusions); HSP90AA1 (see 2 fusions); KPNB1 (see 2 fusions); HSP90AB1 (see 1 fusions); RHO (see 1 fusions); CALR (see 6 fusions); ARF1 (see 2 fusions); PRKDC (see 3 fusions); RANBP9 (see 2 fusions); YWHAZ (see 1 fusions); SRSF1 (see 1 fusions); CDC37 (see 2 fusions); DDB1 (see 2 fusions); KCMF1 (see 3 fusions); NCL (see 3 fusions); JUP/MYH9 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GRK5	parental protein	170	0.038	23605.326	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
2	ABCF1	interactor	6	0.467	7.667	ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037) ABC_tran_Xtn (PF12848, IPR032781): ABC transporter AAA_18 (PF13238): AAA domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820) IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
3	ABI3BP	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
4	ACIN1	interactor	11	0.509	13.253	Calc_CGRP_IAPP (PF00214, IPR021116): Calcitonin / CGRP / IAPP family CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SAP (PF02037, IPR003034, SM00513): SAP domain V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family FAM27 (PF15832, IPR031672): FAM27 D and E protein family DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746) RSB_motif (PF16294, IPR032552): RNSP1-SAP18 binding (RSB) motif SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
5	AFF4	oncoprotein	1	0	0	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
6	AGTR1	suppressor	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7	AKT2	oncoprotein	3	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8	ALYREF	interactor	14	0.551	17.471	FYTT (PF07078, IPR009782): Forty-two-three protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
9	ANKFY1	interactor	1	0	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
10	AP2A1	interactor	5	0.500	4.400	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain HEAT_2 (PF13646): HEAT repeats
11	AP2A2	interactor	5	0.500	3.083	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain HEAT_2 (PF13646): HEAT repeats
12	AP3B1	interactor	4	0.667	2.000	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
13	AP3D1	interactor	3	1.000	0	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal AP3D1 (PF06375): AP-3 complex subunit delta-1
14	AP3M1	interactor	5	0.500	5.000	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
15	AP3M2	oncoprotein	1	0	0	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
16	ARF1	suppressor	5	0.500	3.000	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
17	ARF4	interactor	3	0.667	1.000	Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
18	AVPR1A	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) DUF1856 (PF08983, IPR015076, SM01164): Domain of unknown function (DUF1856) DUF5134 (PF17197): Domain of unknown function (DUF5134)
19	AVPR2	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
20	BAZ1A	interactor	2	1.000	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DDT (PF02791, IPR004022, SM00571): DDT domain GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain PHD (PF00628, IPR019787, SM00249): PHD-finger MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal Bromodomain (PF00439, IPR001487, SM00297): Bromodomain RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1 WSD (PF15613, IPR028941): Williams-Beuren syndrome DDT (WSD), D-TOX E motif
21	BCLAF1	oncoprotein	8	0.393	8.574	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) GRP (PF07172, IPR010800): Glycine rich protein family Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
22	BCR	suppressor	3	1.000	0	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain IQ_SEC7_PH (PF16453, IPR001849): PH domain
23	BMS1	interactor	2	1.000	0	AARP2CN (PF08142, IPR012948, SM00785): AARP2CN (NUC121) domain RIBIOP_C (PF04950, IPR007034): 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal E7 (PF00527, IPR000148): E7 protein, Early protein GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase NOA36 (PF06524, IPR010531): NOA36 protein
24	C1QBP	interactor	11	0.291	28.067	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
25	CABP1	interactor	1	0	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
26	CALM1	interactor	14	0.319	41.898	EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
27	CALR	oncoprotein	5	0.667	1.167	Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain
28	CAND2	interactor	1	0	0	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
29	CAV1	suppressor	9	0.361	16.675	Caveolin (PF01146, IPR001612): Caveolin
30	CDC37	protein found in more fusions	10	0.500	7.109	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
31	CFL1	interactor	6	0.467	7.167	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
32	CKAP5	interactor	2	0	0	HEAT (PF02985, IPR000357): HEAT repeat PAS_6 (PF08348, IPR013559): YheO-like PAS domain UME (PF08064, IPR012993, SM00802): UME (NUC010) domain CLASP_N (PF12348, IPR024395): CLASP N terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
33	CLIC1	interactor	2	1.000	0	GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
34	COPS2	suppressor	10	0.578	16.467	YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
35	COPS4	interactor	13	0.500	20.537	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat
36	COPS7A	interactor	8	0.964	0.286	PCI (PF01399, IPR000717, SM00088): PCI domain
37	CTDP1	interactor	3	0.667	0.667	Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme FCP1_C (PF09309, IPR015388): FCP1, C-terminal NIF (PF03031, IPR004274): NLI interacting factor-like phosphatase SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A PTCB-BRCT (PF12738, IPR001357): twin BRCT domain HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
38	CUL4A	protein found in more fusions	24	0.257	131.063	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
39	CUL4B	oncoprotein	30	0.221	240.746	Cullin (PF00888, IPR001373, SM00182): Cullin family EBP50_C (PF09007, IPR015098): EBP50, C-terminal Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain MDFI (PF15316, IPR026134): MyoD family inhibitor
40	CWC22	interactor	2	1.000	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain MA3 (PF02847, IPR003891, SM00544): MA3 domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349) SOBP (PF15279, IPR026092): Sine oculis-binding protein
41	DAXX	oncoprotein	6	0.400	5.167	Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Nop14 (PF04147, IPR007276): Nop14-like family RF-1 (PF00472, IPR000352): RF-1 domain Vpu (PF00558, IPR008187): Vpu protein DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
42	DCAF5	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2634 (PF10934, IPR020288): Protein of unknown function (DUF2634) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
43	DDB1	protein found in more fusions	16	0.410	47.686	CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
44	DDB2	suppressor	9	0.964	0.286	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
45	DDX21	interactor	12	0.333	32.402	CRT10 (PF08728, IPR014839): CRT10 DEAD (PF00270, IPR011545): DEAD/DEAH box helicase GUCT (PF08152, IPR012562): GUCT (NUC152) domain Sulfatase (PF00884, IPR000917): Sulfatase MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
46	DHX15	interactor	14	0.407	25.345	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain AAA_29 (PF13555): P-loop containing region of AAA domain
47	DHX30	interactor	6	0.600	1.397	Bombolitin (PF08096, IPR012534): Bombolitin family DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
48	DHX9	oncoprotein	20	0.279	85.348	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
49	DLST	oncoprotein	2	1.000	0	2-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)
50	DOCK4	interactor	3	0.667	0.286	DHR-2 (PF06920, IPR010703): Dock homology region 2 SH3_2 (PF07653, IPR011511): Variant SH3 domain DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
51	EEF1A1	suppressor	23	0.268	112.146	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
52	EEF2	interactor	9	0.444	13.277	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
53	EFTUD2	interactor	16	0.429	34.378	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
54	EIF2S3	interactor	1	0	0	eIF2_C (PF09173, IPR015256): Initiation factor eIF2 gamma, C terminal GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
55	EIF3A	oncoprotein	5	0.600	2.067	DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003) Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region PCI (PF01399, IPR000717, SM00088): PCI domain AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
56	EIF4A3	interactor	29	0.238	198.968	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
57	FAM120A	interactor	3	0.667	0.222	TPR_15 (PF13429): Tetratricopeptide repeat
58	FMNL2	interactor	2	1.000	0	Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
59	FRYL	oncoprotein	5	0.600	4.000	MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
60	FTSJ3	interactor	10	0.356	24.000	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase M16C_assoc (PF08367, IPR013578): Peptidase M16C associated Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
61	GEMIN4	interactor	4	0.667	0.667	NA
62	GINS4	interactor	2	1.000	0	Sld5 (PF05916, IPR021151): GINS complex protein SLD5_C (PF16922, IPR031633): DNA replication complex GINS protein SLD5 C-terminus
63	GLG1	interactor	1	0	0	BAT2_N (PF07001, IPR009738): BAT2 N-terminus Cys_rich_FGFR (PF00839, IPR001893): Cysteine rich repeat
64	GOT1L1	interactor	1	0	0	Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
65	GRWD1	interactor	6	0.667	1.533	Voldacs (PF03517): Regulator of volume decrease after cellular swelling WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
66	GYS1	interactor	1	0	0	Glycogen_syn (PF05693, IPR008631): Glycogen synthase
67	HADHB	interactor	4	0.500	2.500	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
68	HDAC6	oncoprotein	17	0.225	76.152	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
69	HNRNPU	interactor	25	0.223	177.175	CDC45 (PF02724, IPR003874): CDC45-like protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
70	HSP90AA1	oncoprotein	32	0.200	265.219	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
71	HSP90AB1	oncoprotein	19	0.288	70.710	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
72	HSPA4	interactor	16	0.258	67.489	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
73	ILF3	oncoprotein	22	0.277	106.872	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
74	JUP	suppressor	7	0.429	5.894	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
75	KANK1	suppressor	3	0.667	0.083	DegQ (PF08181, IPR012554): DegQ (SacQ) family ZapB (PF06005, IPR009252): Cell division protein ZapB Com_YlbF (PF06133, IPR010368): Control of competence regulator ComK, YlbF/YmcA Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4 KN_motif (PF12075, IPR021939): KN motif Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
76	KANK2	interactor	2	0	0	KN_motif (PF12075, IPR021939): KN motif Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
77	KCMF1	oncoprotein	4	1.000	0	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal Ntox28 (PF15605, IPR028948): Bacterial toxin 28
78	KCTD5	interactor	3	1.000	0	BTB_2 (PF02214, IPR003131): BTB/POZ domain
79	KPNB1	protein found in more fusions	7	0.533	5.000	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
80	LARP1	interactor	9	0.417	11.771	La (PF05383, IPR006630, SM00715): La domain Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
81	LRPPRC	interactor	5	0.600	1.483	DED (PF01335, IPR001875, SM00031): Death effector domain MA3 (PF02847, IPR003891, SM00544): MA3 domain PPR (PF01535, IPR002885): PPR repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal PPR_2 (PF13041, IPR002885): PPR repeat family PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain TPR_19 (PF14559): Tetratricopeptide repeat PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
82	LYAR	interactor	8	0.429	9.833	DEK_C (PF08766, IPR014876): DEK C terminal domain zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
83	LYZ	interactor	2	1.000	0	Lys (PF00062, IPR001916, SM00263): C-type lysozyme/alpha-lactalbumin family
84	MADD	suppressor	2	1.000	0	DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain HD-ZIP_N (PF04618, IPR006712): HD-ZIP protein N terminus uDENN (PF03456, IPR005113, SM00800): uDENN domain
85	MAEA	interactor	2	1.000	0	Mic1 (PF07035, IPR009755): Colon cancer-associated protein Mic1-like CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
86	MAP4	oncoprotein	2	1.000	0	SdiA-regulated (PF06977, IPR009722): SdiA-regulated Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
87	MAP4K4	interactor	2	1.000	0	CNH (PF00780, IPR001180, SM00036): CNH domain FUSC (PF04632, IPR006726): Fusaric acid resistance protein family Pkinase (PF00069, IPR000719): Protein kinase domain FAM165 (PF14981, IPR028023): FAM165 family SOBP (PF15279, IPR026092): Sine oculis-binding protein FAM60A (PF15396, IPR026065): Protein Family FAM60A
88	MAT2A	suppressor	3	1.000	0	S-AdoMet_synt_C (PF02773, IPR022630): S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
89	MMS19	interactor	7	0.333	14.000	DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
90	MOV10	interactor	24	0.130	136.221	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
91	MRPS27	interactor	7	0.429	3.990	MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
92	MRTO4	interactor	5	0.700	2.000	Glu_syn_central (PF04898, IPR006982): Glutamate synthase central domain Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
93	MYBBP1A	suppressor	8	0.500	7.900	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
94	MYCN	oncoprotein	1	0	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
95	MYH10	interactor	7	0.476	5.771	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
96	MYH9	suppressor	16	0.283	58.146	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
97	MYO1C	interactor	12	0.303	35.752	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
98	MYO9B	interactor	2	1.000	0	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
99	NAF1	interactor	5	0.400	6.000	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein Gar1 (PF04410, IPR007504): Gar1/Naf1 RNA binding region SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
100	NAT10	interactor	4	0.667	1.250	DUF1726 (PF08351, IPR013562): Domain of unknown function (DUF1726) Helicase_RecD (PF05127, IPR007807): Helicase GNAT_acetyltr_2 (PF13718, IPR000182): GNAT acetyltransferase 2 tRNA_bind_2 (PF13725, IPR027992): Possible tRNA binding domain
101	NCBP1	interactor	7	0.333	9.533	MIF4G (PF02854, IPR003890, SM00543): MIF4G domain MIF4G_like (PF09088, IPR015172): MIF4G like MIF4G_like_2 (PF09090, IPR015174): MIF4G like SlyX (PF04102, IPR007236): SlyX
102	NCL	protein found in more fusions	16	0.305	50.602	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
103	NFIB	oncoprotein	2	1.000	0	CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus MH1 (PF03165, IPR003619, SM00523): MH1 domain DUF3383 (PF11863, IPR021808): Protein of unknown function (DUF3383)
104	NOLC1	interactor	11	0.382	19.918	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
105	NR2F1	oncoprotein	2	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
106	NXF1	interactor	42	0.122	539.560	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
107	OLA1	interactor	3	0.667	0.400	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
108	OTUD4	interactor	3	0.667	1.000	OTU (PF02338, IPR003323): OTU-like cysteine protease Presenilin (PF01080, IPR001108): Presenilin Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
109	PIP	interactor	1	0	0	SVA (PF05326, IPR007990): Seminal vesicle autoantigen (SVA)
110	PIP4K2A	interactor	2	1.000	0	PIP5K (PF01504, IPR002498): Phosphatidylinositol-4-phosphate 5-Kinase
111	PNN	suppressor	7	0.667	3.769	Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
112	PNPLA6	interactor	3	0.667	0.083	Patatin (PF01734, IPR002641): Patatin-like phospholipase PT (PF04886, IPR006970): PT repeat cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
113	PPFIBP1	oncoprotein	8	0.667	1.998	DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342) SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain XkdW (PF09636, IPR019094): XkdW protein ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding DUF3837 (PF12939, IPR024212): Domain of unknown function (DUF3837)
114	PPIG	interactor	4	0.667	0.900	Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Apis_Csd (PF11671, IPR021007): Complementary sex determiner protein PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
115	PPP2R2A	interactor	3	0.667	1.000	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
116	PPP6R3	interactor	8	0.464	9.200	SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
117	PRKDC	protein found in more fusions	13	0.318	30.088	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
118	PSMC1	interactor	8	0.500	12.000	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) DivIC (PF04977, IPR007060): Septum formation initiator DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815) Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
119	PSMC2	protein found in more fusions	9	0.536	10.033	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
120	PSMC6	interactor	10	0.472	14.900	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily) TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
121	PSMD11	interactor	8	0.536	9.400	DUF247 (PF03140, IPR004158): Plant protein of unknown function PCI (PF01399, IPR000717, SM00088): PCI domain AAA_16 (PF13191): AAA ATPase domain TPR_12 (PF13424): Tetratricopeptide repeat
122	PSMD2	oncoprotein	8	0.571	8.050	PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat THAP (PF05485, IPR006612, SM00980): THAP domain HEAT_2 (PF13646): HEAT repeats
123	RAB11FIP5	interactor	3	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain RBD-FIP (PF09457, IPR019018): FIP domain
124	RANBP9	suppressor	7	0.333	8.467	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator LisH (PF08513, IPR013720, SM00667): LisH SPRY (PF00622, IPR003877, SM00449): SPRY domain CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
125	RBMS1	interactor	1	0	0	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
126	RBX1	oncoprotein	11	0.600	10.017	zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
127	RCVRN	interactor	2	1.000	0	CytochromB561_N (PF09786, IPR019176): Cytochrome B561, N terminal
128	RHO	protein found in more fusions	3	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) Rhodopsin_N (PF10413, IPR019477): Amino terminal of the G-protein receptor rhodopsin
129	RPL3	interactor	12	0.500	16.527	Ribosomal_L3 (PF00297, IPR000597): Ribosomal protein L3
130	RPL4	interactor	14	0.407	31.863	Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family Ribos_L4_asso_C (PF14374, IPR025755): 60S ribosomal protein L4 C-terminal domain
131	RUVBL1	oncoprotein	11	0.289	24.467	TIP49 (PF06068, IPR010339): TIP49 C-terminus
132	SAP18	interactor	11	0.400	20.093	SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
133	SIN3A	oncoprotein	8	0.536	8.756	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
134	SKIV2L2	interactor	8	0.393	12.102	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
135	SKP1	oncoprotein	8	0.429	11.900	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
136	SMARCA1	interactor	3	0.667	1.000	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain HAND (PF09110, IPR015194): HAND SLIDE (PF09111, IPR015195): SLIDE SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DBINO (PF13892, IPR020838): DNA-binding domain
137	SNCA	interactor	18	0.243	72.180	Synuclein (PF01387, IPR001058): Synuclein
138	SNCB	interactor	2	1.000	0	Synuclein (PF01387, IPR001058): Synuclein
139	SNCG	oncoprotein	3	0.667	0.500	Synuclein (PF01387, IPR001058): Synuclein
140	SPATA31A7	interactor	1	0	0	FAM75 (PF14650): FAM75 family DUF4599 (PF15371, IPR027970): Domain of unknown function (DUF4599)
141	SPIN1	interactor	3	0.667	0.333	Spin-Ssty (PF02513, IPR003671): Spin/Ssty Family
142	SPIN3	interactor	1	0	0	Spin-Ssty (PF02513, IPR003671): Spin/Ssty Family
143	SPTAN1	oncoprotein	8	0.536	5.156	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
144	SPTBN1	suppressor	8	0.500	5.477	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Spectrin (PF00435, IPR002017): Spectrin repeat PH_9 (PF15410): Pleckstrin homology domain
145	SRPK1	interactor	13	0.359	31.652	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
146	SRRM1	interactor	15	0.438	30.657	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Hepatitis_core (PF00906, IPR002006): Hepatitis core antigen MAP65_ASE1 (PF03999, IPR007145): Microtubule associated protein (MAP65/ASE1 family) PWI (PF01480, IPR002483, SM00311): PWI domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
147	SRRM2	interactor	20	0.358	70.856	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
148	SRSF1	protein found in more fusions	16	0.448	24.819	Corona_nucleoca (PF00937, IPR001218): Coronavirus nucleocapsid protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
149	STK38	interactor	8	0.381	7.819	MEKHLA (PF08670, IPR013978): MEKHLA domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
150	TAB1	interactor	6	0.400	5.167	PP2C (PF00481, IPR001932): Protein phosphatase 2C
151	TACR1	interactor	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
152	TBL2	suppressor	1	0	0	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat FdsD (PF11390, IPR021074): NADH-dependant formate dehydrogenase delta subunit FdsD
153	TBXA2R	interactor	3	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
154	TCOF1	interactor	1	0	0	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755) Gal-3-0_sulfotr (PF06990, IPR009729): Galactose-3-O-sulfotransferase Treacle (PF03546, IPR003993): Treacher Collins syndrome protein Treacle IMUP (PF15761, IPR026621): Immortalisation up-regulated protein AP3D1 (PF06375): AP-3 complex subunit delta-1
155	TNFAIP8L1	oncoprotein	1	0	0	DUF758 (PF05527, IPR008477): Domain of unknown function (DUF758)
156	TOR4A	interactor	1	0	0	Torsin (PF06309, IPR010448): Torsin AAA_22 (PF13401, IPR003593): AAA domain
157	TUFM	interactor	8	0.393	14.833	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
158	U2SURP	interactor	2	1.000	0	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain CTD_bind (PF04818, IPR006903): RNA polymerase II-binding domain. RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spore_III_AB (PF09548, IPR014198): Stage III sporulation protein AB (spore_III_AB) Surp (PF01805, IPR000061, SM00648): Surp module CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3 FAM176 (PF14851): FAM176 family TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2 DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
159	UBE2O	protein found in more fusions	4	0.667	0.500	BUD22 (PF09073, IPR015158): BUD22 UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
160	UBTF	interactor	5	0.500	4.667	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HMG_box_2 (PF09011, IPR009071): HMG-box domain HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473) HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
161	USP15	oncoprotein	5	0.667	1.400	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase DUSP (PF06337, IPR006615, SM00695): DUSP domain Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
162	USP47	interactor	3	0.667	0.333	Sad1_UNC (PF07738, IPR012919): Sad1 / UNC-like C-terminal UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
163	USP9X	interactor	7	0.333	10.900	DUF1722 (PF08349, IPR013560): Protein of unknown function (DUF1722) UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Utp13 (PF08625, IPR013934): Utp13 specific WD40 associated domain
164	WDR12	interactor	6	0.600	3.000	NLE (PF08154, IPR012972): NLE (NUC135) domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
165	WDR82	oncoprotein	4	0.667	0.786	MinC_C (PF03775, IPR005526): Septum formation inhibitor MinC, C-terminal domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
166	XRCC5	suppressor	11	0.311	24.367	Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
167	YWHAB	interactor	14	0.319	41.705	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
168	YWHAG	protein found in more fusions	17	0.300	61.719	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
169	YWHAQ	interactor	21	0.210	100.056	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
170	YWHAZ	protein found in more fusions	19	0.242	96.484	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

Fusion ID: Protein names:	GRK5
Level of PPIs:	or Upload text file:	Update repository

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors