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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GRAMD3 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)23
The number (and %) of the onco-proteins3 (13.04 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)32 (12.65 %)
The number (and %) of affected PPIs23 (71.88 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.435
Assortativity coefficient-0.6084
The network average Clustering coefficient0.308
The number (and %) of a zero Clustering coefficients14 (60.87 %)
The number (and %) of a zero Betweenness Centrality20 (86.96 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GRAMD2B All fusions
Proteins found in more fusions GRAMD3 (see 4 fusions); TXLNA (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GRAMD3parental protein230.026443.000GRAM (PF02893, IPR004182, SM00568): GRAM domain
7TM_GPCR_Srd (PF10317, IPR019421): Serpentine type 7TM GPCR chemoreceptor Srd
2 ABOinteractor100Glyco_transf_6 (PF03414, IPR005076): Glycosyltransferase family 6
3 BNIP1interactor100DUF1537 (PF07005, IPR010737): Putative sugar-binding N-terminal domain
Sec20 (PF03908, IPR005606): Sec20
4 CASC4interactor21.0000Vma12 (PF11712, IPR021013): Endoplasmic reticulum-based factor for assembly of V-ATPase
FAM76 (PF16046, IPR032017): FAM76 protein
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
5 DDRGK1interactor100Sec62 (PF03839, IPR004728): Translocation protein Sec62
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
6 EFCAB14interactor21.0000Choline_kin_N (PF04428, IPR007521): Choline kinase N terminus
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
SlyX (PF04102, IPR007236): SlyX
TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
7 ELAVL1oncoprotein60.4006.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 EXD2interactor100DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
RRXRR (PF14239, IPR025938): RRXRR protein
9 FRMD8oncoprotein21.0000FERM_M (PF00373, IPR019748): FERM central domain
10 GIMAP5interactor100AIG1 (PF04548, IPR006703): AIG1 family
KapB (PF08810, IPR014916): Kinase associated protein B
11 GOLM1interactor100DUF148 (PF02520, IPR003677): Domain of unknown function DUF148
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
GreA_GreB_N (PF03449, IPR022691): Transcription elongation factor, N-terminal
12 GRAMD1Ainteractor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
ORC6 (PF05460, IPR008721): Origin recognition complex subunit 6 (ORC6)
DUF4782 (PF16016, IPR031968): Domain of unknown function (DUF4782)
13 GRAMD1Binteractor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
Presenilin (PF01080, IPR001108): Presenilin
DUF4782 (PF16016, IPR031968): Domain of unknown function (DUF4782)
14 GRAMD1Cinteractor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
TarH (PF02203, IPR003122, SM00319): Tar ligand binding domain homologue
DUF4782 (PF16016, IPR031968): Domain of unknown function (DUF4782)
15 HOMER1interactor100WH1 (PF00568, IPR000697, SM00461): WH1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
16 MARCH5interactor200DUF2517 (PF10725, IPR019663): Protein of unknown function (DUF2517)
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
17 MORF4L2interactor21.0000MRG (PF05712, IPR026541): MRG
18 NAPRTinteractor100NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
19 PAEPinteractor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
20 TXLNAprotein found in more fusions40.6671.000Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
21 TXLNGinteractor21.0000FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
22 TXNDC15interactor100Thioredoxin (PF00085, IPR013766): Thioredoxin
23 YEATS4interactor21.0000YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA

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