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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GORASP1 (from a repository: Tue Feb 21 10:58:58 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins2 (10.00 %)
The number (and %) of the tumor suppressors1 (5.00 %)
Total number of binary PPIs (saturation %)38 (20.00 %)
The number (and %) of affected PPIs20 (52.63 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI3.300
Assortativity coefficient-0.5108
The network average Clustering coefficient0.592
The number (and %) of a zero Clustering coefficients5 (25.00 %)
The number (and %) of a zero Betweenness Centrality14 (70.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: GORASP1 All fusions
: BP260684;
Proteins found in more fusions GORASP1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GORASP1parental protein200.082280.000GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
2 AGPSinteractor100FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
3 CASP3interactor31.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
4 CDK2suppressor40.6671.000Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
5 FBXW8interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 GOLGA2interactor90.25027.000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
7 HIPK3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
8 LONRF1interactor200LON_substr_bdg (PF02190, IPR003111, SM00464): ATP-dependent protease La (LON) substrate-binding domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
DZR (PF12773, IPR025874): Double zinc ribbon
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
TPR_19 (PF14559): Tetratricopeptide repeat
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
9 MAPK6oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
10 PRKD2interactor21.0000ABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
11 SCRN1interactor100AAT (PF03417, IPR005079): Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Peptidase_C69 (PF03577, IPR005322): Peptidase family C69
12 STK25interactor21.0000DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
13 STX12interactor31.0000PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
SNARE (PF05739, IPR000727, SM00397): SNARE domain
DUF2776 (PF10951, IPR021240): Protein of unknown function (DUF2776)
Syntaxin_2 (PF14523): Syntaxin-like protein
14 STX7interactor40.6672.000SNARE (PF05739, IPR000727, SM00397): SNARE domain
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
Syntaxin_2 (PF14523): Syntaxin-like protein
15 TEX35interactor21.0000Tsc35 (PF15079, IPR027874): Testis-specific protein 35
16 TGFAoncoprotein100EGF (PF00008, IPR000742, SM00181): EGF-like domain
Lysis_col (PF02402, IPR003059): Lysis protein
TMEM154 (PF15102, IPR028064): TMEM154 protein family
17 TMED2interactor30.6671.000EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
18 TMED3interactor21.0000EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
19 XPO1interactor40.5003.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
20 YIPF3interactor21.0000Yip1 (PF04893, IPR006977): Yip1 domain
DUF4133 (PF13571, IPR025407): Domain of unknown function (DUF4133)

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CASP3interactorPeptidase_C14 (PF00656, IPR011600): Caspase domainBP260684
2 GORASP1parental proteinGRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domainBP260684
3 HIPK3interactorPkinase (PF00069, IPR000719): Protein kinase domainBP260684
4 MAPK6oncoproteinPkinase (PF00069, IPR000719): Protein kinase domainBP260684
5 TMED2interactorEMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLDBP260684
6 TMED3interactorEMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLDBP260684

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