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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)81
The number (and %) of the onco-proteins15 (18.52 %)
The number (and %) of the tumor suppressors8 (9.88 %)
Total number of binary PPIs (saturation %)135 (4.17 %)
The number (and %) of affected PPIs81 (60.00 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.765
Assortativity coefficient-0.5382
The network average Clustering coefficient0.280
The number (and %) of a zero Clustering coefficients51 (62.96 %)
The number (and %) of a zero Betweenness Centrality65 (80.25 %)


List of the fusions

Proteins found in more fusions ARIH1 (see 4 fusions); HSF1 (see 3 fusions); CLCN3 (see 2 fusions); GOPC (see 2 fusions); SSNA1 (see 1 fusions); CBS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 GOPCparental protein810.0106210.500DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
2 ADRA1Dinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 AKIRIN1interactor100AKNA (PF12443, IPR022150): AT-hook-containing transcription factor
4 APBB2interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
5 ARIH1protein found in more fusions50.6671.333CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
6 ASIC3interactor100ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
7 BATFoncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 BECN1suppressor200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
9 BTF3L4interactor40.8330.500NAC (PF01849, IPR002715): NAC domain
10 BTRConcoprotein70.3339.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
11 C17orf67interactor100DUF4543 (PF15076, IPR027870): Domain of unknown function (DUF4543)
12 CACNG2interactor100CD20 (PF04103, IPR007237): CD20-like family
PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
13 CBSprotein found in more fusions41.0000CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
14 CCDC102Binteractor200Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
15 CCDC151interactor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
DUF2721 (PF11026, IPR021279): Protein of unknown function (DUF2721)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
16 CCDC43interactor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF2247 (PF10004, IPR016630): Uncharacterized protein conserved in bacteria (DUF2247)
17 CD300Cinteractor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
18 CDKN2Csuppressor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
19 CEP170interactor30.6671.000FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
20 CERCAMinteractor100Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
21 CFTRsuppressor50.5003.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
22 CLASP2interactor30.6670.667HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
23 CLCN3protein found in more fusions31.0000CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
24 COPZ1interactor200Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
25 CRYABoncoprotein200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 CSPG5interactor100Chon_Sulph_att (PF06566, IPR010555): Chondroitin sulphate attachment domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
Neural_ProG_Cyt (PF06567, IPR009505): Neural chondroitin sulphate proteoglycan cytoplasmic domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
27 CYYR1interactor100CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
28 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
29 DPYDinteractor100DHO_dh (PF01180, IPR012135): Dihydroorotate dehydrogenase
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_20 (PF14691, IPR028261): Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
Fer4_21 (PF14697): 4Fe-4S dicluster domain
30 DR1interactor50.7002.167CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
31 EVI2Ainteractor100EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
32 FAM90A1interactor100zf-CCHC_6 (PF15288): Zinc knuckle
33 FAM9Ainteractor100Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
GRP (PF07172, IPR010800): Glycine rich protein family
UPF0565 (PF10561, IPR018881): Uncharacterised protein family UPF0565
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
34 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
35 FOSL2oncoprotein21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
36 FYCO1interactor21.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RUN (PF02759, IPR004012, SM00593): RUN domain
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
37 GRID2interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
38 HCKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
39 HSF1protein found in more fusions70.5335.667DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
40 IGHG3oncoprotein100Opy2 (PF09463, IPR018571): Opy2 protein
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
41 JUNoncoprotein50.5003.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
42 KIAA0753interactor21.0000MNR (PF15718, IPR031447): Protein moonraker
43 KPNA1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
44 LCLAT1interactor100Peptidase_U4 (PF03419, IPR005081): Sporulation factor SpoIIGA
Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
45 LRSAM1interactor50.8330.667Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46 MARCH2interactor21.0000Vpu (PF00558, IPR008187): Vpu protein
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
47 MORN4interactor21.0000MORN (PF02493, IPR003409, SM00698): MORN repeat
48 MOV10interactor40.5002.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
49 MRPL1interactor21.0000CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
50 MUM1interactor100PWWP (PF00855, IPR000313, SM00293): PWWP domain
51 MYLKinteractor100Amelogenin (PF02948, IPR004116, SM00818): Amelogenin
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
52 MYOCDinteractor100BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
IncA (PF04156, IPR007285): IncA protein
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
53 NUP62interactor40.6671.000Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
54 NXF1interactor60.4005.667NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
55 PARK7suppressor31.0000DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
56 PID1interactor100PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
57 PPP2R5Dinteractor100B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
58 RELAoncoprotein50.5003.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
59 RHOQinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
60 RNF183interactor100zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
61 RNF220oncoprotein100Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
zf-ribbon_3 (PF13248): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220
62 RPL13AP17interactor100NA
63 SEMA4Ginteractor100PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
64 SLC25A18interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
65 SPATA8interactor100NA
66 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
67 SSTR3interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
68 SSTR5interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
69 STARD3oncoprotein100START (PF01852, IPR002913, SM00234): START domain
MENTAL (PF10457, IPR019498): Cholesterol-capturing domain
70 TCF4suppressor50.4006.000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
71 TGFBR2suppressor100ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
72 TGOLN2interactor100MSA_2 (PF00985, IPR001136): Merozoite Surface Antigen 2 (MSA-2) family
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7
73 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
74 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
75 VIMsuppressor200Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
76 VTNinteractor100Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
77 ZBTB49interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
78 ZNF564interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
KRAB (PF01352, IPR001909, SM00349): KRAB box
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
79 ZNF581interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
80 ZNF587interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
81 ZSCAN1interactor200SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

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