Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GOPC (from a repository: Sat Nov 12 09:32:47 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)81
The number (and %) of the onco-proteins15 (18.52 %)
The number (and %) of the tumor suppressors8 (9.88 %)
Total number of binary PPIs (saturation %)135 (4.17 %)
The number (and %) of affected PPIs81 (60.00 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.765
Assortativity coefficient-0.5382
The network average Clustering coefficient0.280
The number (and %) of a zero Clustering coefficients51 (62.96 %)
The number (and %) of a zero Betweenness Centrality65 (80.25 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions ARIH1 (see 4 fusions); HSF1 (see 3 fusions); CLCN3 (see 2 fusions); GOPC (see 2 fusions); SSNA1 (see 1 fusions); CBS (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GOPCparental protein810.0106210.500DUF903 (PF06004, IPR010305): Bacterial protein of unknown function (DUF903)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF3209 (PF11483, IPR021577): Protein of unknown function (DUF3209)
2 ADRA1Dinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
3 AKIRIN1interactor100AKNA (PF12443, IPR022150): AT-hook-containing transcription factor
4 APBB2interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
5 ARIH1protein found in more fusions50.6671.333CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Med14 (PF08638, IPR013947): Mediator complex subunit MED14
zinc_ribbon_2 (PF13240, IPR026870): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
6 ASIC3interactor100ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
7 BATFoncoprotein31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
8 BECN1suppressor200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
9 BTF3L4interactor40.8330.500NAC (PF01849, IPR002715): NAC domain
10 BTRConcoprotein70.3339.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
11 C17orf67interactor100DUF4543 (PF15076, IPR027870): Domain of unknown function (DUF4543)
12 CACNG2interactor100CD20 (PF04103, IPR007237): CD20-like family
PMP22_Claudin (PF00822, IPR004031): PMP-22/EMP/MP20/Claudin family
13 CBSprotein found in more fusions41.0000CBS (PF00571, IPR000644, SM00116): CBS domain
DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414)
PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
14 CCDC102Binteractor200Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
15 CCDC151interactor100DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
DUF2721 (PF11026, IPR021279): Protein of unknown function (DUF2721)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
16 CCDC43interactor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
DUF2247 (PF10004, IPR016630): Uncharacterized protein conserved in bacteria (DUF2247)
17 CD300Cinteractor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
18 CDKN2Csuppressor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
19 CEP170interactor30.6671.000FHA (PF00498, IPR000253, SM00240): FHA domain
DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254)
CEP170_C (PF15308, IPR029300): CEP170 C-terminus
20 CERCAMinteractor100Glyco_transf_25 (PF01755, IPR002654): Glycosyltransferase family 25 (LPS biosynthesis protein)
Glyco_tranf_2_4 (PF13704): Glycosyl transferase family 2
21 CFTRsuppressor50.5003.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
22 CLASP2interactor30.6670.667HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
23 CLCN3protein found in more fusions31.0000CBS (PF00571, IPR000644, SM00116): CBS domain
Voltage_CLC (PF00654, IPR001807): Voltage gated chloride channel
24 COPZ1interactor200Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
25 CRYABoncoprotein200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 CSPG5interactor100Chon_Sulph_att (PF06566, IPR010555): Chondroitin sulphate attachment domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
Neural_ProG_Cyt (PF06567, IPR009505): Neural chondroitin sulphate proteoglycan cytoplasmic domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
27 CYYR1interactor100CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
28 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
29 DPYDinteractor100DHO_dh (PF01180, IPR012135): Dihydroorotate dehydrogenase
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_20 (PF14691, IPR028261): Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster
Fer4_21 (PF14697): 4Fe-4S dicluster domain
30 DR1interactor50.7002.167CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
SLED (PF12140, IPR021987): SLED domain
31 EVI2Ainteractor100EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
32 FAM90A1interactor100zf-CCHC_6 (PF15288): Zinc knuckle
33 FAM9Ainteractor100Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
GRP (PF07172, IPR010800): Glycine rich protein family
UPF0565 (PF10561, IPR018881): Uncharacterised protein family UPF0565
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
34 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
35 FOSL2oncoprotein21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
36 FYCO1interactor21.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RUN (PF02759, IPR004012, SM00593): RUN domain
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
37 GRID2interactor100ANF_receptor (PF01094, IPR001828): Receptor family ligand binding region
Lig_chan (PF00060, IPR001320): Ligand-gated ion channel
Lig_chan-Glu_bd (PF10613, IPR019594, SM00918): Ligated ion channel L-glutamate- and glycine-binding site
38 HCKoncoprotein100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
39 HSF1protein found in more fusions70.5335.667DUF247 (PF03140, IPR004158): Plant protein of unknown function
Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor
HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding
40 IGHG3oncoprotein100Opy2 (PF09463, IPR018571): Opy2 protein
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
41 JUNoncoprotein50.5003.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
42 KIAA0753interactor21.0000MNR (PF15718, IPR031447): Protein moonraker
43 KPNA1interactor21.0000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
44 LCLAT1interactor100Peptidase_U4 (PF03419, IPR005081): Sporulation factor SpoIIGA
Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase
Acyltransf_C (PF16076, IPR032098): Acyltransferase C-terminus
45 LRSAM1interactor50.8330.667Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
46 MARCH2interactor21.0000Vpu (PF00558, IPR008187): Vpu protein
RINGv (PF12906, IPR011016, SM00744): RING-variant domain
47 MORN4interactor21.0000MORN (PF02493, IPR003409, SM00698): MORN repeat
48 MOV10interactor40.5002.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
49 MRPL1interactor21.0000CUB_2 (PF02408, IPR003366): CUB-like domain
Ribosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
50 MUM1interactor100PWWP (PF00855, IPR000313, SM00293): PWWP domain
51 MYLKinteractor100Amelogenin (PF02948, IPR004116, SM00818): Amelogenin
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
52 MYOCDinteractor100BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
IncA (PF04156, IPR007285): IncA protein
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SAP (PF02037, IPR003034, SM00513): SAP domain
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
53 NUP62interactor40.6671.000Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
54 NXF1interactor60.4005.667NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
55 PARK7suppressor31.0000DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
56 PID1interactor100PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
57 PPP2R5Dinteractor100B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
58 RELAoncoprotein50.5003.000DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
59 RHOQinteractor100Ras (PF00071, IPR001806, SM00173): Ras family
60 RNF183interactor100zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
61 RNF220oncoprotein100Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
zf-ribbon_3 (PF13248): zinc-ribbon domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RNF220 (PF15926, IPR031824): E3 ubiquitin-protein ligase RNF220
62 RPL13AP17interactor100NA
63 SEMA4Ginteractor100PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
Trp_oprn_chp (PF09534, IPR019051): Tryptophan-associated transmembrane protein (Trp_oprn_chp)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
64 SLC25A18interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
65 SPATA8interactor100NA
66 SSNA1protein found in more fusions200APG6 (PF04111, IPR007243): Autophagy protein Apg6
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
67 SSTR3interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
68 SSTR5interactor2007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
69 STARD3oncoprotein100START (PF01852, IPR002913, SM00234): START domain
MENTAL (PF10457, IPR019498): Cholesterol-capturing domain
70 TCF4suppressor50.4006.000CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
71 TGFBR2suppressor100ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
72 TGOLN2interactor100MSA_2 (PF00985, IPR001136): Merozoite Surface Antigen 2 (MSA-2) family
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
TUTF7_u4 (PF16631): Unstructured region 4 on terminal uridylyltransferase 7
73 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
74 TMEM216interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
75 VIMsuppressor200Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
76 VTNinteractor100Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
Somatomedin_B (PF01033, IPR001212, SM00201): Somatomedin B domain
77 ZBTB49interactor100BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PyrI_C (PF02748, IPR020542): Aspartate carbamoyltransferase regulatory chain, metal binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
78 ZNF564interactor100FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
KRAB (PF01352, IPR001909, SM00349): KRAB box
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
79 ZNF581interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
80 ZNF587interactor21.0000KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
81 ZSCAN1interactor200SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
Tautomerase_2 (PF14552, IPR004370): Tautomerase enzyme

B a c k    t o    T o p ⇑