Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GNAZ (from a repository: Sat Jul 13 21:35:50 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins6 (20.69 %)
The number (and %) of the tumor suppressors1 (3.45 %)
Total number of binary PPIs (saturation %)39 (9.61 %)
The number (and %) of affected PPIs29 (74.36 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.345
Assortativity coefficient-0.4467
The network average Clustering coefficient0.282
The number (and %) of a zero Clustering coefficients19 (65.52 %)
The number (and %) of a zero Betweenness Centrality26 (89.66 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GNAZ All fusions
Proteins found in more fusions APP (see 5 fusions); GNAZ (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GNAZparental protein290.016740.000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
2 ABCE1interactor200ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 APOL2interactor100ApoL (PF05461, IPR008405): Apolipoprotein L
4 APPprotein found in more fusions31.0000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
5 ATP6V0A1interactor40.5003.000V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
6 CCNL2interactor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
7 DAAM1interactor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Phage_GPO (PF05929, IPR009228): Phage capsid scaffolding protein (GPO) serine peptidase
8 DCAF10interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9 ELAVL1oncoprotein200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
10 EPHA4interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
SusE (PF14292, IPR025970): SusE outer membrane protein
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
11 EYA2interactor100Hydrolase (PF00702, IPR023214): haloacid dehalogenase-like hydrolase
12 FAM171A2interactor100UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
13 FYTTD1interactor31.0000FYTT (PF07078, IPR009782): Forty-two-three protein
14 GLMPinteractor100NCU-G1 (PF15065, IPR029382): Lysosomal transcription factor, NCU-G1
15 HOXB5interactor21.0000DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
16 MTHFRoncoprotein100MTHFR (PF02219, IPR003171): Methylenetetrahydrofolate reductase
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
17 NUFIP1interactor21.0000NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
18 P2RY8oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
19 RAP1GAPsuppressor100GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
20 RAP1GDS1oncoprotein100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
21 RGS10interactor21.0000FliL (PF03748, IPR005503): Flagellar basal body-associated protein FliL
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
22 RGS19oncoprotein100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
23 RGS20interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
24 RGS7interactor100DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
25 RNF123interactor100SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
26 SLC25A41interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
27 THOC7interactor21.0000EcoEI_R_C (PF08463, IPR013670): EcoEI R protein C-terminal
THOC7 (PF05615, IPR008501): Tho complex subunit 7
UPF0193 (PF05250, IPR007914): Uncharacterised protein family (UPF0193)
28 TMEM185Ainteractor30.6671.000Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
29 TUBB8interactor100Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain

B a c k    t o    T o p ⇑