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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)69
The number (and %) of the onco-proteins18 (26.09 %)
The number (and %) of the tumor suppressors2 (2.90 %)
Total number of binary PPIs (saturation %)220 (9.38 %)
The number (and %) of affected PPIs69 (31.36 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.884
Assortativity coefficient-0.2595
The network average Clustering coefficient0.524
The number (and %) of a zero Clustering coefficients11 (15.94 %)
The number (and %) of a zero Betweenness Centrality26 (37.68 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GNAS All fusions
: BU960781; BF339151; BE171170; BQ720919;
Proteins found in more fusions OPTN (see 1 fusions); GNAS (see 5 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GNASparental protein690.0593636.749G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
2 ADCY2interactor100DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
DUF3487 (PF11990, IPR021877): Protein of unknown function (DUF3487)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
3 ADCY6interactor100DUF1053 (PF06327, IPR009398): Domain of Unknown Function (DUF1053)
HNOBA (PF07701, IPR011645): Heme NO binding associated
PRA1 (PF03208, IPR004895): PRA1 family protein
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
Guanylate_cyc (PF00211, IPR001054, SM00044): Adenylate and Guanylate cyclase catalytic domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
4 ADRB2interactor120.27331.8787tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 ARMCX3interactor100Arm_2 (PF04826, IPR006911): Armadillo-like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
6 AVPR2interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
7 AXIN1oncoprotein31.0000Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
8 C1QBPinteractor60.4675.567MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
9 CALM1interactor110.27333.000EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
10 CATsuppressor40.6670.286Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
11 CCDC8interactor90.35712.567Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
12 CDC5Linteractor70.6004.286OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
13 CHEK2oncoprotein31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
14 CPT2interactor100Carn_acyltransf (PF00755, IPR000542): Choline/Carnitine o-acyltransferase
15 CRHR1interactor21.00007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
16 DBN1oncoprotein80.6794.286Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
17 DIS3interactor31.0000RNB (PF00773, SM00955): RNB domain
rve (PF00665, IPR001584): Integrase core domain
PIN_4 (PF13638, IPR002716): PIN domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
18 DNAJC7interactor50.6002.733DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
19 EGFRoncoprotein90.39313.119Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 EIF4Hinteractor40.8330.400eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 ELMSAN1interactor21.0000ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
22 EML2interactor100CPSF_A (PF03178, IPR004871): CPSF A subunit region
HELP (PF03451, IPR005108): HELP motif
SlyX (PF04102, IPR007236): SlyX
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
KAAG1 (PF15354, IPR029407): Kidney-associated antigen 1
23 FLNAsuppressor100.51113.138CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
24 FSCN1oncoprotein41.0000Fascin (PF06268, IPR022768): Fascin domain
25 FUSoncoprotein60.6003.500Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
26 GIPC1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
27 GNA11oncoprotein50.5001.644G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
28 GNA12oncoprotein30.6671.000G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
29 GNALinteractor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
30 GNAQoncoprotein110.21835.978G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
31 GNB1interactor140.22050.352Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
32 GNB2interactor140.24247.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
33 GNB4interactor90.25012.833Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
34 GNG10interactor40.5000.644G-gamma (PF00631, IPR015898, SM00224): GGL domain
35 GNG2interactor70.5245.644G-gamma (PF00631, IPR015898, SM00224): GGL domain
SidE (PF12252, IPR021014): Dot/Icm substrate protein
36 GNG4interactor40.5000.644G-gamma (PF00631, IPR015898, SM00224): GGL domain
37 GNG5interactor40.5000.644G-gamma (PF00631, IPR015898, SM00224): GGL domain
38 HERC2interactor50.6671.333ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
39 HLA-Aoncoprotein50.6002.619DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
40 JAK3oncoprotein21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
41 LAMTOR1interactor100LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
42 MAGED2interactor60.5336.167CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27
MAGE (PF01454, IPR002190): MAGE family
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
43 MDM2oncoprotein50.5002.400Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
44 METAP2oncoprotein40.6670.952Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
45 MYH9oncoprotein90.55611.786IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
46 NTRK1oncoprotein250.167204.633I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
47 NUCB1interactor21.0000DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
48 NUCB2interactor21.0000Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
Histone_HNS (PF00816, IPR001801): H-NS histone family
Peptidase_U57 (PF05582, IPR008764): YabG peptidase U57
Put_DNA-bind_N (PF06971, IPR009718): Putative DNA-binding protein N-terminus
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
49 OCIAD1interactor50.5001.667OCIA (PF07051, IPR009764): Ovarian carcinoma immunoreactive antigen (OCIA)
50 OPTNprotein found in more fusions31.0000ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
51 PAICSinteractor60.6002.900AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
52 PANX1interactor100Innexin (PF00876, IPR000990): Innexin
Pannexin_like (PF12534, IPR021040): Pannexin-like TM region of LRRC8
53 PCK1interactor50.5004.667PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
54 PFASinteractor60.6003.500AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
55 PTGIRinteractor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
56 RGS2oncoprotein30.6670.400RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
57 RIC8Binteractor30.6670.333Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
58 RUVBL1oncoprotein60.7001.952TIP49 (PF06068, IPR010339): TIP49 C-terminus
59 SHMT2interactor50.5003.567SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
60 SLC25A12interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
61 SNX13interactor100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Nexin_C (PF08628, IPR013937): Sorting nexin C terminal
PX (PF00787, IPR001683, SM00312): PX domain
PXA (PF02194, IPR003114, SM00313): PXA domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
Swi3 (PF07962, IPR012923): Replication Fork Protection Component Swi3
DUF2314 (PF10077, IPR018756): Uncharacterized protein conserved in bacteria (DUF2314)
62 SYNPOinteractor70.5715.600Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
63 TBXA2Rinteractor80.4768.8677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
64 THOC2interactor30.6670.500Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
65 TROinteractor100MAGE (PF01454, IPR002190): MAGE family
DUF3533 (PF12051, IPR022703): Protein of unknown function (DUF3533)
AP3D1 (PF06375): AP-3 complex subunit delta-1
66 TTC1interactor50.4004.333TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
67 VIPR1interactor21.00007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
68 XPO1interactor170.17699.263CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
69 YBEYinteractor21.0000UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054

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