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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins5 (16.67 %)
The number (and %) of the tumor suppressors4 (13.33 %)
Total number of binary PPIs (saturation %)56 (12.87 %)
The number (and %) of affected PPIs28 (50.00 %)
The number of possible different fusions6
PPI diameter2
PPI radiusinf
The average degree of PPI3.133
Assortativity coefficient-0.4477
The network average Clustering coefficient0.486
The number (and %) of a zero Clustering coefficients11 (36.67 %)
The number (and %) of a zero Betweenness Centrality22 (73.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: GNA11,KCNJ13 All fusions
: AB013891; AB013889;
Proteins found in more fusions ABCE1 (see 1 fusions); ATM (see 1 fusions); PLCB1 (see 4 fusions); GNAS (see 8 fusions); SLC9A3R1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GNA11parental protein280.050679.500G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
2 KCNJ13interactor000NA
3 ABCE1protein found in more fusions40.6670.500ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
4 ATMsuppressor31.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 CCNL2interactor21.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
6 CFTRsuppressor31.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
7 CXCR5interactor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
8 EDNRAinteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
9 EDNRBsuppressor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
10 ELAVL1oncoprotein70.33310.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 FBXL18interactor100LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
12 FYTTD1interactor200FYTT (PF07078, IPR009782): Forty-two-three protein
13 GNASoncoprotein60.5004.500G-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunit
14 GNB1interactor60.4008.000Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
15 GNB2interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
16 GNB4interactor70.28614.000Spore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
17 HOXB5interactor21.0000DUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
18 MFSD13Ainteractor21.0000MFS_2 (PF13347): MFS/sugar transport protein
19 MTNR1Ainteractor30.6670.5007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
20 NUFIP1interactor100NUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
21 PAPOLAinteractor21.0000PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
PAP_RNA-bind (PF04926, IPR007010): Poly(A) polymerase predicted RNA binding domain
Macoilin (PF09726, IPR019130): Transmembrane protein
22 PLCB1oncoprotein31.0000DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3987 (PF13148, IPR025048): Protein of unknown function (DUF3987)
zf-C2H2_assoc (PF16606): Unstructured conserved, between two C2H2-type zinc-fingers
23 RGS13interactor100RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
24 RGS14interactor100GoLoco (PF02188, IPR003109, SM00390): GoLoco motif
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
RGS12_us1 (PF16613): Unstructured region of RGS12
25 RGS3oncoprotein100C2 (PF00168, IPR000008, SM00239): C2 domain
CDC45 (PF02724, IPR003874): CDC45-like protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
26 SLC25A41interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
27 SLC9A3R1suppressor40.6671.000EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
28 TBXA2Rinteractor41.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
29 TMEM185Ainteractor21.0000Tmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F protein
30 TMEM63Binteractor21.0000RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CXCR5interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)AB013889, AB013891
2 EDNRAinteractor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)AB013889, AB013891
3 EDNRBsuppressor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)AB013889, AB013891
4 FYTTD1interactorFYTT (PF07078, IPR009782): Forty-two-three proteinAB013889, AB013891
5 GNA11parental proteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunitAB013889, AB013891
6 GNASoncoproteinG-alpha (PF00503, IPR001019, SM00275): G-protein alpha subunitAB013889, AB013891
7 GNB4interactorSpore_YhcN_YlaJ (PF09580, IPR019076): Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
AB013889, AB013891
8 HOXB5interactorDUF739 (PF05339, IPR008003): Protein of unknown function (DUF739)
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
AB013889, AB013891
9 KCNJ13interactorNAAB013889, AB013891
10 MFSD13AinteractorMFS_2 (PF13347): MFS/sugar transport proteinAB013889, AB013891
11 MTNR1Ainteractor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
AB013889, AB013891
12 NUFIP1interactorNUFIP1 (PF10453, IPR019496): Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)
DUF3395 (PF11875, IPR024586): Domain of unknown function (DUF3395)
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
AB013889, AB013891
13 RGS13interactorRGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domainAB013889, AB013891
14 RGS14interactorGoLoco (PF02188, IPR003109, SM00390): GoLoco motif
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
RGS12_us1 (PF16613): Unstructured region of RGS12
AB013889, AB013891
15 RGS3oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
CDC45 (PF02724, IPR003874): CDC45-like protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
Astro_capsid_p (PF12226, IPR022027): Turkey astrovirus capsid protein
AB013889, AB013891
16 TBXA2Rinteractor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)AB013889, AB013891
17 TMEM185AinteractorTmemb_185A (PF10269, IPR019396): Transmembrane Fragile-X-F proteinAB013889, AB013891

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