Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins GFAP (from a repository: Mon Dec 5 01:22:07 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 58 The number (and %) of the onco-proteins 20 (34.48 %) The number (and %) of the tumor suppressors 7 (12.07 %) Total number of binary PPIs (saturation %) 197 (11.92 %) The number (and %) of affected PPIs 58 (29.44 %) The number of possible different fusions 13 PPI diameter 2 PPI radius 1 The average degree of PPI 5.724 Assortativity coefficient -0.2223 The network average Clustering coefficient 0.582 The number (and %) of a zero Clustering coefficients 6 (10.34 %) The number (and %) of a zero Betweenness Centrality 21 (36.21 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: GFAP	All fusions : BQ343685; CV326566; CB153203;
Proteins found in more fusions	ERBB3 (see 2 fusions); AP2M1 (see 3 fusions); APP/ALB (see 2 fusions); SHC1 (see 1 fusions); APP (see 4 fusions); AES (see 3 fusions); GRB2 (see 1 fusions); CDC37 (see 2 fusions); ERRFI1 (see 1 fusions); STAT1 (see 1 fusions); GFAP (see 3 fusions); PIAS2 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	GFAP	parental protein	58	0.068	2549.600	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
2	AES	protein found in more fusions	11	0.356	24.300	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3	AKT1	oncoprotein	10	0.444	15.233	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4	ALB	protein found in more fusions	6	0.400	8.333	Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5	ALG3	interactor	1	0	0	ALG3 (PF05208, IPR007873): ALG3 protein CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
6	AP2M1	protein found in more fusions	5	0.667	1.667	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7	APP	protein found in more fusions	15	0.231	62.067	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8	AURKB	interactor	6	0.700	1.500	Pkinase (PF00069, IPR000719): Protein kinase domain
9	BIRC2	oncoprotein	3	1.000	0	BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10	CDC37	protein found in more fusions	12	0.400	24.333	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
11	CEBPA	suppressor	3	1.000	0	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
12	CEP76	interactor	3	0.667	1.000	Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
13	CFAP206	interactor	3	1.000	0	THP2 (PF09432, IPR018557): Tho complex subunit THP2 DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
14	CRYAB	oncoprotein	4	1.000	0	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15	DNASE1L1	interactor	1	0	0	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
16	ERBB3	oncoprotein	7	0.733	1.900	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17	ERRFI1	suppressor	6	0.900	0.400	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
18	ESRRB	suppressor	6	0.733	2.400	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19	FAM50B	interactor	2	1.000	0	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
20	FBXO25	suppressor	4	0.500	2.067	Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
21	GOLGA2	interactor	8	0.286	16.733	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
22	GRAP2	interactor	2	1.000	0	NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23	GRB2	oncoprotein	16	0.295	63.933	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
24	HGS	interactor	6	0.533	5.500	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
25	HSPA5	oncoprotein	15	0.308	50.700	HSP70 (PF00012, IPR013126): Hsp70 protein
26	IKBKG	interactor	5	0.667	2.000	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
27	KIAA0408	interactor	3	0.667	0.400	IncA (PF04156, IPR007285): IncA protein DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
28	KRT13	interactor	5	0.400	4.733	Filament (PF00038, IPR001664): Intermediate filament protein FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus Keratin_2_head (PF16208, IPR032444): Keratin type II head
29	KRT15	interactor	10	0.311	24.300	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
30	LGALS14	interactor	2	1.000	0	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
31	LMO2	oncoprotein	7	0.600	5.067	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal LIM (PF00412, IPR001781, SM00132): LIM domain
32	MEN1	suppressor	2	1.000	0	Menin (PF05053, IPR007747): Menin
33	MOS	oncoprotein	5	0.400	3.133	Pkinase (PF00069, IPR000719): Protein kinase domain
34	MYO15B	interactor	2	1.000	0	FERM_M (PF00373, IPR019748): FERM central domain MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) SH3_9 (PF14604, IPR001452): Variant SH3 domain BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
35	NT5DC1	interactor	1	0	0	5_nucleotid (PF05761, IPR008380): 5' nucleotidase family
36	NXF1	interactor	8	0.381	10.900	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
37	P2RY8	oncoprotein	1	0	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
38	PDCD6IP	interactor	3	1.000	0	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
39	PDLIM1	interactor	4	0.667	1.000	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
40	PDLIM7	interactor	3	0.667	0.667	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
41	PDZK1	interactor	4	1.000	0	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
42	PIAS2	protein found in more fusions	5	0.500	2.400	SAP (PF02037, IPR003034, SM00513): SAP domain zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger PINIT (PF14324, IPR023321): PINIT domain
43	PIH1D2	interactor	2	0	0	PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
44	POM121	interactor	3	0.667	1.000	Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region POM121 (PF15229): POM121 family
45	PRKCG	interactor	3	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
46	PSEN1	oncoprotein	5	0.833	0.667	Presenilin (PF01080, IPR001108): Presenilin LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
47	PSEN2	oncoprotein	4	1.000	0	Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1) Presenilin (PF01080, IPR001108): Presenilin
48	RIBC2	interactor	3	0.667	0.400	RIB43A (PF05914, IPR008805): RIB43A
49	RORA	interactor	1	0	0	zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
50	SH3YL1	interactor	2	1.000	0	Ysc84 (PF04366, IPR007461): Las17-binding protein actin regulator SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51	SHC1	oncoprotein	11	0.400	19.400	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
52	STAT1	suppressor	3	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
53	TRIM27	oncoprotein	9	0.286	15.133	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
54	TUBGCP4	interactor	6	0.333	5.933	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
55	UBASH3B	interactor	8	0.714	3.467	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
56	UBE3A	oncoprotein	5	0.500	2.333	HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
57	VIM	suppressor	12	0.200	39.067	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
58	ZC2HC1C	interactor	3	0.667	0.333	zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type

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