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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)58
The number (and %) of the onco-proteins20 (34.48 %)
The number (and %) of the tumor suppressors7 (12.07 %)
Total number of binary PPIs (saturation %)197 (11.92 %)
The number (and %) of affected PPIs58 (29.44 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI5.724
Assortativity coefficient-0.2223
The network average Clustering coefficient0.582
The number (and %) of a zero Clustering coefficients6 (10.34 %)
The number (and %) of a zero Betweenness Centrality21 (36.21 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GFAP All fusions
: BQ343685; CV326566; CB153203;
Proteins found in more fusions ERBB3 (see 2 fusions); AP2M1 (see 3 fusions); APP/ALB (see 2 fusions); SHC1 (see 1 fusions); APP (see 4 fusions); AES (see 3 fusions); GRB2 (see 1 fusions); CDC37 (see 2 fusions); ERRFI1 (see 1 fusions); STAT1 (see 1 fusions); GFAP (see 3 fusions); PIAS2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GFAPparental protein580.0682549.600Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
2 AESprotein found in more fusions110.35624.300TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 AKT1oncoprotein100.44415.233PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
4 ALBprotein found in more fusions60.4008.333Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
5 ALG3interactor100ALG3 (PF05208, IPR007873): ALG3 protein
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
6 AP2M1protein found in more fusions50.6671.667Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
7 APPprotein found in more fusions150.23162.067APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8 AURKBinteractor60.7001.500Pkinase (PF00069, IPR000719): Protein kinase domain
9 BIRC2oncoprotein31.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
10 CDC37protein found in more fusions120.40024.333CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
11 CEBPAsuppressor31.0000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
12 CEP76interactor30.6671.000Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
CEP76-C2 (PF15627, IPR028926): CEP76 C2 domain
13 CFAP206interactor31.0000THP2 (PF09432, IPR018557): Tho complex subunit THP2
DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
14 CRYABoncoprotein41.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15 DNASE1L1interactor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
16 ERBB3oncoprotein70.7331.900Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
17 ERRFI1suppressor60.9000.400GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
18 ESRRBsuppressor60.7332.400zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 FAM50Binteractor21.0000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
XAP5 (PF04921, IPR007005): XAP5, circadian clock regulator
20 FBXO25suppressor40.5002.067Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
21 GOLGA2interactor80.28616.733ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
22 GRAP2interactor21.0000NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
SH2 (PF00017, IPR000980, SM00252): SH2 domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
23 GRB2oncoprotein160.29563.933SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
24 HGSinteractor60.5335.500FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
25 HSPA5oncoprotein150.30850.700HSP70 (PF00012, IPR013126): Hsp70 protein
26 IKBKGinteractor50.6672.000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
27 KIAA0408interactor30.6670.400IncA (PF04156, IPR007285): IncA protein
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
28 KRT13interactor50.4004.733Filament (PF00038, IPR001664): Intermediate filament protein
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
Keratin_2_head (PF16208, IPR032444): Keratin type II head
29 KRT15interactor100.31124.300Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
30 LGALS14interactor21.0000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
31 LMO2oncoprotein70.6005.067CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
LIM (PF00412, IPR001781, SM00132): LIM domain
32 MEN1suppressor21.0000Menin (PF05053, IPR007747): Menin
33 MOSoncoprotein50.4003.133Pkinase (PF00069, IPR000719): Protein kinase domain
34 MYO15Binteractor21.0000FERM_M (PF00373, IPR019748): FERM central domain
MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
35 NT5DC1interactor1005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
36 NXF1interactor80.38110.900NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
37 P2RY8oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
38 PDCD6IPinteractor31.0000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
39 PDLIM1interactor40.6671.000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
40 PDLIM7interactor30.6670.667LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
41 PDZK1interactor41.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
42 PIAS2protein found in more fusions50.5002.400SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
43 PIH1D2interactor200PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
44 POM121interactor30.6671.000Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
POM121 (PF15229): POM121 family
45 PRKCGinteractor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
46 PSEN1oncoprotein50.8330.667Presenilin (PF01080, IPR001108): Presenilin
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
47 PSEN2oncoprotein41.0000Herpes_LMP1 (PF05297, IPR007961): Herpesvirus latent membrane protein 1 (LMP1)
Presenilin (PF01080, IPR001108): Presenilin
48 RIBC2interactor30.6670.400RIB43A (PF05914, IPR008805): RIB43A
49 RORAinteractor100zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
50 SH3YL1interactor21.0000Ysc84 (PF04366, IPR007461): Las17-binding protein actin regulator
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51 SHC1oncoprotein110.40019.400PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
52 STAT1suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
53 TRIM27oncoprotein90.28615.133IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
54 TUBGCP4interactor60.3335.933Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
55 UBASH3Binteractor80.7143.467His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
56 UBE3Aoncoprotein50.5002.333HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
AZUL (PF16558, IPR032353): Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
57 VIMsuppressor120.20039.067Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
58 ZC2HC1Cinteractor30.6670.333zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type

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