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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GCLC, ATP11B (from a repository: Thu Jul 6 04:55:55 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins1 (9.09 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)12 (21.82 %)
The number (and %) of affected PPIs9 (75.00 %)
The number of possible different fusions1
PPI diameter4
PPI radius2
The average degree of PPI2.000
Assortativity coefficient-0.6397
The network average Clustering coefficient0.124
The number (and %) of a zero Clustering coefficients8 (72.73 %)
The number (and %) of a zero Betweenness Centrality8 (72.73 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: GCLC,ATP11B All fusions
: AA010005;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GCLCparental protein80.03678.000GCS (PF03074, IPR004308): Glutamate-cysteine ligase
2 ATP11Bparental protein100ATP-synt_8 (PF00895, IPR001421): ATP synthase protein 8
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
Hydrolase_6 (PF13344, IPR006357): Haloacid dehalogenase-like hydrolase
PhoLip_ATPase_N (PF16209, IPR032631): Phospholipid-translocating ATPase N-terminal
PhoLip_ATPase_C (PF16212, IPR032630): Phospholipid-translocating P-type ATPase C-terminal
3 AGLinteractor100GDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
4 CCL22interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
5 DHRS11interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
NmrA (PF05368, IPR008030): NmrA-like family
6 DPH5interactor100TP_methylase (PF00590, IPR000878): Tetrapyrrole (Corrin/Porphyrin) Methylases
7 ELAVL1oncoprotein40.33332.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
8 GCLMinteractor100Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
9 PAXIP1interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
10 PPIDinteractor100Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
11 TMEM30Ainteractor2018.000CDC50 (PF03381, IPR005045): LEM3 (ligand-effect modulator 3) family / CDC50 family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AGLinteractorGDE_C (PF06202, IPR010401): Amylo-alpha-1,6-glucosidase
hGDE_N (PF14699, IPR029436): N-terminal domain from the human glycogen debranching enzyme
hDGE_amylase (PF14701, IPR032792): Glucanotransferase of human glycogen debranching enzyme
hGDE_central (PF14702, IPR032788): Central domain of human glycogen debranching enzyme
AA010005
2 ATP11Bparental proteinATP-synt_8 (PF00895, IPR001421): ATP synthase protein 8
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
Hydrolase_6 (PF13344, IPR006357): Haloacid dehalogenase-like hydrolase
PhoLip_ATPase_N (PF16209, IPR032631): Phospholipid-translocating ATPase N-terminal
PhoLip_ATPase_C (PF16212, IPR032630): Phospholipid-translocating P-type ATPase C-terminal
AA010005
3 CCL22interactorIL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 likeAA010005
4 DHRS11interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
NmrA (PF05368, IPR008030): NmrA-like family
AA010005
5 DPH5interactorTP_methylase (PF00590, IPR000878): Tetrapyrrole (Corrin/Porphyrin) MethylasesAA010005
6 GCLCparental proteinGCS (PF03074, IPR004308): Glutamate-cysteine ligaseAA010005
7 GCLMinteractorAldo_ket_red (PF00248, IPR023210): Aldo/keto reductase familyAA010005
8 PAXIP1interactorBRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
AA010005
9 PPIDinteractorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
AA010005

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