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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GC (from a repository: Wed Nov 16 07:48:42 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins4 (36.36 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)16 (29.09 %)
The number (and %) of affected PPIs11 (68.75 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.182
Assortativity coefficient-0.5581
The network average Clustering coefficient0.246
The number (and %) of a zero Clustering coefficients7 (63.64 %)
The number (and %) of a zero Betweenness Centrality9 (81.82 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: GC All fusions
: AI174810;
Proteins found in more fusions GC (see 1 fusions); GRB2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GCparental protein110.04485.000VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
2 ACTA1interactor100Actin (PF00022, IPR004000, SM00268): Actin
3 CCND3oncoprotein100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
4 CDC73suppressor100CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
5 CUBNoncoprotein200B1 (PF02246, IPR003147): Protein L b1 domain
CUB (PF00431, IPR000859, SM00042): CUB domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
6 GRB2oncoprotein40.6671.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
7 LRIF1interactor200LRIF1 (PF15741, IPR026191): Ligand-dependent nuclear receptor-interacting factor 1
8 LRP2oncoprotein100Arylesterase (PF01731, IPR002640): Arylesterase
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Form-deh_trans (PF09163, IPR015246): Formate dehydrogenase N, transmembrane
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
9 PIK3R3interactor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
10 PPP2R2Ainteractor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Y_phosphatase2 (PF03162, IPR004861): Tyrosine phosphatase family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
11 SERF2interactor1004F5 (PF04419, IPR007513): 4F5 protein family

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 GCparental proteinVitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
AI174810

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