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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins GAS7 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins8 (36.36 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)50 (21.65 %)
The number (and %) of affected PPIs22 (44.00 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.818
Assortativity coefficient-0.4750
The network average Clustering coefficient0.538
The number (and %) of a zero Clustering coefficients6 (27.27 %)
The number (and %) of a zero Betweenness Centrality10 (45.45 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: GAS7 All fusions
: AA323217;
Proteins found in more fusions KHDRBS1 (see 1 fusions); FMNL1 (see 1 fusions); SFPQ (see 5 fusions); SF1 (see 1 fusions); GAPDH (see 2 fusions); GAS7 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 GAS7parental protein220.100357.400DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
WW (PF00397, IPR001202, SM00456): WW domain
YscO (PF07321, IPR009929): Type III secretion protein YscO
SH3_9 (PF14604, IPR001452): Variant SH3 domain
WW_FCH_linker (PF16623): Unstructured linker region between on GAS7 protein
2 ABI1oncoprotein60.8001.400Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 APBB1IPinteractor21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
MLANA (PF14991, IPR029242): Protein melan-A
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
4 ATXN1Linteractor200AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
5 CREB3L2interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
6 CYFIP1interactor50.8001.000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
7 CYFIP2interactor60.6005.000DUF1394 (PF07159, IPR009828): Protein of unknown function (DUF1394)
FragX_IP (PF05994, IPR008081): Cytoplasmic Fragile-X interacting family
zf-CW (PF07496, IPR011124): CW-type Zinc Finger
8 DIAPH1interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Drf_DAD (PF06345, IPR010465): DRF Autoregulatory Domain
Drf_FH1 (PF06346, IPR009408): Formin Homology Region 1
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
Glucan_synthase (PF02364, IPR003440): 1,3-beta-glucan synthase component
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
9 FMNL1protein found in more fusions200CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
10 GAPDHoncoprotein200Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
OstA (PF03968, IPR005653): OstA-like protein
11 HNRNPUinteractor30.6671.000CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
12 KHDRBS1protein found in more fusions40.6671.000KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
13 NCKAP1interactor50.9000.400Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
14 NCKAP1Linteractor40.8330.400Nckap1 (PF09735, IPR019137): Membrane-associated apoptosis protein
15 PACSIN1interactor60.4006.000FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
16 RPLP0interactor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_L10 (PF00466, IPR001790): Ribosomal protein L10
17 SF1protein found in more fusions31.0000UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
18 SF3A1interactor40.5003.000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Surp (PF01805, IPR000061, SM00648): Surp module
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
19 SFPQoncoprotein40.6671.000GRP (PF07172, IPR010800): Glycine rich protein family
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
20 WASoncoprotein21.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
21 WASF2oncoprotein50.9000.400RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
WH2 (PF02205, IPR003124, SM00246): WH2 motif
WASH_WAHD (PF11945, IPR021854): WAHD domain of WASH complex
22 WDYHV1interactor100Nt_Gln_amidase (PF09764, IPR023128): N-terminal glutamine amidase

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