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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins G6PD (from a repository: Sun Dec 4 13:14:53 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins18 (29.51 %)
The number (and %) of the tumor suppressors5 (8.20 %)
Total number of binary PPIs (saturation %)341 (18.63 %)
The number (and %) of affected PPIs61 (17.89 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI10.557
Assortativity coefficient-0.2580
The network average Clustering coefficient0.610
The number (and %) of a zero Clustering coefficients4 (6.56 %)
The number (and %) of a zero Betweenness Centrality14 (22.95 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: G6PD All fusions
: BM688674; BE816962; BQ352059;
Proteins found in more fusions YWHAG (see 1 fusions); BAG3 (see 4 fusions); YWHAZ (see 1 fusions); MCM2 (see 1 fusions); G6PD (see 3 fusions); HSPB1 (see 4 fusions); VCL (see 2 fusions); FN1/YWHAG (see 1 fusions); PAK2 (see 2 fusions); SLC9A3R1 (see 2 fusions); TGM2 (see 4 fusions); MYO6 (see 3 fusions); YWHAH (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 G6PDparental protein610.1481989.989G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
2 ALDH7A1interactor100.5568.220Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ARFIP1interactor21.0000Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
4 ARMT1interactor21.0000DUF89 (PF01937, IPR002791): Protein of unknown function DUF89
5 BAG3oncoprotein120.60010.562BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
6 BLMHinteractor31.0000Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
7 CA10interactor100Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
8 CAPN1interactor120.43923.125Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
9 CCT4interactor50.9000.111Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CDAoncoprotein31.0000dCMP_cyt_deam_1 (PF00383, IPR002125): Cytidine and deoxycytidylate deaminase zinc-binding region
dCMP_cyt_deam_2 (PF08211, IPR013171): Cytidine and deoxycytidylate deaminase zinc-binding region
11 CKBinteractor110.6915.956ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
12 CNDP2suppressor110.50919.117Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
13 CTR9interactor40.8330.111DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
14 DUTinteractor41.0000dUTPase (PF00692, IPR008180): dUTPase
15 EIF4Hinteractor90.5008.086eIF-4B (PF06273, IPR010433): Plant specific eukaryotic initiation factor 4B
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
16 EIF5interactor170.54426.887CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
17 ERP44interactor100.6004.980Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
18 FDPSinteractor40.8330.500polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
19 FN1oncoprotein190.52032.172fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
20 GBP2interactor60.7333.667GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
21 GLAinteractor110.40024.933Melibiase_2 (PF16499, IPR002241): Alpha galactosidase A
22 GNSinteractor60.8001.467Sulfatase (PF00884, IPR000917): Sulfatase
DUF4976 (PF16347, IPR032506): Domain of unknown function (DUF4976)
23 HARSinteractor31.0000HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
24 HSPA9oncoprotein120.6369.122HSP70 (PF00012, IPR013126): Hsp70 protein
25 HSPB1oncoprotein170.56732.409HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 IDH2oncoprotein21.0000Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
27 ISOC1interactor120.6828.083Isochorismatase (PF00857, IPR000868): Isochorismatase family
Glyco_trans_4_4 (PF13579, IPR028098): Glycosyl transferase 4-like domain
28 LDHBinteractor200.50333.670Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
29 MAT2Binteractor100.44414.103RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
30 MCM2oncoprotein240.39191.239AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
31 MYO6protein found in more fusions50.8330.667BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
32 NDRG1suppressor60.4006.900Ndr (PF03096, IPR004142): Ndr family
33 NTRK1oncoprotein320.288234.164I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 PAK2protein found in more fusions170.53325.022PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
35 PDXKoncoprotein21.0000Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase
Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family
36 PGAM1interactor21.0000His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
37 PGDoncoprotein100.55611.2716PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
38 PPATinteractor21.0000Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
39 PPP1R2interactor60.6003.889IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
40 RAD23Bsuppressor40.6672.000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
41 RPEinteractor200OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Ribul_P_3_epim (PF00834, IPR000056): Ribulose-phosphate 3 epimerase family
42 SEPHS1interactor70.5335.119AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
43 SFNsuppressor120.60010.11614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
44 SLC9A3R1suppressor120.6735.837EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
45 TANGO2interactor100TANGO2 (PF05742, IPR008551): Transport and Golgi organisation 2
46 TGM2protein found in more fusions160.55219.737Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
47 TSTA3interactor50.6003.250Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
NICE-3 (PF07406, IPR010876): NICE-3 protein
Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein
48 UBE2V1interactor70.9050.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
49 UBFD1interactor160.45836.434ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50 UFM1interactor40.5003.000Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
51 UNC13Dinteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
Membr_traf_MHD (PF10540, IPR019558): Munc13 (mammalian uncoordinated) homology domain
52 VCLoncoprotein170.61716.485Vinculin (PF01044, IPR006077): Vinculin family
53 XPO1interactor200.41174.056CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
54 YWHABinteractor150.6959.82814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
55 YWHAEoncoprotein180.62720.96214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
56 YWHAGprotein found in more fusions230.52439.40114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
57 YWHAHprotein found in more fusions190.65414.75314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
58 YWHAQinteractor240.46070.28414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
59 YWHAZprotein found in more fusions240.52247.66814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
60 ZFYVE19interactor60.6674.250Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Rpr2 (PF04032, IPR007175): RNAse P Rpr2/Rpp21/SNM1 subunit domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
61 ZNF622interactor50.5001.900S-antigen (PF05756, IPR008825): S-antigen protein
Stm1_N (PF09598, IPR019084): Stm1
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)

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