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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)17
The number (and %) of the onco-proteins5 (29.41 %)
The number (and %) of the tumor suppressors4 (23.53 %)
Total number of binary PPIs (saturation %)34 (25.00 %)
The number (and %) of affected PPIs17 (50.00 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI2.941
Assortativity coefficient-0.2729
The network average Clustering coefficient0.483
The number (and %) of a zero Clustering coefficients7 (41.18 %)
The number (and %) of a zero Betweenness Centrality14 (82.35 %)


List of the fusions

PPI for parental proteins: FOXP2 All fusions
Proteins found in more fusions FOXP2 (see 2 fusions); AES (see 3 fusions); HSP90AA1 (see 2 fusions); CTBP1 (see 2 fusions); FOXP1 (see 3 fusions); CTBP2 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 FOXP2parental protein170.075213.000Auxin_repressed (PF05564, IPR008406): Dormancy/auxin associated protein
CDC45 (PF02724, IPR003874): CDC45-like protein
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Draxin (PF15550, IPR029094): Draxin
SPATA3 (PF15662, IPR026717): Spermatogenesis-associated protein 3 family
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
2 AESprotein found in more fusions40.6671.000TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
3 CCNCsuppressor100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
4 CTBP1protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
5 CTBP2protein found in more fusions41.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
6 FAM124Ainteractor21.0000FAM124 (PF15067, IPR029380): FAM124 family
7 FOXP1suppressor70.4678.000Auxin_repressed (PF05564, IPR008406): Dormancy/auxin associated protein
DOPA_dioxygen (PF08883, IPR014980): Dopa 4,5-dioxygenase family
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
8 FOXP3suppressor31.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
9 FOXP4interactor41.0000TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
10 GATAD2Binteractor21.0000DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
DUF3619 (PF12279, IPR022064): Protein of unknown function (DUF3619)
P66_CC (PF16563, IPR032346): Coiled-coil and interaction region of P66A and P66B with MBD2
11 HSP90AA1oncoprotein200HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
12 MAPK3oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
13 PIN1suppressor100Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
14 RPIAinteractor200Rib_5-P_isom_A (PF06026, IPR004788): Ribose 5-phosphate isomerase A (phosphoriboisomerase A)
Sugar-bind (PF04198, IPR007324): Putative sugar-binding domain
15 SDCBPinteractor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
16 SP4interactor100zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Macoilin (PF09726, IPR019130): Transmembrane protein
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
17 TSACCinteractor100SSTK-IP (PF15836, IPR031679): SSTK-interacting protein, TSSK6-activating co-chaperone protein

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