1 |
FOXO1 | parental protein | 54 | 0.137 | 1666.937 | K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
2 |
AKT1 | oncoprotein | 20 | 0.450 | 45.721 | PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
3 |
AR | oncoprotein | 20 | 0.456 | 38.106 | Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
4 |
ATG7 | interactor | 3 | 1.000 | 0 | ThiF (PF00899, IPR000594): ThiF family ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus |
5 |
CCNB1 | oncoprotein | 7 | 0.667 | 2.519 | Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain |
6 |
CDKN1A | oncoprotein | 14 | 0.505 | 22.945 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor |
7 |
CEBPB | oncoprotein | 11 | 0.689 | 4.129 | RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 |
8 |
CREBBP | oncoprotein | 23 | 0.403 | 76.611 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834) |
9 |
CUX1 | oncoprotein | 4 | 0.500 | 1.100 | Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein CUT (PF02376, IPR003350, SM01109): CUT domain DegS (PF05384, IPR008595): Sensor protein DegS DivIC (PF04977, IPR007060): Septum formation initiator DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Swi5 (PF07061, IPR010760): Swi5 TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein ApoO (PF09769, IPR019166): Apolipoprotein O Homeobox (PF00046, IPR001356, SM00389): Homeobox domain RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
10 |
DLX5 | interactor | 2 | 0 | 0 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal |
11 |
DNAJC9 | interactor | 1 | 0 | 0 | DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) |
12 |
EP300 | oncoprotein | 24 | 0.379 | 89.319 | Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type |
13 |
ESR1 | oncoprotein | 21 | 0.405 | 48.834 | Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal |
14 |
FHL2 | oncoprotein | 9 | 0.857 | 0.636 | LIM (PF00412, IPR001781, SM00132): LIM domain zf-ribbon_3 (PF13248): zinc-ribbon domain |
15 |
FOXO3B | interactor | 2 | 1.000 | 0 | NA |
16 |
FOXO4 | oncoprotein | 11 | 0.545 | 14.348 | Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
17 |
FOXO6 | suppressor | 3 | 0.667 | 1.000 | CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family |
18 |
FSHR | interactor | 2 | 1.000 | 0 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
19 |
GSK3B | oncoprotein | 9 | 0.607 | 3.843 | Pkinase (PF00069, IPR000719): Protein kinase domain |
20 |
HNF4A | suppressor | 10 | 0.611 | 4.181 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
21 |
HOXA11 | interactor | 1 | 0 | 0 | DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3528 (PF12045, IPR021918): Protein of unknown function (DUF3528) |
22 |
HOXA5 | interactor | 1 | 0 | 0 | Chorion_2 (PF03964, IPR005649): Chorion family 2 Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Terminase_5 (PF06056, IPR010332): Putative ATPase subunit of terminase (gpP-like) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
23 |
HOXD13 | oncoprotein | 2 | 1.000 | 0 | Homeobox (PF00046, IPR001356, SM00389): Homeobox domain HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal |
24 |
IRF3 | suppressor | 8 | 0.667 | 1.994 | IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3 |
25 |
LRPPRC | interactor | 3 | 0.667 | 0.250 | DED (PF01335, IPR001875, SM00031): Death effector domain MA3 (PF02847, IPR003891, SM00544): MA3 domain PPR (PF01535, IPR002885): PPR repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal PPR_2 (PF13041, IPR002885): PPR repeat family PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain TPR_19 (PF14559): Tetratricopeptide repeat PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR |
26 |
MDM2 | oncoprotein | 22 | 0.333 | 81.804 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
27 |
MORF4L2 | interactor | 2 | 1.000 | 0 | MRG (PF05712, IPR026541): MRG |
28 |
MST1 | interactor | 1 | 0 | 0 | Kringle (PF00051, IPR000001): Kringle domain PAN_1 (PF00024, IPR003014): PAN domain Trypsin (PF00089, IPR001254, SM00020): Trypsin |
29 |
NCOA1 | oncoprotein | 11 | 0.644 | 5.413 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein |
30 |
NLK | protein found in more fusions | 7 | 0.733 | 1.082 | Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit |
31 |
PARP1 | suppressor | 8 | 0.810 | 1.033 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
32 |
PIK3R3 | interactor | 2 | 1.000 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
33 |
PML | oncoprotein | 10 | 0.556 | 6.444 | zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
34 |
RARA | oncoprotein | 10 | 0.667 | 3.725 | zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor |
35 |
RB1 | oncoprotein | 15 | 0.352 | 46.095 | RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592) |
36 |
RECQL | oncoprotein | 2 | 1.000 | 0 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Lipoprotein_3 (PF00938, IPR001595): Lipoprotein RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2 |
37 |
RFWD2 | suppressor | 4 | 0.667 | 0.333 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain |
38 |
SATB1 | oncoprotein | 5 | 0.600 | 1.917 | CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3 |
39 |
SATB2 | interactor | 1 | 0 | 0 | CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB |
40 |
SETD7 | protein found in more fusions | 7 | 0.800 | 0.648 | MORN (PF02493, IPR003409, SM00698): MORN repeat MORN_2 (PF07661, IPR011652): MORN repeat variant SET (PF00856, IPR001214, SM00317): SET domain |
41 |
SIRT1 | oncoprotein | 19 | 0.288 | 68.433 | DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain |
42 |
SIRT2 | suppressor | 4 | 0.667 | 0.583 | SIR2 (PF02146, IPR003000): Sir2 family RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding |
43 |
SKP2 | oncoprotein | 11 | 0.600 | 9.371 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat |
44 |
SMAD3 | oncoprotein | 19 | 0.484 | 31.220 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
45 |
SMAD4 | oncoprotein | 17 | 0.500 | 23.544 | MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain |
46 |
SMARCA4 | oncoprotein | 11 | 0.655 | 6.500 | DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box |
47 |
SNX17 | interactor | 2 | 1.000 | 0 | FERM_M (PF00373, IPR019748): FERM central domain PX (PF00787, IPR001683, SM00312): PX domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain |
48 |
STUB1 | suppressor | 8 | 0.857 | 0.550 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
49 |
TNS2 | interactor | 1 | 0 | 0 | PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) cEGF (PF12662, IPR026823): Complement Clr-like EGF-like PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
50 |
TSC2 | oncoprotein | 8 | 0.607 | 4.425 | Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 |
51 |
XPO1 | interactor | 13 | 0.269 | 36.772 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
52 |
YWHAG | protein found in more fusions | 6 | 0.700 | 0.872 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
53 |
YWHAQ | interactor | 10 | 0.400 | 16.689 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
54 |
YWHAZ | protein found in more fusions | 9 | 0.464 | 8.075 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |