Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	54
The number (and %) of the onco-proteins	30 (55.56 %)
The number (and %) of the tumor suppressors	7 (12.96 %)
Total number of binary PPIs (saturation %)	268 (18.73 %)
The number (and %) of affected PPIs	54 (20.15 %)
The number of possible different fusions	17
PPI diameter	2
PPI radius	1
The average degree of PPI	8.963
Assortativity coefficient	-0.4022
The network average Clustering coefficient	0.553
The number (and %) of a zero Clustering coefficients	7 (12.96 %)
The number (and %) of a zero Betweenness Centrality	15 (27.78 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: FOXO1	All fusions : BI495640;
Proteins found in more fusions	CREBBP (see 5 fusions); RARA/PML (see 20 fusions); SMAD4 (see 2 fusions); YWHAG (see 1 fusions); SETD7 (see 2 fusions); FOXO1 (see 1 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); STUB1 (see 1 fusions); GSK3B (see 1 fusions); NLK (see 4 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); NCOA1 (see 2 fusions); PML (see 4 fusions); SMAD3 (see 3 fusions);

List of the fusions

PPI for parental proteins: FOXO1

All fusions

: BI495640;

Proteins found in more fusions

CREBBP (see 5 fusions); RARA/PML (see 20 fusions); SMAD4 (see 2 fusions); YWHAG (see 1 fusions); SETD7 (see 2 fusions); FOXO1 (see 1 fusions); RARA (see 4 fusions); YWHAZ (see 1 fusions); STUB1 (see 1 fusions); GSK3B (see 1 fusions); NLK (see 4 fusions); PARP1 (see 1 fusions); EP300 (see 1 fusions); NCOA1 (see 2 fusions); PML (see 4 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	FOXO1	parental protein	54	0.137	1666.937	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
2	AKT1	oncoprotein	20	0.450	45.721	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3	AR	oncoprotein	20	0.456	38.106	Androgen_recep (PF02166, IPR001103): Androgen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
4	ATG7	interactor	3	1.000	0	ThiF (PF00899, IPR000594): ThiF family ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
5	CCNB1	oncoprotein	7	0.667	2.519	Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6	CDKN1A	oncoprotein	14	0.505	22.945	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
7	CEBPB	oncoprotein	11	0.689	4.129	RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
8	CREBBP	oncoprotein	23	0.403	76.611	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9	CUX1	oncoprotein	4	0.500	1.100	Baculo_p24 (PF05073, IPR007765): Baculovirus P24 capsid protein CUT (PF02376, IPR003350, SM01109): CUT domain DegS (PF05384, IPR008595): Sensor protein DegS DivIC (PF04977, IPR007060): Septum formation initiator DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein Swi5 (PF07061, IPR010760): Swi5 TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein ApoO (PF09769, IPR019166): Apolipoprotein O Homeobox (PF00046, IPR001356, SM00389): Homeobox domain RIC3 (PF15361, IPR032763): Resistance to inhibitors of cholinesterase homologue 3 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
10	DLX5	interactor	2	0	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DLL_N (PF12413, IPR022135): Homeobox protein distal-less-like N terminal
11	DNAJC9	interactor	1	0	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
12	EP300	oncoprotein	24	0.379	89.319	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
13	ESR1	oncoprotein	21	0.405	48.834	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
14	FHL2	oncoprotein	9	0.857	0.636	LIM (PF00412, IPR001781, SM00132): LIM domain zf-ribbon_3 (PF13248): zinc-ribbon domain
15	FOXO3B	interactor	2	1.000	0	NA
16	FOXO4	oncoprotein	11	0.545	14.348	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
17	FOXO6	suppressor	3	0.667	1.000	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2 FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
18	FSHR	interactor	2	1.000	0	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain GnHR_trans (PF12369, IPR024635): Gonadotropin hormone receptor transmembrane region LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_5 (PF13306, IPR026906): Leucine rich repeats (6 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
19	GSK3B	oncoprotein	9	0.607	3.843	Pkinase (PF00069, IPR000719): Protein kinase domain
20	HNF4A	suppressor	10	0.611	4.181	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
21	HOXA11	interactor	1	0	0	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3528 (PF12045, IPR021918): Protein of unknown function (DUF3528)
22	HOXA5	interactor	1	0	0	Chorion_2 (PF03964, IPR005649): Chorion family 2 Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein Terminase_5 (PF06056, IPR010332): Putative ATPase subunit of terminase (gpP-like) Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
23	HOXD13	oncoprotein	2	1.000	0	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
24	IRF3	suppressor	8	0.667	1.994	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
25	LRPPRC	interactor	3	0.667	0.250	DED (PF01335, IPR001875, SM00031): Death effector domain MA3 (PF02847, IPR003891, SM00544): MA3 domain PPR (PF01535, IPR002885): PPR repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal PPR_2 (PF13041, IPR002885): PPR repeat family PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain TPR_19 (PF14559): Tetratricopeptide repeat PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
26	MDM2	oncoprotein	22	0.333	81.804	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
27	MORF4L2	interactor	2	1.000	0	MRG (PF05712, IPR026541): MRG
28	MST1	interactor	1	0	0	Kringle (PF00051, IPR000001): Kringle domain PAN_1 (PF00024, IPR003014): PAN domain Trypsin (PF00089, IPR001254, SM00020): Trypsin
29	NCOA1	oncoprotein	11	0.644	5.413	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
30	NLK	protein found in more fusions	7	0.733	1.082	Pkinase (PF00069, IPR000719): Protein kinase domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
31	PARP1	suppressor	8	0.810	1.033	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
32	PIK3R3	interactor	2	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
33	PML	oncoprotein	10	0.556	6.444	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
34	RARA	oncoprotein	10	0.667	3.725	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
35	RB1	oncoprotein	15	0.352	46.095	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
36	RECQL	oncoprotein	2	1.000	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Lipoprotein_3 (PF00938, IPR001595): Lipoprotein RQC (PF09382, IPR018982, SM00956): RQC domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
37	RFWD2	suppressor	4	0.667	0.333	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain
38	SATB1	oncoprotein	5	0.600	1.917	CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
39	SATB2	interactor	1	0	0	CUT (PF02376, IPR003350, SM01109): CUT domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain ULD (PF16534, IPR032392): Ubiquitin-like oligomerisation domain of SATB CUTL (PF16557, IPR032355): CUT1-like DNA-binding domain of SATB
40	SETD7	protein found in more fusions	7	0.800	0.648	MORN (PF02493, IPR003409, SM00698): MORN repeat MORN_2 (PF07661, IPR011652): MORN repeat variant SET (PF00856, IPR001214, SM00317): SET domain
41	SIRT1	oncoprotein	19	0.288	68.433	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
42	SIRT2	suppressor	4	0.667	0.583	SIR2 (PF02146, IPR003000): Sir2 family RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
43	SKP2	oncoprotein	11	0.600	9.371	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
44	SMAD3	oncoprotein	19	0.484	31.220	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
45	SMAD4	oncoprotein	17	0.500	23.544	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
46	SMARCA4	oncoprotein	11	0.655	6.500	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
47	SNX17	interactor	2	1.000	0	FERM_M (PF00373, IPR019748): FERM central domain PX (PF00787, IPR001683, SM00312): PX domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
48	STUB1	suppressor	8	0.857	0.550	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
49	TNS2	interactor	1	0	0	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) cEGF (PF12662, IPR026823): Complement Clr-like EGF-like PRIMA1 (PF16101): Proline-rich membrane anchor 1
50	TSC2	oncoprotein	8	0.607	4.425	Rap_GAP (PF02145, IPR000331): Rap/ran-GAP Tuberin (PF03542, IPR018515): Tuberin DUF3384 (PF11864, IPR024584): Domain of unknown function (DUF3384) Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
51	XPO1	interactor	13	0.269	36.772	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
52	YWHAG	protein found in more fusions	6	0.700	0.872	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
53	YWHAQ	interactor	10	0.400	16.689	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
54	YWHAZ	protein found in more fusions	9	0.464	8.075	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

Fusion ID: Protein names:	FOXO1
Level of PPIs:	or Upload text file:	Update repository

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List of active interactors