Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins FOS (from a repository: Fri Nov 11 23:19:39 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 130 The number (and %) of the onco-proteins 51 (39.23 %) The number (and %) of the tumor suppressors 20 (15.38 %) Total number of binary PPIs (saturation %) 631 (7.53 %) The number (and %) of affected PPIs 130 (20.60 %) The number of possible different fusions 34 PPI diameter 2 PPI radius 1 The average degree of PPI 8.769 Assortativity coefficient -0.3103 The network average Clustering coefficient 0.560 The number (and %) of a zero Clustering coefficients 21 (16.15 %) The number (and %) of a zero Betweenness Centrality 49 (37.69 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: FOS	All fusions : BE710328; BF089597; BP215108;
Proteins found in more fusions	APP (see 4 fusions); VDR (see 2 fusions); MAPK1 (see 1 fusions); KDM2B (see 1 fusions); RPS6KA2 (see 1 fusions); NCOA1 (see 2 fusions); NCOA6 (see 1 fusions); MAPK9 (see 3 fusions); USF1 (see 3 fusions); TCL1A (see 1 fusions); EEF1D (see 3 fusions); GTF2E2 (see 2 fusions); RUNX1 (see 1 fusions); CREBBP (see 5 fusions); NFIX (see 3 fusions); ATF2/DDIT3 (see 1 fusions); NELFB (see 1 fusions); POLR2E (see 2 fusions); XBP1 (see 2 fusions); EGFR (see 2 fusions); FOS (see 4 fusions); NQO1 (see 2 fusions); CSNK2A1 (see 1 fusions); SMARCC1 (see 2 fusions); DDX17 (see 3 fusions); EP300 (see 1 fusions); TSC22D3 (see 2 fusions); PML (see 4 fusions); USF2 (see 1 fusions); PSMC5 (see 2 fusions); CLU (see 5 fusions); STAT1 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	FOS	parental protein	130	0.053	12361.493	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
2	ABL1	oncoprotein	7	0.467	4.176	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	AHCY	interactor	4	0.667	0.250	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
4	ANKHD1	interactor	1	0	0	DUF572 (PF04502, IPR007590): Family of unknown function (DUF572) Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein KH_1 (PF00013, IPR004088, SM00322): KH domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
5	ANKRD17	interactor	1	0	0	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein Mucin (PF01456, IPR000458): Mucin-like glycoprotein DUF2536 (PF10750, IPR019686): Protein of unknown function (DUF2536) KH_1 (PF00013, IPR004088, SM00322): KH domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
6	ANP32E	interactor	1	0	0	BUD22 (PF09073, IPR015158): BUD22 LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_9 (PF14580): Leucine-rich repeat
7	APP	protein found in more fusions	23	0.160	164.330	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
8	AQP1	interactor	2	0	0	MIP (PF00230, IPR000425): Major intrinsic protein
9	ARFGAP1	interactor	2	1.000	0	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
10	ARL6IP4	interactor	3	1.000	0	SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
11	ATF2	oncoprotein	25	0.362	90.688	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
12	ATF3	suppressor	20	0.462	42.315	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
13	ATF4	oncoprotein	19	0.444	43.984	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
14	ATF7	interactor	3	1.000	0	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
15	ATP5I	interactor	1	0	0	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
16	BCL3	oncoprotein	7	0.857	0.869	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
17	CABP1	interactor	1	0	0	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) EF-hand_7 (PF13499, IPR011992): EF-hand domain pair EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
18	CARM1	oncoprotein	11	0.545	10.905	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
19	CEBPA	suppressor	17	0.467	28.075	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator DUF2514 (PF10721, IPR019659): Protein of unknown function (DUF2514) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
20	CEBPE	interactor	12	0.564	12.471	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
21	CEBPG	interactor	9	0.929	0.472	bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
22	CENPO	interactor	1	0	0	CENP-O (PF09496, IPR018464): Cenp-O kinetochore centromere component Takusan (PF04822, IPR006907): Takusan MnmE_helical (PF12631, IPR025867): MnmE helical domain
23	CHEK2	suppressor	7	0.600	1.958	FHA (PF00498, IPR000253, SM00240): FHA domain Pkinase (PF00069, IPR000719): Protein kinase domain
24	CLU	suppressor	5	0.833	0.400	Clusterin (PF01093, IPR000753): Clusterin
25	COPS4	interactor	3	0.667	0.667	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) PCI (PF01399, IPR000717, SM00088): PCI domain TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat
26	CREB5	interactor	6	0.700	1.533	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Zip (PF02535, IPR003689): ZIP Zinc transporter Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
27	CREBBP	suppressor	36	0.304	206.898	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
28	CSNK2A1	oncoprotein	21	0.279	97.302	Pkinase (PF00069, IPR000719): Protein kinase domain
29	CYTH4	interactor	1	0	0	MazG (PF03819, IPR004518): MazG nucleotide pyrophosphohydrolase domain PH (PF00169, IPR001849, SM00233): PH domain Sec7 (PF01369, IPR000904, SM00222): Sec7 domain
30	DDIT3	oncoprotein	16	0.524	22.794	IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
31	DDX17	protein found in more fusions	8	0.571	2.760	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
32	DET1	interactor	3	1.000	0	Det1 (PF09737, IPR019138): De-etiolated protein 1 Det1
33	DNMT3L	interactor	11	0.618	6.285	CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
34	EEF1D	protein found in more fusions	9	0.536	9.467	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
35	EGFR	oncoprotein	12	0.273	25.944	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
36	EP300	oncoprotein	39	0.263	286.410	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
37	ESR1	suppressor	31	0.251	221.393	Oest_recep (PF02159, IPR001292): Oestrogen receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
38	ETS2	suppressor	10	0.467	15.217	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
39	FAAP100	interactor	2	1.000	0	FANCAA (PF15146, IPR029251): Fanconi anemia-associated
40	FNBP1L	interactor	1	0	0	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat DEDD_Tnp_IS110 (PF01548, IPR002525): Transposase SH3_1 (PF00018, IPR001452, SM00326): SH3 domain GTP-bdg_M (PF16360, IPR032305): GTP-binding GTPase Middle Region
41	FOSB	oncoprotein	6	0.600	1.425	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Motilin_ghrelin (PF04644, IPR006738): Motilin/ghrelin
42	GAMT	interactor	1	0	0	Methyltransf_25 (PF13649): Methyltransferase domain
43	GLB1	oncoprotein	1	0	0	Glyco_hydro_35 (PF01301, IPR001944): Glycosyl hydrolases family 35 BetaGal_dom4_5 (PF13364, IPR025300): Beta-galactosidase jelly roll domain
44	GLO1	interactor	2	1.000	0	Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
45	GNG11	interactor	1	0	0	G-gamma (PF00631, IPR015898, SM00224): GGL domain
46	GRHPR	interactor	3	0.667	1.000	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
47	GTF2E2	protein found in more fusions	7	0.800	1.300	TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain VCX_VCY (PF15231, IPR026653): Variable charge X/Y family
48	GTF2F1	interactor	9	0.583	8.019	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
49	GTF2F2	interactor	7	0.667	5.067	TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
50	HNF1A	oncoprotein	7	0.800	0.867	HNF-1_N (PF04814, IPR006899): Hepatocyte nuclear factor 1 (HNF-1), N terminus HNF-1A_C (PF04813, IPR006898): Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus HNF-1B_C (PF04812, IPR006897): Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
51	HOXD13	oncoprotein	4	0.833	0.250	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain HoxA13_N (PF12284, IPR022067): Hox protein A13 N terminal
52	HSD17B4	interactor	2	1.000	0	adh_short (PF00106, IPR002198): short chain dehydrogenase MaoC_dehydratas (PF01575, IPR002539): MaoC like domain SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family MaoC_dehydrat_N (PF13452): N-terminal half of MaoC dehydratase
53	HSPA1A	interactor	3	0.667	0.333	HSP70 (PF00012, IPR013126): Hsp70 protein
54	JUN	oncoprotein	61	0.164	1091.940	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
55	JUNB	oncoprotein	12	0.424	20.958	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
56	JUND	oncoprotein	12	0.455	16.026	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
57	KBTBD7	interactor	1	0	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_2 (PF07646, IPR011498): Kelch motif Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_4 (PF13418): Galactose oxidase, central domain Kelch_6 (PF13964): Kelch motif
58	KDM2A	interactor	4	0.667	0.422	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain F-box (PF00646, IPR001810, SM00256): F-box domain DZR (PF12773, IPR025874): Double zinc ribbon LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat PHD_4 (PF16866, IPR019787): PHD-finger
59	KDM2B	oncoprotein	5	0.667	1.333	zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain F-box (PF00646, IPR001810, SM00256): F-box domain LRR_6 (PF13516, IPR001611): Leucine Rich repeat Cupin_8 (PF13621): Cupin-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat MRI (PF15325, IPR028278): Modulator of retrovirus infection PHD_4 (PF16866, IPR019787): PHD-finger
60	KHSRP	interactor	4	1.000	0	DUF1897 (PF09005, IPR015096): Domain of unknown function (DUF1897) KH_1 (PF00013, IPR004088, SM00322): KH domain
61	LMO3	oncoprotein	1	0	0	LIM (PF00412, IPR001781, SM00132): LIM domain
62	LUZP4	interactor	4	0.667	1.000	Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
63	MAF	oncoprotein	10	0.500	9.617	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein Metal_resist (PF13801, IPR025961): Heavy-metal resistance
64	MAFB	oncoprotein	5	0.667	0.650	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor Maf_N (PF08383, IPR013592): Maf N-terminal region
65	MAFF	interactor	4	1.000	0	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
66	MAP1B	interactor	2	1.000	0	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup Striatin (PF08232, IPR013258): Striatin family IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
67	MAPK1	oncoprotein	15	0.505	26.338	Pkinase (PF00069, IPR000719): Protein kinase domain
68	MAPK7	oncoprotein	4	0.667	0.222	Pkinase (PF00069, IPR000719): Protein kinase domain Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
69	MAPK9	suppressor	9	0.357	12.845	Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like
70	MAZ	interactor	3	1.000	0	zf-BED (PF02892, IPR003656, SM00614): BED zinc finger zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF2057 (PF09829, IPR018635): Uncharacterized protein conserved in bacteria (DUF2057) zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597) DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) zf-met (PF12874): Zinc-finger of C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
71	MED17	oncoprotein	2	1.000	0	Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
72	MITF	oncoprotein	5	0.600	1.341	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
73	MTERF4	interactor	2	1.000	0	Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein mTERF (PF02536, IPR003690, SM00733): mTERF
74	MTMR1	interactor	1	0	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain 3-PAP (PF12578, IPR022587): Myotubularin-associated protein Myb_CC_LHEQLE (PF14379, IPR025756): MYB-CC type transfactor, LHEQLE motif
75	NACA	oncoprotein	3	1.000	0	NAC (PF01849, IPR002715): NAC domain RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain CitT (PF12431, IPR028141): Transcriptional regulator
76	NCOA1	oncoprotein	20	0.456	49.186	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
77	NCOA2	oncoprotein	11	0.655	7.488	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein
78	NCOA3	oncoprotein	18	0.451	41.226	DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
79	NCOA6	oncoprotein	17	0.600	20.266	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
80	NCOR2	oncoprotein	12	0.727	4.183	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal MAS20 (PF02064, IPR002056): MAS20 protein import receptor OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain PSK (PF06404, IPR009438): Phytosulfokine precursor protein (PSK) SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Gti1_Pac2 (PF09729, IPR018608): Gti1/Pac2 family PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Spt20 (PF12090, IPR021950): Spt20 family DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4518 (PF15008, IPR026698): Domain of unknown function (DUF4518) GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
81	NEFM	interactor	2	1.000	0	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
82	NELFB	protein found in more fusions	5	0.833	0.400	COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
83	NFATC1	oncoprotein	10	0.578	7.827	RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
84	NFATC2IP	interactor	1	0	0	Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
85	NFIX	oncoprotein	4	1.000	0	CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus MH1 (PF03165, IPR003619, SM00523): MH1 domain
86	NQO1	oncoprotein	2	0	0	Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
87	NR2F1	oncoprotein	4	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
88	NR2F6	oncoprotein	4	1.000	0	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
89	PML	suppressor	24	0.320	93.141	zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger DUF3583 (PF12126, IPR021978): Protein of unknown function (DUF3583) zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
90	POLR2E	protein found in more fusions	5	0.500	1.333	RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
91	PPP1R12A	interactor	2	1.000	0	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Mucin (PF01456, IPR000458): Mucin-like glycoprotein RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
92	PRKAA2	suppressor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
93	PSMC5	protein found in more fusions	6	0.900	0.143	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Laminin_II (PF06009, IPR010307): Laminin Domain II RILP (PF11461, IPR021563): Rab interacting lysosomal protein AAA_16 (PF13191): AAA ATPase domain
94	RB1	suppressor	20	0.337	76.456	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
95	RELA	oncoprotein	25	0.322	113.320	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
96	RFWD2	suppressor	11	0.289	26.468	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein IncA (PF04156, IPR007285): IncA protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) WD40_like (PF17005, IPR031544): WD40-like domain
97	RPS6KA2	suppressor	5	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
98	RPS6KA4	interactor	2	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
99	RUNX1	suppressor	11	0.689	5.253	Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
100	RUNX2	suppressor	7	0.857	0.518	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) Runt (PF00853, IPR013524): Runt domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722)
101	SET	oncoprotein	5	0.500	1.119	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
102	SIRT1	suppressor	15	0.440	25.790	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
103	SMAD3	oncoprotein	25	0.402	75.764	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
104	SMARCC1	suppressor	10	0.639	6.091	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
105	SMARCC2	interactor	10	0.467	12.825	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
106	SMARCE1	interactor	7	0.762	1.578	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
107	SPI1	suppressor	10	0.467	11.162	Ets (PF00178, IPR000418, SM00413): Ets-domain p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
108	SRA1	interactor	9	0.500	6.423	SRA1 (PF07304, IPR009917): Steroid receptor RNA activator (SRA1)
109	SSU72	interactor	2	1.000	0	Ssu72 (PF04722, IPR006811): Ssu72-like protein
110	STAT1	suppressor	12	0.600	8.987	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
111	STK40	interactor	4	0.667	1.667	Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like
112	TAF1	oncoprotein	8	0.714	2.431	Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit LcrG (PF07216, IPR009863): LcrG protein Opi1 (PF08618, IPR013927): Transcription factor Opi1 Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal TBP-binding (PF09247, IPR009067): TATA box-binding protein binding U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated Bromodomain (PF00439, IPR001487, SM00297): Bromodomain DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591) zf-CCHC_6 (PF15288): Zinc knuckle
113	TBP	interactor	18	0.478	33.678	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
114	TCL1A	oncoprotein	5	0.833	0.182	TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
115	TRAPPC13	interactor	1	0	0	DUF974 (PF06159, IPR010378): Protein of unknown function (DUF974) Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain Trs65 (PF12735, IPR024662): TRAPP trafficking subunit Trs65
116	TRIB1	interactor	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
117	TSC22D3	protein found in more fusions	4	1.000	0	TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
118	TSPAN2	interactor	1	0	0	Tetraspannin (PF00335, IPR018499): Tetraspanin family
119	UBE2D1	interactor	8	0.429	9.067	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
120	UBE2I	interactor	24	0.328	99.783	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
121	UBE2L3	interactor	4	0.667	0.182	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
122	UBR1	interactor	2	1.000	0	ATPase_2 (PF01637, IPR011579): ATPase domain predominantly from Archaea ClpS (PF02617, IPR003769): ATP-dependent Clp protease adaptor protein ClpS zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box) zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
123	USF1	oncoprotein	5	0.667	1.222	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
124	USF2	protein found in more fusions	6	0.700	1.733	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
125	UTP4	interactor	2	1.000	0	CPSF_A (PF03178, IPR004871): CPSF A subunit region PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 (PF13360, IPR002372): PQQ-like domain
126	VARS	interactor	4	0.667	0.722	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
127	VDR	suppressor	18	0.522	22.377	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
128	XBP1	protein found in more fusions	4	1.000	0	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF2630 (PF10944, IPR020311): Protein of unknown function (DUF2630)
129	YEATS4	interactor	1	0	0	YEATS (PF03366, IPR005033): YEATS family SOGA (PF11365, IPR027881): Protein SOGA
130	ZNF133	interactor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger

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