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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FGFR2 (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins14 (40.00 %)
The number (and %) of the tumor suppressors4 (11.43 %)
Total number of binary PPIs (saturation %)73 (12.27 %)
The number (and %) of affected PPIs35 (47.95 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI3.257
Assortativity coefficient-0.5337
The network average Clustering coefficient0.348
The number (and %) of a zero Clustering coefficients18 (51.43 %)
The number (and %) of a zero Betweenness Centrality24 (68.57 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FGFR2 All fusions
: CN345552; BG984043;
Proteins found in more fusions FGFR2 (see 3 fusions); STAT3 (see 2 fusions); FYN (see 1 fusions); LYN (see 1 fusions); ERRFI1 (see 1 fusions); APP (see 4 fusions); CBL (see 1 fusions); PIK3R1 (see 1 fusions); NEDD4 (see 1 fusions); PDLIM2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FGFR2parental protein350.0411029.333Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
2 APPprotein found in more fusions60.4006.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3 BEX1interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
4 BEX2interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
5 C8orf74interactor100CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
6 CBLoncoprotein100.36121.667Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
7 ERRFI1oncoprotein200GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
8 FGF1oncoprotein200FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
9 FGF10interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
10 FGF23interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
11 FGF5interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
12 FGF7interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
13 FGF8interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
TraC_F_IV (PF11130, IPR025955): F pilus assembly Type-IV secretion system for plasmid transfer
14 FRS2interactor31.0000IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
15 FYNoncoprotein60.7003.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
16 GLCEinteractor100C5-epim_C (PF06662, IPR010598): D-glucuronyl C5-epimerase C-terminus
EspG (PF06872, IPR009669): EspG protein
17 HGSinteractor30.6671.000FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
18 HOXC6interactor21.0000Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
19 ITGA5suppressor21.0000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
20 LYNoncoprotein50.8330.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
21 MTA3interactor100BAH (PF01426, IPR001025, SM00439): BAH domain
ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
GATA (PF00320, IPR000679, SM00401): GATA zinc finger
22 NEDD4suppressor40.6671.000Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
23 PDLIM2protein found in more fusions200LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
24 PGRsuppressor50.6671.667Prog_receptor (PF02161, IPR000128): Progesterone receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
25 PIK3R1oncoprotein51.0000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
26 PLCG1oncoprotein21.0000C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
27 PPM1Ainteractor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
28 RASL10Bsuppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
29 RHOBTB2oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Ras (PF00071, IPR001806, SM00173): Ras family
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
30 S100A14interactor100S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
31 STAT3oncoprotein80.5249.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
32 STAT5Aoncoprotein40.6670.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
33 STAT5Boncoprotein50.6672.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
34 TFF1oncoprotein200Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
35 TSPAN3interactor100Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family

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