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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)57
The number (and %) of the onco-proteins23 (40.35 %)
The number (and %) of the tumor suppressors10 (17.54 %)
Total number of binary PPIs (saturation %)168 (10.53 %)
The number (and %) of affected PPIs56 (33.33 %)
The number of possible different fusions17
PPI diameter5
PPI radius3
The average degree of PPI5.053
Assortativity coefficient-0.3606
The network average Clustering coefficient0.480
The number (and %) of a zero Clustering coefficients15 (26.32 %)
The number (and %) of a zero Betweenness Centrality28 (49.12 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FGFR1,PLAG1 All fusions
: EF525170;
Proteins found in more fusions JAK2 (see 3 fusions); ERBB3 (see 2 fusions); CREBBP (see 6 fusions); STAT3 (see 2 fusions); KPNB1 (see 2 fusions); CDH1 (see 3 fusions); FRS3 (see 1 fusions); FGFR1 (see 2 fusions); PIAS1 (see 2 fusions); HSP90AA1 (see 2 fusions); PIK3R1 (see 1 fusions); NEDD4 (see 1 fusions); CTPS2 (see 1 fusions); SMAD3 (see 3 fusions); PIAS2 (see 2 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FGFR1parental protein500.0632379.180I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 PLAG1parental protein60.267182.637zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
3 ALBinteractor100Serum_albumin (PF00273, IPR014760, SM00103): Serum albumin family
4 BNIP2interactor200BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
5 CDC20oncoprotein31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
6 CDH1suppressor60.7001.567Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
7 CDK9protein found in more fusions60.30086.743Pkinase (PF00069, IPR000719): Protein kinase domain
8 CEACAM21interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
9 CREBBPsuppressor100.278126.688Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
10 CRKoncoprotein70.6195.400SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
11 CTNNB1oncoprotein60.46769.106Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
12 CTPS2protein found in more fusions200CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
13 DLK1suppressor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
14 ERBB3oncoprotein130.43931.589Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
15 EVI2Ainteractor100EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
16 FDPSinteractor100polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
17 FGF1oncoprotein200FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
18 FGF2oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
19 FGF23interactor100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
20 FGF8oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
TraC_F_IV (PF11130, IPR025955): F pilus assembly Type-IV secretion system for plasmid transfer
21 FRS2interactor31.0000IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
22 FRS3suppressor31.0000IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
23 GINM1interactor21.0000NA
24 GOLGA7Binteractor100Serglycin (PF04360, IPR007455): Serglycin
Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
25 GRB14interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
26 HEPACAM2interactor21.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
27 HSP90AA1oncoprotein130.31842.042HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
28 IL20RBinteractor100Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
29 ITKoncoprotein70.60053.457BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
30 JAK2oncoprotein110.51126.257FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
31 KPNA2interactor50105.529Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
32 KPNB1protein found in more fusions60.200185.518Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
33 LDLRAD4interactor40.50047.332Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
34 LGALS8interactor100Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
35 LTBRoncoprotein31.0000Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
36 MREGinteractor100MREG (PF15812, IPR031638): Melanoregulin
37 NCAM1interactor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Syndecan (PF01034, IPR027789): Syndecan domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
38 NCK1oncoprotein40.8330.400SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
39 NEDD4suppressor70.40061.669Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
40 PIAS1suppressor31.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
UPF0544 (PF15749, IPR032739): Uncharacterised protein family UPF0544
41 PIAS2protein found in more fusions50.66740.052SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
42 PIAS4interactor40.66732.739CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
43 PIK3R1oncoprotein130.40932.587RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
44 PKMoncoprotein21.0000PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
45 PLCG1oncoprotein100.40027.349C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
46 PPP2R1Bsuppressor41.0000HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
47 PTK6interactor41.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
48 RPS6KA3interactor40.5001.567Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
49 SHBinteractor60.7331.519Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
50 SMAD3oncoprotein100.167299.988MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
51 SOS1oncoprotein60.5334.519Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
52 SRConcoprotein150.38550.769Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
53 STAT3suppressor90.53611.779SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
54 TGFBR2suppressor40.6671.000ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
55 TNFRSF10Bsuppressor50.4006.000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
56 TSPAN3interactor21.0000Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
57 VAV1oncoprotein60.8001.019PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain

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