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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FER (from a repository: Thu Nov 24 23:43:29 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins9 (45.00 %)
The number (and %) of the tumor suppressors2 (10.00 %)
Total number of binary PPIs (saturation %)71 (37.37 %)
The number (and %) of affected PPIs20 (28.17 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI5.900
Assortativity coefficient-0.3513
The network average Clustering coefficient0.622
The number (and %) of a zero Clustering coefficients3 (15.00 %)
The number (and %) of a zero Betweenness Centrality6 (30.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FER All fusions
: DW420350;
Proteins found in more fusions ERBB3 (see 2 fusions); HSP90AA1 (see 2 fusions); CDH1 (see 3 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); FER (see 1 fusions); CDC37 (see 2 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FERparental protein200.234192.967DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain
PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Med29 (PF11568, IPR021018): Mediator complex subunit 29
2 CDC37protein found in more fusions80.7143.833CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
3 CDH1suppressor50.8330.400Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
4 CRKoncoprotein60.9330.400SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
5 CTNNB1oncoprotein60.6672.833Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
6 CTTNoncoprotein50.8330.667FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
7 DNM1interactor41.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
8 DNM2interactor50.6004.000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
9 DNM3interactor31.0000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
10 EGFRoncoprotein140.41035.800Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
11 ERBB2oncoprotein110.6229.467Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 ERBB3oncoprotein90.7503.400Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
13 HSP90AA1oncoprotein80.7143.333HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
14 KCTD4interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
15 LIMA1suppressor30.6670.333LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
16 NXF1interactor70.6003.567NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
17 PIK3R1oncoprotein70.8671.000RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
18 PIK3R3interactor51.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
19 PPP1R7interactor100LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_9 (PF14580): Leucine-rich repeat
20 TMF1interactor100Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
NHase_beta (PF02211, IPR024690): Nitrile hydratase beta subunit
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PilW (PF16074, IPR032092): Type IV Pilus-assembly protein W
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2

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