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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FECH (from a repository: Tue Nov 15 16:15:48 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)21
The number (and %) of the onco-proteins7 (33.33 %)
The number (and %) of the tumor suppressors4 (19.05 %)
Total number of binary PPIs (saturation %)47 (22.38 %)
The number (and %) of affected PPIs21 (44.68 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.524
Assortativity coefficient-0.3866
The network average Clustering coefficient0.573
The number (and %) of a zero Clustering coefficients6 (28.57 %)
The number (and %) of a zero Betweenness Centrality13 (61.90 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: FECH All fusions
: AW607390;
Proteins found in more fusions MME (see 1 fusions); FECH (see 1 fusions); USP20 (see 1 fusions); CUL3 (see 1 fusions); COPS5 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FECHparental protein210.089330.333Ferrochelatase (PF00762, IPR001015): Ferrochelatase
2 ABCB7interactor21.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
3 ATMsuppressor31.0000FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
4 B3GNT3interactor100Galactosyl_T (PF01762, IPR002659): Galactosyltransferase
5 C15orf48interactor21.0000B12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
6 COPS5protein found in more fusions60.7002.333JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 COPS6interactor50.8330.667DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
8 COQ9interactor40.6671.000COQ9 (PF08511, IPR013718): COQ9
9 CUL3protein found in more fusions70.6005.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 ELAVL1oncoprotein60.6003.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 FBXO6interactor31.0000FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
12 MINOS1interactor100DUF543 (PF04418, IPR007512): Domain of unknown function (DUF543)
13 MMEsuppressor200Peptidase_M13 (PF01431, IPR018497): Peptidase family M13
Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
14 POU5F1oncoprotein31.0000Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
15 PPP2CAsuppressor40.8330.667Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
16 PPP2CBsuppressor31.0000Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
17 PPP2R1Aoncoprotein50.7002.333TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
18 TIMP2oncoprotein100TIMP (PF00965, IPR001820): Tissue inhibitor of metalloproteinase
19 TRIM74interactor100Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
20 USP20protein found in more fusions200UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
DUSP (PF06337, IPR006615, SM00695): DUSP domain
21 USP42interactor21.0000TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
AP3D1 (PF06375): AP-3 complex subunit delta-1

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 COPS5interactorJAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin proteaseAW607390
2 FECHparental proteinFerrochelatase (PF00762, IPR001015): FerrochelataseAW607390

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