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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FCHSD2 (from a repository: Thu Jan 31 17:14:07 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors1 (3.57 %)
Total number of binary PPIs (saturation %)57 (15.08 %)
The number (and %) of affected PPIs28 (49.12 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.357
Assortativity coefficient-0.5545
The network average Clustering coefficient0.359
The number (and %) of a zero Clustering coefficients13 (46.43 %)
The number (and %) of a zero Betweenness Centrality18 (64.29 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FCHSD2 All fusions
: AK056634;
Proteins found in more fusions ITSN2 (see 1 fusions); VCP (see 4 fusions); HSP90AB1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FCHSD2parental protein280.057630.333Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4665 (PF15679, IPR031389): Domain of unknown function (DUF4665)
Rit1_C (PF17184): Rit1 N-terminal domain
2 ABCF3interactor21.0000ABC_tran (PF00005, IPR003439): ABC transporter
Peptidase_C25 (PF01364, IPR001769): Peptidase family C25
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
ABC_tran_Xtn (PF12848, IPR032781): ABC transporter
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
AAA_33 (PF13671): AAA domain
3 C2orf73interactor100GDWWSH (PF15667, IPR031365): Protein of unknown function with motif GDWWSH
4 C9orf78interactor100DHOR (PF06537, IPR010538): Di-haem oxidoreductase, putative peroxidase
Hep_59 (PF07052, IPR010756): Hepatocellular carcinoma-associated antigen 59
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
5 CASKinteractor21.0000L27 (PF02828, IPR014775, SM00569): L27 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
6 CCDC158interactor100CCDC158 (PF15921, IPR031809): Coiled-coil domain-containing protein 158
7 CCDC85Binteractor100CCDC85 (PF10226, IPR019359): CCDC85 family
8 CCT2interactor31.0000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CFAP36interactor100DUF1068 (PF06364, IPR010471): Protein of unknown function (DUF1068)
ARL2_Bind_BART (PF11527, IPR023379): The ARF-like 2 binding protein BART
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
10 CHKAoncoprotein100Choline_kinase (PF01633): Choline/ethanolamine kinase
11 DAPP1interactor100PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
12 ELAVL1oncoprotein60.4005.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
13 FAM9Binteractor200Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
14 HSP90AB1oncoprotein60.6003.333HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
15 HSPA5oncoprotein50.6672.000HSP70 (PF00012, IPR013126): Hsp70 protein
16 ITSN1interactor60.6003.333C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
17 ITSN2protein found in more fusions60.6003.000C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
18 KIFC3oncoprotein200Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
19 MAGI1interactor100PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_C58 (PF03543, IPR006473): Yersinia/Haemophilus virulence surface antigen
Serglycin (PF04360, IPR007455): Serglycin
WW (PF00397, IPR001202, SM00456): WW domain
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
PDZ_2 (PF13180, IPR001478): PDZ domain
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
DUF4770 (PF15994, IPR031935): Domain of unknown function (DUF4770)
MAGI_u1 (PF16663): Unstructured region on MAGI
MAGI_u5 (PF16666): Unstructured region on MAGI
20 MSL1interactor100Herpes_UL6 (PF01763, IPR002660): Herpesvirus UL6 like
KLRAQ (PF10205, IPR019343): Predicted coiled-coil domain-containing protein
PEHE (PF15275, IPR029332): PEHE domain
MSL1_dimer (PF16801, IPR031840): Dimerisation domain of Male-specific-Lethal 1
21 MTUS2suppressor40.6670.667DUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
22 PDE4DIPoncoprotein40.5002.333ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Med9 (PF07544, IPR011425): RNA polymerase II transcription mediator complex subunit 9
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1220 (PF06758, IPR010630, SM01148): Repeat of unknown function (DUF1220)
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
IncA (PF04156, IPR007285): IncA protein
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
FAM76 (PF16046, IPR032017): FAM76 protein
MPS2 (PF17060, IPR031433): Monopolar spindle protein 2
23 SH3BGRinteractor100SH3BGR (PF04908, IPR006993): SH3-binding, glutamic acid-rich protein
24 SRP72interactor100BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
25 VCPprotein found in more fusions70.4677.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
26 VCPIP1interactor21.0000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-C3H1 (PF10650, IPR019607, SM00356): Putative zinc-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SDP_N (PF12278, IPR022063): Sex determination protein N terminal
27 WASoncoprotein31.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
PRIMA1 (PF16101): Proline-rich membrane anchor 1
28 WASLinteractor50.5004.333Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
WH1 (PF00568, IPR000697, SM00461): WH1 domain
WH2 (PF02205, IPR003124, SM00246): WH2 motif
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
Caskin-Pro-rich (PF16907): Proline rich region of Caskin proteins

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