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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FCHO2, CLTC (from a repository: Thu Nov 24 09:46:12 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)282
The number (and %) of the onco-proteins75 (26.60 %)
The number (and %) of the tumor suppressors32 (11.35 %)
Total number of binary PPIs (saturation %)2987 (7.54 %)
The number (and %) of affected PPIs293 (9.81 %)
The number of possible different fusions45
PPI diameter3
PPI radius2
The average degree of PPI20.560
Assortativity coefficient-0.2069
The network average Clustering coefficient0.456
The number (and %) of a zero Clustering coefficients6 (2.13 %)
The number (and %) of a zero Betweenness Centrality25 (8.87 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: CLTC,FCHO2 All fusions
: AI989296;
Proteins found in more fusions PLEKHA5 (see 1 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); GRB2 (see 1 fusions); FYN (see 1 fusions); REPS1 (see 1 fusions); CHMP1A (see 2 fusions); SORBS2 (see 4 fusions); MYBL2 (see 4 fusions); HDAC5 (see 1 fusions); IKBKB (see 2 fusions); EP300 (see 1 fusions); RPA1 (see 1 fusions); SNX9 (see 2 fusions); ATR (see 1 fusions); HUWE1 (see 2 fusions); OFD1 (see 1 fusions); STOM (see 1 fusions); CLINT1 (see 2 fusions); TROAP (see 1 fusions); SHC1 (see 1 fusions); STAU1 (see 2 fusions); EPS15 (see 1 fusions); CUL7 (see 2 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); RAC1 (see 1 fusions); MAPRE1 (see 1 fusions); VCL (see 2 fusions); COPS5 (see 1 fusions); LRRK2 (see 1 fusions); MYO6 (see 3 fusions); TP53 (see 3 fusions); AP2M1 (see 3 fusions); ATP1A1/VDAC3 (see 2 fusions); FCHO2/CLTC (see 1 fusions); HERC1 (see 1 fusions); EDC3 (see 1 fusions); ERBIN (see 4 fusions); SH3KBP1 (see 1 fusions); MCM2 (see 1 fusions); MAP3K7 (see 7 fusions); CSNK1E (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 CLTCparental protein2770.06645384.168Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
2 FCHO2parental protein170.559343.366DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
PIN_2 (PF10130, IPR002716): PIN domain
muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
3 AAK1interactor100.8001.425eIF-3_zeta (PF05091, IPR007783): Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
Pkinase (PF00069, IPR000719): Protein kinase domain
4 ABCA2interactor21.0000ABC_tran (PF00005, IPR003439): ABC transporter
ABC2_membrane_3 (PF12698): ABC-2 family transporter protein
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
DUF4162 (PF13732, IPR025302): Domain of unknown function (DUF4162)
5 ADRB2interactor240.29268.4317tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 AKT1oncoprotein210.30557.540PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
7 AMPHoncoprotein120.37920.843BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PBP_N (PF17093, IPR031375): Penicillin-binding protein N-terminus
8 ANLNoncoprotein300.59144.660Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
9 AP1B1interactor230.37568.215Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
10 AP1G1interactor130.55118.442Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
11 AP2A1interactor510.362456.660Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
12 AP2A2interactor290.44364.416Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
13 AP2B1interactor400.408166.944Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
14 AP2M1protein found in more fusions510.347372.750Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
15 AP3B2interactor40.8330.077Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
16 AP3D1interactor80.5005.108Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
AP3D1 (PF06375): AP-3 complex subunit delta-1
17 ARMCX3oncoprotein21.0000Arm_2 (PF04826, IPR006911): Armadillo-like
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
18 ARRB1interactor210.32465.718Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
19 ARRB2interactor350.271210.453Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
20 ARXinteractor80.8570.359CbiD (PF01888, IPR002748): CbiD
DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
OAR (PF03826, IPR003654): OAR domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
21 ATG16L1interactor90.28656.025ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2332 (PF10094, IPR011200): Uncharacterized protein conserved in bacteria (DUF2332)
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
22 ATP1A1protein found in more fusions400.323219.440Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
23 ATP1A2interactor70.4763.517Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Sigma70_r4 (PF04545, IPR007630): Sigma-70, region 4
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
24 ATP1A3interactor60.6671.468Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
25 ATP4Ainteractor60.5002.700Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
H-K_ATPase_N (PF09040, IPR015127): Gastric H+/K+-ATPase, N terminal domain
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
HAD (PF12710): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
26 ATP5C1interactor280.44264.770ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
27 ATP6V0A1interactor70.4766.724V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
28 ATP6V0D1interactor190.33366.497vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
29 ATP6V1B2interactor130.34623.388ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
DUF2481 (PF10654, IPR018916): Protein of unknown function (DUF2481)
30 ATP6V1Dinteractor60.6004.233ATP-synt_D (PF01813, IPR002699): ATP synthase subunit D
31 ATRsuppressor120.43613.783FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
32 AVPR2interactor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
33 BIN1suppressor80.5713.667BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
34 BLOC1S1interactor21.0000GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1)
DUF4677 (PF15726, IPR031458): Domain of unknown function (DUF4677)
35 BMP2Kinteractor230.67635.743Pkinase (PF00069, IPR000719): Protein kinase domain
TCP (PF03634, IPR005333): TCP family transcription factor
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
EOS1 (PF12326, IPR021100): N-glycosylation protein
BMP2K_C (PF15282, IPR028182): BMP-2-inducible protein kinase C-terminus
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
FAM60A (PF15396, IPR026065): Protein Family FAM60A
36 BTBD3interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
PHR (PF08005, IPR012983): PHR domain
37 C10orf88interactor31.0000DUF4506 (PF14958, IPR028043): Domain of unknown function (DUF4506)
38 CADoncoprotein280.37381.275Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain
CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain
GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
MGS (PF02142, IPR011607, SM00851): MGS-like domain
OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
39 CAND1interactor410.335195.663Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
40 CANXinteractor330.381100.092Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
41 CAPZA2interactor440.405193.908F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
42 CAV1suppressor190.28161.113Caveolin (PF01146, IPR001612): Caveolin
43 CCDC115interactor100NA
44 CCDC47interactor70.6194.237DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
45 CCDC8interactor480.259328.232Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
46 CCT3interactor340.337139.238Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
47 CCT6Ainteractor350.321129.814Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
48 CCT6Binteractor80.5365.990Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
49 CDK2suppressor510.277317.757Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
50 CEP97interactor70.4295.526IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
LRR_8 (PF13855, IPR001611): Leucine rich repeat
LRR_9 (PF14580): Leucine-rich repeat
51 CHMP1Aprotein found in more fusions80.5246.687Snf7 (PF03357, IPR005024): Snf7
52 CHMP1Binteractor70.6674.167Snf7 (PF03357, IPR005024): Snf7
53 CHMP4Binteractor210.221103.768Snf7 (PF03357, IPR005024): Snf7
54 CISD1interactor51.0000zf-CDGSH (PF09360, IPR018967, SM00704): Iron-binding zinc finger CDGSH type
MitoNEET_N (PF10660, IPR019610): Iron-containing outer mitochondrial membrane protein N-terminus
55 CLINT1protein found in more fusions380.411192.466ENTH (PF01417, IPR001026, SM00273): ENTH domain
56 CLTAinteractor390.367161.000Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
57 CLTBinteractor450.425195.063Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
58 CLTCL1oncoprotein250.330100.803Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
59 CNTRLoncoprotein110.29129.283APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
60 COPS5protein found in more fusions430.300276.876JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
61 CPSF7interactor180.39916.481CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
PRIMA1 (PF16101): Proline-rich membrane anchor 1
62 CPVLinteractor40.5002.167Peptidase_S10 (PF00450, IPR001563): Serine carboxypeptidase
63 CRTC2oncoprotein60.4002.499TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
64 CRTC3oncoprotein40.6670.686TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
65 CSNK1A1suppressor230.30470.864Pkinase (PF00069, IPR000719): Protein kinase domain
66 CSNK1Eprotein found in more fusions200.32765.975APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase (PF00069, IPR000719): Protein kinase domain
67 CUL1suppressor390.349164.232Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
68 CUL2suppressor300.322143.121Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
69 CUL3protein found in more fusions720.187993.087Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
70 CUL5suppressor220.519325.735Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
71 CUL7protein found in more fusions410.310143.516ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
72 CYC1interactor140.6815.642Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
73 DAB2suppressor310.49992.918PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
zf-C2H2_assoc3 (PF16637): Putative zinc-finger between two C2H2 zinc-fingers on Patz
74 DBN1oncoprotein510.398256.582Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
75 DCP1Ainteractor70.5716.636DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
76 DCTN1interactor180.27252.327Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
77 DCUN1D1interactor150.6958.534Cullin_binding (PF03556, IPR005176): Cullin binding
UBA_4 (PF14555): UBA-like domain
78 DDOSTinteractor300.42894.592DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
79 DENND1Ainteractor70.8100.898dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
80 DHX38interactor50.7000.200DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
81 DNAJA3suppressor90.4449.993DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
82 DNAJC6oncoprotein100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
83 DNAJC7interactor170.39721.386DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
Rapsyn_N (PF10579, IPR019568): Rapsyn N-terminal myristoylation and linker region
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_17 (PF13431): Tetratricopeptide repeat
84 DSTYKinteractor21.0000APH (PF01636, IPR002575): Phosphotransferase enzyme family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
85 DYRK1Aoncoprotein120.25526.116DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Pkinase (PF00069, IPR000719): Protein kinase domain
FAM199X (PF15814, IPR029672): Protein family FAM199X
86 EDC3protein found in more fusions70.7331.881FDF (PF09532, IPR019050, SM01199): FDF domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
LSM14 (PF12701, IPR025609): Scd6-like Sm domain
Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3
DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096)
87 EDC4interactor130.34618.822DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
88 EEDsuppressor230.29458.788WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
89 EGFL7interactor100Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
EMI (PF07546, IPR011489): EMI domain
SlyX (PF04102, IPR007236): SlyX
90 EHD1interactor100.50011.236Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
91 EHD2interactor60.4671.878Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
92 EHD4interactor70.6672.194GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
93 EIF6interactor160.35032.590eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
94 EP300oncoprotein180.30953.748Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
95 EPHA2suppressor110.66726.437fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
96 EPN1interactor170.52948.171ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
97 EPN2interactor30.6670.167ENTH (PF01417, IPR001026, SM00273): ENTH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
98 EPS15oncoprotein440.391357.512Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
99 ERBB2oncoprotein140.37218.206Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
100 ERBINoncoprotein130.37921.446LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
101 ERGoncoprotein70.5711.090Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
102 ESR1suppressor480.241349.530Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
103 FAM83Ainteractor30.6670.581DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
104 FAM83Binteractor90.6393.874Cauli_AT (PF03233, IPR004917): Aphid transmission protein
DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
105 FAM83Hinteractor90.5834.314DUF1669 (PF07894, IPR012461): Protein of unknown function (DUF1669)
106 FASTKD2interactor31.0000FAST_1 (PF06743, IPR010622): FAST kinase-like protein, subdomain 1
FAST_2 (PF08368, IPR013579): FAST kinase-like protein, subdomain 2
RAP (PF08373, IPR013584, SM00952): RAP domain
107 FBF1interactor160.30048.133DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
108 FBXO6interactor370.269190.761FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
109 FBXW11interactor200.28159.983WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
110 FLNAsuppressor630.311482.507CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
111 FN1oncoprotein580.229459.636fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
112 FYNoncoprotein140.29540.529Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
113 GAKoncoprotein420.286271.226DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
114 GGA1oncoprotein70.6003.833Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
Hormone_3 (PF00159, IPR001955): Pancreatic hormone peptide
VHS (PF00790, IPR002014, SM00288): VHS domain
AP3B1_C (PF14796, IPR029390): Clathrin-adaptor complex-3 beta-1 subunit C-terminal
115 GGA2interactor60.5334.091Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
116 GGA3interactor50.7001.750Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
117 GJB5interactor100Connexin (PF00029, IPR013092, SM00037): Connexin
118 GRB2oncoprotein450.249385.582SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
119 GTSE1interactor770.1561563.009GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
120 HDAC5protein found in more fusions360.36868.556Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
121 HELZinteractor60.4671.968PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
TetR_C_8 (PF14278): Transcriptional regulator C-terminal region
122 HERC1protein found in more fusions40.6671.000Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
123 HGSinteractor200.205110.340FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
124 HIP1oncoprotein90.5714.555ANTH (PF07651, IPR011417): ANTH domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
125 HIP1Rinteractor170.46324.422ANTH (PF07651, IPR011417): ANTH domain
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
126 HNRNPA1interactor540.321313.587RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
127 HSP90B1suppressor320.371116.026CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
128 HSPA1Ainteractor350.279170.113HSP70 (PF00012, IPR013126): Hsp70 protein
129 HSPA4interactor370.254248.773Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
130 HTR6interactor40.5001.4677tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
131 HUWE1oncoprotein350.374106.822BUD22 (PF09073, IPR015158): BUD22
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Nop14 (PF04147, IPR007276): Nop14-like family
PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
WWE (PF02825, IPR004170, SM00678): WWE domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
132 IKBKBprotein found in more fusions120.41815.273FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
133 IKBKEinteractor80.3817.143IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
134 IPO5interactor210.39540.788HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
135 IQGAP1interactor600.295472.625CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
136 ISG15suppressor100.3786.351ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
137 IST1interactor70.6194.115Ist1 (PF03398, IPR005061): Regulator of Vps4 activity in the MVB pathway
138 ITGA4interactor460.271230.926FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
139 ITSN1interactor150.35234.681C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
140 KIAA0430interactor30.6670.500NYN (PF01936, IPR021139): NYN domain
FlbD (PF06289, IPR009384): Flagellar protein (FlbD)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
OST-HTH (PF12872, IPR025605): OST-HTH/LOTUS domain
141 KIDINS220interactor70.5242.377KAP_NTPase (PF07693, IPR011646): KAP family P-loop domain
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
142 KIToncoprotein50.7001.550ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
143 LDLRAP1interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
144 LGR4interactor210.18481.1527tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
145 LIMA1suppressor560.348332.139LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
146 LRRK2oncoprotein150.34129.497Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
147 MAP1LC3Ainteractor80.3577.257Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
148 MAP3K10interactor40.6671.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
149 MAP3K7oncoprotein90.4296.487Mnd1 (PF03962, IPR005647): Mnd1 family
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
150 MAPRE1oncoprotein300.288135.451CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
151 MCCsuppressor50.4002.848ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
FAM76 (PF16046, IPR032017): FAM76 protein
152 MCM2oncoprotein680.229797.780AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
153 MITD1interactor21.0000MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
MIT_C (PF16565, IPR032341): Phospholipase D-like domain at C-terminus of MIT
154 MT-CO2interactor160.5759.017NA
155 MTCH2interactor200.52131.816Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
156 MTUS1suppressor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
ZapB (PF06005, IPR009252): Cell division protein ZapB
SRP19 (PF01922, IPR002778): SRP19 protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF4337 (PF14235, IPR025570): Domain of unknown function (DUF4337)
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
157 MVPoncoprotein100.38910.784Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
158 MYBL2oncoprotein60.8000.650Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
159 MYH9suppressor630.324461.982IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
160 MYO18Ainteractor320.536131.613Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
161 MYO19interactor390.437151.042IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
162 MYO6protein found in more fusions250.49652.811BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
163 NDRG1suppressor110.27313.401Ndr (PF03096, IPR004142): Ndr family
164 NDUFA9interactor120.48511.479Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family
165 NDUFB9interactor80.6073.309Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
166 NDUFS1interactor190.40931.285NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
Molybdopterin (PF00384, IPR006656): Molybdopterin oxidoreductase
NADH-G_4Fe-4S_3 (PF10588, IPR019574, SM00929): NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
Fer2_4 (PF13510): 2Fe-2S iron-sulfur cluster binding domain
167 NECAP1interactor51.0000DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
168 NEDD8interactor200.47436.520ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
169 NLRP1interactor40.6670.786Birna_VP5 (PF03042, IPR004284): Birnavirus VP5 protein
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Herpes_U30 (PF04523, IPR007611): Herpes virus tegument protein U30
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
FIIND (PF13553, IPR025307): Function to find
170 NPHP1interactor80.3816.769SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FAM176 (PF14851): FAM176 family
Speriolin_N (PF15058, IPR029385): Speriolin N terminus
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
171 NPM1suppressor520.300309.214Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
172 NTRK1oncoprotein1180.1283515.663I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
173 NUMBsuppressor120.7582.713NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
174 NXF1interactor540.140735.735NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
175 OBSL1interactor390.290142.431BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
176 OCRLinteractor60.5331.258Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
OCRL_clath_bd (PF16726, IPR031995): Inositol polyphosphate 5-phosphatase clathrin binding domain
177 OFD1protein found in more fusions240.229196.283APG6 (PF04111, IPR007243): Autophagy protein Apg6
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
GrpE (PF01025, IPR000740): GrpE
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
DUF3372 (PF11852, IPR024561): Domain of unknown function (DUF3372)
LisH_2 (PF16045, IPR006594): LisH
178 PAN2interactor280.33197.229RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
179 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
180 PAXIP1interactor130.25629.143BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
181 PCM1oncoprotein180.26888.351FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
182 PDLIM7interactor200.52138.323LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
183 PHBsuppressor360.337121.606Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
184 PHB2interactor290.308108.154DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
185 PICALMoncoprotein420.426208.940ANTH (PF07651, IPR011417): ANTH domain
186 PIK3C2Ainteractor260.49884.389C2 (PF00168, IPR000008, SM00239): C2 domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PX (PF00787, IPR001683, SM00312): PX domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
187 PKP3interactor100.4446.792Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
188 PKP4interactor70.4294.211Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
189 PLEKHA5protein found in more fusions70.4003.174PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
190 POC1Binteractor40.6671.167WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
191 POC5interactor80.35710.848vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
192 PPME1protein found in more fusions90.5364.210Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
193 PPP1CAsuppressor390.321181.017Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
194 PPP1CConcoprotein330.375127.674Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
195 PPP2R1Aoncoprotein420.228346.666TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
196 PPP2R1Bsuppressor80.5244.833HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
197 PRKACAinteractor170.24357.295Pkinase (PF00069, IPR000719): Protein kinase domain
198 PRKAR2Ainteractor70.6192.683RIIa (PF02197, IPR003117, SM00394): Regulatory subunit of type II PKA R-subunit
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
199 PTAFRinteractor31.00007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
200 PTPN23suppressor90.41710.958BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
SOGA (PF11365, IPR027881): Protein SOGA
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
201 PTRH2interactor31.0000PTH2 (PF01981, IPR002833): Peptidyl-tRNA hydrolase PTH2
202 QARSinteractor160.5178.367tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
203 RAB11Aoncoprotein170.23574.263Ras (PF00071, IPR001806, SM00173): Ras family
204 RAB5Boncoprotein120.28825.452Ras (PF00071, IPR001806, SM00173): Ras family
205 RAC1oncoprotein140.39724.450Ras (PF00071, IPR001806, SM00173): Ras family
206 RANBP2oncoprotein180.36022.575Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
DUF2693 (PF10902, IPR024401): Protein of unknown function (DUF2693)
IR1-M (PF12185, IPR022011): Nup358/RanBP2 E3 ligase domain
Dmrt1 (PF12374, IPR022114): Double-sex mab3 related transcription factor 1
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
207 RANBP6interactor50.7001.875HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
208 RBM14suppressor260.36345.393RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
209 REPS1protein found in more fusions80.42919.346Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC)
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
210 RHOUinteractor201.192Ras (PF00071, IPR001806, SM00173): Ras family
SLBP_RNA_bind (PF15247, IPR029344): Histone RNA hairpin-binding protein RNA-binding domain
211 RICTORinteractor60.5332.482RasGEF_N_2 (PF14663, IPR029453): Rapamycin-insensitive companion of mTOR RasGEF_N domain
RICTOR_N (PF14664, IPR028267): Rapamycin-insensitive companion of mTOR, N-term
RICTOR_phospho (PF14665, IPR029259): Rapamycin-insensitive companion of mTOR, phosphorylation-site
RICTOR_M (PF14666, IPR029451): Rapamycin-insensitive companion of mTOR, middle domain
RICTOR_V (PF14668, IPR029452): Rapamycin-insensitive companion of mTOR, domain 5
212 RPA1suppressor400.351158.718Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
213 RPA2oncoprotein330.36995.156RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
214 RPA3interactor310.34598.127Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
215 RPN1oncoprotein430.341212.620Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
216 RPSAinteractor270.45039.813Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
217 SCYL2interactor90.3338.209CENP-B_N (PF04218, IPR007889): CENP-B N-terminal DNA-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
218 SEC13interactor170.46718.663WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
219 SEC16Ainteractor540.261521.509APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
220 SEC23Ainteractor220.40347.578Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
221 SEC24Binteractor110.6186.310Gelsolin (PF00626, IPR007123): Gelsolin repeat
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
222 SEC24Cinteractor200.40040.307Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
223 SH3KBP1protein found in more fusions220.24388.203Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
224 SHC1oncoprotein190.49720.480PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
225 SIRT7interactor430.228247.395DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
226 SLC25A3interactor410.329211.838Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
227 SLC25A41interactor150.27635.839Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
228 SLC35B2interactor100UAA (PF08449, IPR013657): UAA transporter family
229 SMURF1interactor180.31633.974C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
230 SNAP91interactor31.0000ANTH (PF07651, IPR011417): ANTH domain
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
231 SNCAinteractor180.24358.469Synuclein (PF01387, IPR001058): Synuclein
232 SNX5oncoprotein40.5001.567PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
233 SNX9protein found in more fusions120.34511.206PX (PF00787, IPR001683, SM00312): PX domain
BAR_3_WASP_bdg (PF10456, IPR019497): WASP-binding domain of Sorting nexin protein
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
234 SOAT1interactor40.5002.333DUF843 (PF05814, IPR008561): Baculovirus protein of unknown function (DUF843)
MBOAT (PF03062, IPR004299): MBOAT, membrane-bound O-acyltransferase family
235 SORBS2oncoprotein130.7733.102Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
236 SPC25interactor60.2006.238Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
237 SPG20interactor50.4004.068MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
238 SRConcoprotein240.292116.797Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
239 SSR3interactor120.51519.975TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
240 STAMinteractor110.29123.628GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
241 STAMBPinteractor120.37925.195USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
242 STAMBPL1interactor50.9000.091CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
243 STAU1protein found in more fusions360.355117.380dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
244 STOMprotein found in more fusions160.40016.441Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
245 STON2interactor210.65231.338Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Stonin2_N (PF12016, IPR022699): Stonin 2
246 SVILinteractor210.53324.076Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
247 SYNJ1interactor90.5564.754DUF1866 (PF08952, IPR015047, SM01165): Domain of unknown function (DUF1866)
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
Syja_N (PF02383, IPR002013): SacI homology domain
YppG (PF14179, IPR025555): YppG-like protein
248 SYNPOinteractor330.56153.100Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
249 TECRinteractor230.42759.109Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
250 TFE3oncoprotein70.3333.585HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371)
MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
251 TMCO1interactor120.5917.667DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
252 TNK1suppressor70.6671.325Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
253 TNK2interactor180.26560.268CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
254 TNRC6Ainteractor80.5364.828CreD (PF06123, IPR010364): Inner membrane protein CreD
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Ago_hook (PF10427, IPR019486): Argonaute hook
M_domain (PF12938, IPR026805): M domain of GW182
TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain
255 TNRC6Binteractor150.44832.380DUF1421 (PF07223, IPR010820): Protein of unknown function (DUF1421)
Totivirus_coat (PF05518, IPR008871): Totivirus coat protein
Ago_hook (PF10427, IPR019486): Argonaute hook
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain
RRM_occluded (PF16842, IPR031766): Occluded RNA-recognition motif
256 TOM1oncoprotein60.4672.743GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
257 TOM1L1interactor80.3939.841GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
258 TOM1L2suppressor30.3330.803GAT (PF03127, IPR004152): GAT domain
VHS (PF00790, IPR002014, SM00288): VHS domain
259 TOMM22interactor100.5337.503Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
260 TP53suppressor540.253440.659DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
261 TRAFD1interactor30.3330.914zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
DM (PF00751, IPR001275, SM00301): DM DNA binding domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type
262 TROAPprotein found in more fusions40.6670.500Strep_pep (PF14404, IPR025744): Ribosomally synthesized peptide in Streptomyces species
263 TUFMinteractor320.35988.743GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
264 U2AF2protein found in more fusions310.42563.220RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
265 UBL4Ainteractor140.4519.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
266 UNKinteractor160.22546.995MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
267 UQCRC2oncoprotein380.346172.237Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
268 UQCRQinteractor120.48513.160UcrQ (PF02939, IPR004205): UcrQ family
269 USO1interactor110.4898.379Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
MG1 (PF11974, IPR021868): Alpha-2-macroglobulin MG1 domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
270 VCAM1interactor450.237232.237C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
271 VCLoncoprotein180.36033.250Vinculin (PF01044, IPR006077): Vinculin family
272 VDAC1interactor330.314170.665Porin_3 (PF01459, IPR027246): Eukaryotic porin
273 VDAC2interactor340.348143.534Porin_3 (PF01459, IPR027246): Eukaryotic porin
274 VDAC3protein found in more fusions220.51536.637Porin_3 (PF01459, IPR027246): Eukaryotic porin
275 VTI1Binteractor21.0000Fusion_gly (PF00523, IPR000776): Fusion glycoprotein F0
V-SNARE (PF05008, IPR007705): Vesicle transport v-SNARE protein N-terminus
V-SNARE_C (PF12352): Snare region anchored in the vesicle membrane C-terminus
276 WNK1interactor110.42211.552SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
277 XPO1interactor800.1131785.180CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
278 XPR1interactor41.0000EXS (PF03124, IPR004342): EXS family
SPX (PF03105, IPR004331): SPX domain
279 XRCC6oncoprotein380.284167.810Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain
280 YWHAQinteractor320.288148.02714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
281 ZFYVE9interactor70.4297.386FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SARA (PF11409, IPR024608): Smad anchor for receptor activation (SARA)
DUF3480 (PF11979, IPR022557): Domain of unknown function (DUF3480)
282 ZMPSTE24interactor31.0000Peptidase_M48 (PF01435, IPR001915): Peptidase family M48
Peptidase_M48_N (PF16491, IPR032456): CAAX prenyl protease N-terminal, five membrane helices

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