Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FBLN1 (from a repository: Sun Nov 20 11:42:07 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)42
The number (and %) of the onco-proteins8 (19.05 %)
The number (and %) of the tumor suppressors11 (26.19 %)
Total number of binary PPIs (saturation %)85 (9.87 %)
The number (and %) of affected PPIs42 (49.41 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI3.524
Assortativity coefficient-0.3040
The network average Clustering coefficient0.568
The number (and %) of a zero Clustering coefficients11 (26.19 %)
The number (and %) of a zero Betweenness Centrality27 (64.29 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: FBLN1 All fusions
: BE929893; BG827383; BE931220;
Proteins found in more fusions ATN1 (see 1 fusions); APP (see 4 fusions); NID1 (see 1 fusions); FBLN1 (see 3 fusions); SMAD4 (see 2 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FBLN1parental protein420.0401508.000ANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
2 ADAMTSL2interactor100ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
Ribosomal_S27 (PF01599, IPR002906): Ribosomal protein S27a
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
3 ADAMTSL4interactor21.0000ADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
Zn_ribbon_17 (PF17120): Zinc-ribbon, C4HC2 type
4 APOA1interactor40.6671.000ApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
5 APPprotein found in more fusions90.28620.000APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
6 ATN1protein found in more fusions40.6671.000Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
7 BHLHE40interactor200Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
8 CACNA1Ainteractor21.0000Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
9 CTGFsuppressor100Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
10 DKK1suppressor100Dickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
UPF0506 (PF11703, IPR021712): UPF0506
11 EDC4interactor100DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
12 ELNoncoprotein21.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
DUF4169 (PF13770, IPR025227): Domain of unknown function (DUF4169)
13 FCN1interactor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
14 FGBinteractor30.6671.000Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
15 FN1oncoprotein70.28615.000fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
16 GFI1Boncoprotein21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
17 IFI30oncoprotein100GILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)
18 KCTD9interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
Pentapeptide (PF00805, IPR001646): Pentapeptide repeats (8 copies)
KHA (PF11834, IPR021789): KHA, dimerisation domain of potassium ion channel
19 LGALS9interactor30.6671.000Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
20 LTBP4interactor50.4006.000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
TB (PF00683, IPR017878): TB domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
21 MPGinteractor21.0000Pur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)
22 NEDD1interactor100NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
FliM (PF02154, IPR001689): Flagellar motor switch protein FliM
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23 NID1protein found in more fusions40.6671.000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
G2F (PF07474, IPR006605, SM00682): G2F domain
NIDO (PF06119, IPR003886, SM00539): Nidogen-like
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
Thyroglobulin_1 (PF00086, IPR000716, SM00211): Thyroglobulin type-1 repeat
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
24 NLGN3interactor31.0000COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
25 NOTCH3suppressor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
26 NOVsuppressor21.0000Cys_knot (PF00007, IPR006208): Cystine-knot domain
VWC (PF00093, IPR001007, SM00214): von Willebrand factor type C domain
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
27 PLSCR1interactor50.4006.000Scramblase (PF03803, IPR005552): Scramblase
28 PLSCR4interactor21.0000Scramblase (PF03803, IPR005552): Scramblase
29 PSG1interactor31.0000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
30 PSG3interactor40.6672.000V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
31 PTPRKsuppressor21.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Protocadherin (PF08374, IPR013585): Protocadherin
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
32 SFRP4suppressor100NTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Fz (PF01392, IPR020067, SM00063): Fz domain
33 SKILsuppressor60.5005.000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
34 SMAD3oncoprotein60.6004.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
35 SMAD4suppressor50.6672.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
36 TAF9interactor21.0000TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
37 TANKsuppressor41.0000DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
38 TCF7L2suppressor100CTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
39 TDGF1suppressor100CFC (PF09443, IPR019011): Cripto_Frl-1_Cryptic (CFC)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
40 WNT4interactor21.0000MEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family
41 YWHAQinteractor21.000014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
42 ZFP41interactor30.6671.000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

B a c k    t o    T o p ⇑


List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADAMTSL2interactorADAM_spacer1 (PF05986, IPR010294): ADAM-TS Spacer 1
PLAC (PF08686, IPR010909, SM00022): PLAC (protease and lacunin) domain
Ribosomal_S27 (PF01599, IPR002906): Ribosomal protein S27a
TSP_1 (PF00090, IPR000884, SM00209): Thrombospondin type 1 domain
BE931220
2 APOA1interactorApoA-II (PF04711, IPR006801): Apolipoprotein A-II (ApoA-II)
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
BE931220
3 BHLHE40interactorHairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
BE931220
4 DKK1suppressorDickkopf_N (PF04706, IPR006796): Dickkopf N-terminal cysteine-rich region
UPF0506 (PF11703, IPR021712): UPF0506
BE931220
5 EDC4interactorDUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
BE931220
6 ELNoncoproteinForkhead_N (PF08430, IPR013638): Forkhead N-terminal region
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Rifin_STEVOR (PF02009, IPR002858): Rifin/stevor family
Sporozoite_P67 (PF05642, IPR008845): Sporozoite P67 surface antigen
DUF4169 (PF13770, IPR025227): Domain of unknown function (DUF4169)
BE931220
7 FBLN1parental proteinANATO (PF01821, IPR000020, SM00104): Anaphylotoxin-like domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
BE931220, BG827383
8 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
BE931220
9 IFI30oncoproteinGILT (PF03227, IPR004911): Gamma interferon inducible lysosomal thiol reductase (GILT)BE931220
10 KCTD9interactorBTB_2 (PF02214, IPR003131): BTB/POZ domain
Pentapeptide (PF00805, IPR001646): Pentapeptide repeats (8 copies)
KHA (PF11834, IPR021789): KHA, dimerisation domain of potassium ion channel
BE931220
11 LGALS9interactorGal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
Peptidase_C62 (PF12380, IPR024348): Gill-associated viral 3C-like peptidase
BE931220
12 MPGinteractorPur_DNA_glyco (PF02245, IPR003180): Methylpurine-DNA glycosylase (MPG)BE931220
13 NEDD1interactorNRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
FliM (PF02154, IPR001689): Flagellar motor switch protein FliM
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
BE931220
14 PLSCR1interactorScramblase (PF03803, IPR005552): ScramblaseBE931220
15 PLSCR4interactorScramblase (PF03803, IPR005552): ScramblaseBE931220
16 SFRP4suppressorNTR (PF01759, IPR018933, SM00206): UNC-6/NTR/C345C module
Fz (PF01392, IPR020067, SM00063): Fz domain
BE931220
17 TAF9interactorTFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
BE931220
18 TANKsuppressorDUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
TBD (PF12845, IPR024581): TBD domain
BE931220
19 TCF7L2suppressorCTNNB1_binding (PF08347, IPR013558): N-terminal CTNNB1 binding
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
BE931220
20 TDGF1suppressorCFC (PF09443, IPR019011): Cripto_Frl-1_Cryptic (CFC)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
BE931220
21 WNT4interactorMEF2_binding (PF09047, IPR015134): MEF2 binding
wnt (PF00110, IPR005817, SM00097): wnt family
BE931220
22 YWHAQinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 proteinBE931220

B a c k    t o    T o p ⇑