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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)30
The number (and %) of the onco-proteins8 (26.67 %)
The number (and %) of the tumor suppressors4 (13.33 %)
Total number of binary PPIs (saturation %)106 (24.37 %)
The number (and %) of affected PPIs30 (28.30 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI6.267
Assortativity coefficient-0.3610
The network average Clustering coefficient0.559
The number (and %) of a zero Clustering coefficients8 (26.67 %)
The number (and %) of a zero Betweenness Centrality12 (40.00 %)


List of the fusions

PPI for parental proteins: FANCL All fusions
: BE694283; BE694274;
Proteins found in more fusions FANCA (see 1 fusions); FANCG (see 1 fusions); PCNA (see 1 fusions); FANCL (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 FANCLparental protein300.160607.579WD-3 (PF09765, IPR019162): WD-repeat region
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
2 CCDC36interactor100DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
3 CENPSsuppressor110.8911.579CENP-S (PF15630, IPR029003): CENP-S protein
COMMD1_N (PF17221): COMMD1 N-terminal domain
4 CENPXinteractor90.9440.500CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
5 CHCHD3interactor30.6671.000DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
6 DOCK8interactor200DHR-2 (PF06920, IPR010703): Dock homology region 2
DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398)
DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins
DOCK_N (PF16172, IPR032376): DOCK N-terminus
7 EIF4ENIF1interactor21.0000EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
8 FAAP100interactor110.8911.579FANCAA (PF15146, IPR029251): Fanconi anemia-associated
9 FAAP20interactor110.7649.405UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
10 FAAP24interactor90.9440.508Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_2 (PF12826): Helix-hairpin-helix motif
11 FANCAoncoprotein140.69215.246Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
12 FANCBinteractor81.0000DP (PF08781, IPR014889, SM01138): Transcription factor DP
13 FANCConcoprotein110.7457.222Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
14 FANCD2oncoprotein60.4007.667FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
15 FANCFoncoprotein100.8672.222FANCF (PF11107): Fanconi anemia group F protein (FANCF)
16 FANCGsuppressor140.70511.913BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
17 FANCIinteractor30.6670.500DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
18 FANCMinteractor130.75811.579ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MRC1 (PF09444, IPR018564): MRC1-like domain
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HHH_2 (PF12826): Helix-hairpin-helix motif
FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
19 GRNoncoprotein100Granulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
20 HES1oncoprotein51.0000Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
21 IKZF3suppressor200C1_2 (PF03107, IPR004146): C1 domain
Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_7 (PF15269): Zinc-finger
22 KIFC3oncoprotein40.6671.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23 LZTS2suppressor30.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127)
Fez1 (PF06818): Fez1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
24 PCNAoncoprotein40.6670.500PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
25 RBM45interactor200RNA_bind (PF08675, IPR014789): RNA binding domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26 RIMBP3interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
G-gamma (PF00631, IPR015898, SM00224): GGL domain
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
27 SSX2IPinteractor40.6671.000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
28 TFCP2interactor100CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
29 UBE2Tinteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30 UBE2Winteractor200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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