Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins FANCL (from a repository: Sat Nov 12 16:33:49 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 30 The number (and %) of the onco-proteins 8 (26.67 %) The number (and %) of the tumor suppressors 4 (13.33 %) Total number of binary PPIs (saturation %) 106 (24.37 %) The number (and %) of affected PPIs 30 (28.30 %) The number of possible different fusions 5 PPI diameter 2 PPI radius 1 The average degree of PPI 6.267 Assortativity coefficient -0.3610 The network average Clustering coefficient 0.559 The number (and %) of a zero Clustering coefficients 8 (26.67 %) The number (and %) of a zero Betweenness Centrality 12 (40.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: FANCL	All fusions : BE694283; BE694274;
Proteins found in more fusions	FANCA (see 1 fusions); FANCG (see 1 fusions); PCNA (see 1 fusions); FANCL (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	FANCL	parental protein	30	0.160	607.579	WD-3 (PF09765, IPR019162): WD-repeat region FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
2	CCDC36	interactor	1	0	0	DUF4700 (PF15771, IPR031529): Domain of unknown function (DUF4700)
3	CENPS	suppressor	11	0.891	1.579	CENP-S (PF15630, IPR029003): CENP-S protein COMMD1_N (PF17221): COMMD1 N-terminal domain
4	CENPX	interactor	9	0.944	0.500	CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
5	CHCHD3	interactor	3	0.667	1.000	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) eIF3g (PF12353, IPR024675): Eukaryotic translation initiation factor 3 subunit G
6	DOCK8	interactor	2	0	0	DHR-2 (PF06920, IPR010703): Dock homology region 2 DUF3398 (PF11878, IPR021816): Domain of unknown function (DUF3398) DOCK-C2 (PF14429, IPR027007): C2 domain in Dock180 and Zizimin proteins DOCK_N (PF16172, IPR032376): DOCK N-terminus
7	EIF4ENIF1	interactor	2	1.000	0	EIF4E-T (PF10477, IPR018862): Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
8	FAAP100	interactor	11	0.891	1.579	FANCAA (PF15146, IPR029251): Fanconi anemia-associated
9	FAAP20	interactor	11	0.764	9.405	UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
10	FAAP24	interactor	9	0.944	0.508	Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 (PF12826): Helix-hairpin-helix motif
11	FANCA	oncoprotein	14	0.692	15.246	Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
12	FANCB	interactor	8	1.000	0	DP (PF08781, IPR014889, SM01138): Transcription factor DP
13	FANCC	oncoprotein	11	0.745	7.222	Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
14	FANCD2	oncoprotein	6	0.400	7.667	FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
15	FANCF	oncoprotein	10	0.867	2.222	FANCF (PF11107): Fanconi anemia group F protein (FANCF)
16	FANCG	suppressor	14	0.705	11.913	BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain Hpt (PF01627, IPR008207, SM00073): Hpt domain TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
17	FANCI	interactor	3	0.667	0.500	DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972) FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1 FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2 FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3 FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4 FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1 FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
18	FANCM	interactor	13	0.758	11.579	ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain MRC1 (PF09444, IPR018564): MRC1-like domain ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain HHH_2 (PF12826): Helix-hairpin-helix motif FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
19	GRN	oncoprotein	1	0	0	Granulin (PF00396, IPR000118, SM00277): Granulin Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
20	HES1	oncoprotein	5	1.000	0	Hairy_orange (PF07527, IPR003650): Hairy Orange HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
21	IKZF3	suppressor	2	0	0	C1_2 (PF03107, IPR004146): C1 domain Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger zf-C2H2_7 (PF15269): Zinc-finger
22	KIFC3	oncoprotein	4	0.667	1.000	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
23	LZTS2	suppressor	3	0.667	1.000	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF1127 (PF06568, IPR009506): Domain of unknown function (DUF1127) Fez1 (PF06818): Fez1 ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding DUF4250 (PF14056, IPR025346): Domain of unknown function (DUF4250)
24	PCNA	oncoprotein	4	0.667	0.500	PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
25	RBM45	interactor	2	0	0	RNA_bind (PF08675, IPR014789): RNA binding domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26	RIMBP3	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SH3_2 (PF07653, IPR011511): Variant SH3 domain tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain G-gamma (PF00631, IPR015898, SM00224): GGL domain Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
27	SSX2IP	interactor	4	0.667	1.000	ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein
28	TFCP2	interactor	1	0	0	CP2 (PF04516, IPR007604): CP2 transcription factor DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
29	UBE2T	interactor	3	1.000	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
30	UBE2W	interactor	2	0	0	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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