Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FANCG (from a repository: Sat Nov 12 16:41:03 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)46
The number (and %) of the onco-proteins16 (34.78 %)
The number (and %) of the tumor suppressors6 (13.04 %)
Total number of binary PPIs (saturation %)175 (16.91 %)
The number (and %) of affected PPIs46 (26.29 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI7.000
Assortativity coefficient-0.3622
The network average Clustering coefficient0.514
The number (and %) of a zero Clustering coefficients12 (26.09 %)
The number (and %) of a zero Betweenness Centrality17 (36.96 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FANCG All fusions
: BQ224571;
Proteins found in more fusions KRT19 (see 1 fusions); FANCA (see 1 fusions); FANCG (see 1 fusions); FAN1 (see 1 fusions); FANCL (see 2 fusions); RPA1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FANCGparental protein460.1171483.406BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
2 BLMsuppressor120.54519.505BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
3 BRCA2suppressor60.4008.000BRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
4 BRCC3interactor50.6672.000JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
5 CAPN1interactor41.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
6 CDK1oncoprotein60.6002.619Pkinase (PF00069, IPR000719): Protein kinase domain
7 CENPSsuppressor150.69510.806CENP-S (PF15630, IPR029003): CENP-S protein
COMMD1_N (PF17221): COMMD1 N-terminal domain
8 CENPXinteractor120.7734.529CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
9 CTNNB1oncoprotein40.6672.000Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
10 CYP2E1interactor100p450 (PF00067, IPR001128): Cytochrome P450
11 DOK5interactor100IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
12 ERCC1oncoprotein30.6671.000Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_5 (PF14520): Helix-hairpin-helix domain
13 ERCC4oncoprotein40.6672.000ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
LUC7 (PF03194, IPR004882): LUC7 N_terminus
T2SSM_b (PF10741, IPR007690): Type II secretion system (T2SS), protein M subtype b
HHH_5 (PF14520): Helix-hairpin-helix domain
14 FAAP100interactor140.7367.768FANCAA (PF15146, IPR029251): Fanconi anemia-associated
15 FAAP20interactor110.8731.872UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
16 FAAP24interactor90.9440.486Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_2 (PF12826): Helix-hairpin-helix motif
17 FAM175Ainteractor31.0000DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SRC-1 (PF08832, IPR014935): Steroid receptor coactivator
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
18 FAN1protein found in more fusions41.0000VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
19 FANCAoncoprotein230.40790.972Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
20 FANCBinteractor81.0000DP (PF08781, IPR014889, SM01138): Transcription factor DP
21 FANCConcoprotein160.51732.815Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
22 FANCD2oncoprotein80.39312.039FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
23 FANCEoncoprotein130.65212.633FA_FANCE (PF11510, IPR021025): Fanconi Anaemia group E protein FANCE
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
24 FANCFoncoprotein120.7885.048FANCF (PF11107): Fanconi anemia group F protein (FANCF)
25 FANCLprotein found in more fusions140.7059.990WD-3 (PF09765, IPR019162): WD-repeat region
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
26 FANCMinteractor160.69510.806ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MRC1 (PF09444, IPR018564): MRC1-like domain
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HHH_2 (PF12826): Helix-hairpin-helix motif
FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
27 FTSJ3interactor100DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase
M16C_assoc (PF08367, IPR013578): Peptidase M16C associated
Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein
Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
28 GABPB1oncoprotein100Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_23 (PF13476): AAA domain
Ank_4 (PF13637): Ankyrin repeats (many copies)
DUF4265 (PF14085, IPR025361): Domain of unknown function (DUF4265)
29 HES1oncoprotein70.8570.982Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
30 KIF15interactor100Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
STE (PF02200, IPR003120, SM00424): STE like transcription factor
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
FlxA (PF14282, IPR025577): FlxA-like protein
HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
31 KRT19suppressor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
32 NLGN3interactor100COesterase (PF00135, IPR002018): Carboxylesterase family
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
33 POLNinteractor30.6670.333DNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
34 PRDX3interactor200AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
35 PSMB1interactor100Proteasome (PF00227, IPR001353): Proteasome subunit
36 RPA1suppressor110.55612.319Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
37 RTN2interactor100Reticulon (PF02453, IPR003388): Reticulon
38 SAMD3interactor100SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
RecG_wedge (PF17191): RecG wedge domain
39 SPTAN1oncoprotein80.6076.286EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
40 TOP3Aoncoprotein70.9520.286A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-GRF (PF06839, IPR010666): GRF zinc finger
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
41 UIMC1suppressor50.5004.500Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
42 USHBP1interactor40.6671.000DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SlyX (PF04102, IPR007236): SlyX
MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome
YlqD (PF11068, IPR021297): YlqD protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
CAGE1 (PF15066, IPR029381): Cancer-associated gene protein 1 family
TEX13 (PF15186, IPR028193): Testis-expressed sequence 13 protein family
43 VPS50interactor100Vps54_N (PF10475, IPR019515): Vacuolar-sorting protein 54, of GARP complex
DUF2451 (PF10474, IPR019514): Protein of unknown function C-terminus (DUF2451)
44 XPO1interactor30.6671.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
45 XRCC3oncoprotein30.6671.000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
46 ZBED1interactor200Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)

B a c k    t o    T o p ⇑