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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FANCA (from a repository: Sat Nov 12 16:41:29 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)71
The number (and %) of the onco-proteins23 (32.39 %)
The number (and %) of the tumor suppressors12 (16.90 %)
Total number of binary PPIs (saturation %)295 (11.87 %)
The number (and %) of affected PPIs71 (24.07 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI7.521
Assortativity coefficient-0.3419
The network average Clustering coefficient0.542
The number (and %) of a zero Clustering coefficients13 (18.31 %)
The number (and %) of a zero Betweenness Centrality24 (33.80 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FANCA All fusions
Proteins found in more fusions FANCG (see 1 fusions); HSP90AA1 (see 2 fusions); NPM1 (see 1 fusions); FANCA (see 1 fusions); IKBKB (see 2 fusions); PCNA (see 1 fusions); FANCL (see 2 fusions); SGK1 (see 2 fusions); MSH2 (see 1 fusions); RPA1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FANCAparental protein710.0823718.942Fanconi_A (PF03511, IPR003516): Fanconi anaemia group A protein
Fanconi_A_N (PF15865, IPR031729): Fanconi anaemia group A protein N terminus
2 AKT1oncoprotein110.51114.533PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 ALDOAinteractor60.7001.567Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4 ATP5Binteractor30.6670.500AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
NACHT (PF05729): NACHT domain
5 ATRsuppressor100.44415.571FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
6 AZIN1interactor21.0000Orn_Arg_deC_N (PF02784, IPR022644): Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Orn_DAP_Arg_deC (PF00278, IPR022643): Pyridoxal-dependent decarboxylase, C-terminal sheet domain
7 BLMsuppressor160.49537.975BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
8 BRCA1suppressor150.39638.052BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
9 BSGinteractor21.0000Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
10 CAPN1interactor41.0000Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
11 CCT3interactor40.5003.000Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CD79Aoncoprotein100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
13 CDK1oncoprotein80.5714.219Pkinase (PF00069, IPR000719): Protein kinase domain
14 CENPEinteractor40.6670.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
VIT1 (PF01988, IPR008217): VIT family
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_13 (PF13166, IPR026866): AAA domain
DUF4023 (PF13215, IPR025097): Protein of unknown function (DUF4023)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
15 CENPSsuppressor170.64017.323CENP-S (PF15630, IPR029003): CENP-S protein
COMMD1_N (PF17221): COMMD1 N-terminal domain
16 CENPXinteractor130.7445.849CENP-X (PF09415, IPR018552): CENP-S associating Centromere protein X
17 CHUKsuppressor60.9000.333Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
18 CTNNB1oncoprotein80.46410.467Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
19 DAXXoncoprotein31.0000Daxx (PF03344, IPR005012): Daxx N-terminal Rassf1C-interacting domain
Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Nop14 (PF04147, IPR007276): Nop14-like family
RF-1 (PF00472, IPR000352): RF-1 domain
Vpu (PF00558, IPR008187): Vpu protein
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
20 DDX39Binteractor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
21 DNAJB1suppressor50.5003.400DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
22 DUS4Linteractor100Dus (PF01207, IPR001269): Dihydrouridine synthase (Dus)
23 ENO1oncoprotein60.7331.900Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
24 ERCC4oncoprotein50.5004.167ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
LUC7 (PF03194, IPR004882): LUC7 N_terminus
T2SSM_b (PF10741, IPR007690): Type II secretion system (T2SS), protein M subtype b
HHH_5 (PF14520): Helix-hairpin-helix domain
25 FAAP100interactor160.66714.254FANCAA (PF15146, IPR029251): Fanconi anemia-associated
26 FAAP20interactor110.8731.872UBZ_FAAP20 (PF15750, IPR031490): Ubiquitin-binding zinc-finger
FANCA_interact (PF15751, IPR031491): FAAP20 FANCA interaction domain
27 FAAP24interactor100.7786.052Rad10 (PF03834, IPR004579): Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
HHH_2 (PF12826): Helix-hairpin-helix motif
28 FANCBinteractor81.0000DP (PF08781, IPR014889, SM01138): Transcription factor DP
29 FANCConcoprotein230.289142.515Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
30 FANCEoncoprotein120.7276.933FA_FANCE (PF11510, IPR021025): Fanconi Anaemia group E protein FANCE
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
31 FANCFoncoprotein130.7318.337FANCF (PF11107): Fanconi anemia group F protein (FANCF)
32 FANCGsuppressor230.40787.868BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
33 FANCLprotein found in more fusions140.69211.624WD-3 (PF09765, IPR019162): WD-repeat region
FANCL_C (PF11793, IPR026850): FANCL C-terminal domain
34 FANCMinteractor180.64017.323ERCC4 (PF02732, IPR006166, SM00891): ERCC4 domain
MRC1 (PF09444, IPR018564): MRC1-like domain
ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
HHH_2 (PF12826): Helix-hairpin-helix motif
FANCM-MHF_bd (PF16783, IPR031879): FANCM to MHF binding domain
35 GNB2interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
CALM_bind (PF16025): Calcium-dependent calmodulin binding
WD40_like (PF17005, IPR031544): WD40-like domain
36 HES1oncoprotein80.7503.148Hairy_orange (PF07527, IPR003650): Hairy Orange
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
37 HPRT1interactor200Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
38 HSP90AA1oncoprotein170.27571.719HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
39 HSP90B1suppressor50.4004.667CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
40 IFIT3interactor200TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
41 IKBKBprotein found in more fusions60.9000.333FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
42 KRASoncoprotein40.6671.000Ras (PF00071, IPR001806, SM00173): Ras family
43 KRT1interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
44 LIPGinteractor200Lipase (PF00151, IPR013818): Lipase
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
45 MKNK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
46 MSH2suppressor90.53611.067MutS_I (PF01624, IPR007695): MutS domain I
MutS_II (PF05188, IPR007860): MutS domain II
MutS_V (PF00488, IPR000432, SM00534): MutS domain V
MutS_III (PF05192, IPR007696, SM00533): MutS domain III
AAA_27 (PF13514): AAA domain
47 MX1interactor40.6671.000Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
48 NAMPTinteractor100NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
49 NPM1suppressor120.41822.119Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
50 NUB1interactor100Glyphos_transf (PF04464, IPR007554): CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
TPR_12 (PF13424): Tetratricopeptide repeat
HOIP-UBA (PF16678, IPR032065): UB-associated-like domain of HOIP or E3 ubiquitin-protein ligase
51 P2RY8oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
52 PCNAoncoprotein110.31124.582PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
53 POLNinteractor40.5001.200DNA_pol_A (PF00476, IPR001098, SM00482): DNA polymerase family A
54 PRPF31interactor40.6671.000Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin
Cytokin_check_N (PF10407, IPR018844): Cdc14 phosphatase binding protein N-terminus
Prp31_C (PF09785, IPR019175): Prp31 C terminal domain
55 PSMA5oncoprotein30.6671.000Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
56 RMI1interactor100.8222.471RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
RMI1_C (PF16099, IPR032199): Recq-mediated genome instability protein 1, C-terminal OB-fold
57 RMI2oncoprotein71.0000RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
58 RNF4interactor31.0000Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
59 RPA1suppressor190.32773.406Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
60 RPL18interactor50.6002.533Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
61 SGK1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
62 SMARCA4suppressor60.4676.400DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
63 SNX5oncoprotein100PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
64 SPTA1interactor21.0000EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
65 SPTAN1oncoprotein110.40025.438EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
66 TAF10interactor40.5003.000TFIID_30kDa (PF03540, IPR003923): Transcription initiation factor TFIID 23-30kDa subunit
67 TCERG1interactor40.8330.200FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
68 TCP1interactor50.6003.333Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
69 TOP3Aoncoprotein90.8891.139A2L_zn_ribbon (PF08792, IPR014900): A2L zinc ribbon domain
Topoisom_bac (PF01131, IPR013497): DNA topoisomerase
Toprim (PF01751, IPR006171, SM00493): Toprim domain
zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-GRF (PF06839, IPR010666): GRF zinc finger
zf-C2H2_10 (PF16588, IPR001878): C2H2 zinc-finger
70 TPT1interactor21.0000TCTP (PF00838, IPR018105): Translationally controlled tumour protein
71 ZNF24interactor100SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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