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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAN1 (from a repository: Thu Dec 1 20:23:50 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)35
The number (and %) of the onco-proteins14 (40.00 %)
The number (and %) of the tumor suppressors6 (17.14 %)
Total number of binary PPIs (saturation %)83 (13.95 %)
The number (and %) of affected PPIs35 (42.17 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.114
Assortativity coefficient-0.2946
The network average Clustering coefficient0.485
The number (and %) of a zero Clustering coefficients11 (31.43 %)
The number (and %) of a zero Betweenness Centrality19 (54.29 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions KPNB1 (see 2 fusions); NCOA5 (see 1 fusions); FANCG (see 1 fusions); FAN1 (see 1 fusions); YWHAZ (see 1 fusions); PCNA (see 1 fusions); UBC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FAN1parental protein350.068943.233VRR_NUC (PF08774, IPR014883, SM00990): VRR-NUC domain
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363)
2 AKR7A2interactor31.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
3 ANKLE2interactor21.0000Cauli_VI (PF01693, IPR011320): Caulimovirus viroplasmin
LEM (PF03020, IPR003887, SM00540): LEM domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Telomere_Sde2_2 (PF13297): Telomere stability C-terminal
4 ANXA7suppressor100Annexin (PF00191, IPR018502, SM00335): Annexin
5 AP2A2interactor100Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
6 BLMsuppressor60.6003.667BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
7 C1orf52interactor100MRI (PF15325, IPR028278): Modulator of retrovirus infection
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
DUF4660 (PF15559, IPR029089): Domain of unknown function (DUF4660)
8 CD99L2interactor100CD99L2 (PF12301, IPR022078): CD99 antigen like protein 2
9 FANCD2oncoprotein70.4769.400FancD2 (PF14631, IPR029448): Fanconi anaemia protein FancD2 nuclease
10 FANCGsuppressor41.0000BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
11 FANCIinteractor30.6671.000DUF3972 (PF13118, IPR025002): Protein of unknown function (DUF3972)
FANCI_S1-cap (PF14674, IPR029305): FANCI solenoid 1 cap
FANCI_S1 (PF14675, IPR029308): FANCI solenoid 1
FANCI_S2 (PF14676, IPR026171): FANCI solenoid 2
FANCI_S3 (PF14677, IPR029313): FANCI solenoid 3
FANCI_S4 (PF14678, IPR029314): FANCI solenoid 4
FANCI_HD1 (PF14679, IPR029310): FANCI helical domain 1
FANCI_HD2 (PF14680, IPR029312): FANCI helical domain 2
12 H3F3Concoprotein100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
13 HEXAinteractor21.0000Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
14 KPNB1protein found in more fusions70.5336.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
HEAT_EZ (PF13513): HEAT-like repeat
15 MIER1oncoprotein100CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
ELM2 (PF01448, IPR000949): ELM2 domain
HpaP (PF09483, IPR013390): Type III secretion protein (HpaP)
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
16 MLH1suppressor100.42221.233DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
17 MLH3suppressor21.0000DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
18 NCOA5suppressor200Macoilin (PF09726, IPR019130): Transmembrane protein
19 PCNAoncoprotein90.35716.167PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
20 PIK3C2Binteractor100C2 (PF00168, IPR000008, SM00239): C2 domain
PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PX (PF00787, IPR001683, SM00312): PX domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
21 PLEKHA8oncoprotein30.6671.000GLTP (PF08718, IPR014830): Glycolipid transfer protein (GLTP)
PH (PF00169, IPR001849, SM00233): PH domain
AKNA (PF12443, IPR022150): AT-hook-containing transcription factor
22 PMS1oncoprotein60.7002.333DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
MRP-L46 (PF11788, IPR021757): 39S mitochondrial ribosomal protein L46
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
23 PMS2oncoprotein50.8001.067DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
MORN_2 (PF07661, IPR011652): MORN repeat variant
MutL_C (PF08676, IPR014790, SM00853): MutL C terminal dimerisation domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
24 PPP2R1Aoncoprotein50.7003.000TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
25 PRPF4Boncoprotein100Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
Ureide_permease (PF07168, IPR009834): Ureide permease
Pkinase (PF00069, IPR000719): Protein kinase domain
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
26 PSMD11interactor21.0000DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
27 RFC3interactor40.6671.067CHB_HEX (PF03173, IPR004866, SM01081): Putative carbohydrate binding domain
DNA_pol3_delta (PF06144, IPR010372): DNA polymerase III, delta subunit
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
DNA_pol3_delta2 (PF13177): DNA polymerase III, delta subunit
28 RFC4interactor40.6671.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
29 SDPRinteractor200ALMT (PF11744, IPR020966): Aluminium activated malate transporter
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
Caskin-tail (PF16632, IPR032117): C-terminal region of Caskin
30 SUPT5Hinteractor21.0000KOW (PF00467, IPR005824, SM00739): KOW motif
Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit
Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
31 TRAP1oncoprotein21.0000HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
32 UBCprotein found in more fusions120.30933.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
33 WDR75interactor100WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
34 YWHAEoncoprotein30.6670.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
35 YWHAZprotein found in more fusions40.6670.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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