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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAM208B (from a repository: Fri Nov 11 23:35:11 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)27
The number (and %) of the onco-proteins5 (18.52 %)
The number (and %) of the tumor suppressors1 (3.70 %)
Total number of binary PPIs (saturation %)58 (16.52 %)
The number (and %) of affected PPIs27 (46.55 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.333
Assortativity coefficient-0.4919
The network average Clustering coefficient0.444
The number (and %) of a zero Clustering coefficients10 (37.04 %)
The number (and %) of a zero Betweenness Centrality17 (62.96 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FAM208B All fusions
: BM683999;
Proteins found in more fusions STAT3 (see 2 fusions); CUL3 (see 1 fusions); MPHOSPH8 (see 5 fusions); FAM208B (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FAM208Bparental protein270.058579.167DUF3699 (PF12480, IPR022168): Protein of unknown function (DUF3699)
DUF3715 (PF12509, IPR022188): Protein of unknown function (DUF3715)
2 ATRIPinteractor21.0000Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
3 CARD9interactor70.4677.167CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
4 CCDC85Binteractor50.4005.000CCDC85 (PF10226, IPR019359): CCDC85 family
5 CCNG2interactor100Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
6 COX5Binteractor21.0000COX5B (PF01215, IPR002124): Cytochrome c oxidase subunit Vb
7 CUL3protein found in more fusions50.5003.000Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
8 ERHinteractor100ER (PF01133, IPR000781): Enhancer of rudimentary
9 FBF1interactor40.5002.500DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
YlqD (PF11068, IPR021297): YlqD protein
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
10 KCTD9interactor60.5005.000BTB_2 (PF02214, IPR003131): BTB/POZ domain
Pentapeptide (PF00805, IPR001646): Pentapeptide repeats (8 copies)
KHA (PF11834, IPR021789): KHA, dimerisation domain of potassium ion channel
11 KLHL40interactor100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
12 LDOC1oncoprotein31.0000DUF4939 (PF16297, IPR032549): Domain of unknown function (DUF4939)
13 LMO1oncoprotein21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
14 MORN3interactor100MORN (PF02493, IPR003409, SM00698): MORN repeat
TFIIIC_sub6 (PF10419, IPR019481): TFIIIC subunit
15 MPHOSPH8protein found in more fusions31.0000Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
YqzE (PF14038, IPR025622): YqzE-like protein
16 NEK6interactor40.6670.500Pkinase (PF00069, IPR000719): Protein kinase domain
17 NFX1interactor100R3H (PF01424, IPR001374, SM00393): R3H domain
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
zf-NF-X1 (PF01422, IPR000967, SM00438): NF-X1 type zinc finger
18 POLR1Cinteractor30.6671.000RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
19 PPP1R16Boncoprotein21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
20 PRKAB2interactor200AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain
AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
21 SCAMP1interactor200SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
22 SIRT7interactor100DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
23 STAT3suppressor200SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
24 TRIM23interactor70.4008.000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
FemAB (PF02388, IPR003447): FemAB family
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
25 TRIM42interactor50.8330.667CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
26 ZNF200interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3113 (PF11310, IPR021461): Protein of unknown function (DUF3113)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
27 ZNF597interactor31.0000zf-RING_7 (PF02591, IPR003743): C4-type zinc ribbon domain
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2H2_9 (PF16293, IPR032553): C2H2 type zinc-finger (1 copy)

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