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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins FAM136A (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)20
The number (and %) of the onco-proteins1 (5.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)30 (15.79 %)
The number (and %) of affected PPIs20 (66.67 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.700
Assortativity coefficient-0.5558
The network average Clustering coefficient0.352
The number (and %) of a zero Clustering coefficients11 (55.00 %)
The number (and %) of a zero Betweenness Centrality17 (85.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: FAM136A All fusions
: AA662580;
Proteins found in more fusions RBFOX2 (see 2 fusions); FAM136A (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 FAM136Aparental protein200.047310.000DUF842 (PF05811, IPR008560): Eukaryotic protein of unknown function (DUF842)
2 ACSL5interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
3 ATP5F1interactor40.6672.000Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
4 ATP5Hinteractor31.0000Mt_ATP-synt_D (PF05873, IPR008689): ATP synthase D chain, mitochondrial (ATP5H)
5 BCKDHAinteractor100E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
6 C1QBPinteractor21.0000MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
7 CHCHD2interactor80.33314.000CHCH (PF06747, IPR010625): CHCH domain
DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076)
8 CLPBinteractor100AAA_2 (PF07724, IPR013093): AAA domain (Cdc48 subfamily)
Torsin (PF06309, IPR010448): Torsin
ClpB_D2-small (PF10431, IPR019489, SM01086): C-terminal, D2-small domain, of ClpB protein
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
AAA_33 (PF13671): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
9 CYB5R3interactor21.0000FAD_binding_6 (PF00970, IPR008333): Oxidoreductase FAD-binding domain
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
10 DHX30interactor100Bombolitin (PF08096, IPR012534): Bombolitin family
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
11 ECH1interactor21.0000ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
12 HCCSinteractor100Cyto_heme_lyase (PF01265, IPR000511): Cytochrome c/c1 heme lyase
13 IDEinteractor21.0000Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
14 MRPS16interactor100Ribosomal_S16 (PF00886, IPR000307): Ribosomal protein S16
FtsK_4TM (PF13491, IPR025199): 4TM region of DNA translocase FtsK/SpoIIIE
15 NDUFS6interactor100Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
zf-CHCC (PF10276, IPR019401, SM00400): Zinc-finger domain
16 NUDCD3interactor100CS (PF04969, IPR007052): CS domain
DUF1737 (PF08410, IPR013619): Domain of unknown function (DUF1737)
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
17 OBFC1interactor100STN1_2 (PF09170, IPR015253): CST, Suppressor of cdc thirteen homolog, complex subunit STN1
RUN (PF02759, IPR004012, SM00593): RUN domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
Stn1 (PF10451, IPR018856): Telomere regulation protein Stn1
18 OTUB1interactor100Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
19 POLDIP2interactor21.0000DUF525 (PF04379, IPR007474): Protein of unknown function (DUF525)
YccV-like (PF08755, IPR011722, SM00992): Hemimethylated DNA-binding protein YccV like
20 RBFOX2protein found in more fusions200RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Fox-1_C (PF12414, IPR025670): Calcitonin gene-related peptide regulator C terminal

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