1 |
EZR | parental protein | 136 | 0.068 | 12695.226 | DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
2 |
ACAA2 | interactor | 13 | 0.667 | 11.542 | Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain |
3 |
ACTN1 | protein found in more fusions | 11 | 0.467 | 13.681 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation |
4 |
ADORA2B | interactor | 3 | 0.667 | 1.000 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C (PF11970, IPR022596): G protein-coupled glucose receptor regulating Gpa2 C-term |
5 |
AHNAK | suppressor | 11 | 0.511 | 6.257 | DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37 |
6 |
AKR1B1 | suppressor | 14 | 0.637 | 18.020 | Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family |
7 |
ARHGDIA | interactor | 24 | 0.411 | 98.900 | Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor |
8 |
ARPC3 | interactor | 8 | 0.571 | 2.958 | P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit |
9 |
ASB6 | interactor | 5 | 0.600 | 2.500 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box |
10 |
AURKA | oncoprotein | 7 | 0.400 | 7.733 | Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding |
11 |
B4GALT7 | interactor | 1 | 0 | 0 | Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7 |
12 |
BAG3 | oncoprotein | 16 | 0.219 | 63.275 | BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain |
13 |
BID | oncoprotein | 14 | 0.859 | 9.619 | BID (PF06393, IPR010479): BH3 interacting domain (BID) |
14 |
BRCA1 | suppressor | 9 | 0.464 | 9.260 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
15 |
CALR | oncoprotein | 19 | 0.471 | 30.633 | Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain |
16 |
CASP10 | interactor | 14 | 0.859 | 10.667 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
17 |
CASP8 | suppressor | 13 | 1.000 | 0 | DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
18 |
CD44 | suppressor | 7 | 0.524 | 4.299 | VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit Xlink (PF00193, IPR000538, SM00445): Extracellular link domain S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial |
19 |
CDH1 | suppressor | 9 | 0.357 | 12.638 | Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain |
20 |
CFTR | suppressor | 9 | 0.286 | 13.767 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain |
21 |
CLIC4 | oncoprotein | 6 | 0.400 | 5.533 | GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain |
22 |
CLIC5 | interactor | 3 | 0.667 | 0.667 | GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain |
23 |
CROCC | interactor | 1 | 0 | 0 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Rho_Binding (PF08912, IPR015008): Rho Binding Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KxDL (PF10241, IPR019371): Uncharacterized conserved protein SOGA (PF11365, IPR027881): Protein SOGA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion |
24 |
CTNNB1 | oncoprotein | 17 | 0.346 | 52.968 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
25 |
CUL7 | protein found in more fusions | 21 | 0.342 | 53.821 | ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7 |
26 |
DCC | suppressor | 3 | 0.667 | 1.000 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
27 |
DGKQ | interactor | 3 | 1.000 | 0 | RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_acc (PF00609, IPR000756, SM00045): Diacylglycerol kinase accessory domain DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain |
28 |
DLG1 | suppressor | 2 | 1.000 | 0 | L27_1 (PF09058, IPR015143): L27_1 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037) MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase |
29 |
ECE2 | interactor | 3 | 0.667 | 0.667 | Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13 Peptidase_M48 (PF01435, IPR001915): Peptidase family M48 Methyltransf_25 (PF13649): Methyltransferase domain |
30 |
EGFR | oncoprotein | 26 | 0.207 | 149.580 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
31 |
EIF5A2 | interactor | 3 | 0.667 | 1.000 | EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold |
32 |
EIF5AL1 | interactor | 3 | 1.000 | 0 | EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold |
33 |
ELAVL1 | oncoprotein | 26 | 0.217 | 162.181 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
34 |
ENO1 | oncoprotein | 27 | 0.385 | 85.828 | Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain |
35 |
ENO2 | interactor | 19 | 0.556 | 28.287 | Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain |
36 |
FABP5 | interactor | 14 | 0.725 | 6.601 | Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family |
37 |
FADD | suppressor | 12 | 1.000 | 0 | Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain |
38 |
FAS | suppressor | 15 | 0.780 | 12.652 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH |
39 |
FASLG | interactor | 15 | 0.676 | 25.000 | PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
40 |
FBXO6 | interactor | 11 | 0.309 | 25.070 | FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like |
41 |
FH | suppressor | 13 | 0.295 | 38.360 | Lyase_1 (PF00206, IPR022761): Lyase FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus |
42 |
FKBP9 | interactor | 6 | 0.600 | 3.667 | FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
43 |
FN1 | oncoprotein | 22 | 0.286 | 99.947 | fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) |
44 |
GABARAPL2 | interactor | 4 | 0.667 | 0.500 | Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like |
45 |
GDI2 | interactor | 10 | 0.467 | 8.888 | GDI (PF00996, IPR018203): GDP dissociation inhibitor |
46 |
GNPDA1 | interactor | 6 | 0.533 | 5.233 | Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase |
47 |
GPX4 | interactor | 10 | 0.844 | 1.345 | GSHPx (PF00255, IPR000889): Glutathione peroxidase |
48 |
GTF3C4 | interactor | 9 | 0.361 | 18.083 | TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex |
49 |
GZMM | interactor | 1 | 0 | 0 | Trypsin (PF00089, IPR001254, SM00020): Trypsin |
50 |
H2AFZ | interactor | 7 | 0.571 | 5.308 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A |
51 |
HEXA | interactor | 6 | 0.600 | 4.500 | Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like |
52 |
HEXB | interactor | 7 | 0.400 | 5.667 | Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like |
53 |
HLA-B | oncoprotein | 4 | 1.000 | 0 | MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain |
54 |
HSD17B10 | interactor | 27 | 0.410 | 95.351 | adh_short (PF00106, IPR002198): short chain dehydrogenase |
55 |
HSPA4 | interactor | 15 | 0.371 | 35.500 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
56 |
HSPA4L | interactor | 7 | 0.714 | 1.043 | HSP70 (PF00012, IPR013126): Hsp70 protein |
57 |
HSPE1 | interactor | 20 | 0.474 | 35.985 | Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit |
58 |
HSPH1 | oncoprotein | 14 | 0.484 | 22.289 | HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain |
59 |
ICAM1 | oncoprotein | 4 | 0.500 | 1.143 | Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
60 |
ICAM2 | interactor | 3 | 0.667 | 0.074 | ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex Ig_2 (PF13895, IPR007110): Immunoglobulin domain |
61 |
ICAM3 | interactor | 2 | 1.000 | 0 | C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain |
62 |
IPO5 | interactor | 11 | 0.309 | 22.417 | HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat AAA_30 (PF13604): AAA domain HEAT_2 (PF13646): HEAT repeats PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal |
63 |
IQGAP1 | interactor | 17 | 0.346 | 44.471 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain |
64 |
ISG15 | suppressor | 18 | 0.261 | 57.962 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
65 |
ISYNA1 | interactor | 10 | 0.711 | 4.742 | NAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase |
66 |
L1CAM | oncoprotein | 3 | 0.667 | 0.222 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein Bravo_FIGEY (PF13882, IPR026966): Bravo-like intracellular region Ig_3 (PF13927): Immunoglobulin domain |
67 |
LCP1 | oncoprotein | 6 | 0.467 | 1.825 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
68 |
MAPK10 | suppressor | 4 | 0.667 | 0.074 | Pkinase (PF00069, IPR000719): Protein kinase domain |
69 |
MAPK8 | oncoprotein | 16 | 0.714 | 13.949 | DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain |
70 |
MC1R | interactor | 7 | 0.476 | 9.667 | 7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) 7tm_4 (PF13853): Olfactory receptor |
71 |
MCC | suppressor | 2 | 1.000 | 0 | ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair FAM76 (PF16046, IPR032017): FAM76 protein |
72 |
MCM2 | oncoprotein | 27 | 0.338 | 125.153 | AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain |
73 |
MDM2 | oncoprotein | 8 | 0.333 | 9.622 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
74 |
MPP3 | interactor | 2 | 1.000 | 0 | L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase |
75 |
MSN | oncoprotein | 58 | 0.169 | 982.584 | DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
76 |
NF2 | suppressor | 9 | 0.321 | 12.033 | ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
77 |
NOLC1 | interactor | 5 | 0.600 | 3.154 | DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2 |
78 |
NTRK1 | oncoprotein | 44 | 0.190 | 492.510 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
79 |
OAT | interactor | 6 | 0.533 | 4.789 | Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III |
80 |
OBSL1 | interactor | 17 | 0.425 | 27.313 | BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
81 |
OGFOD1 | interactor | 8 | 0.607 | 6.900 | Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily |
82 |
P4HB | interactor | 22 | 0.414 | 57.774 | Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain |
83 |
PALLD | interactor | 5 | 0.800 | 0.367 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain |
84 |
PDCD10 | interactor | 8 | 0.286 | 16.067 | DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1 |
85 |
PDCD6IP | interactor | 12 | 0.400 | 16.760 | BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV |
86 |
PDXK | oncoprotein | 3 | 0.667 | 0.667 | Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family |
87 |
PGD | oncoprotein | 9 | 0.667 | 3.607 | 6PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase |
88 |
PHLPP2 | suppressor | 4 | 0.500 | 2.167 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat IMUP (PF15761, IPR026621): Immortalisation up-regulated protein |
89 |
PIK3R1 | oncoprotein | 9 | 0.536 | 7.252 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
90 |
PLS1 | interactor | 5 | 0.700 | 0.796 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain EF-hand_5 (PF13202, IPR002048): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
91 |
PLS3 | interactor | 13 | 0.564 | 13.634 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EF-hand_5 (PF13202, IPR002048): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
92 |
PPA2 | interactor | 2 | 1.000 | 0 | Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase |
93 |
PPL | interactor | 1 | 0 | 0 | ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DivIC (PF04977, IPR007060): Septum formation initiator MCU (PF04678, IPR006769): Mitochondrial calcium uniporter ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FliT (PF05400, IPR008622): Flagellar protein FliT M (PF02370, IPR003345): M protein repeat Mnd1 (PF03962, IPR005647): Mnd1 family Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spectrin (PF00435, IPR002017): Spectrin repeat Plectin (PF00681, IPR001101, SM00250): Plectin repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) |
94 |
PPME1 | protein found in more fusions | 11 | 0.467 | 13.022 | Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family |
95 |
PRKAB1 | oncoprotein | 1 | 0 | 0 | AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase |
96 |
PRKCA | interactor | 12 | 0.364 | 25.800 | C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
97 |
PRX | interactor | 2 | 0 | 0 | Cornifin (PF02389, IPR003302): Cornifin (SPRR) family CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal |
98 |
PTK2 | protein found in more fusions | 11 | 0.378 | 21.368 | FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein |
99 |
PTTG1 | oncoprotein | 3 | 1.000 | 0 | Securin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor |
100 |
PYGL | interactor | 9 | 0.571 | 7.519 | Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase |
101 |
RCN1 | interactor | 12 | 0.561 | 13.261 | EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
102 |
RDX | interactor | 31 | 0.260 | 191.262 | ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain |
103 |
RHOA | suppressor | 16 | 0.625 | 37.319 | Ras (PF00071, IPR001806, SM00173): Ras family |
104 |
RIC8A | interactor | 4 | 0.833 | 0.667 | PUL (PF08324, IPR013535): PUL domain Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn |
105 |
S100P | oncoprotein | 3 | 1.000 | 0 | S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
106 |
SCARNA22 | interactor | 3 | 0.667 | 1.000 | NA |
107 |
SCYL3 | interactor | 1 | 0 | 0 | Pkinase (PF00069, IPR000719): Protein kinase domain |
108 |
SDC2 | protein found in more fusions | 5 | 0.833 | 0.500 | Glycophorin_A (PF01102, IPR001195): Glycophorin A Syndecan (PF01034, IPR027789): Syndecan domain DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275) |
109 |
SELL | interactor | 3 | 0.667 | 0.333 | EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit |
110 |
SELP | interactor | 1 | 0 | 0 | EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain |
111 |
SHMT2 | interactor | 11 | 0.364 | 23.434 | SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase |
112 |
SLC9A3R1 | suppressor | 11 | 0.378 | 17.208 | EBP50_C (PF09007, IPR015098): EBP50, C-terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
113 |
SLC9A3R2 | interactor | 5 | 0.400 | 5.000 | EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) |
114 |
SPN | interactor | 3 | 0.667 | 0.286 | BatA (PF07584, IPR024163): Aerotolerance regulator N-terminal MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK |
115 |
SPTA1 | interactor | 2 | 1.000 | 0 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
116 |
STIP1 | interactor | 25 | 0.470 | 54.024 | TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP |
117 |
TAGLN2 | interactor | 26 | 0.397 | 96.574 | Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain |
118 |
TIMM13 | interactor | 2 | 1.000 | 0 | zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger |
119 |
TKT | protein found in more fusions | 29 | 0.410 | 91.069 | Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain |
120 |
TNFRSF10B | suppressor | 13 | 0.885 | 3.560 | Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
121 |
TNFRSF1A | oncoprotein | 16 | 0.705 | 15.279 | Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region |
122 |
TPD52 | oncoprotein | 7 | 0.467 | 4.500 | TPD52 (PF04201, IPR007327): Tumour protein D52 family |
123 |
TPD52L2 | protein found in more fusions | 7 | 0.467 | 5.710 | TPD52 (PF04201, IPR007327): Tumour protein D52 family |
124 |
TRNT1 | interactor | 6 | 0.733 | 2.167 | PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain PolyA_pol_RNAbd (PF12627, IPR032828): Probable RNA and SrmB- binding site of polymerase A |
125 |
TSC1 | suppressor | 4 | 0.667 | 0.667 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein |
126 |
TXNRD2 | interactor | 3 | 1.000 | 0 | Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain |
127 |
U2AF2 | protein found in more fusions | 27 | 0.345 | 100.000 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein |
128 |
UBA1 | protein found in more fusions | 19 | 0.248 | 77.656 | ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site |
129 |
UBE2R2 | protein found in more fusions | 5 | 0.500 | 1.786 | NOA36 (PF06524, IPR010531): NOA36 protein UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme |
130 |
UCHL3 | interactor | 19 | 0.451 | 45.554 | Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 |
131 |
VCAM1 | interactor | 13 | 0.385 | 21.253 | C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
132 |
VPS11 | interactor | 5 | 0.600 | 0.843 | DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal TPR_11 (PF13414, IPR011990): TPR repeat zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
133 |
WDR1 | interactor | 13 | 0.577 | 11.669 | eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain |
134 |
WFDC1 | suppressor | 1 | 0 | 0 | WAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core' MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain |
135 |
WWP1 | oncoprotein | 2 | 0 | 0 | C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
136 |
XPNPEP1 | interactor | 10 | 0.400 | 21.519 | Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24 Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain |