Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins EZR (from a repository: Wed Nov 16 17:19:11 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 136 The number (and %) of the onco-proteins 39 (28.68 %) The number (and %) of the tumor suppressors 22 (16.18 %) Total number of binary PPIs (saturation %) 801 (8.73 %) The number (and %) of affected PPIs 136 (16.98 %) The number of possible different fusions 24 PPI diameter 2 PPI radius 1 The average degree of PPI 11.059 Assortativity coefficient -0.2291 The network average Clustering coefficient 0.524 The number (and %) of a zero Clustering coefficients 10 (7.35 %) The number (and %) of a zero Betweenness Centrality 25 (18.38 %)

ACTIVE INTERACTORS MISSING INTERACTORS (in fusions)

List of the fusions
PPI for parental proteins: EZR	All fusions : BF916833; BF084744;
Proteins found in more fusions	HLA-B (see 2 fusions); TKT (see 5 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); ACTN1 (see 3 fusions); PPME1 (see 1 fusions); AHNAK (see 2 fusions); SLC9A3R1 (see 2 fusions); CALR (see 6 fusions); UBA1 (see 2 fusions); TNFRSF1A (see 2 fusions); WWP1 (see 1 fusions); UBE2R2 (see 1 fusions); NF2 (see 1 fusions); CDH1 (see 3 fusions); BAG3 (see 4 fusions); EZR (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); PIK3R1 (see 1 fusions); PTK2 (see 2 fusions); SDC2 (see 2 fusions); TPD52L2 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EZR	parental protein	136	0.068	12695.226	DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
2	ACAA2	interactor	13	0.667	11.542	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3	ACTN1	protein found in more fusions	11	0.467	13.681	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
4	ADORA2B	interactor	3	0.667	1.000	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C (PF11970, IPR022596): G protein-coupled glucose receptor regulating Gpa2 C-term
5	AHNAK	suppressor	11	0.511	6.257	DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37
6	AKR1B1	suppressor	14	0.637	18.020	Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
7	ARHGDIA	interactor	24	0.411	98.900	Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
8	ARPC3	interactor	8	0.571	2.958	P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
9	ASB6	interactor	5	0.600	2.500	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
10	AURKA	oncoprotein	7	0.400	7.733	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
11	B4GALT7	interactor	1	0	0	Glyco_transf_7C (PF02709, IPR027791): N-terminal domain of galactosyltransferase Glyco_transf_7N (PF13733, IPR027995): N-terminal region of glycosyl transferase group 7
12	BAG3	oncoprotein	16	0.219	63.275	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
13	BID	oncoprotein	14	0.859	9.619	BID (PF06393, IPR010479): BH3 interacting domain (BID)
14	BRCA1	suppressor	9	0.464	9.260	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
15	CALR	oncoprotein	19	0.471	30.633	Calreticulin (PF00262, IPR001580): Calreticulin family DDHD (PF02862, IPR004177, SM01127): DDHD domain
16	CASP10	interactor	14	0.859	10.667	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
17	CASP8	suppressor	13	1.000	0	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
18	CD44	suppressor	7	0.524	4.299	VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit Xlink (PF00193, IPR000538, SM00445): Extracellular link domain S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
19	CDH1	suppressor	9	0.357	12.638	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
20	CFTR	suppressor	9	0.286	13.767	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
21	CLIC4	oncoprotein	6	0.400	5.533	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
22	CLIC5	interactor	3	0.667	0.667	GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
23	CROCC	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Rho_Binding (PF08912, IPR015008): Rho Binding Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KxDL (PF10241, IPR019371): Uncharacterized conserved protein SOGA (PF11365, IPR027881): Protein SOGA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
24	CTNNB1	oncoprotein	17	0.346	52.968	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
25	CUL7	protein found in more fusions	21	0.342	53.821	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
26	DCC	suppressor	3	0.667	1.000	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neogenin_C (PF06583, IPR010560): Neogenin C-terminus DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
27	DGKQ	interactor	3	1.000	0	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) DAGK_acc (PF00609, IPR000756, SM00045): Diacylglycerol kinase accessory domain DAGK_cat (PF00781, IPR001206, SM00046): Diacylglycerol kinase catalytic domain
28	DLG1	suppressor	2	1.000	0	L27_1 (PF09058, IPR015143): L27_1 PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037) MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
29	ECE2	interactor	3	0.667	0.667	Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13 Peptidase_M48 (PF01435, IPR001915): Peptidase family M48 Methyltransf_25 (PF13649): Methyltransferase domain
30	EGFR	oncoprotein	26	0.207	149.580	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
31	EIF5A2	interactor	3	0.667	1.000	EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
32	EIF5AL1	interactor	3	1.000	0	EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
33	ELAVL1	oncoprotein	26	0.217	162.181	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34	ENO1	oncoprotein	27	0.385	85.828	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
35	ENO2	interactor	19	0.556	28.287	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
36	FABP5	interactor	14	0.725	6.601	Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
37	FADD	suppressor	12	1.000	0	Death (PF00531, IPR000488, SM00005): Death domain DED (PF01335, IPR001875, SM00031): Death effector domain Hpt (PF01627, IPR008207, SM00073): Hpt domain
38	FAS	suppressor	15	0.780	12.652	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
39	FASLG	interactor	15	0.676	25.000	PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO) TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family PRIMA1 (PF16101): Proline-rich membrane anchor 1
40	FBXO6	interactor	11	0.309	25.070	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
41	FH	suppressor	13	0.295	38.360	Lyase_1 (PF00206, IPR022761): Lyase FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
42	FKBP9	interactor	6	0.600	3.667	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
43	FN1	oncoprotein	22	0.286	99.947	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
44	GABARAPL2	interactor	4	0.667	0.500	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
45	GDI2	interactor	10	0.467	8.888	GDI (PF00996, IPR018203): GDP dissociation inhibitor
46	GNPDA1	interactor	6	0.533	5.233	Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
47	GPX4	interactor	10	0.844	1.345	GSHPx (PF00255, IPR000889): Glutathione peroxidase
48	GTF3C4	interactor	9	0.361	18.083	TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
49	GZMM	interactor	1	0	0	Trypsin (PF00089, IPR001254, SM00020): Trypsin
50	H2AFZ	interactor	7	0.571	5.308	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
51	HEXA	interactor	6	0.600	4.500	Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
52	HEXB	interactor	7	0.400	5.667	Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2 Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
53	HLA-B	oncoprotein	4	1.000	0	MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
54	HSD17B10	interactor	27	0.410	95.351	adh_short (PF00106, IPR002198): short chain dehydrogenase
55	HSPA4	interactor	15	0.371	35.500	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
56	HSPA4L	interactor	7	0.714	1.043	HSP70 (PF00012, IPR013126): Hsp70 protein
57	HSPE1	interactor	20	0.474	35.985	Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
58	HSPH1	oncoprotein	14	0.484	22.289	HSP70 (PF00012, IPR013126): Hsp70 protein SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
59	ICAM1	oncoprotein	4	0.500	1.143	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
60	ICAM2	interactor	3	0.667	0.074	ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex Ig_2 (PF13895, IPR007110): Immunoglobulin domain
61	ICAM3	interactor	2	1.000	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
62	IPO5	interactor	11	0.309	22.417	HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat AAA_30 (PF13604): AAA domain HEAT_2 (PF13646): HEAT repeats PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
63	IQGAP1	interactor	17	0.346	44.471	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
64	ISG15	suppressor	18	0.261	57.962	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
65	ISYNA1	interactor	10	0.711	4.742	NAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase
66	L1CAM	oncoprotein	3	0.667	0.222	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein Bravo_FIGEY (PF13882, IPR026966): Bravo-like intracellular region Ig_3 (PF13927): Immunoglobulin domain
67	LCP1	oncoprotein	6	0.467	1.825	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
68	MAPK10	suppressor	4	0.667	0.074	Pkinase (PF00069, IPR000719): Protein kinase domain
69	MAPK8	oncoprotein	16	0.714	13.949	DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530) Pkinase (PF00069, IPR000719): Protein kinase domain
70	MC1R	interactor	7	0.476	9.667	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) 7tm_4 (PF13853): Olfactory receptor
71	MCC	suppressor	2	1.000	0	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair FAM76 (PF16046, IPR032017): FAM76 protein
72	MCM2	oncoprotein	27	0.338	125.153	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
73	MDM2	oncoprotein	8	0.333	9.622	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
74	MPP3	interactor	2	1.000	0	L27 (PF02828, IPR014775, SM00569): L27 domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) SH3_2 (PF07653, IPR011511): Variant SH3 domain Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
75	MSN	oncoprotein	58	0.169	982.584	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
76	NF2	suppressor	9	0.321	12.033	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
77	NOLC1	interactor	5	0.600	3.154	DTHCT (PF08070, IPR012542): DTHCT (NUC029) region SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain Stm1_N (PF09598, IPR019084): Stm1 stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain NST1 (PF13945, IPR025279): Salt tolerance down-regulator SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) PAF (PF15715, IPR031444): PCNA-associated factor IMUP (PF15761, IPR026621): Immortalisation up-regulated protein NuDC (PF16273, IPR032572): Nuclear distribution C domain PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
78	NTRK1	oncoprotein	44	0.190	492.510	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
79	OAT	interactor	6	0.533	4.789	Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
80	OBSL1	interactor	17	0.425	27.313	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
81	OGFOD1	interactor	8	0.607	6.900	Ofd1_CTDD (PF10637, IPR019601): Oxoglutarate and iron-dependent oxygenase degradation C-term 2OG-FeII_Oxy_4 (PF13661): 2OG-Fe(II) oxygenase superfamily
82	P4HB	interactor	22	0.414	57.774	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
83	PALLD	interactor	5	0.800	0.367	I-set (PF07679, IPR013098): Immunoglobulin I-set domain
84	PDCD10	interactor	8	0.286	16.067	DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241) CENP-L (PF13092, IPR025204): Kinetochore complex Sim4 subunit Fta1
85	PDCD6IP	interactor	12	0.400	16.760	BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
86	PDXK	oncoprotein	3	0.667	0.667	Phos_pyr_kin (PF08543, IPR013749): Phosphomethylpyrimidine kinase Staphylokinase (PF02821, IPR004093): Staphylokinase/Streptokinase family
87	PGD	oncoprotein	9	0.667	3.607	6PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
88	PHLPP2	suppressor	4	0.500	2.167	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat PH (PF00169, IPR001849, SM00233): PH domain PP2C (PF00481, IPR001932): Protein phosphatase 2C SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
89	PIK3R1	oncoprotein	9	0.536	7.252	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
90	PLS1	interactor	5	0.700	0.796	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain EF-hand_5 (PF13202, IPR002048): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
91	PLS3	interactor	13	0.564	13.634	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EF-hand_5 (PF13202, IPR002048): EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
92	PPA2	interactor	2	1.000	0	Pyrophosphatase (PF00719, IPR008162): Inorganic pyrophosphatase
93	PPL	interactor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil DivIC (PF04977, IPR007060): Septum formation initiator MCU (PF04678, IPR006769): Mitochondrial calcium uniporter ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family FliT (PF05400, IPR008622): Flagellar protein FliT M (PF02370, IPR003345): M protein repeat Mnd1 (PF03962, IPR005647): Mnd1 family Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spectrin (PF00435, IPR002017): Spectrin repeat Plectin (PF00681, IPR001101, SM00250): Plectin repeat TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
94	PPME1	protein found in more fusions	11	0.467	13.022	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
95	PRKAB1	oncoprotein	1	0	0	AMPKBI (PF04739, IPR006828, SM01010): 5'-AMP-activated protein kinase beta subunit, interaction domain AMPK1_CBM (PF16561, IPR032640): Glycogen recognition site of AMP-activated protein kinase
96	PRKCA	interactor	12	0.364	25.800	C2 (PF00168, IPR000008, SM00239): C2 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
97	PRX	interactor	2	0	0	Cornifin (PF02389, IPR003302): Cornifin (SPRR) family CCDC74_C (PF14917, IPR029422): Coiled coil protein 74, C terminal
98	PTK2	protein found in more fusions	11	0.378	21.368	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
99	PTTG1	oncoprotein	3	1.000	0	Securin (PF04856, IPR006940): Securin sister-chromatid separation inhibitor
100	PYGL	interactor	9	0.571	7.519	Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
101	RCN1	interactor	12	0.561	13.261	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
102	RDX	interactor	31	0.260	191.262	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain
103	RHOA	suppressor	16	0.625	37.319	Ras (PF00071, IPR001806, SM00173): Ras family
104	RIC8A	interactor	4	0.833	0.667	PUL (PF08324, IPR013535): PUL domain Ric8 (PF10165, IPR019318): Guanine nucleotide exchange factor synembryn
105	S100P	oncoprotein	3	1.000	0	S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
106	SCARNA22	interactor	3	0.667	1.000	NA
107	SCYL3	interactor	1	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain
108	SDC2	protein found in more fusions	5	0.833	0.500	Glycophorin_A (PF01102, IPR001195): Glycophorin A Syndecan (PF01034, IPR027789): Syndecan domain DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
109	SELL	interactor	3	0.667	0.333	EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
110	SELP	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
111	SHMT2	interactor	11	0.364	23.434	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
112	SLC9A3R1	suppressor	11	0.378	17.208	EBP50_C (PF09007, IPR015098): EBP50, C-terminal PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
113	SLC9A3R2	interactor	5	0.400	5.000	EBP50_C (PF09007, IPR015098): EBP50, C-terminal GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
114	SPN	interactor	3	0.667	0.286	BatA (PF07584, IPR024163): Aerotolerance regulator N-terminal MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
115	SPTA1	interactor	2	1.000	0	EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
116	STIP1	interactor	25	0.470	54.024	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
117	TAGLN2	interactor	26	0.397	96.574	Calponin (PF00402, IPR000557): Calponin family repeat CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
118	TIMM13	interactor	2	1.000	0	zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
119	TKT	protein found in more fusions	29	0.410	91.069	Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
120	TNFRSF10B	suppressor	13	0.885	3.560	Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
121	TNFRSF1A	oncoprotein	16	0.705	15.279	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
122	TPD52	oncoprotein	7	0.467	4.500	TPD52 (PF04201, IPR007327): Tumour protein D52 family
123	TPD52L2	protein found in more fusions	7	0.467	5.710	TPD52 (PF04201, IPR007327): Tumour protein D52 family
124	TRNT1	interactor	6	0.733	2.167	PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain PolyA_pol_RNAbd (PF12627, IPR032828): Probable RNA and SrmB- binding site of polymerase A
125	TSC1	suppressor	4	0.667	0.667	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) Hamartin (PF04388, IPR007483): Hamartin protein
126	TXNRD2	interactor	3	1.000	0	Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
127	U2AF2	protein found in more fusions	27	0.345	100.000	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
128	UBA1	protein found in more fusions	19	0.248	77.656	ThiF (PF00899, IPR000594): ThiF family E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
129	UBE2R2	protein found in more fusions	5	0.500	1.786	NOA36 (PF06524, IPR010531): NOA36 protein UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
130	UCHL3	interactor	19	0.451	45.554	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
131	VCAM1	interactor	13	0.385	21.253	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
132	VPS11	interactor	5	0.600	0.843	DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal TPR_11 (PF13414, IPR011990): TPR repeat zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
133	WDR1	interactor	13	0.577	11.669	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
134	WFDC1	suppressor	1	0	0	WAP (PF00095, IPR008197, SM00217): WAP-type (Whey Acidic Protein) 'four-disulfide core' MDMPI_N (PF11716, IPR024344): Mycothiol maleylpyruvate isomerase N-terminal domain
135	WWP1	oncoprotein	2	0	0	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
136	XPNPEP1	interactor	10	0.400	21.519	Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24 Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

B a c k    t o    T o p ⇑

List of missing interactors (in fusions)

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ARPC3	interactor	P21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit	BF084744
2	EZR	parental protein	DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 ERM (PF00769, IPR011259): Ezrin/radixin/moesin family FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain FERM_M (PF00373, IPR019748): FERM central domain FERM_N (PF09379, IPR018979): FERM N-terminal domain	BF084744, BF916833
3	FBXO6	interactor	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like	BF084744
4	GZMM	interactor	Trypsin (PF00089, IPR001254, SM00020): Trypsin	BF084744
5	SCARNA22	interactor	NA	BF084744, BF916833

B a c k    t o    T o p ⇑