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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EXOSC6 (from a repository: Sun Sep 16 08:43:06 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)52
The number (and %) of the onco-proteins9 (17.31 %)
The number (and %) of the tumor suppressors2 (3.85 %)
Total number of binary PPIs (saturation %)254 (19.16 %)
The number (and %) of affected PPIs52 (20.47 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI9.192
Assortativity coefficient-0.2373
The network average Clustering coefficient0.653
The number (and %) of a zero Clustering coefficients5 (9.62 %)
The number (and %) of a zero Betweenness Centrality15 (28.85 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EXOSC6 All fusions
Proteins found in more fusions CUL3 (see 1 fusions); NUDT21 (see 2 fusions); GSE1 (see 1 fusions); EXOSC6 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EXOSC6parental protein520.1471651.032RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
2 AICDAinteractor111.0000APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
3 C1QBPinteractor50.8000.889MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
4 CEP250interactor30.6670.667ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
5 CHPFinteractor21.0000CHGN (PF05679, IPR008428): Chondroitin N-acetylgalactosaminyltransferase
Fringe (PF02434, IPR003378): Fringe-like
6 CUL3protein found in more fusions170.28370.539Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 DCP1Binteractor50.7002.333DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
8 DIS3Linteractor120.9240.993RNB (PF00773, SM00955): RNB domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
9 DNAJC30interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
10 EIF3Ioncoprotein21.0000ISN1 (PF06437, IPR009453): IMP-specific 5'-nucleotidase
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
11 ELAVL1oncoprotein70.4676.222RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12 ESRRAoncoprotein100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
13 EXOSC1interactor170.72111.733EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
14 EXOSC10interactor220.48171.587DNA_pol_A_exo1 (PF01612, IPR002562, SM00474): 3'-5' exonuclease
HRDC (PF00570, IPR002121, SM00341): HRDC domain
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Sec62 (PF03839, IPR004728): Translocation protein Sec62
15 EXOSC2interactor160.66717.525EXOSC1 (PF10447, IPR019495): Exosome component EXOSC1/CSL4
ECR1_N (PF14382, IPR025721): Exosome complex exonuclease RRP4 N-terminal region
KH_6 (PF15985, IPR004088): KH domain
16 EXOSC3interactor180.71313.517KH_6 (PF15985, IPR004088): KH domain
17 EXOSC4interactor210.56840.934RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
18 EXOSC5interactor210.55745.149RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
19 EXOSC7interactor160.7836.350RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
20 EXOSC8interactor220.53360.164RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
21 EXOSC9interactor190.57333.701RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
22 GSE1oncoprotein31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
DUF3736 (PF12540, IPR022207): Protein of unknown function (DUF3736)
AAA_11 (PF13086): AAA domain
DUF4228 (PF14009, IPR025322): Domain of unknown function (DUF4228)
23 HBS1Linteractor100.8671.762HBS1_N (PF08938, IPR015033): HBS1 N-terminus
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
24 HDGFinteractor50.7002.067PWWP (PF00855, IPR000313, SM00293): PWWP domain
25 IFI16suppressor100.7119.134HIN (PF02760, IPR004021): HIN-200/IF120x domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
26 LSM1interactor31.0000LSM (PF01423, IPR001163): LSM domain
27 LSM7interactor30.6670.667LSM (PF01423, IPR001163): LSM domain
28 LSM8interactor40.5002.167LSM (PF01423, IPR001163): LSM domain
29 MAN2C1interactor21.0000Alpha-mann_mid (PF09261, IPR015341, SM00872): Alpha mannosidase middle domain
Glyco_hydro_38 (PF01074, IPR000602): Glycosyl hydrolases family 38 N-terminal domain
Glyco_hydro_38C (PF07748, IPR011682): Glycosyl hydrolases family 38 C-terminal domain
30 MDM2oncoprotein40.6670.667Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
31 MIF4GDinteractor100MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
32 MOCS3interactor100ThiF (PF00899, IPR000594): ThiF family
Nbl1_Borealin_N (PF10444, IPR018851): Nbl1 / Borealin N terminal
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
33 MPHOSPH6interactor101.0000MPP6 (PF10175, IPR019324): M-phase phosphoprotein 6
34 MRPL4interactor41.0000Ribosomal_L4 (PF00573, IPR002136): Ribosomal protein L4/L1 family
35 MRPS18Binteractor30.6670.667Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
HTH_21 (PF13276, IPR025948): HTH-like domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
36 NDUFA13interactor21.0000GRIM-19 (PF06212, IPR009346): GRIM-19 protein
37 NUDT21protein found in more fusions50.8330.222NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
38 OBSL1interactor100.36113.733BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
39 PSMA1interactor90.8930.983Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
40 PSMA2interactor100.7504.300Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
41 PSMA3interactor100.7227.650Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
42 PSMA5oncoprotein100.7335.769Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
43 PSMA6interactor90.8332.150Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
44 PSMB1interactor61.0000Proteasome (PF00227, IPR001353): Proteasome subunit
45 RAB3GAP2interactor100RAB3GAP2_N (PF14655, IPR032839): Rab3 GTPase-activating protein regulatory subunit N-terminus
RAB3GAP2_C (PF14656, IPR029257): Rab3 GTPase-activating protein regulatory subunit C-terminus
46 RBM7interactor110.7647.043RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
47 SKIV2L2interactor160.57525.865DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DSHCT (PF08148, IPR012961, SM01142): DSHCT (NUC185) domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
rRNA_proc-arch (PF13234, IPR025696): rRNA-processing arch domain
48 SRSF3oncoprotein70.4298.789DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
49 TUFMinteractor50.8000.889GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
50 UPF2interactor130.51522.634DDHD (PF02862, IPR004177, SM01127): DDHD domain
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Upf2 (PF04050, IPR007193): Up-frameshift suppressor 2
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
SUFU_C (PF12470, IPR024314): Suppressor of Fused Gli/Ci N terminal binding domain
51 XRN1interactor110.49123.008XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
52 ZFP36suppressor50.9000.500zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

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