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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)48
The number (and %) of the onco-proteins11 (22.92 %)
The number (and %) of the tumor suppressors4 (8.33 %)
Total number of binary PPIs (saturation %)138 (12.23 %)
The number (and %) of affected PPIs48 (34.78 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI5.125
Assortativity coefficient-0.4859
The network average Clustering coefficient0.490
The number (and %) of a zero Clustering coefficients17 (35.42 %)
The number (and %) of a zero Betweenness Centrality29 (60.42 %)


List of the fusions

PPI for parental proteins: EXOC5 All fusions
: AA728867;
Proteins found in more fusions EXOC5 (see 1 fusions); EGFR (see 2 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 EXOC5parental protein480.0701827.321Sec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
2 ACTR3Binteractor100Actin (PF00022, IPR004000, SM00268): Actin
3 ADCK1interactor200ABC1 (PF03109, IPR004147): ABC1 family
APH (PF01636, IPR002575): Phosphotransferase enzyme family
4 ARF6oncoprotein21.0000Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
5 BARD1suppressor31.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
6 BRMS1Lsuppressor21.0000Sds3 (PF08598, IPR013907): Sds3-like
Tup_N (PF08581, IPR013890): Tup N-terminal
Myb_DNA-bind_4 (PF13837): Myb/SANT-like DNA-binding domain
7 CA14interactor60.6671.783Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
NicO (PF03824, IPR011541): High-affinity nickel-transport protein
8 CCDC102Binteractor200Filament (PF00038, IPR001664): Intermediate filament protein
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
9 CDC5Linteractor71.0000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
10 CDH2interactor21.0000Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
11 DEUP1suppressor40.6671.000APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
12 DSN1interactor31.0000MIS13 (PF08202, IPR013218): Mis12-Mtw1 protein family
13 DTNBP1interactor80.5369.583Dysbindin (PF04440, IPR007531): Dysbindin (Dystrobrevin binding protein 1)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
14 EDRF1oncoprotein100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2315 (PF10231, IPR018796): Uncharacterised conserved protein (DUF2315)
15 EGFRoncoprotein130.45530.783Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 ENO2interactor21.0000Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
17 EXOC2interactor100.7784.219PhzC-PhzF (PF02567, IPR003719): Phenazine biosynthesis-like protein
TIG (PF01833, IPR002909): IPT/TIG domain
Sec5 (PF15469): Exocyst complex component Sec5
18 EXOC3interactor100.8003.252Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
Sec6 (PF06046, IPR010326): Exocyst complex component Sec6
Tma16 (PF11176, IPR021346): Translation machinery-associated protein 16
19 EXOC4oncoprotein120.63615.552DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Vps51 (PF08700): Vps51/Vps67
20 EXOC6interactor130.60612.605Sec15 (PF04091, IPR007225): Exocyst complex subunit Sec15-like
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
21 EXOC6Binteractor80.6433.619ZapB (PF06005, IPR009252): Cell division protein ZapB
Sec15 (PF04091, IPR007225): Exocyst complex subunit Sec15-like
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
22 EXOC7interactor170.44150.788Exo70 (PF03081, IPR004140): Exo70 exocyst complex subunit
COG5 (PF10392, IPR019465): Golgi transport complex subunit 5
23 EXOC8interactor110.7275.521K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PH (PF00169, IPR001849, SM00233): PH domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Vps51 (PF08700): Vps51/Vps67
Syntaxin_2 (PF14523): Syntaxin-like protein
Exo84_C (PF16528, IPR032403): Exocyst component 84 C-terminal
24 FRMD6interactor100FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
HTH_24 (PF13412, IPR011991): Winged helix-turn-helix DNA-binding
25 HDDC3interactor100HD_4 (PF13328, IPR003607): HD domain
26 ICA1interactor100Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
ICA69 (PF04629, IPR006723): Islet cell autoantigen ICA69, C-terminal domain
27 KXD1interactor31.0000KxDL (PF10241, IPR019371): Uncharacterized conserved protein
28 MAGEA6interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
29 NTRK1oncoprotein150.49534.169I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
30 OAS1interactor100NTP_transf_2 (PF01909, IPR002934): Nucleotidyltransferase domain
OAS1_C (PF10421, IPR018952): 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
31 PNKDinteractor30.6670.333Lactamase_B (PF00753, IPR001279, SM00849): Metallo-beta-lactamase superfamily
HAGH_C (PF16123, IPR032282): Hydroxyacylglutathione hydrolase C-terminus
32 PRKCGinteractor200C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
33 PTK6interactor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
34 PYCARDsuppressor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
35 RAB14oncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
36 RAB4Aoncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
37 RAB4Boncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
38 SCN2Binteractor70.6672.850DUF1191 (PF06697, IPR010605): Protein of unknown function (DUF1191)
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
39 SEC61Binteractor31.0000Sec61_beta (PF03911, IPR016482): Sec61beta family
40 SETDB1interactor30.6671.000MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
41 SNW1protein found in more fusions80.9520.333SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
42 SOX10oncoprotein100Beta-lactamase (PF00144, IPR001466): Beta-lactamase
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
43 SPACA9interactor100DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
44 TBX21oncoprotein100T-box (PF00907, IPR001699, SM00425): T-box
T-box_assoc (PF16176, IPR032385): T-box transcription factor-associated
45 TNPO2interactor60.4004.286Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Dopey_N (PF04118, IPR007249): Dopey, N-terminal
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
DUF2573 (PF10835, IPR020393): Protein of unknown function (DUF2573)
DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
46 TTC23Linteractor100COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
DUF4398 (PF14346, IPR025511): Domain of unknown function (DUF4398)
47 TXLNBinteractor40.6671.000DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
Taxilin (PF09728, IPR026183): Myosin-like coiled-coil protein
48 TXNL4Ainteractor100DIM1 (PF02966, IPR004123): Mitosis protein DIM1

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EXOC5parental proteinSec10 (PF07393, IPR009976): Exocyst complex component Sec10
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1

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