Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ERRFI1 (from a repository: Mon Dec 5 08:10:35 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 50 The number (and %) of the onco-proteins 22 (44.00 %) The number (and %) of the tumor suppressors 6 (12.00 %) Total number of binary PPIs (saturation %) 204 (16.65 %) The number (and %) of affected PPIs 50 (24.51 %) The number of possible different fusions 11 PPI diameter 2 PPI radius 1 The average degree of PPI 7.360 Assortativity coefficient -0.4005 The network average Clustering coefficient 0.515 The number (and %) of a zero Clustering coefficients 11 (22.00 %) The number (and %) of a zero Betweenness Centrality 19 (38.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ERRFI1	All fusions
Proteins found in more fusions	SHC1 (see 1 fusions); ACTG1/ACTB (see 1 fusions); ACTB (see 3 fusions); GRB2 (see 1 fusions); FGFR2 (see 3 fusions); ACTG1 (see 4 fusions); ERRFI1 (see 1 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); GFAP (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ERRFI1	parental protein	50	0.115	1606.279	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
2	ACTA1	interactor	5	0.700	1.833	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTA2	interactor	5	0.600	3.200	Actin (PF00022, IPR004000, SM00268): Actin
4	ACTB	oncoprotein	10	0.611	6.350	Actin (PF00022, IPR004000, SM00268): Actin
5	ACTBL2	interactor	3	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
6	ACTC1	interactor	2	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
7	ACTG1	protein found in more fusions	10	0.556	10.683	Actin (PF00022, IPR004000, SM00268): Actin
8	ACTG2	interactor	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin
9	ALK	oncoprotein	4	1.000	0	MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
10	ANXA2	interactor	5	0.800	0.367	Annexin (PF00191, IPR018502, SM00335): Annexin
11	ATM	suppressor	4	0.667	0.333	FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
12	AURKA	oncoprotein	7	0.667	1.752	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
13	AXL	oncoprotein	4	0.667	0.917	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2627 (PF11118, IPR020138): Protein of unknown function (DUF2627) Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
14	BAG4	interactor	3	0.667	0.333	BAG (PF02179, IPR003103, SM00264): BAG domain DMP12 (PF16779, IPR031891): DNA-mimic protein
15	BCAR3	oncoprotein	2	1.000	0	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
16	CASP8	suppressor	2	0	0	DED (PF01335, IPR001875, SM00031): Death effector domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
17	CCT3	interactor	4	0.833	0.286	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18	CDC42	oncoprotein	4	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
19	EGFR	oncoprotein	18	0.426	46.436	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20	ELAVL1	oncoprotein	12	0.327	28.583	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21	ERBB2	oncoprotein	10	0.500	12.717	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22	ESRRB	suppressor	14	0.484	22.090	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23	FGFR2	oncoprotein	2	0	0	Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
24	FGFR4	oncoprotein	2	0	0	APH (PF01636, IPR002575): Phosphotransferase enzyme family I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_3 (PF13927): Immunoglobulin domain
25	GFAP	protein found in more fusions	6	0.900	0.167	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
26	GRB2	oncoprotein	24	0.320	112.140	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
27	HSPA1A	interactor	9	0.583	7.352	HSP70 (PF00012, IPR013126): Hsp70 protein
28	HSPA8	oncoprotein	14	0.505	28.671	HSP70 (PF00012, IPR013126): Hsp70 protein
29	LTK	interactor	1	0	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
30	MASP1	interactor	1	0	0	CUB (PF00431, IPR000859, SM00042): CUB domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Trypsin (PF00089, IPR001254, SM00020): Trypsin FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
31	PALB2	suppressor	2	0	0	IncA (PF04156, IPR007285): IncA protein PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
32	PDGFRB	oncoprotein	5	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain Ig_3 (PF13927): Immunoglobulin domain TonB_N (PF16031): TonB N-terminal region
33	POTEE	interactor	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) CCDC144C (PF14915): CCDC144C protein coiled-coil region
34	POTEF	oncoprotein	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin Toxin_16 (PF07945, IPR012499): Janus-atracotoxin Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) CCDC144C (PF14915): CCDC144C protein coiled-coil region
35	POTEKP	interactor	3	0.667	0.400	NA
36	PPM1D	oncoprotein	1	0	0	PP2C (PF00481, IPR001932): Protein phosphatase 2C
37	RB1CC1	suppressor	1	0	0	Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II DHC (PF09626, IPR018588): Dihaem cytochrome c DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) ATG11 (PF10377, IPR019460): Autophagy-related protein 11 DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Jag_N (PF14804, IPR032782): Jag N-terminus NPBW (PF15180, IPR013297): Neuropeptides B and W HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2 Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
38	RPS27A	interactor	4	1.000	0	DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
39	SFN	suppressor	7	0.667	3.167	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
40	SHC1	oncoprotein	20	0.351	66.410	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
41	SHC2	interactor	3	1.000	0	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
42	TUBA1A	oncoprotein	8	0.750	2.205	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
43	TUBA1B	interactor	8	0.679	2.986	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
44	TUBA1C	interactor	9	0.583	7.167	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
45	TUBB	interactor	17	0.529	26.679	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
46	UBASH3B	interactor	15	0.484	23.652	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
47	XPO1	interactor	10	0.489	10.938	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
48	YWHAE	oncoprotein	10	0.578	7.919	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
49	YWHAQ	interactor	15	0.457	30.905	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
50	YWHAZ	protein found in more fusions	10	0.611	9.083	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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