Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ERRFI1 (from a repository: Mon Dec 5 08:10:35 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins22 (44.00 %)
The number (and %) of the tumor suppressors6 (12.00 %)
Total number of binary PPIs (saturation %)204 (16.65 %)
The number (and %) of affected PPIs50 (24.51 %)
The number of possible different fusions11
PPI diameter2
PPI radius1
The average degree of PPI7.360
Assortativity coefficient-0.4005
The network average Clustering coefficient0.515
The number (and %) of a zero Clustering coefficients11 (22.00 %)
The number (and %) of a zero Betweenness Centrality19 (38.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ERRFI1 All fusions
Proteins found in more fusions SHC1 (see 1 fusions); ACTG1/ACTB (see 1 fusions); ACTB (see 3 fusions); GRB2 (see 1 fusions); FGFR2 (see 3 fusions); ACTG1 (see 4 fusions); ERRFI1 (see 1 fusions); YWHAZ (see 1 fusions); EGFR (see 2 fusions); GFAP (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ERRFI1parental protein500.1151606.279GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
2 ACTA1interactor50.7001.833Actin (PF00022, IPR004000, SM00268): Actin
3 ACTA2interactor50.6003.200Actin (PF00022, IPR004000, SM00268): Actin
4 ACTBoncoprotein100.6116.350Actin (PF00022, IPR004000, SM00268): Actin
5 ACTBL2interactor31.0000Actin (PF00022, IPR004000, SM00268): Actin
6 ACTC1interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
7 ACTG1protein found in more fusions100.55610.683Actin (PF00022, IPR004000, SM00268): Actin
8 ACTG2interactor100Actin (PF00022, IPR004000, SM00268): Actin
9 ALKoncoprotein41.0000MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
10 ANXA2interactor50.8000.367Annexin (PF00191, IPR018502, SM00335): Annexin
11 ATMsuppressor40.6670.333FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
12 AURKAoncoprotein70.6671.752Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
13 AXLoncoprotein40.6670.917fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2627 (PF11118, IPR020138): Protein of unknown function (DUF2627)
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
14 BAG4interactor30.6670.333BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
15 BCAR3oncoprotein21.0000RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
16 CASP8suppressor200DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
17 CCT3interactor40.8330.286Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CDC42oncoprotein41.0000Ras (PF00071, IPR001806, SM00173): Ras family
19 EGFRoncoprotein180.42646.436Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 ELAVL1oncoprotein120.32728.583RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
21 ERBB2oncoprotein100.50012.717Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22 ESRRBsuppressor140.48422.090zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
23 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
24 FGFR4oncoprotein200APH (PF01636, IPR002575): Phosphotransferase enzyme family
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
25 GFAPprotein found in more fusions60.9000.167Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
26 GRB2oncoprotein240.320112.140SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
27 HSPA1Ainteractor90.5837.352HSP70 (PF00012, IPR013126): Hsp70 protein
28 HSPA8oncoprotein140.50528.671HSP70 (PF00012, IPR013126): Hsp70 protein
29 LTKinteractor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
30 MASP1interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
31 PALB2suppressor200IncA (PF04156, IPR007285): IncA protein
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
32 PDGFRBoncoprotein51.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
Ig_3 (PF13927): Immunoglobulin domain
TonB_N (PF16031): TonB N-terminal region
33 POTEEinteractor100Actin (PF00022, IPR004000, SM00268): Actin
DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
34 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
35 POTEKPinteractor30.6670.400NA
36 PPM1Doncoprotein100PP2C (PF00481, IPR001932): Protein phosphatase 2C
37 RB1CC1suppressor100Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
38 RPS27Ainteractor41.0000DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
39 SFNsuppressor70.6673.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
40 SHC1oncoprotein200.35166.410PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
41 SHC2interactor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
42 TUBA1Aoncoprotein80.7502.205Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
43 TUBA1Binteractor80.6792.986Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
44 TUBA1Cinteractor90.5837.167Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
45 TUBBinteractor170.52926.679Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
46 UBASH3Binteractor150.48423.652His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily
SH3_9 (PF14604, IPR001452): Variant SH3 domain
47 XPO1interactor100.48910.938CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
48 YWHAEoncoprotein100.5787.91914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
49 YWHAQinteractor150.45730.90514-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
50 YWHAZprotein found in more fusions100.6119.08314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k    t o    T o p ⇑