Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins ERBB3 (from a repository: Fri Nov 11 23:12:55 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 146 The number (and %) of the onco-proteins 56 (38.36 %) The number (and %) of the tumor suppressors 7 (4.79 %) Total number of binary PPIs (saturation %) 740 (6.99 %) The number (and %) of affected PPIs 146 (19.73 %) The number of possible different fusions 26 PPI diameter 2 PPI radius 1 The average degree of PPI 9.521 Assortativity coefficient -0.2537 The network average Clustering coefficient 0.565 The number (and %) of a zero Clustering coefficients 18 (12.33 %) The number (and %) of a zero Betweenness Centrality 41 (28.08 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: ERBB3	All fusions : BF369721;
Proteins found in more fusions	ABL2 (see 2 fusions); PTPN11 (see 1 fusions); SYK (see 1 fusions); HLA-B (see 2 fusions); HSP90AA1 (see 2 fusions); GFAP (see 3 fusions); JAK2 (see 3 fusions); HNRNPH3 (see 1 fusions); ACTG1/ACTB (see 1 fusions); HSP90AB1 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); LGALS3BP (see 2 fusions); FER (see 1 fusions); ERBB3 (see 2 fusions); ACTB (see 3 fusions); ACTG1 (see 4 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); SHC1 (see 1 fusions); FGFR1 (see 1 fusions); B2M (see 9 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	ERBB3	parental protein	146	0.053	15384.455	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
2	ABL1	oncoprotein	25	0.428	67.541	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ABL2	oncoprotein	15	0.505	18.670	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NHS (PF15273, IPR024845): NHS-like
4	ACTA1	interactor	7	0.476	5.956	Actin (PF00022, IPR004000, SM00268): Actin
5	ACTA2	interactor	3	0.667	1.000	Actin (PF00022, IPR004000, SM00268): Actin
6	ACTB	oncoprotein	16	0.390	28.752	Actin (PF00022, IPR004000, SM00268): Actin
7	ACTBL2	interactor	3	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
8	ACTC1	interactor	2	1.000	0	Actin (PF00022, IPR004000, SM00268): Actin
9	ACTG1	protein found in more fusions	12	0.491	17.548	Actin (PF00022, IPR004000, SM00268): Actin
10	ACTG2	interactor	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin
11	AIFM1	oncoprotein	4	1.000	0	Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
12	AKT1	oncoprotein	21	0.321	74.594	PH (PF00169, IPR001849, SM00233): PH domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
13	ANXA2	interactor	4	0.667	2.000	Annexin (PF00191, IPR018502, SM00335): Annexin
14	AP1M2	interactor	2	1.000	0	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
15	ATP5A1	protein found in more fusions	10	0.556	8.519	ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
16	B2M	oncoprotein	5	0.667	1.333	C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
17	B3GLCT	interactor	1	0	0	Fringe (PF02434, IPR003378): Fringe-like
18	BCAR3	oncoprotein	2	1.000	0	RasGEF (PF00617, IPR001895, SM00147): RasGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
19	C1QBP	interactor	13	0.308	44.450	MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
20	CANX	interactor	7	0.619	4.006	Calreticulin (PF00262, IPR001580): Calreticulin family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
21	CD82	suppressor	4	0.667	0.515	Tetraspannin (PF00335, IPR018499): Tetraspanin family
22	CDC37	protein found in more fusions	22	0.295	98.570	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
23	CHN2	interactor	1	0	0	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4127 (PF13552, IPR025394): Protein of unknown function (DUF4127)
24	CRK	oncoprotein	24	0.409	68.500	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
25	CRKL	oncoprotein	12	0.652	13.825	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26	CSK	interactor	9	0.611	6.397	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27	DAB1	interactor	2	1.000	0	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
28	DAPP1	interactor	3	0.667	0.400	PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
29	DNAJA1	interactor	9	0.806	2.732	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
30	DNAJB11	interactor	8	0.679	6.533	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
31	DPPA4	interactor	6	0.600	2.567	Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family DCR (PF14047, IPR025891): Dppa2/4 conserved region Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
32	EGF	oncoprotein	4	1.000	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EGF_3 (PF12947, IPR024731): EGF domain FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
33	EGFR	oncoprotein	69	0.142	1456.956	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
34	EGR1	suppressor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
35	EIF1AX	oncoprotein	1	0	0	eIF-1a (PF01176, IPR006196): Translation initiation factor 1A / IF-1
36	ERBB2	oncoprotein	44	0.203	472.480	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37	FER	protein found in more fusions	9	0.750	1.688	DivIC (PF04977, IPR007060): Septum formation initiator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain Med29 (PF11568, IPR021018): Mediator complex subunit 29
38	FGFR1	oncoprotein	13	0.439	12.783	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
39	GFAP	protein found in more fusions	7	0.733	0.645	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
40	GRB2	oncoprotein	48	0.226	512.048	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
41	GRB7	interactor	2	1.000	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
42	HBA1	interactor	3	0.667	0.667	Globin (PF00042, IPR000971): Globin
43	HBB	interactor	3	0.667	0.667	Globin (PF00042, IPR000971): Globin
44	HBD	interactor	3	0.667	1.000	Globin (PF00042, IPR000971): Globin
45	HBE1	interactor	1	0	0	Globin (PF00042, IPR000971): Globin
46	HBG1	interactor	1	0	0	Globin (PF00042, IPR000971): Globin
47	HBG2	interactor	2	0	0	Globin (PF00042, IPR000971): Globin
48	HCK	oncoprotein	12	0.485	12.293	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
49	HDAC6	oncoprotein	13	0.561	9.929	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP) zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
50	HLA-A	oncoprotein	5	0.500	4.000	DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202) MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
51	HLA-B	oncoprotein	5	0.667	1.333	MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2 MHC_I_C (PF06623, IPR010579): MHC_I C-terminus C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
52	HLA-DPA1	interactor	4	0.500	2.667	MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
53	HNRNPA2B1	oncoprotein	11	0.491	19.700	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
54	HNRNPAB	interactor	6	0.600	6.000	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain GRP (PF07172, IPR010800): Glycine rich protein family NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
55	HNRNPF	interactor	7	0.762	3.500	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14 zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
56	HNRNPH1	oncoprotein	9	0.667	6.133	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
57	HNRNPH2	interactor	10	0.500	14.900	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
58	HNRNPH3	protein found in more fusions	7	1.000	0	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
59	HSP90AA1	oncoprotein	31	0.333	161.192	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
60	HSP90AB1	oncoprotein	19	0.588	18.734	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
61	HSPA1A	interactor	16	0.542	29.809	HSP70 (PF00012, IPR013126): Hsp70 protein
62	HSPA5	oncoprotein	33	0.270	250.980	HSP70 (PF00012, IPR013126): Hsp70 protein
63	HSPA8	oncoprotein	24	0.413	82.963	HSP70 (PF00012, IPR013126): Hsp70 protein
64	IL6ST	oncoprotein	9	0.722	3.283	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
65	ITK	oncoprotein	9	0.857	0.748	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
66	JAK2	oncoprotein	17	0.567	25.218	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
67	JAK3	oncoprotein	3	0.667	0.667	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
68	LGALS3BP	oncoprotein	14	0.538	19.652	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
69	LRIG1	suppressor	4	0.833	0.500	I-set (PF07679, IPR013098): Immunoglobulin I-set domain LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
70	LRPPRC	interactor	4	0.833	0.500	DED (PF01335, IPR001875, SM00031): Death effector domain MA3 (PF02847, IPR003891, SM00544): MA3 domain PPR (PF01535, IPR002885): PPR repeat TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal PPR_2 (PF13041, IPR002885): PPR repeat family PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain TPR_19 (PF14559): Tetratricopeptide repeat PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
71	MASP1	interactor	3	0.667	0.400	CUB (PF00431, IPR000859, SM00042): CUB domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat) Trypsin (PF00089, IPR001254, SM00020): Trypsin FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
72	MDM2	oncoprotein	20	0.304	76.283	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
73	MRPS14	interactor	3	1.000	0	Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
74	MRPS17	interactor	1	0	0	Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
75	MRPS18B	interactor	7	0.619	5.567	Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18 HTH_21 (PF13276, IPR025948): HTH-like domain zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
76	MRPS22	interactor	10	0.556	12.200	MRP-S22 (PF10245, IPR019374): Mitochondrial 28S ribosomal protein S22
77	MRPS23	interactor	5	0.900	0.400	MRP-S23 (PF10484, IPR023611): Mitochondrial ribosomal protein S23
78	MRPS25	interactor	5	0.700	2.000	L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
79	MRPS26	interactor	5	0.900	0.333	MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
80	MRPS27	interactor	5	0.900	0.400	MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
81	MRPS28	interactor	7	0.762	2.300	MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
82	MRPS34	interactor	4	0.500	2.333	MRP-S34 (PF16053, IPR032053): Mitochondrial 28S ribosomal protein S34
83	MUC1	oncoprotein	7	0.762	5.000	SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter
84	NANOG	interactor	7	0.400	6.500	Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
85	NCK1	oncoprotein	13	0.462	18.952	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
86	NCK2	interactor	8	0.524	6.152	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
87	NEDD4	suppressor	10	0.611	4.366	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
88	NRG1	interactor	3	1.000	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neuregulin (PF02158, IPR002154): Neuregulin family
89	NRG2	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neuregulin (PF02158, IPR002154): Neuregulin family CiPC (PF15800, IPR031602): Clock interacting protein circadian
90	ODF2L	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 RNA_bind_2 (PF10133, IPR019300): Predicted RNA-binding protein SOGA (PF11365, IPR027881): Protein SOGA DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
91	PA2G4	interactor	6	0.600	3.900	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein TraC (PF07820, IPR012930): TraC-like protein
92	PCGF1	interactor	6	0.500	2.900	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
93	PDF	interactor	1	0	0	Pep_deformylase (PF01327, IPR023635): Polypeptide deformylase
94	PHLDA1	oncoprotein	2	1.000	0	Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region PH (PF00169, IPR001849, SM00233): PH domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) TonB_N (PF16031): TonB N-terminal region
95	PIK3CA	oncoprotein	7	0.714	1.610	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
96	PIK3CB	oncoprotein	9	0.694	2.995	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) RWD (PF05773, IPR006575, SM00591): RWD domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
97	PIK3R1	oncoprotein	24	0.443	63.503	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
98	PIK3R2	oncoprotein	17	0.603	16.914	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
99	PIK3R3	interactor	13	0.603	10.528	SH2 (PF00017, IPR000980, SM00252): SH2 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
100	PLCG1	oncoprotein	16	0.567	17.113	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
101	PON2	interactor	5	0.800	1.167	Arylesterase (PF01731, IPR002640): Arylesterase
102	POTEE	interactor	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641) Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) CCDC144C (PF14915): CCDC144C protein coiled-coil region
103	POTEF	oncoprotein	1	0	0	Actin (PF00022, IPR004000, SM00268): Actin Toxin_16 (PF07945, IPR012499): Janus-atracotoxin Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) CCDC144C (PF14915): CCDC144C protein coiled-coil region
104	POTEKP	interactor	1	0	0	NA
105	POU5F1	oncoprotein	13	0.227	39.669	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
106	PTCD3	interactor	8	0.536	8.800	PPR (PF01535, IPR002885): PPR repeat PPR_2 (PF13041, IPR002885): PPR repeat family PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
107	PTK6	interactor	6	0.800	0.367	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
108	PTPN11	suppressor	11	0.822	2.162	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
109	RAE1	interactor	3	0.667	0.250	Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
110	RASA1	oncoprotein	11	0.709	4.900	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
111	RGS4	interactor	2	1.000	0	RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
112	RIN1	interactor	4	1.000	0	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
113	RNF41	interactor	2	0	0	Sina (PF03145, IPR018121): Seven in absentia protein family USP8_interact (PF08941, IPR015036): USP8 interacting zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
114	RPL23	interactor	14	0.242	53.318	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
115	RPN1	oncoprotein	8	0.464	9.133	Ribophorin_I (PF04597, IPR007676): Ribophorin I CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
116	RPS27	interactor	5	0.800	0.533	Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
117	RPS27A	interactor	6	0.467	3.986	DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
118	RPS27L	interactor	6	0.667	2.533	E7 (PF00527, IPR000148): E7 protein, Early protein Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27 zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
119	S100A10	oncoprotein	3	1.000	0	S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
120	SH2B3	suppressor	6	0.800	1.467	PH (PF00169, IPR001849, SM00233): PH domain Phe_ZIP (PF08916, IPR015012): Phenylalanine zipper SH2 (PF00017, IPR000980, SM00252): SH2 domain
121	SH2D1A	interactor	3	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain
122	SHC1	oncoprotein	33	0.321	177.786	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
123	SHC3	interactor	3	1.000	0	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
124	SLC25A5	interactor	7	0.381	7.744	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
125	SLC25A6	interactor	3	0.667	0.154	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
126	SLC31A1	interactor	2	0	0	Ctr (PF04145, IPR007274): Ctr copper transporter family
127	SRC	oncoprotein	24	0.423	59.364	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
128	SRPK2	oncoprotein	11	0.244	21.606	DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
129	SSR1	interactor	3	1.000	0	TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
130	SYK	suppressor	16	0.543	17.053	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
131	TNS2	interactor	5	0.600	1.586	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) cEGF (PF12662, IPR026823): Complement Clr-like EGF-like PRIMA1 (PF16101): Proline-rich membrane anchor 1
132	TNS3	interactor	4	0.667	0.619	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
133	TNS4	interactor	3	1.000	0	PTB (PF08416, IPR013625): Phosphotyrosine-binding domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
134	TUBA1B	interactor	8	0.500	6.419	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
135	TUBA4A	interactor	8	0.536	9.210	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
136	TUBB	interactor	22	0.411	63.871	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
137	TUBB8	interactor	3	0.667	0.667	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
138	TUFM	interactor	7	0.429	8.638	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
139	TXK	interactor	2	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
140	UQCR10	interactor	1	0	0	UCR_UQCRX_QCR9 (PF05365, IPR008027): Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
141	VAV1	oncoprotein	13	0.667	7.216	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
142	VAV2	oncoprotein	7	0.571	5.286	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain CotJB (PF12652, IPR024207): CotJB protein
143	VAV3	oncoprotein	5	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326) C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain PH_10 (PF15411): Pleckstrin homology domain
144	YBEY	interactor	2	1.000	0	UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
145	ZAP70	interactor	14	0.667	9.351	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
146	ZNF207	interactor	1	0	0	MCPVI (PF02993, IPR004243): Minor capsid protein VI SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 (PF13894): C2H2-type zinc finger

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