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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)146
The number (and %) of the onco-proteins56 (38.36 %)
The number (and %) of the tumor suppressors7 (4.79 %)
Total number of binary PPIs (saturation %)740 (6.99 %)
The number (and %) of affected PPIs146 (19.73 %)
The number of possible different fusions26
PPI diameter2
PPI radius1
The average degree of PPI9.521
Assortativity coefficient-0.2537
The network average Clustering coefficient0.565
The number (and %) of a zero Clustering coefficients18 (12.33 %)
The number (and %) of a zero Betweenness Centrality41 (28.08 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ERBB3 All fusions
: BF369721;
Proteins found in more fusions ABL2 (see 2 fusions); PTPN11 (see 1 fusions); SYK (see 1 fusions); HLA-B (see 2 fusions); HSP90AA1 (see 2 fusions); GFAP (see 3 fusions); JAK2 (see 3 fusions); HNRNPH3 (see 1 fusions); ACTG1/ACTB (see 1 fusions); HSP90AB1 (see 1 fusions); SRPK2 (see 1 fusions); GRB2 (see 1 fusions); LGALS3BP (see 2 fusions); FER (see 1 fusions); ERBB3 (see 2 fusions); ACTB (see 3 fusions); ACTG1 (see 4 fusions); EGFR (see 2 fusions); PIK3R1 (see 1 fusions); SHC1 (see 1 fusions); FGFR1 (see 1 fusions); B2M (see 9 fusions); CDC37 (see 2 fusions); ATP5A1 (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ERBB3parental protein1460.05315384.455Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
2 ABL1oncoprotein250.42867.541Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 ABL2oncoprotein150.50518.670Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NHS (PF15273, IPR024845): NHS-like
4 ACTA1interactor70.4765.956Actin (PF00022, IPR004000, SM00268): Actin
5 ACTA2interactor30.6671.000Actin (PF00022, IPR004000, SM00268): Actin
6 ACTBoncoprotein160.39028.752Actin (PF00022, IPR004000, SM00268): Actin
7 ACTBL2interactor31.0000Actin (PF00022, IPR004000, SM00268): Actin
8 ACTC1interactor21.0000Actin (PF00022, IPR004000, SM00268): Actin
9 ACTG1protein found in more fusions120.49117.548Actin (PF00022, IPR004000, SM00268): Actin
10 ACTG2interactor100Actin (PF00022, IPR004000, SM00268): Actin
11 AIFM1oncoprotein41.0000Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence
12 AKT1oncoprotein210.32174.594PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
13 ANXA2interactor40.6672.000Annexin (PF00191, IPR018502, SM00335): Annexin
14 AP1M2interactor21.0000Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
15 ATP5A1protein found in more fusions100.5568.519ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
16 B2Moncoprotein50.6671.333C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
17 B3GLCTinteractor100Fringe (PF02434, IPR003378): Fringe-like
18 BCAR3oncoprotein21.0000RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
19 C1QBPinteractor130.30844.450MAM33 (PF02330, IPR003428): Mitochondrial glycoprotein
DUF3053 (PF11254, IPR021413): Protein of unknown function (DUF3053)
20 CANXinteractor70.6194.006Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
21 CD82suppressor40.6670.515Tetraspannin (PF00335, IPR018499): Tetraspanin family
22 CDC37protein found in more fusions220.29598.570CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain
CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain
CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding
Rho_Binding (PF08912, IPR015008): Rho Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
23 CHN2interactor100RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
DUF4127 (PF13552, IPR025394): Protein of unknown function (DUF4127)
24 CRKoncoprotein240.40968.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
25 CRKLoncoprotein120.65213.825SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
26 CSKinteractor90.6116.397Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
27 DAB1interactor21.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
28 DAPP1interactor30.6670.400PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
29 DNAJA1interactor90.8062.732DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
30 DNAJB11interactor80.6796.533DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
31 DPPA4interactor60.6002.567Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
32 EGFoncoprotein41.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
SGL (PF08450, IPR013658): SMP-30/Gluconolaconase/LRE-like region
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_3 (PF12947, IPR024731): EGF domain
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
DUF5050 (PF16472, IPR032485): Domain of unknown function (DUF5050)
33 EGFRoncoprotein690.1421456.956Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
34 EGR1suppressor21.0000zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
DUF3432 (PF11914, IPR021839): Domain of unknown function (DUF3432)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
35 EIF1AXoncoprotein100eIF-1a (PF01176, IPR006196): Translation initiation factor 1A / IF-1
36 ERBB2oncoprotein440.203472.480Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
37 FERprotein found in more fusions90.7501.688DivIC (PF04977, IPR007060): Septum formation initiator
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
Glyco_transf_28 (PF03033, IPR004276): Glycosyltransferase family 28 N-terminal domain
PEP-utilisers_N (PF05524, IPR008731): PEP-utilising enzyme, N-terminal
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Med29 (PF11568, IPR021018): Mediator complex subunit 29
38 FGFR1oncoprotein130.43912.783I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
39 GFAPprotein found in more fusions70.7330.645Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
40 GRB2oncoprotein480.226512.048SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
41 GRB7interactor21.0000BPS (PF08947, IPR015042): BPS (Between PH and SH2)
PH (PF00169, IPR001849, SM00233): PH domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
42 HBA1interactor30.6670.667Globin (PF00042, IPR000971): Globin
43 HBBinteractor30.6670.667Globin (PF00042, IPR000971): Globin
44 HBDinteractor30.6671.000Globin (PF00042, IPR000971): Globin
45 HBE1interactor100Globin (PF00042, IPR000971): Globin
46 HBG1interactor100Globin (PF00042, IPR000971): Globin
47 HBG2interactor200Globin (PF00042, IPR000971): Globin
48 HCKoncoprotein120.48512.293Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
49 HDAC6oncoprotein130.5619.929Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PSGP (PF07276, IPR009900): Apopolysialoglycoprotein (PSGP)
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
50 HLA-Aoncoprotein50.5004.000DUF202 (PF02656, IPR003807): Domain of unknown function (DUF202)
MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
51 HLA-Boncoprotein50.6671.333MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
52 HLA-DPA1interactor40.5002.667MHC_II_alpha (PF00993, IPR001003, SM00920): Class II histocompatibility antigen, alpha domain
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
C1-set_C (PF16196, IPR032431): C1-set C-terminal domain
53 HNRNPA2B1oncoprotein110.49119.700RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
54 HNRNPABinteractor60.6006.000CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
GRP (PF07172, IPR010800): Glycine rich protein family
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF2462 (PF09495, IPR019034): Protein of unknown function (DUF2462)
55 HNRNPFinteractor70.7623.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
56 HNRNPH1oncoprotein90.6676.133RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
57 HNRNPH2interactor100.50014.900RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
58 HNRNPH3protein found in more fusions71.0000Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
59 HSP90AA1oncoprotein310.333161.192HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
60 HSP90AB1oncoprotein190.58818.734HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
61 HSPA1Ainteractor160.54229.809HSP70 (PF00012, IPR013126): Hsp70 protein
62 HSPA5oncoprotein330.270250.980HSP70 (PF00012, IPR013126): Hsp70 protein
63 HSPA8oncoprotein240.41382.963HSP70 (PF00012, IPR013126): Hsp70 protein
64 IL6SToncoprotein90.7223.283fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
65 ITKoncoprotein90.8570.748BTK (PF00779, IPR001562, SM00107): BTK motif
PH (PF00169, IPR001849, SM00233): PH domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
66 JAK2oncoprotein170.56725.218FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
67 JAK3oncoprotein30.6670.667Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
68 LGALS3BPoncoprotein140.53819.652BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
SRCR (PF00530, IPR001190): Scavenger receptor cysteine-rich domain
SRCR_2 (PF15494, IPR017448): Scavenger receptor cysteine-rich domain
69 LRIG1suppressor40.8330.500I-set (PF07679, IPR013098): Immunoglobulin I-set domain
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
70 LRPPRCinteractor40.8330.500DED (PF01335, IPR001875, SM00031): Death effector domain
MA3 (PF02847, IPR003891, SM00544): MA3 domain
PPR (PF01535, IPR002885): PPR repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
ApoB100_C (PF12491, IPR022176): Apolipoprotein B100 C terminal
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
TPR_19 (PF14559): Tetratricopeptide repeat
PPR_long (PF17177): Pentacotripeptide-repeat region of PROPR
71 MASP1interactor30.6670.400CUB (PF00431, IPR000859, SM00042): CUB domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Trypsin (PF00089, IPR001254, SM00020): Trypsin
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
72 MDM2oncoprotein200.30476.283Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
73 MRPS14interactor31.0000Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
74 MRPS17interactor100Ribosomal_S17 (PF00366, IPR000266): Ribosomal protein S17
75 MRPS18Binteractor70.6195.567Ribosomal_S18 (PF01084, IPR001648): Ribosomal protein S18
HTH_21 (PF13276, IPR025948): HTH-like domain
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
76 MRPS22interactor100.55612.200MRP-S22 (PF10245, IPR019374): Mitochondrial 28S ribosomal protein S22
77 MRPS23interactor50.9000.400MRP-S23 (PF10484, IPR023611): Mitochondrial ribosomal protein S23
78 MRPS25interactor50.7002.000L51_S25_CI-B8 (PF05047, IPR007741, SM00916): Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain
79 MRPS26interactor50.9000.333MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
80 MRPS27interactor50.9000.400MRP-S27 (PF10037, IPR019266): Mitochondrial 28S ribosomal protein S27
81 MRPS28interactor70.7622.300MRP-S35 (PF10246, IPR019375): Mitochondrial ribosomal protein MRP-S35
82 MRPS34interactor40.5002.333MRP-S34 (PF16053, IPR032053): Mitochondrial 28S ribosomal protein S34
83 MUC1oncoprotein70.7625.000SEA (PF01390, IPR000082, SM00200): SEA domain
Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator
Collectrin (PF16959, IPR031588): Renal amino acid transporter
84 NANOGinteractor70.4006.500Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
85 NCK1oncoprotein130.46218.952SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
86 NCK2interactor80.5246.152SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
87 NEDD4suppressor100.6114.366Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
88 NRG1interactor31.0000EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
89 NRG2interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
CiPC (PF15800, IPR031602): Clock interacting protein circadian
90 ODF2Linteractor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
RNA_bind_2 (PF10133, IPR019300): Predicted RNA-binding protein
SOGA (PF11365, IPR027881): Protein SOGA
DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107)
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
91 PA2G4interactor60.6003.900Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Ribosomal_S25 (PF03297, IPR004977): S25 ribosomal protein
TraC (PF07820, IPR012930): TraC-like protein
92 PCGF1interactor60.5002.900zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
93 PDFinteractor100Pep_deformylase (PF01327, IPR023635): Polypeptide deformylase
94 PHLDA1oncoprotein21.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PH (PF00169, IPR001849, SM00233): PH domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
TonB_N (PF16031): TonB N-terminal region
95 PIK3CAoncoprotein70.7141.610PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
96 PIK3CBoncoprotein90.6942.995PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
RWD (PF05773, IPR006575, SM00591): RWD domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
97 PIK3R1oncoprotein240.44363.503RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
98 PIK3R2oncoprotein170.60316.914RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
99 PIK3R3interactor130.60310.528SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
100 PLCG1oncoprotein160.56717.113C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
101 PON2interactor50.8001.167Arylesterase (PF01731, IPR002640): Arylesterase
102 POTEEinteractor100Actin (PF00022, IPR004000, SM00268): Actin
DUF3641 (PF12345, IPR024521): Protein of unknown function (DUF3641)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
103 POTEFoncoprotein100Actin (PF00022, IPR004000, SM00268): Actin
Toxin_16 (PF07945, IPR012499): Janus-atracotoxin
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CCDC144C (PF14915): CCDC144C protein coiled-coil region
104 POTEKPinteractor100NA
105 POU5F1oncoprotein130.22739.669Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
106 PTCD3interactor80.5368.800PPR (PF01535, IPR002885): PPR repeat
PPR_2 (PF13041, IPR002885): PPR repeat family
PPR_3 (PF13812, IPR002885): Pentatricopeptide repeat domain
107 PTK6interactor60.8000.367Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
108 PTPN11suppressor110.8222.162SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
109 RAE1interactor30.6670.250Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
110 RASA1oncoprotein110.7094.900C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
111 RGS4interactor21.0000RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
112 RIN1interactor41.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
113 RNF41interactor200Sina (PF03145, IPR018121): Seven in absentia protein family
USP8_interact (PF08941, IPR015036): USP8 interacting
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
114 RPL23interactor140.24253.318Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e
115 RPN1oncoprotein80.4649.133Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
116 RPS27interactor50.8000.533Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
DUF3795 (PF12675, IPR024227): Protein of unknown function (DUF3795)
117 RPS27Ainteractor60.4673.986DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
118 RPS27Linteractor60.6672.533E7 (PF00527, IPR000148): E7 protein, Early protein
Ribosomal_S27e (PF01667, IPR000592): Ribosomal protein S27
zf-C2HC5 (PF06221, IPR009349): Putative zinc finger motif, C2HC5-type
DUF3382 (PF11862, IPR021807): Domain of unknown function (DUF3382)
119 S100A10oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
120 SH2B3suppressor60.8001.467PH (PF00169, IPR001849, SM00233): PH domain
Phe_ZIP (PF08916, IPR015012): Phenylalanine zipper
SH2 (PF00017, IPR000980, SM00252): SH2 domain
121 SH2D1Ainteractor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
122 SHC1oncoprotein330.321177.786PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
123 SHC3interactor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
124 SLC25A5interactor70.3817.744Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
125 SLC25A6interactor30.6670.154Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
126 SLC31A1interactor200Ctr (PF04145, IPR007274): Ctr copper transporter family
127 SRConcoprotein240.42359.364Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
128 SRPK2oncoprotein110.24421.606DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
129 SSR1interactor31.0000TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
130 SYKsuppressor160.54317.053Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
131 TNS2interactor50.6001.586PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
PRIMA1 (PF16101): Proline-rich membrane anchor 1
132 TNS3interactor40.6670.619PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
133 TNS4interactor31.0000PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
134 TUBA1Binteractor80.5006.419Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
135 TUBA4Ainteractor80.5369.210Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
136 TUBBinteractor220.41163.871Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
137 TUBB8interactor30.6670.667Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
138 TUFMinteractor70.4298.638GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
139 TXKinteractor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
140 UQCR10interactor100UCR_UQCRX_QCR9 (PF05365, IPR008027): Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
141 VAV1oncoprotein130.6677.216PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
142 VAV2oncoprotein70.5715.286PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
CotJB (PF12652, IPR024207): CotJB protein
143 VAV3oncoprotein51.0000PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326)
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
PH_10 (PF15411): Pleckstrin homology domain
144 YBEYinteractor21.0000UPF0054 (PF02130, IPR002036): Uncharacterized protein family UPF0054
145 ZAP70interactor140.6679.351Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
146 ZNF207interactor100MCPVI (PF02993, IPR004243): Minor capsid protein VI
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
zf-FCS (PF06467, IPR010507): MYM-type Zinc finger with FCS sequence motif
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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