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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)131
The number (and %) of the onco-proteins47 (35.88 %)
The number (and %) of the tumor suppressors7 (5.34 %)
Total number of binary PPIs (saturation %)987 (11.59 %)
The number (and %) of affected PPIs131 (13.27 %)
The number of possible different fusions24
PPI diameter2
PPI radius1
The average degree of PPI14.443
Assortativity coefficient-0.2322
The network average Clustering coefficient0.584
The number (and %) of a zero Clustering coefficients5 (3.82 %)
The number (and %) of a zero Betweenness Centrality20 (15.27 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EPS15 All fusions
: AA572905;
Proteins found in more fusions SH3BP4 (see 2 fusions); ITSN2 (see 1 fusions); AP2M1 (see 3 fusions); RNF11 (see 1 fusions); EPS15 (see 1 fusions); DCAF1 (see 1 fusions); GRB2 (see 1 fusions); FCHO2/CLTC (see 1 fusions); MAPK14 (see 1 fusions); OPTN (see 1 fusions); UBQLN1 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2H (see 4 fusions); MAPRE1 (see 1 fusions); ACTB (see 3 fusions); PRDX1 (see 1 fusions); CLINT1 (see 2 fusions); EGFR (see 2 fusions); UBQLN2 (see 2 fusions); RAB11FIP2 (see 1 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EPS15parental protein1310.0979575.082Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 ABL1oncoprotein180.49325.246Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3 ACTBoncoprotein180.52922.375Actin (PF00022, IPR004000, SM00268): Actin
4 AGFG1interactor50.7000.833ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
5 AGFG2interactor30.6670.333ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
6 ANLNoncoprotein210.7909.371Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
7 AP1B1interactor150.61016.843Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
8 AP1G1interactor140.60413.060Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
9 AP2A1interactor420.389232.755Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
10 AP2A2interactor190.68411.963Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
HEAT_2 (PF13646): HEAT repeats
11 AP2B1interactor330.47391.487Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
12 AP2M1protein found in more fusions670.234951.654Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
13 AP2S1interactor150.56214.798Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
14 AURKAoncoprotein110.42212.182Pkinase (PF00069, IPR000719): Protein kinase domain
MTBP_C (PF14920, IPR029418): MDM2-binding
15 BMP2Kinteractor220.64518.904Pkinase (PF00069, IPR000719): Protein kinase domain
TCP (PF03634, IPR005333): TCP family transcription factor
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
EOS1 (PF12326, IPR021100): N-glycosylation protein
BMP2K_C (PF15282, IPR028182): BMP-2-inducible protein kinase C-terminus
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
FAM60A (PF15396, IPR026065): Protein Family FAM60A
16 CAPZA2interactor230.73515.753F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
17 CCT3interactor100.5788.918Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18 CD4suppressor60.7002.000ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
19 CLINT1protein found in more fusions260.63735.870ENTH (PF01417, IPR001026, SM00273): ENTH domain
20 CLTBinteractor280.64830.440Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
21 CLTConcoprotein400.418198.573Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
22 CORO7interactor50.7000.938DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
23 CRKoncoprotein310.277152.538SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24 CRKLoncoprotein60.8670.515SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
25 DBN1oncoprotein290.63146.581Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
26 DCAF1protein found in more fusions70.5333.371DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
27 DNM2interactor100.5786.043Dynamin_M (PF01031, IPR000375): Dynamin central region
GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain
PH (PF00169, IPR001849, SM00233): PH domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
28 EGFRoncoprotein380.291237.262Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
29 ELAVL1oncoprotein240.249118.211RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
30 EPHA2oncoprotein130.6068.897fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
31 EPN1interactor250.343125.105ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
32 EPN3interactor50.6002.567ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
33 FCHO2protein found in more fusions140.69211.645DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
PIN_2 (PF10130, IPR002716): PIN domain
muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
34 FLNAsuppressor290.57452.296CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
35 FN1oncoprotein410.293230.232fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
36 GAKoncoprotein170.7794.828DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
37 GJA1suppressor41.0000Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43)
Connexin (PF00029, IPR013092, SM00037): Connexin
SieB (PF14163, IPR025982): Super-infection exclusion protein B
38 GRB2oncoprotein560.199806.034SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
39 GTSE1interactor260.61533.275GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
40 HGSinteractor180.33370.538FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
41 HIST4H4interactor31.0000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
42 HSPA1Binteractor90.7221.519HSP70 (PF00012, IPR013126): Hsp70 protein
43 HSPA1Linteractor100.40013.497HSP70 (PF00012, IPR013126): Hsp70 protein
44 HSPA5oncoprotein190.40546.955HSP70 (PF00012, IPR013126): Hsp70 protein
45 HSPA8oncoprotein200.47940.369HSP70 (PF00012, IPR013126): Hsp70 protein
46 HSPA9oncoprotein130.55110.663HSP70 (PF00012, IPR013126): Hsp70 protein
47 IQGAP1interactor260.60635.525CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
48 ITGA4interactor330.339129.691FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
49 ITSN1interactor140.33337.439C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
50 ITSN2protein found in more fusions60.8000.556C2 (PF00168, IPR000008, SM00239): C2 domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26
VIR_N (PF15912, IPR031801): Virilizer, N-terminal
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
51 KRT1interactor110.8182.178Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
52 KRT10interactor120.7424.720Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
53 KRT14interactor70.8101.621Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
54 KRT16interactor90.7504.506Filament (PF00038, IPR001664): Intermediate filament protein
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
55 KRT17interactor51.0000DUF1798 (PF08807, IPR014913): Bacterial domain of unknown function (DUF1798)
Filament (PF00038, IPR001664): Intermediate filament protein
56 KRT2interactor100.7564.632Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
57 KRT3interactor51.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
58 KRT32interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
59 KRT33Binteractor40.6671.000Filament (PF00038, IPR001664): Intermediate filament protein
60 KRT34interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Peroxin-22 (PF12827, IPR024359): Peroxisomal biogenesis protein family
61 KRT35interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
62 KRT36interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
63 KRT37interactor100Filament (PF00038, IPR001664): Intermediate filament protein
64 KRT38interactor80.32111.633Filament (PF00038, IPR001664): Intermediate filament protein
65 KRT4interactor50.6001.786Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
66 KRT5interactor120.65211.717Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
67 KRT6Ainteractor80.6075.152Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
68 KRT73oncoprotein41.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
69 KRT75interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
70 KRT79interactor50.5002.567Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
71 KRT82interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
72 KRT83interactor30.6670.286Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
73 KRT85interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
74 KRT86interactor31.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
75 KRT9interactor80.8570.405Filament (PF00038, IPR001664): Intermediate filament protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
76 KRTAP9-3interactor100Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
77 LAPTM5oncoprotein50.7001.452Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter
78 LIMA1suppressor280.63531.552LIM (PF00412, IPR001781, SM00132): LIM domain
ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
79 MAP4oncoprotein60.8000.299SdiA-regulated (PF06977, IPR009722): SdiA-regulated
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
80 MAPK14oncoprotein80.4297.134Pkinase (PF00069, IPR000719): Protein kinase domain
81 MAPRE1oncoprotein150.51615.705CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
82 MCCC2interactor40.6670.167Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
83 MYH9oncoprotein290.64033.468IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
84 MYO19interactor220.78414.484IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
85 NAGPAinteractor31.0000EGF_2 (PF07974, IPR013111): EGF-like domain
NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
86 NECAP1interactor60.8670.450DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
87 NECAP2interactor130.50016.321DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
88 NEDD4suppressor160.33343.919Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
89 NONOoncoprotein100.5832.675GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF
NOPS (PF08075, IPR012975): NOPS (NUC059) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PAS_7 (PF12860): PAS fold
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
90 NTRK1oncoprotein450.241374.599I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
91 NUMBsuppressor130.6677.741NumbF (PF06311, IPR010449): NUMB domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
92 OCLNinteractor40.8330.250MARVEL (PF01284, IPR008253): Membrane-associating domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
93 OPTNprotein found in more fusions50.8330.333ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
94 PARK2suppressor240.229131.856IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
95 PCCBinteractor21.0000Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
96 PDLIM7interactor140.67014.047LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
97 PICALMoncoprotein270.59039.931ANTH (PF07651, IPR011417): ANTH domain
98 PPP1CBinteractor210.59531.533Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
99 PRDX1oncoprotein110.40010.876AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
100 RAB11FIP2protein found in more fusions40.6670.286C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
101 RABL6oncoprotein40.6670.571eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Ras (PF00071, IPR001806, SM00173): Ras family
102 RAD23Aoncoprotein90.5715.078UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
103 REPS2oncoprotein40.8330.154DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737)
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
104 RNF11protein found in more fusions180.34656.424zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
105 SCAMP1interactor50.5002.500SCAMP (PF04144, IPR007273): SCAMP family
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
106 SH3BP4protein found in more fusions50.5001.952SH3_2 (PF07653, IPR011511): Variant SH3 domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
107 SLC25A41interactor90.5833.750Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
108 SLC6A3oncoprotein40.5001.036SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
109 SNAP91interactor31.0000ANTH (PF07651, IPR011417): ANTH domain
MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
110 SPC25interactor30.6670.143Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
111 SPG20interactor50.5001.120MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain
Senescence (PF06911, IPR009686): Senescence-associated protein
112 STAM2interactor130.41028.403GAT (PF03127, IPR004152): GAT domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
113 STON2interactor220.59324.008Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Stonin2_N (PF12016, IPR022699): Stonin 2
114 SYNPOinteractor220.70118.189Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
115 TFAP2Aoncoprotein60.4005.841TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2
CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1
Peptidase_Prp (PF04327): Cysteine protease Prp
116 TGFB1interactor100TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide
TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
117 TMEM17interactor120.25829.410Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
118 TRAF2interactor130.31824.346MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
119 TUBBinteractor160.51720.817Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
120 UBCprotein found in more fusions350.271235.682ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
121 UBE2D1interactor90.7143.336UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
122 UBE2D2oncoprotein100.6116.252UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
123 UBE2D3interactor90.5006.833UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
124 UBE2E1protein found in more fusions60.5001.983UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
125 UBE2Hprotein found in more fusions50.5001.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
126 UBQLN1protein found in more fusions120.45514.260Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
127 UBQLN2protein found in more fusions90.6074.755Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
SUZ (PF12752, IPR024771): SUZ domain
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
128 USP8interactor100.50012.586DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
SET (PF00856, IPR001214, SM00317): SET domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
129 VCAM1interactor320.317114.121C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
130 VSIG8interactor100V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
131 XPO1interactor310.316166.140CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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