Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins EPS15 (from a repository: Thu Nov 10 14:59:26 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PNG file PDF file SVG file SIF file XML file GraphML file

Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 131 The number (and %) of the onco-proteins 47 (35.88 %) The number (and %) of the tumor suppressors 7 (5.34 %) Total number of binary PPIs (saturation %) 987 (11.59 %) The number (and %) of affected PPIs 131 (13.27 %) The number of possible different fusions 24 PPI diameter 2 PPI radius 1 The average degree of PPI 14.443 Assortativity coefficient -0.2322 The network average Clustering coefficient 0.584 The number (and %) of a zero Clustering coefficients 5 (3.82 %) The number (and %) of a zero Betweenness Centrality 20 (15.27 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EPS15	All fusions : AA572905;
Proteins found in more fusions	SH3BP4 (see 2 fusions); ITSN2 (see 1 fusions); AP2M1 (see 3 fusions); RNF11 (see 1 fusions); EPS15 (see 1 fusions); DCAF1 (see 1 fusions); GRB2 (see 1 fusions); FCHO2/CLTC (see 1 fusions); MAPK14 (see 1 fusions); OPTN (see 1 fusions); UBQLN1 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2H (see 4 fusions); MAPRE1 (see 1 fusions); ACTB (see 3 fusions); PRDX1 (see 1 fusions); CLINT1 (see 2 fusions); EGFR (see 2 fusions); UBQLN2 (see 2 fusions); RAB11FIP2 (see 1 fusions); UBE2E1 (see 2 fusions); UBC (see 1 fusions); NEDD4 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EPS15	parental protein	131	0.097	9575.082	Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2	ABL1	oncoprotein	18	0.493	25.246	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	ACTB	oncoprotein	18	0.529	22.375	Actin (PF00022, IPR004000, SM00268): Actin
4	AGFG1	interactor	5	0.700	0.833	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
5	AGFG2	interactor	3	0.667	0.333	ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
6	ANLN	oncoprotein	21	0.790	9.371	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
7	AP1B1	interactor	15	0.610	16.843	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
8	AP1G1	interactor	14	0.604	13.060	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain
9	AP2A1	interactor	42	0.389	232.755	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain HEAT_2 (PF13646): HEAT repeats
10	AP2A2	interactor	19	0.684	11.963	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain HEAT_2 (PF13646): HEAT repeats
11	AP2B1	interactor	33	0.473	91.487	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain
12	AP2M1	protein found in more fusions	67	0.234	951.654	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
13	AP2S1	interactor	15	0.562	14.798	Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
14	AURKA	oncoprotein	11	0.422	12.182	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
15	BMP2K	interactor	22	0.645	18.904	Pkinase (PF00069, IPR000719): Protein kinase domain TCP (PF03634, IPR005333): TCP family transcription factor Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal EOS1 (PF12326, IPR021100): N-glycosylation protein BMP2K_C (PF15282, IPR028182): BMP-2-inducible protein kinase C-terminus PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator FAM60A (PF15396, IPR026065): Protein Family FAM60A
16	CAPZA2	interactor	23	0.735	15.753	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
17	CCT3	interactor	10	0.578	8.918	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
18	CD4	suppressor	6	0.700	2.000	ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain CD4-extracel (PF09191, IPR015274): CD4, extracellular ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
19	CLINT1	protein found in more fusions	26	0.637	35.870	ENTH (PF01417, IPR001026, SM00273): ENTH domain
20	CLTB	interactor	28	0.648	30.440	Clathrin_lg_ch (PF01086, IPR000996): Clathrin light chain
21	CLTC	oncoprotein	40	0.418	198.573	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS Clathrin_H_link (PF13838): Clathrin-H-link
22	CORO7	interactor	5	0.700	0.938	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain WD40_4 (PF16300): Type of WD40 repeat
23	CRK	oncoprotein	31	0.277	152.538	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
24	CRKL	oncoprotein	6	0.867	0.515	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
25	DBN1	oncoprotein	29	0.631	46.581	Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
26	DCAF1	protein found in more fusions	7	0.533	3.371	DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) LisH (PF08513, IPR013720, SM00667): LisH ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
27	DNM2	interactor	10	0.578	6.043	Dynamin_M (PF01031, IPR000375): Dynamin central region GED (PF02212, IPR003130, SM00302): Dynamin GTPase effector domain PH (PF00169, IPR001849, SM00233): PH domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
28	EGFR	oncoprotein	38	0.291	237.262	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
29	ELAVL1	oncoprotein	24	0.249	118.211	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
30	EPHA2	oncoprotein	13	0.606	8.897	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
31	EPN1	interactor	25	0.343	125.105	ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
32	EPN3	interactor	5	0.600	2.567	ENTH (PF01417, IPR001026, SM00273): ENTH domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
33	FCHO2	protein found in more fusions	14	0.692	11.645	DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain PIN_2 (PF10130, IPR002716): PIN domain muHD (PF10291, IPR018808): Muniscin C-terminal mu homology domain
34	FLNA	suppressor	29	0.574	52.296	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
35	FN1	oncoprotein	41	0.293	230.232	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
36	GAK	oncoprotein	17	0.779	4.828	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
37	GJA1	suppressor	4	1.000	0	Connexin43 (PF03508, IPR013124): Gap junction alpha-1 protein (Cx43) Connexin (PF00029, IPR013092, SM00037): Connexin SieB (PF14163, IPR025982): Super-infection exclusion protein B
38	GRB2	oncoprotein	56	0.199	806.034	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
39	GTSE1	interactor	26	0.615	33.275	GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
40	HGS	interactor	18	0.333	70.538	FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate PIEZO (PF15917, IPR031805): Piezo
41	HIST4H4	interactor	3	1.000	0	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
42	HSPA1B	interactor	9	0.722	1.519	HSP70 (PF00012, IPR013126): Hsp70 protein
43	HSPA1L	interactor	10	0.400	13.497	HSP70 (PF00012, IPR013126): Hsp70 protein
44	HSPA5	oncoprotein	19	0.405	46.955	HSP70 (PF00012, IPR013126): Hsp70 protein
45	HSPA8	oncoprotein	20	0.479	40.369	HSP70 (PF00012, IPR013126): Hsp70 protein
46	HSPA9	oncoprotein	13	0.551	10.663	HSP70 (PF00012, IPR013126): Hsp70 protein
47	IQGAP1	interactor	26	0.606	35.525	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
48	ITGA4	interactor	33	0.339	129.691	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
49	ITSN1	interactor	14	0.333	37.439	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
50	ITSN2	protein found in more fusions	6	0.800	0.556	C2 (PF00168, IPR000008, SM00239): C2 domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) SH3_9 (PF14604, IPR001452): Variant SH3 domain MRP-S26 (PF14943, IPR026140): Mitochondrial ribosome subunit S26 VIR_N (PF15912, IPR031801): Virilizer, N-terminal PH_13 (PF16652, IPR001849): Pleckstrin homology domain
51	KRT1	interactor	11	0.818	2.178	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Keratin_2_head (PF16208, IPR032444): Keratin type II head Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
52	KRT10	interactor	12	0.742	4.720	Filament (PF00038, IPR001664): Intermediate filament protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
53	KRT14	interactor	7	0.810	1.621	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Keratin_2_head (PF16208, IPR032444): Keratin type II head
54	KRT16	interactor	9	0.750	4.506	Filament (PF00038, IPR001664): Intermediate filament protein zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
55	KRT17	interactor	5	1.000	0	DUF1798 (PF08807, IPR014913): Bacterial domain of unknown function (DUF1798) Filament (PF00038, IPR001664): Intermediate filament protein
56	KRT2	interactor	10	0.756	4.632	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
57	KRT3	interactor	5	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
58	KRT32	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
59	KRT33B	interactor	4	0.667	1.000	Filament (PF00038, IPR001664): Intermediate filament protein
60	KRT34	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Peroxin-22 (PF12827, IPR024359): Peroxisomal biogenesis protein family
61	KRT35	interactor	2	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein
62	KRT36	interactor	3	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein
63	KRT37	interactor	1	0	0	Filament (PF00038, IPR001664): Intermediate filament protein
64	KRT38	interactor	8	0.321	11.633	Filament (PF00038, IPR001664): Intermediate filament protein
65	KRT4	interactor	5	0.600	1.786	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
66	KRT5	interactor	12	0.652	11.717	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
67	KRT6A	interactor	8	0.607	5.152	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
68	KRT73	oncoprotein	4	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
69	KRT75	interactor	1	0	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
70	KRT79	interactor	5	0.500	2.567	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
71	KRT82	interactor	3	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
72	KRT83	interactor	3	0.667	0.286	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
73	KRT85	interactor	3	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
74	KRT86	interactor	3	1.000	0	Filament (PF00038, IPR001664): Intermediate filament protein Keratin_2_head (PF16208, IPR032444): Keratin type II head
75	KRT9	interactor	8	0.857	0.405	Filament (PF00038, IPR001664): Intermediate filament protein FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
76	KRTAP9-3	interactor	1	0	0	Keratin_B2_2 (PF13885, IPR002494): Keratin, high sulfur B2 protein
77	LAPTM5	oncoprotein	5	0.700	1.452	Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter
78	LIMA1	suppressor	28	0.635	31.552	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
79	MAP4	oncoprotein	6	0.800	0.299	SdiA-regulated (PF06977, IPR009722): SdiA-regulated Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
80	MAPK14	oncoprotein	8	0.429	7.134	Pkinase (PF00069, IPR000719): Protein kinase domain
81	MAPRE1	oncoprotein	15	0.516	15.705	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EB1 (PF03271, IPR004953): EB1-like C-terminal motif SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
82	MCCC2	interactor	4	0.667	0.167	Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
83	MYH9	oncoprotein	29	0.640	33.468	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
84	MYO19	interactor	22	0.784	14.484	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
85	NAGPA	interactor	3	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain NAGPA (PF09992, IPR018711): Phosphodiester glycosidase
86	NECAP1	interactor	6	0.867	0.450	DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
87	NECAP2	interactor	13	0.500	16.321	DUF1681 (PF07933, IPR012466): Protein of unknown function (DUF1681)
88	NEDD4	suppressor	16	0.333	43.919	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
89	NONO	oncoprotein	10	0.583	2.675	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF NOPS (PF08075, IPR012975): NOPS (NUC059) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PAS_7 (PF12860): PAS fold SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
90	NTRK1	oncoprotein	45	0.241	374.599	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
91	NUMB	suppressor	13	0.667	7.741	NumbF (PF06311, IPR010449): NUMB domain PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
92	OCLN	interactor	4	0.833	0.250	MARVEL (PF01284, IPR008253): Membrane-associating domain Occludin_ELL (PF07303, IPR010844): Occludin homology domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
93	OPTN	protein found in more fusions	5	0.833	0.333	ARD (PF03079, IPR004313): ARD/ARD' family bZIP_1 (PF00170, IPR004827): bZIP transcription factor HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
94	PARK2	suppressor	24	0.229	131.856	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
95	PCCB	interactor	2	1.000	0	Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
96	PDLIM7	interactor	14	0.670	14.047	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
97	PICALM	oncoprotein	27	0.590	39.931	ANTH (PF07651, IPR011417): ANTH domain
98	PPP1CB	interactor	21	0.595	31.533	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
99	PRDX1	oncoprotein	11	0.400	10.876	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
100	RAB11FIP2	protein found in more fusions	4	0.667	0.286	C2 (PF00168, IPR000008, SM00239): C2 domain RBD-FIP (PF09457, IPR019018): FIP domain
101	RABL6	oncoprotein	4	0.667	0.571	eIF3_subunit (PF08597, IPR013906): Translation initiation factor eIF3 subunit Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain Ras (PF00071, IPR001806, SM00173): Ras family
102	RAD23A	oncoprotein	9	0.571	5.078	UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
103	REPS2	oncoprotein	4	0.833	0.154	DUF737 (PF05300, IPR007964): Protein of unknown function (DUF737) Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
104	RNF11	protein found in more fusions	18	0.346	56.424	zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
105	SCAMP1	interactor	5	0.500	2.500	SCAMP (PF04144, IPR007273): SCAMP family DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
106	SH3BP4	protein found in more fusions	5	0.500	1.952	SH3_2 (PF07653, IPR011511): Variant SH3 domain ZU5 (PF00791, IPR000906, SM00218): ZU5 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
107	SLC25A41	interactor	9	0.583	3.750	Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
108	SLC6A3	oncoprotein	4	0.500	1.036	SNF (PF00209, IPR000175): Sodium:neurotransmitter symporter family
109	SNAP91	interactor	3	1.000	0	ANTH (PF07651, IPR011417): ANTH domain MGC-24 (PF05283, IPR007947): Multi-glycosylated core protein 24 (MGC-24), sialomucin Mucin (PF01456, IPR000458): Mucin-like glycoprotein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
110	SPC25	interactor	3	0.667	0.143	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Spindle_Spc25 (PF08234, IPR013255): Chromosome segregation protein Spc25
111	SPG20	interactor	5	0.500	1.120	MIT (PF04212, IPR007330, SM00745): MIT (microtubule interacting and transport) domain Senescence (PF06911, IPR009686): Senescence-associated protein
112	STAM2	interactor	13	0.410	28.403	GAT (PF03127, IPR004152): GAT domain UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VHS (PF00790, IPR002014, SM00288): VHS domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
113	STON2	interactor	22	0.593	24.008	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Stonin2_N (PF12016, IPR022699): Stonin 2
114	SYNPO	interactor	22	0.701	18.189	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
115	TFAP2A	oncoprotein	6	0.400	5.841	TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2 CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1 Peptidase_Prp (PF04327): Cysteine protease Prp
116	TGFB1	interactor	1	0	0	TGFb_propeptide (PF00688, IPR001111): TGF-beta propeptide TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
117	TMEM17	interactor	12	0.258	29.410	Transmemb_17 (PF09799, IPR019184): Predicted membrane protein DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
118	TRAF2	interactor	13	0.318	24.346	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
119	TUBB	interactor	16	0.517	20.817	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
120	UBC	protein found in more fusions	35	0.271	235.682	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
121	UBE2D1	interactor	9	0.714	3.336	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
122	UBE2D2	oncoprotein	10	0.611	6.252	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
123	UBE2D3	interactor	9	0.500	6.833	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
124	UBE2E1	protein found in more fusions	6	0.500	1.983	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
125	UBE2H	protein found in more fusions	5	0.500	1.500	UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
126	UBQLN1	protein found in more fusions	12	0.455	14.260	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B FAM199X (PF15814, IPR029672): Protein family FAM199X
127	UBQLN2	protein found in more fusions	9	0.607	4.755	Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain XPC-binding (PF09280, IPR015360): XPC-binding domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family SUZ (PF12752, IPR024771): SUZ domain Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
128	USP8	interactor	10	0.500	12.586	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain SET (PF00856, IPR001214, SM00317): SET domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
129	VCAM1	interactor	32	0.317	114.121	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
130	VSIG8	interactor	1	0	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
131	XPO1	interactor	31	0.316	166.140	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑