Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins EPAS1 (from a repository: Thu Nov 17 20:45:42 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 102 The number (and %) of the onco-proteins 30 (29.41 %) The number (and %) of the tumor suppressors 21 (20.59 %) Total number of binary PPIs (saturation %) 649 (12.60 %) The number (and %) of affected PPIs 102 (15.72 %) The number of possible different fusions 24 PPI diameter 2 PPI radius 1 The average degree of PPI 11.902 Assortativity coefficient -0.2165 The network average Clustering coefficient 0.605 The number (and %) of a zero Clustering coefficients 6 (5.88 %) The number (and %) of a zero Betweenness Centrality 16 (15.69 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EPAS1	All fusions
Proteins found in more fusions	EWSR1/MED15 (see 3 fusions); TERF2IP (see 1 fusions); MCM7 (see 2 fusions); HSP90AA1 (see 2 fusions); TRIM33 (see 1 fusions); NPM1 (see 1 fusions); SQSTM1 (see 5 fusions); SMARCB1 (see 12 fusions); VHL (see 1 fusions); SP1 (see 1 fusions); BAG2 (see 1 fusions); CREBBP (see 5 fusions); EWSR1 (see 2 fusions); APC (see 1 fusions); STUB1 (see 1 fusions); BATF3 (see 1 fusions); KDM1A (see 2 fusions); SMARCC1 (see 2 fusions); EPAS1 (see 1 fusions); EP300 (see 1 fusions); UBC (see 1 fusions); EGLN1 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EPAS1	parental protein	102	0.100	6894.127	Corona_I (PF03187, IPR004876): Corona nucleocapsid I protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 PAS_11 (PF14598): PAS domain
2	AKAP8L	interactor	3	0.667	0.500	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
3	APC	suppressor	8	0.476	5.836	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4	ARID1B	oncoprotein	8	1.000	0	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin (PF01080, IPR001108): Presenilin DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Spt20 (PF12090, IPR021950): Spt20 family
5	ARNT	oncoprotein	6	0.600	2.404	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
6	ARNT2	interactor	3	0.667	1.000	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold PAP2 (PF01569, IPR000326, SM00014): PAP2 superfamily
7	ARNTL	suppressor	6	0.733	1.136	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_11 (PF14598): PAS domain
8	BAG2	protein found in more fusions	7	0.800	0.821	IncA (PF04156, IPR007285): IncA protein Mnd1 (PF03962, IPR005647): Mnd1 family ParD_antitoxin (PF03693, IPR022789): Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH
9	BATF	oncoprotein	7	0.667	3.567	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
10	BATF2	suppressor	4	0.833	0.400	bZIP_1 (PF00170, IPR004827): bZIP transcription factor PRIMA1 (PF16101): Proline-rich membrane anchor 1
11	BATF3	protein found in more fusions	6	0.900	0.400	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
12	BBS1	interactor	1	0	0	BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1 BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
13	BBS2	interactor	1	0	0	BBS2_N (PF14781, IPR029430): Ciliary BBSome complex subunit 2, N-terminal BBS2_C (PF14782, IPR029333): Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
14	BBS4	interactor	1	0	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Mu-like_Pro (PF10123, IPR012106): Mu-like prophage I protein TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
15	BCL7C	suppressor	8	1.000	0	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
16	CNOT1	interactor	5	0.700	1.400	Not1 (PF04054, IPR007196): CCR4-Not complex component, Not1 DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439) DUF3819 (PF12842, IPR024557): Domain of unknown function (DUF3819) EF-hand_8 (PF13833, IPR002048): EF-hand domain pair CNOT1_CAF1_bind (PF16415, IPR032191): CCR4-NOT transcription complex subunit 1 CAF1-binding domain CNOT1_TTP_bind (PF16417, IPR032193): CCR4-NOT transcription complex subunit 1 TTP binding domain CNOT1_HEAT (PF16418, IPR032194): CCR4-NOT transcription complex subunit 1 HEAT repeat
17	CNOT10	interactor	5	0.600	2.833	DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948) POX (PF07526, IPR006563, SM00574): Associated with HOX Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 (PF13428): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat SRP_TPR_like (PF17004, IPR031545): Putative TPR-like repeat
18	CNOT7	interactor	5	0.700	1.667	CAF1 (PF04857, IPR006941): CAF1 family ribonuclease
19	CREBBP	suppressor	19	0.392	50.514	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
20	CTNNB1	oncoprotein	15	0.390	34.731	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
21	DBP	interactor	5	0.800	1.000	bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
22	DCAF7	interactor	4	0.500	0.900	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
23	DDIT3	oncoprotein	9	0.607	7.233	IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
24	DNAJA2	interactor	9	0.556	5.404	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
25	DPF2	interactor	8	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
26	DPY30	interactor	3	1.000	0	Dpy-30 (PF05186, IPR007858): Dpy-30 motif
27	EGLN1	suppressor	5	0.833	0.667	zf-MYND (PF01753, IPR002893): MYND finger 2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
28	EGLN2	interactor	4	1.000	0	2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
29	EGLN3	suppressor	6	0.700	2.000	2OG-FeII_Oxy_3 (PF13640, IPR005123): 2OG-Fe(II) oxygenase superfamily
30	ELAVL1	oncoprotein	23	0.221	125.933	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31	EMD	interactor	11	0.333	22.050	LEM (PF03020, IPR003887, SM00540): LEM domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
32	EP300	oncoprotein	27	0.249	155.932	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
33	ETS1	oncoprotein	8	0.750	1.898	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
34	EWSR1	oncoprotein	19	0.320	70.825	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
35	F12	interactor	3	1.000	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain Kringle (PF00051, IPR000001): Kringle domain Trypsin (PF00089, IPR001254, SM00020): Trypsin
36	GTF3C3	interactor	6	0.467	2.838	BUD22 (PF09073, IPR015158): BUD22 PGA2 (PF07543, IPR011431): Protein trafficking PGA2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Foie-gras_1 (PF11817, IPR021773): Foie gras liver health family 1 DUF3369 (PF11849, IPR021800): Domain of unknown function (DUF3369) ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat TPR_20 (PF14561): Tetratricopeptide repeat
37	HIF1A	suppressor	32	0.204	314.361	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
38	HSP90AA1	oncoprotein	18	0.368	47.060	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
39	HSPA4	interactor	12	0.515	16.765	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
40	IKBKAP	interactor	2	0	0	IKI3 (PF04762, IPR006849): IKI3 family Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS MMU163 (PF17119, IPR031342): Mitochondrial protein up-regulated during meiosis
41	JUN	oncoprotein	21	0.326	81.824	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
42	KDM1A	protein found in more fusions	8	0.381	8.638	Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain SWIRM (PF04433, IPR007526): SWIRM domain DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
43	KLHL20	interactor	5	0.667	1.500	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
44	LAMP1	interactor	3	1.000	0	Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
45	MAP1LC3A	interactor	3	1.000	0	Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
46	MAX	suppressor	9	0.571	4.091	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SlyX (PF04102, IPR007236): SlyX
47	MCM3	interactor	6	0.533	5.200	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
48	MCM7	protein found in more fusions	5	0.833	0.400	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
49	MED1	interactor	22	0.871	7.785	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Med1 (PF10744, IPR019680): Mediator of RNA polymerase II transcription subunit 1 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
50	MED10	interactor	20	0.942	1.552	Med10 (PF09748, IPR019145): Transcription factor subunit Med10 of Mediator complex
51	MED11	interactor	18	0.974	0.533	Med11 (PF10280, IPR019404): Mediator complex protein
52	MED12	oncoprotein	22	0.797	25.285	Med12 (PF09497, IPR019035): Transcription mediator complex subunit Med12 Peptidase_S15 (PF02129, IPR000383): X-Pro dipeptidyl-peptidase (S15 family) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF2877 (PF11392, IPR021530): Protein of unknown function (DUF2877) Med12-PQL (PF12144, IPR021989): Eukaryotic Mediator 12 catenin-binding domain Med12-LCEWAV (PF12145, IPR021990): Eukaryotic Mediator 12 subunit domain CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
53	MED14	interactor	20	0.889	6.603	Med14 (PF08638, IPR013947): Mediator complex subunit MED14
54	MED15	protein found in more fusions	22	0.762	23.053	Med15 (PF09606, IPR019087): ARC105 or Med15 subunit of Mediator complex non-fungal
55	MED16	interactor	19	0.965	0.836	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Med16 (PF11635, IPR021665): Mediator complex subunit 16
56	MED17	oncoprotein	21	0.857	17.785	Med17 (PF10156, IPR019313): Subunit 17 of Mediator complex
57	MED18	interactor	19	0.971	0.644	Med18 (PF09637, IPR019095): Med18 protein
58	MED20	interactor	22	0.753	36.644	Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
59	MED22	interactor	15	0.990	0.111	Med22 (PF06179, IPR009332): Surfeit locus protein 5 subunit 22 of Mediator complex
60	MED23	interactor	27	0.530	112.754	Med23 (PF11573, IPR021629): Mediator complex subunit 23
61	MED24	interactor	21	0.862	12.635	Med24_N (PF11277, IPR021429): Mediator complex subunit 24 N-terminal
62	MED25	interactor	16	0.886	6.400	Med25 (PF11232, IPR021394): Mediator complex subunit 25 PTOV activation and synapsin 2 Med25_SD1 (PF11235, IPR021397): Mediator complex subunit 25 synapsin 1 Med25_NR-box (PF11244, IPR021406): Mediator complex subunit 25 C-terminal NR box-containing Med25_VWA (PF11265, IPR021419): Mediator complex subunit 25 von Willebrand factor type A
63	MED26	interactor	21	0.871	7.935	Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
64	MED27	interactor	19	0.971	0.644	Med27 (PF11571, IPR021627): Mediator complex subunit 27
65	MED29	interactor	21	0.942	1.552	Med29 (PF11568, IPR021018): Mediator complex subunit 29
66	MED4	interactor	27	0.556	120.002	Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
67	MED7	interactor	20	0.942	1.552	Med7 (PF05983, IPR009244): MED7 protein DotU (PF09850, IPR017732): Type VI secretion system protein DotU
68	MED8	interactor	20	0.826	22.094	Med8 (PF10232, IPR019364): Mediator of RNA polymerase II transcription complex subunit 8
69	MEF2C	oncoprotein	4	0.833	0.250	SRF-TF (PF00319, IPR002100, SM00432): SRF-type transcription factor (DNA-binding and dimerisation domain) HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat
70	MITF	oncoprotein	5	0.500	2.015	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain DUF3371 (PF11851, IPR021802): Domain of unknown function (DUF3371) DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355) Di19_C (PF14571, IPR027935): Stress-induced protein Di19, C-terminal MITF_TFEB_C_3_N (PF15951, IPR031867): MITF/TFEB/TFEC/TFE3 N-terminus
71	NCAPD3	interactor	2	1.000	0	DUF3013 (PF11217, IPR021380): Protein of unknown function (DUF3013) CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
72	NDN	suppressor	3	1.000	0	MAGE (PF01454, IPR002190): MAGE family
73	NPM1	suppressor	17	0.367	41.060	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
74	PHB	suppressor	10	0.378	18.786	Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
75	PHB2	interactor	5	0.500	3.500	DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605) Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
76	PSMB1	interactor	6	0.667	3.500	Proteasome (PF00227, IPR001353): Proteasome subunit
77	PSMC3	interactor	9	0.464	10.852	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
78	PSMD1	interactor	8	0.536	7.002	PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin) PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat HEAT_2 (PF13646): HEAT repeats
79	SIN3A	oncoprotein	13	0.526	18.417	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
80	SIRT1	suppressor	13	0.455	16.314	DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592) SIR2 (PF02146, IPR003000): Sir2 family TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
81	SMAD3	oncoprotein	23	0.299	102.638	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
82	SMARCA2	suppressor	13	0.590	15.392	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
83	SMARCA4	suppressor	19	0.398	63.330	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
84	SMARCB1	suppressor	14	0.564	16.116	SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
85	SMARCC1	suppressor	17	0.492	30.190	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
86	SMARCC2	interactor	17	0.441	42.757	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
87	SOX10	oncoprotein	1	0	0	Beta-lactamase (PF00144, IPR001466): Beta-lactamase HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
88	SP1	protein found in more fusions	19	0.438	40.134	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
89	SPP1	oncoprotein	1	0	0	Osteopontin (PF00865, IPR002038, SM00017): Osteopontin
90	SQSTM1	oncoprotein	14	0.321	36.831	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
91	SSBP3	oncoprotein	4	0.667	2.000	SSDP (PF04503): Single-stranded DNA binding protein, SSDP
92	STAT5A	suppressor	5	0.500	0.819	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
93	STUB1	suppressor	12	0.509	14.429	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
94	TCEB2	interactor	5	0.600	2.667	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
95	TERF2IP	protein found in more fusions	5	0.500	1.400	BRF1 (PF07741, IPR011665): Brf1-like TBP-binding domain Histone_HNS (PF00816, IPR001801): H-NS histone family Myb_DNA-bind_2 (PF08914, IPR015010): Rap1 Myb domain Rap1_C (PF11626, IPR021661): TRF2-interacting telomeric protein/Rap1 - C terminal domain DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
96	TFAP2A	suppressor	10	0.511	8.437	TF_AP-2 (PF03299, IPR013854): Transcription factor AP-2 CYYR1 (PF10873, IPR022640): Cysteine and tyrosine-rich protein 1 Peptidase_Prp (PF04327): Cysteine protease Prp
97	TRIM33	oncoprotein	10	0.472	12.083	PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Siva (PF05458, IPR022773): Cd27 binding protein (Siva) Spectrin (PF00435, IPR002017): Spectrin repeat TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
98	UBC	protein found in more fusions	18	0.265	70.657	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
99	VHL	suppressor	17	0.350	49.192	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein VHL_C (PF17211): VHL box domain
100	WRNIP1	interactor	4	0.667	0.286	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
101	XPO1	interactor	23	0.154	172.219	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
102	YTHDF2	interactor	4	0.667	0.472	YTH (PF04146, IPR007275): YT521-B-like domain DUF4106 (PF13388, IPR025179): Protein of unknown function (DUF4106)

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