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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)11
The number (and %) of the onco-proteins7 (63.64 %)
The number (and %) of the tumor suppressors1 (9.09 %)
Total number of binary PPIs (saturation %)34 (61.82 %)
The number (and %) of affected PPIs11 (32.35 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI4.545
Assortativity coefficient-0.3906
The network average Clustering coefficient0.633
The number (and %) of a zero Clustering coefficients1 (9.09 %)
The number (and %) of a zero Betweenness Centrality4 (36.36 %)


List of the fusions

PPI for parental proteins: ENC1 All fusions
: AA593360;
Proteins found in more fusions CUL3 (see 1 fusions); ACTB (see 3 fusions); HSP90AA1 (see 2 fusions); SQSTM1 (see 5 fusions); ENC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ENC1parental protein110.33337.667BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
HTH_12 (PF08461, IPR013668): Ribonuclease R winged-helix domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
2 ACTBoncoprotein40.6670.500Actin (PF00022, IPR004000, SM00268): Actin
3 CUL3protein found in more fusions90.42913.500Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
4 HSP90AA1oncoprotein50.6671.167HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
5 KEAP1oncoprotein70.6673.167BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
6 NACC1interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
7 NFE2L2oncoprotein41.0000bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
8 RB1suppressor100RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
9 RBX1oncoprotein41.0000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
10 SNCAinteractor50.5001.833Synuclein (PF01387, IPR001058): Synuclein
11 SQSTM1oncoprotein60.7002.167PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain

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