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Visible interactions: all affected independent (normal) missing (in fusions) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EMILIN1 (from a repository: Mon Nov 14 04:16:43 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins3 (15.79 %)
The number (and %) of the tumor suppressors2 (10.53 %)
Total number of binary PPIs (saturation %)31 (18.13 %)
The number (and %) of affected PPIs19 (61.29 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.421
Assortativity coefficient-0.5077
The network average Clustering coefficient0.370
The number (and %) of a zero Clustering coefficients11 (57.89 %)
The number (and %) of a zero Betweenness Centrality18 (94.74 %)

ACTIVE INTERACTORS
MISSING INTERACTORS (in fusions)


List of the fusions

PPI for parental proteins: EMILIN1 All fusions
: BF514389; CN350362;
Proteins found in more fusions MTMR9 (see 1 fusions); EMILIN1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EMILIN1parental protein190.033296.000C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EMI (PF07546, IPR011489): EMI domain
IncA (PF04156, IPR007285): IncA protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Unstab_antitox (PF09720, IPR013406): Putative addiction module component
DUF2802 (PF10975, IPR021244): Protein of unknown function (DUF2802)
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
2 BEX3interactor200BEX (PF04538, IPR021156): Brain expressed X-linked like family
3 BEX5interactor200BEX (PF04538, IPR021156): Brain expressed X-linked like family
4 CDC23interactor41.0000ANAPC8 (PF04049, IPR007192): Anaphase promoting complex subunit 8 / Cdc23
DUF772 (PF05598, IPR008490): Transposase domain (DUF772)
Menin (PF05053, IPR007747): Menin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
5 CDC27oncoprotein41.0000TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
6 DCTN2interactor31.0000Dynamitin (PF04912): Dynamitin
7 DYNC1I1interactor21.0000CDC45 (PF02724, IPR003874): CDC45-like protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Dynein_IC2 (PF11540, IPR025956): Cytoplasmic dynein 1 intermediate chain 2
AviRa (PF11599, IPR024268): RRNA methyltransferase AviRa
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
8 EMILIN2interactor100APG6 (PF04111, IPR007243): Autophagy protein Apg6
Apolipoprotein (PF01442, IPR000074): Apolipoprotein A1/A4/E domain
C1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EMI (PF07546, IPR011489): EMI domain
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
9 FZR1suppressor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
10 IFT20interactor100IFT20 (PF14931, IPR028172): Intraflagellar transport complex B, subunit 20
11 LAIR2interactor100Ig_2 (PF13895, IPR007110): Immunoglobulin domain
12 MIA2suppressor100NESP55 (PF06390, IPR009434): Neuroendocrine-specific golgi protein P55 (NESP55)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
13 MTMR9protein found in more fusions31.0000Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
14 NMIinteractor31.0000IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
15 NUMA1oncoprotein100Colicin (PF01024, IPR000293): Colicin pore forming domain
Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF848 (PF05852, IPR008566): Gammaherpesvirus protein of unknown function (DUF848)
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
16 PLAC9interactor100PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
17 RIBC1interactor100RIB43A (PF05914, IPR008805): RIB43A
18 TAX1BP1interactor100CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
19 ZC2HC1Cinteractor100zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
zf-C2HC_2 (PF13913): zinc-finger of a C2HC-type

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List of missing interactors (in fusions)

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 EMILIN1parental proteinC1q (PF00386, IPR001073, SM00110): C1q domain
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
EMI (PF07546, IPR011489): EMI domain
IncA (PF04156, IPR007285): IncA protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Unstab_antitox (PF09720, IPR013406): Putative addiction module component
DUF2802 (PF10975, IPR021244): Protein of unknown function (DUF2802)
DUF3720 (PF12517, IPR022195): Protein of unknown function (DUF3720)
MscS_porin (PF12795, IPR024393): Mechanosensitive ion channel porin domain
Nup54 (PF13874, IPR025712): Nucleoporin complex subunit 54
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
CN350362

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