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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins ELF3 (from a repository: Sun Dec 4 19:12:47 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)29
The number (and %) of the onco-proteins12 (41.38 %)
The number (and %) of the tumor suppressors7 (24.14 %)
Total number of binary PPIs (saturation %)90 (22.17 %)
The number (and %) of affected PPIs29 (32.22 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI5.103
Assortativity coefficient-0.3404
The network average Clustering coefficient0.599
The number (and %) of a zero Clustering coefficients5 (17.24 %)
The number (and %) of a zero Betweenness Centrality13 (44.83 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: ELF3 All fusions
: BF804203; BF804202;
Proteins found in more fusions ELF3 (see 2 fusions); JAK1 (see 1 fusions); CALR (see 6 fusions); EEF1D (see 3 fusions); EP300 (see 1 fusions); MYC (see 1 fusions); NFKB1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 ELF3parental protein290.122565.333AT_hook (PF02178, IPR017956, SM00384): AT hook motif
Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
2 ARoncoprotein90.42913.167Androgen_recep (PF02166, IPR001103): Androgen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
3 ATIConcoprotein30.6671.000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
4 BTRConcoprotein60.9000.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 CALRoncoprotein50.6671.500Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
6 CBR3interactor100adh_short (PF00106, IPR002198): short chain dehydrogenase
7 DDX3Xsuppressor100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 EEF1Dprotein found in more fusions31.0000EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
9 EHFsuppressor31.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
MVL (PF12151, IPR021992): Mannan-binding protein
10 EP300oncoprotein100.55610.333Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
11 ERBB2oncoprotein40.6671.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
12 GADD45GIP1suppressor21.0000CR6_interact (PF10147, IPR018472): Growth arrest and DNA-damage-inducible proteins-interacting protein 1
13 GANABsuppressor70.5717.833Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
DUF5110 (PF17137): Domain of unknown function (DUF5110)
14 ISG15suppressor60.5337.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
15 JAK1oncoprotein40.6671.000FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
16 KRT31interactor100Filament (PF00038, IPR001664): Intermediate filament protein
17 KRT82interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 MED23interactor31.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
19 MYConcoprotein100.52812.833HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
20 NFKB1suppressor51.0000Death (PF00531, IPR000488, SM00005): Death domain
GHMP_kinases_C (PF08544, IPR013750): GHMP kinases C terminal
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
21 P4HBinteractor41.0000Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
22 PAK1oncoprotein40.6671.000PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23 RELAoncoprotein120.40027.500DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
24 RPL6interactor100Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e
Ribosomal_L6e_N (PF03868, IPR005568): Ribosomal protein L6, N-terminal domain
25 TAF9interactor41.0000TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
26 TARSinteractor21.0000HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
TGS (PF02824, IPR004095): TGS domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
27 TBPinteractor70.8001.500TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
28 XRCC5suppressor80.6194.667Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
29 XRCC6oncoprotein90.5717.833Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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