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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins16 (26.23 %)
The number (and %) of the tumor suppressors3 (4.92 %)
Total number of binary PPIs (saturation %)240 (13.11 %)
The number (and %) of affected PPIs61 (25.42 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI7.016
Assortativity coefficient-0.3482
The network average Clustering coefficient0.543
The number (and %) of a zero Clustering coefficients11 (18.03 %)
The number (and %) of a zero Betweenness Centrality24 (39.34 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EIF4A2 All fusions
: AW840050; BG979271;
Proteins found in more fusions HSPB1 (see 2 fusions); PABPC1 (see 2 fusions); BAG3 (see 4 fusions); CRY2 (see 3 fusions); EIF4A2 (see 2 fusions); VCP (see 4 fusions); MCM2 (see 1 fusions); VAC14 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EIF4A2parental protein610.0872722.569DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
2 AIMP1suppressor21.0000DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
tRNA_bind (PF01588, IPR002547): Putative tRNA binding domain
3 AKAP17Ainteractor21.0000Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
NEMP (PF10225, IPR019358): NEMP family
4 ALPIinteractor21.0000Alk_phosphatase (PF00245, IPR001952, SM00098): Alkaline phosphatase
5 ATRXinteractor100DDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
6 BAG3oncoprotein70.5334.800BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
7 BRCA1oncoprotein110.33323.033BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
8 CD2BP2interactor30.6670.667GYF (PF02213, IPR003169, SM00444): GYF domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hist_rich_Ca-bd (PF10529, IPR019552): Histidine-rich Calcium-binding repeat region
9 CD4suppressor80.5714.117ATP1G1_PLM_MAT8 (PF02038, IPR000272): ATP1G1/PLM/MAT8 family
C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
CD4-extracel (PF09191, IPR015274): CD4, extracellular
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Tcell_CD4_C (PF12104, IPR021963): T cell CD4 receptor C terminal region
10 CD81interactor130.54514.621Tetraspannin (PF00335, IPR018499): Tetraspanin family
11 CDC5Linteractor90.32116.286OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
12 CETN2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
13 CMBLinteractor30.6670.667DLH (PF01738, IPR002925): Dienelactone hydrolase family
14 CRY1interactor60.6003.500DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
15 CRY2protein found in more fusions70.4675.033DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
16 DDX39Binteractor30.6670.500DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17 DDX3Xsuppressor130.53822.738DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
18 DPPA4interactor31.0000Ribosomal_L40e (PF01020, IPR001975): Ribosomal L40e family
DCR (PF14047, IPR025891): Dppa2/4 conserved region
Dppa2_A (PF14049, IPR025892): Dppa2/4 conserved region in higher vertebrates
19 ECT2oncoprotein21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
20 EIF3Aoncoprotein130.61514.757DUF1003 (PF06210, IPR010406): Protein of unknown function (DUF1003)
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
PCI (PF01399, IPR000717, SM00088): PCI domain
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
21 EIF3Dinteractor100.7335.355eIF-3_zeta (PF05091, IPR007783): Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
22 EIF3Foncoprotein140.57119.962JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
23 EIF3Hinteractor140.54921.221Androgen_recep (PF02166, IPR001103): Androgen receptor
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
NHS (PF15273, IPR024845): NHS-like
24 EIF3Kinteractor90.9170.869CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
25 EIF3Linteractor100.8222.490Paf67 (PF10255, IPR019382): RNA polymerase I-associated factor PAF67
26 EIF3Minteractor80.7863.900Death (PF00531, IPR000488, SM00005): Death domain
PCI (PF01399, IPR000717, SM00088): PCI domain
27 EIF4A1interactor160.34254.274DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
28 EIF4A3interactor70.5335.567DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
29 EIF4Eoncoprotein70.6675.583IF4E (PF01652, IPR001040): Eukaryotic initiation factor 4E
30 EIF4G1oncoprotein140.46230.576DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
Neisseria_TspB (PF05616, IPR008708): Neisseria meningitidis TspB protein
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
31 EIF4G2interactor90.6675.319MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
32 EIF4G3interactor90.6115.969MA3 (PF02847, IPR003891, SM00544): MA3 domain
MIF4G (PF02854, IPR003890, SM00543): MIF4G domain
W2 (PF02020, IPR003307, SM00515): eIF4-gamma/eIF5/eIF2-epsilon
33 GOLGA2interactor21.0000ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
GOLGA2L5 (PF15070, IPR024858): Putative golgin subfamily A member 2-like protein 5
34 HNRNPA1interactor160.41037.257RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
35 HSPB1oncoprotein130.31833.719HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
36 HSPB2interactor31.0000Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
37 IPO11interactor21.0000DUF1539 (PF07560, IPR011436): Domain of Unknown Function (DUF1539)
HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
HEAT_2 (PF13646): HEAT repeats
38 LAGE3interactor31.0000Pcc1 (PF09341, IPR015419): Transcription factor Pcc1
39 MCM2oncoprotein180.32465.869AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
40 MDFIinteractor50.5003.000MDFI (PF15316, IPR026134): MyoD family inhibitor
41 MYO1Binteractor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_TH1 (PF06017, IPR010926): Unconventional myosin tail, actin- and lipid-binding
RNA_pol (PF00940, IPR002092): DNA-dependent RNA polymerase
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
AAA_23 (PF13476): AAA domain
42 NEK2interactor40.6670.400Pkinase (PF00069, IPR000719): Protein kinase domain
43 P4HBinteractor80.5716.533Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
44 PABPC1oncoprotein150.38538.629RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
45 PDCD4oncoprotein90.5289.757Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family
MA3 (PF02847, IPR003891, SM00544): MA3 domain
46 PFDN1interactor100Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
47 PIH1D2interactor31.0000PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
48 PTPRSinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Ig_3 (PF13927): Immunoglobulin domain
49 RPAP2interactor21.0000NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
RPAP2_Rtr1 (PF04181, IPR007308): Rtr1/RPAP2 family
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
50 RPS29interactor31.0000Ribosomal_S14 (PF00253, IPR001209): Ribosomal protein S14p/S29e
51 RPSAinteractor110.43620.671Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
52 SLC16A9interactor100MFS_1 (PF07690, IPR011701): Major Facilitator Superfamily
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
53 SPAG9interactor100DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
IncA (PF04156, IPR007285): IncA protein
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
54 SSX2IPinteractor31.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
55 TK1oncoprotein200TK (PF00265, IPR001267, SM00203): Thymidine kinase
56 TPM3oncoprotein60.5002.686Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
57 TRIM36interactor200ATP-synt_B (PF00430, IPR002146): ATP synthase B/B' CF(0)
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
58 TRIM39interactor200Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
59 UNKinteractor70.8101.452MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
60 VAC14oncoprotein200TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
Vac14_Fig4_bd (PF11916, IPR021841): Vacuolar protein 14 C-terminal Fig4p binding
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
61 VCPprotein found in more fusions110.40017.652AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)

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