Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	89
The number (and %) of the onco-proteins	32 (35.96 %)
The number (and %) of the tumor suppressors	5 (5.62 %)
Total number of binary PPIs (saturation %)	554 (14.15 %)
The number (and %) of affected PPIs	89 (16.06 %)
The number of possible different fusions	18
PPI diameter	2
PPI radius	1
The average degree of PPI	11.618
Assortativity coefficient	-0.1634
The network average Clustering coefficient	0.594
The number (and %) of a zero Clustering coefficients	2 (2.25 %)
The number (and %) of a zero Betweenness Centrality	13 (14.61 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EIF2AK2	All fusions : BU156279;
Proteins found in more fusions	TRAF6 (see 1 fusions); STAU1 (see 2 fusions); HSP90AA1 (see 2 fusions); NPM1 (see 1 fusions); CUL3 (see 1 fusions); STAT3 (see 2 fusions); EIF2AK2 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); JAK1 (see 1 fusions); MAP3K7 (see 7 fusions); HNRNPC (see 1 fusions); IKBKB (see 2 fusions); MAP3K5 (see 1 fusions); CDC37 (see 2 fusions); STAT1 (see 1 fusions); TP53 (see 3 fusions);

List of the fusions

PPI for parental proteins: EIF2AK2

All fusions

: BU156279;

Proteins found in more fusions

TRAF6 (see 1 fusions); STAU1 (see 2 fusions); HSP90AA1 (see 2 fusions); NPM1 (see 1 fusions); CUL3 (see 1 fusions); STAT3 (see 2 fusions); EIF2AK2 (see 1 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); JAK1 (see 1 fusions); MAP3K7 (see 7 fusions); HNRNPC (see 1 fusions); IKBKB (see 2 fusions); MAP3K5 (see 1 fusions); CDC37 (see 2 fusions); STAT1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EIF2AK2	parental protein	89	0.112	4302.167	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Pkinase (PF00069, IPR000719): Protein kinase domain
2	ATP6V1F	interactor	2	1.000	0	ATP-synt_F (PF01990, IPR008218): ATP synthase (F/14-kDa) subunit
3	CAND1	interactor	39	0.300	247.847	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
4	CCDC124	interactor	6	0.733	1.372	DUF1014 (PF06244, IPR010422): Protein of unknown function (DUF1014) Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR DUF4569 (PF15133, IPR027869): Domain of unknown function (DUF4569)
5	CCNA2	oncoprotein	6	0.400	4.667	Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
6	CDC37	protein found in more fusions	12	0.455	18.505	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
7	CDCA5	interactor	3	1.000	0	Sororin (PF09666, IPR018605): Sororin protein
8	CDK3	interactor	3	0.667	0.667	Pkinase (PF00069, IPR000719): Protein kinase domain
9	CHMP4B	interactor	4	0.667	0.333	Snf7 (PF03357, IPR005024): Snf7
10	CHUK	suppressor	12	0.582	8.895	Pkinase (PF00069, IPR000719): Protein kinase domain IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
11	CUL3	protein found in more fusions	36	0.296	209.480	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
12	CYP1A1	oncoprotein	3	0.667	0.500	p450 (PF00067, IPR001128): Cytochrome P450
13	DBNL	interactor	2	1.000	0	RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein SH3_9 (PF14604, IPR001452): Variant SH3 domain
14	DHX30	interactor	12	0.697	7.096	Bombolitin (PF08096, IPR012534): Bombolitin family DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15	DHX58	interactor	7	0.429	5.158	ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain RIG-I_C-RD (PF11648, IPR021673): C-terminal domain of RIG-I Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport AAA_19 (PF13245): Part of AAA domain
16	DHX9	oncoprotein	19	0.520	37.569	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold T2SSE (PF00437, IPR001482): Type II/IV secretion system protein HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2) Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
17	DICER1	oncoprotein	13	0.515	13.708	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Dicer_dimer (PF03368, IPR005034): Dicer dimerisation domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
18	DNAJC3	interactor	1	0	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_21 (PF09976, IPR018704): Tetratricopeptide repeat-like domain Ndufs5 (PF10200, IPR019342): NADH:ubiquinone oxidoreductase, NDUFS5-15kDa TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat DUF4363 (PF14276, IPR025373): Domain of unknown function (DUF4363) TPR_19 (PF14559): Tetratricopeptide repeat
19	EBNA1BP2	interactor	17	0.551	22.546	Ebp2 (PF05890, IPR008610): Eukaryotic rRNA processing protein EBP2
20	EDC4	interactor	6	0.733	1.256	DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445) SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756) DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
21	EGFR	oncoprotein	14	0.385	28.608	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
22	EIF2A	interactor	5	0.600	2.556	Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
23	EIF2S1	interactor	6	0.733	0.815	EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
24	EIF6	interactor	14	0.473	26.386	eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
25	ELAVL1	oncoprotein	25	0.246	148.813	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
26	ELMSAN1	interactor	3	0.667	0.500	ELM2 (PF01448, IPR000949): ELM2 domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
27	FANCC	oncoprotein	4	0.667	0.622	Fanconi_C (PF02106, IPR000686): Fanconi anaemia group C protein
28	FARSA	interactor	6	0.667	2.192	tRNA-synt_2d (PF01409, IPR002319): tRNA synthetases class II core domain (F) MarR_2 (PF12802): MarR family
29	FARSB	interactor	5	0.800	0.952	B3_4 (PF03483, IPR005146, SM00873): B3/4 domain B5 (PF03484, IPR005147, SM00874): tRNA synthetase B5 domain
30	FTSJ3	interactor	11	0.818	2.084	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) FtsJ (PF01728, IPR002877): FtsJ-like methyltransferase M16C_assoc (PF08367, IPR013578): Peptidase M16C associated Orthopox_F8 (PF05886, IPR008726): Orthopoxvirus F8 protein Spb1_C (PF07780, IPR012920): Spb1 C-terminal domain DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) RRP14 (PF15459, IPR029188): 60S ribosome biogenesis protein Rrp14
31	GLTSCR2	oncoprotein	7	0.667	2.323	Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
32	GNL3	interactor	14	0.626	11.591	GN3L_Grn1 (PF08701, IPR014813): GNL3L/Grn1 putative GTPase GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family FAM176 (PF14851): FAM176 family
33	GTPBP4	suppressor	17	0.515	30.845	DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 MRC1 (PF09444, IPR018564): MRC1-like domain NOG1 (PF06858, IPR010674): Nucleolar GTP-binding protein 1 (NOG1) NOGCT (PF08155, IPR012973): NOGCT (NUC087) domain Lip_prot_lig_C (PF10437, IPR019491): Bacterial lipoate protein ligase C-terminus AAA_16 (PF13191): AAA ATPase domain
34	HDGF	interactor	16	0.408	27.431	PWWP (PF00855, IPR000313, SM00293): PWWP domain
35	HECW2	interactor	4	1.000	0	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
36	HIST1H1C	oncoprotein	9	0.667	2.870	Amelin (PF05111, IPR007798, SM00817): Ameloblastin precursor (Amelin) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
37	HIST2H2AC	interactor	3	1.000	0	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
38	HNRNPC	protein found in more fusions	14	0.705	8.382	APG6 (PF04111, IPR007243): Autophagy protein Apg6 RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
39	HNRNPCL1	interactor	4	1.000	0	FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XhlA (PF10779, IPR019715): Haemolysin XhlA
40	HSP90AA1	oncoprotein	23	0.290	110.854	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
41	IFI16	suppressor	14	0.440	19.881	HIN (PF02760, IPR004021): HIN-200/IF120x domain PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
42	IFRD1	interactor	3	1.000	0	IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
43	IGF2BP2	interactor	6	0.867	0.411	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
44	IGF2BP3	interactor	12	0.712	6.082	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KH_1 (PF00013, IPR004088, SM00322): KH domain KH_4 (PF13083): KH domain
45	IKBKB	protein found in more fusions	13	0.470	22.857	FliT (PF05400, IPR008622): Flagellar protein FliT Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain SlyX (PF04102, IPR007236): SlyX ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
46	IL7R	interactor	11	0.436	10.029	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
47	ILF2	interactor	24	0.449	64.367	DZF (PF07528, IPR006561, SM00572): DZF domain
48	ILF3	oncoprotein	17	0.559	29.065	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
49	ISG15	suppressor	5	0.700	0.872	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
50	JAK1	oncoprotein	10	0.639	5.875	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
51	KCTD17	interactor	5	0.833	0.167	BTB_2 (PF02214, IPR003131): BTB/POZ domain SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
52	LYAR	interactor	12	0.667	5.215	DEK_C (PF08766, IPR014876): DEK C terminal domain zf-LYAR (PF08790, IPR014898): LYAR-type C2HC zinc finger DUF3499 (PF12005, IPR021888): Protein of unknown function (DUF3499) U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
53	MACROD1	oncoprotein	3	0.667	0.667	DUF1108 (PF06531, IPR009494): Protein of unknown function (DUF1108) DUF1502 (PF07397, IPR010871): Repeat of unknown function (DUF1502) Macro (PF01661, IPR002589, SM00506): Macro domain
54	MAP3K5	protein found in more fusions	7	0.800	1.286	Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
55	MAP3K7	oncoprotein	13	0.530	16.952	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
56	MAVS	interactor	8	0.714	4.233	Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat CARD_2 (PF16739, IPR031964): Caspase recruitment domain
57	MCM2	oncoprotein	22	0.348	88.635	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
58	METAP2	oncoprotein	2	1.000	0	Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24 SRP72 (PF08492, IPR013699): SRP72 RNA-binding domain TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1
59	MOV10	interactor	22	0.398	78.602	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
60	NOC3L	interactor	9	0.583	4.969	CBF (PF03914, IPR005612, SM00521): CBF/Mak21 family Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562 DsrD (PF08679, IPR014793): Dissimilatory sulfite reductase D (DsrD) GAGA_bind (PF06217, IPR010409): GAGA binding protein-like family NOC3p (PF07540, IPR011501): Nucleolar complex-associated protein Scm3 (PF10384, IPR018465): Centromere protein Scm3
61	NOP2	interactor	16	0.650	11.395	BSP_II (PF05432, IPR008412): Bone sialoprotein II (BSP-II) Methyltr_RsmB-F (PF01189, IPR001678): 16S rRNA methyltransferase RsmB/F P120R (PF08062, IPR012586): P120R (NUC006) repeat Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein DUF2477 (PF10631, IPR018904): Protein of unknown function (DUF2477) FAM176 (PF14851): FAM176 family Methyltr_RsmF_N (PF17125, IPR031341): N-terminal domain of 16S rRNA methyltransferase RsmF
62	NPM1	oncoprotein	31	0.313	162.997	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
63	NTRK1	oncoprotein	49	0.215	582.608	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
64	PABPC4	interactor	10	0.756	2.543	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
65	PDGFRB	oncoprotein	6	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase V-set (PF07686, IPR013106): Immunoglobulin V-set domain C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain Ig_3 (PF13927): Immunoglobulin domain TonB_N (PF16031): TonB N-terminal region
66	PPP1CA	oncoprotein	9	0.500	7.702	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
67	PPP1CC	oncoprotein	10	0.444	11.725	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
68	PPP2R5A	interactor	1	0	0	B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
69	PRKRA	interactor	15	0.495	20.738	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
70	PRKRIP1	interactor	2	1.000	0	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
71	PTGES3	interactor	5	0.833	0.333	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
72	PURA	interactor	5	0.700	0.545	PurA (PF04845, IPR006628, SM00712): PurA ssDNA and RNA-binding protein DUF3276 (PF11680, IPR021694): Protein of unknown function (DUF3276) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
73	RPL10	oncoprotein	23	0.518	44.616	Ribosomal_L16 (PF00252, IPR016180): Ribosomal protein L16p/L10e
74	SCARB2	interactor	2	1.000	0	CD36 (PF01130, IPR002159): CD36 family
75	SSB	interactor	9	0.472	10.674	HMA (PF00403, IPR006121): Heavy-metal-associated domain La (PF05383, IPR006630, SM00715): La domain Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family Ribosomal_L6e (PF01159, IPR000915): Ribosomal protein L6e RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 (PF08777, IPR014886): RNA binding motif
76	STAT1	suppressor	11	0.400	16.719	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
77	STAT3	oncoprotein	13	0.439	17.502	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
78	STAU1	protein found in more fusions	25	0.453	64.391	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
79	STAU2	interactor	8	0.464	7.075	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif LPP20 (PF02169, IPR024952): LPP20 lipoprotein Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
80	TARBP2	interactor	9	0.571	4.891	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
81	TOLLIP	interactor	5	0.500	1.317	C2 (PF00168, IPR000008, SM00239): C2 domain CUE (PF02845, IPR003892, SM00546): CUE domain
82	TOP1	oncoprotein	15	0.495	22.952	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
83	TP53	oncoprotein	21	0.242	94.529	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
84	TRAF2	interactor	12	0.491	18.150	MATH (PF00917, IPR002083, SM00061): MATH domain Sina (PF03145, IPR018121): Seven in absentia protein family SlyX (PF04102, IPR007236): SlyX zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
85	TRAF5	interactor	8	0.762	2.383	Sina (PF03145, IPR018121): Seven in absentia protein family zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal Spc29 (PF17082, IPR031392): Spindle Pole Component 29
86	TRAF6	protein found in more fusions	13	0.439	22.060	SlyX (PF04102, IPR007236): SlyX zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
87	TYK2	interactor	6	0.600	1.222	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
88	XRN2	interactor	10	0.489	13.111	XRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus
89	ZNF346	interactor	8	0.536	6.067	zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding zf-met (PF12874): Zinc-finger of C2H2 type

B a c k t o T o p ⇑

Fusion ID: Protein names:	EIF2AK2
Level of PPIs:	or Upload text file:	Update repository

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