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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EHMT1 (from a repository: Sun Dec 4 16:24:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)36
The number (and %) of the onco-proteins11 (30.56 %)
The number (and %) of the tumor suppressors8 (22.22 %)
Total number of binary PPIs (saturation %)165 (26.19 %)
The number (and %) of affected PPIs36 (21.82 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI8.000
Assortativity coefficient-0.4071
The network average Clustering coefficient0.646
The number (and %) of a zero Clustering coefficients4 (11.11 %)
The number (and %) of a zero Betweenness Centrality12 (33.33 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EHMT1 All fusions
: BF997880; BQ370417;
Proteins found in more fusions MPHOSPH8 (see 5 fusions); CTBP1 (see 2 fusions); BCL6 (see 2 fusions); EZH2 (see 1 fusions); ATXN1 (see 3 fusions); LZTR1 (see 2 fusions); CTBP2 (see 2 fusions); TP53 (see 3 fusions); EHMT1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EHMT1parental protein360.183607.198Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
XRCC4 (PF06632, IPR010585): DNA double-strand break repair and V(D)J recombination protein XRCC4
Zip (PF02535, IPR003689): ZIP Zinc transporter
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
2 ATXN1protein found in more fusions31.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
3 BCL6oncoprotein61.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
4 BMI1oncoprotein60.5003.119zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
5 CBX5suppressor90.5366.638Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Chromo_shadow (PF01393, IPR008251, SM00300): Chromo shadow domain
6 CTBP1protein found in more fusions120.6737.3602-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
7 CTBP2protein found in more fusions80.8101.2582-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
8 DNMT3Asuppressor80.7144.233DNA_methylase (PF00145, IPR001525): C-5 cytosine-specific DNA methylase
PWWP (PF00855, IPR000313, SM00293): PWWP domain
9 EEDsuppressor130.57613.727WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
10 EHMT2interactor240.324109.826CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
11 EZH2suppressor120.6737.825CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
12 GMNNinteractor100Geminin (PF07412, IPR022786): Geminin
13 GSG2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3635 (PF12330, IPR024604): Domain of unknown function (DUF3635)
14 H3F3Aoncoprotein40.8330.333Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
15 HDAC1suppressor210.36371.496FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
16 HDAC2suppressor200.40454.593Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
17 HIST1H2BAinteractor41.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
18 HIST1H3Ainteractor130.45529.133Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
19 HIST3H3interactor110.60010.958Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
20 JARID2interactor51.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
TLP-20 (PF06088, IPR009092): Nucleopolyhedrovirus telokin-like protein-20 (TLP20)
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
Macoilin (PF09726, IPR019130): Transmembrane protein
21 LZTR1oncoprotein200BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Sigma70_r3 (PF04539, IPR007624): Sigma-70 region 3
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
22 MDM2oncoprotein100.6394.905Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
23 MIER2interactor60.8001.417ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
24 MPHOSPH8protein found in more fusions50.6671.333Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_5 (PF13857): Ankyrin repeats (many copies)
YqzE (PF14038, IPR025622): YqzE-like protein
25 PCBD1interactor200Pterin_4a (PF01329, IPR001533): Pterin 4 alpha carbinolamine dehydratase
26 PPP4R3Ainteractor31.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
27 PRDM6interactor51.0000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
28 RELAoncoprotein70.8670.556DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
29 SMARCAD1interactor50.9000.250CUE (PF02845, IPR003892, SM00546): CUE domain
Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
30 SUV39H2interactor50.9000.500Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
Tox-GHH (PF15636, IPR028916): GHH signature containing HNH/Endo VII superfamily nuclease toxin
31 TFAP4oncoprotein70.9050.650DivIC (PF04977, IPR007060): Septum formation initiator
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF2407 (PF10302, IPR019413): DUF2407 ubiquitin-like domain
32 TP53suppressor110.6009.739DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
33 TRIM15suppressor200Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
34 WIZinteractor130.43624.452AnfO_nitrog (PF09582, IPR014287): Iron only nitrogenase protein AnfO (AnfO_nitrog)
C1_2 (PF03107, IPR004146): C1 domain
Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
Enterotoxin_ST (PF02048, IPR001489): Heat-stable enterotoxin ST
zf-C2H2_4 (PF13894): C2H2-type zinc finger
35 ZBTB46interactor31.0000ADK_lid (PF05191, IPR007862): Adenylate kinase, active site lid
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
C1_2 (PF03107, IPR004146): C1 domain
Ribosomal_L37ae (PF01780, IPR002674): Ribosomal L37ae protein family
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
DUF4428 (PF14471, IPR027872): Domain of unknown function (DUF4428)
36 ZNF644interactor50.9000.500Zn-ribbon_8 (PF09723, IPR013429, SM00834): Zinc ribbon domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain
zf-C2H2_8 (PF15909, IPR031799): C2H2-type zinc ribbon

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