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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)155
The number (and %) of the onco-proteins44 (28.39 %)
The number (and %) of the tumor suppressors23 (14.84 %)
Total number of binary PPIs (saturation %)1035 (8.67 %)
The number (and %) of affected PPIs155 (14.98 %)
The number of possible different fusions33
PPI diameter2
PPI radius1
The average degree of PPI12.568
Assortativity coefficient-0.3005
The network average Clustering coefficient0.495
The number (and %) of a zero Clustering coefficients20 (12.90 %)
The number (and %) of a zero Betweenness Centrality42 (27.10 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: EEF1G All fusions
: BI046948;
Proteins found in more fusions EEF1G (see 1 fusions); STAU1 (see 2 fusions); EEF1A1 (see 1 fusions); ZDHHC17 (see 2 fusions); GSK3B (see 1 fusions); NPM1 (see 1 fusions); HNRNPH3 (see 1 fusions); CUL7 (see 2 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); RANGAP1 (see 2 fusions); MYC (see 1 fusions); ARF1 (see 2 fusions); ARIH2 (see 2 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); FN1/YWHAG (see 1 fusions); NUDT21 (see 2 fusions); PLOD3 (see 2 fusions); SNW1 (see 1 fusions); SAT1 (see 5 fusions); YWHAG (see 1 fusions); PABPC1 (see 2 fusions); COPS5/HNRNPH3 (see 3 fusions); EEF1D (see 3 fusions); GTF2E2 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); DKC1 (see 2 fusions); PTK2 (see 2 fusions); TNNT1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EEF1Gparental protein1550.07016403.147EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain
SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
2 ABCC9interactor100ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_21 (PF13304, IPR003959): AAA domain, putative AbiEii toxin, Type IV TA system
FAM177 (PF14774, IPR028260): FAM177 family
3 ABL1oncoprotein110.5787.890Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ADAP2interactor100ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
5 ADRB2interactor80.6671.2527tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 AGO4interactor21.0000ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
7 AKT1oncoprotein130.24234.613PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8 ARF1suppressor70.6000.705Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
9 ARIH2protein found in more fusions60.8000.213IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
10 ATL3interactor31.0000GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
11 C11orf58interactor21.0000DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
12 C1orf174interactor100UPF0688 (PF15772, IPR031530): UPF0688 family
13 CAND1interactor380.416129.071Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
14 CARSoncoprotein70.6194.237tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
15 CBX8interactor70.5334.417Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
16 CCDC106interactor100CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
17 CCDC8interactor250.39549.598Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
18 CCT3interactor240.33065.736Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
19 CCT7interactor190.35733.704Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
20 CDC42oncoprotein60.6000.798Ras (PF00071, IPR001806, SM00173): Ras family
21 CDK2suppressor280.37665.085Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
22 CDK2AP2interactor21.0000CDK2AP (PF09806, IPR019187): Cyclin-dependent kinase 2-associated protein
23 CDK5RAP2interactor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
DUF1993 (PF09351, IPR018531): Domain of unknown function (DUF1993)
IncA (PF04156, IPR007285): IncA protein
LPP (PF04728, IPR006817): Lipoprotein leucine-zipper
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
Cyclin_C_2 (PF16899, IPR031658): Cyclin C-terminal domain
24 CHFRsuppressor31.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Glyco_hydro_92 (PF07971, IPR012939): Glycosyl hydrolase family 92
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
LAX (PF15681, IPR031393): Lymphocyte activation family X
25 CHMP4Binteractor50.5003.000Snf7 (PF03357, IPR005024): Snf7
26 COPS5protein found in more fusions280.49065.505JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
27 CRELD1interactor100DUF326 (PF03860, IPR005560): Domain of Unknown Function (DUF326)
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
DUF3456 (PF11938, IPR021852): TLR4 regulator and MIR-interacting MSAP
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
28 CSTF2interactor60.5335.333RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CSTF_C (PF14304, IPR026896): Transcription termination and cleavage factor C-terminal
CSTF2_hinge (PF14327, IPR025742): Hinge domain of cleavage stimulation factor subunit 2
29 CUL1suppressor320.47163.518Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
30 CUL2suppressor260.49550.294Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
31 CUL3protein found in more fusions440.305217.029Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
32 CUL7protein found in more fusions330.304112.958ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
33 CXCL13interactor100IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
34 DKC1oncoprotein80.6190.983DKCLD (PF08068, IPR012960, SM01136): DKCLD (NUC011) domain
PUA (PF01472, IPR002478, SM00359): PUA domain
RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5
TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
35 DLEU1suppressor30.6670.500DD_K (PF12121, IPR022731): Dermaseptin
36 ECH1interactor60.4674.618ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
37 EEDsuppressor250.196123.206WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
38 EEF1A1suppressor490.249531.021GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
39 EEF1A2oncoprotein160.49219.096GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
40 EEF1B2interactor270.36090.075EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
41 EEF1Dprotein found in more fusions290.307135.020EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
42 EEF1DP3interactor100NA
43 EFNA1interactor100Ephrin (PF00812, IPR001799): Ephrin
44 EGFRoncoprotein220.28187.978Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
45 ENOX1interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
46 ERBB2oncoprotein70.8001.567Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
47 EXOSC9interactor90.38913.802RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
48 FBXO6interactor280.29198.805FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
49 FEN1oncoprotein90.4448.2725_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
XPG_I (PF00867, IPR006086, SM00484): XPG I-region
XPG_N (PF00752, IPR006085, SM00485): XPG N-terminal domain
50 FLNCinteractor140.39629.814CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
PapC_N (PF13954, IPR025885): PapC N-terminal domain
51 FN1oncoprotein390.221231.570fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
52 FOXG1oncoprotein31.0000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
53 FUSsuppressor290.50053.119Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Limkain-b1 (PF11608, IPR024582): Limkain b1
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
54 GADD45Asuppressor50.8330.667Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
55 GADD45Gsuppressor40.6671.500Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
56 GET4interactor40.5001.833DUF410 (PF04190, IPR007317): Protein of unknown function (DUF410)
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
57 GRB2oncoprotein240.38381.180SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
58 GSK3Bsuppressor80.3337.169Pkinase (PF00069, IPR000719): Protein kinase domain
59 GSTO1interactor40.6670.725GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
60 GTF2E1interactor30.6671.000DUF1980 (PF09323, IPR015402): Domain of unknown function (DUF1980)
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
TFIIE_alpha (PF02002, IPR024550): TFIIE alpha subunit
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
61 GTF2E2protein found in more fusions40.6671.000TFIIE_beta (PF02186, IPR003166): TFIIE beta subunit core domain
VCX_VCY (PF15231, IPR026653): Variable charge X/Y family
62 HARSinteractor70.5716.158HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
63 HDAC5protein found in more fusions200.35133.920Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
64 HMOX2interactor21.0000Heme_oxygenase (PF01126, IPR016053): Heme oxygenase
65 HNRNPA1interactor440.319302.757RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
66 HNRNPA3oncoprotein260.45238.048IATP (PF04568, IPR007648): Mitochondrial ATPase inhibitor, IATP
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
67 HNRNPH3protein found in more fusions180.5448.621Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
68 IGSF8oncoprotein170.34624.288V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
69 ILF2interactor270.50437.168DZF (PF07528, IPR006561, SM00572): DZF domain
70 INPPL1oncoprotein100.5566.699Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
71 IPO4interactor70.6671.745HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
72 ISG15suppressor80.3577.914ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
73 KARSinteractor110.5098.396tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
74 KIF20Binteractor21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
YlqD (PF11068, IPR021297): YlqD protein
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
75 KLHL18interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
76 KTN1oncoprotein50.8000.583ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP)
Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
77 LARSinteractor160.34228.964Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
78 LZTS1suppressor100DivIC (PF04977, IPR007060): Septum formation initiator
Fez1 (PF06818): Fez1
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
79 MCM2oncoprotein410.322235.946AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
80 MCRIP2interactor100DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
FAM195 (PF14799, IPR029428): FAM195 family
81 MED31interactor70.28613.200Med31 (PF05669, IPR008831): SOH1
82 MKKSinteractor100Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
83 MLH1suppressor50.7001.800DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
84 MTNR1Ainteractor1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
TctB (PF07331, IPR009936): Tripartite tricarboxylate transporter TctB family
85 MVDinteractor31.0000GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
86 MYConcoprotein140.39724.078HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
87 NACAoncoprotein90.4727.049NAC (PF01849, IPR002715): NAC domain
RNA_pol_Rpo13 (PF12136, IPR021985): RNA polymerase Rpo13 subunit HTH domain
CitT (PF12431, IPR028141): Transcriptional regulator
88 NADKinteractor41.0000NAD_kinase (PF01513, IPR002504): ATP-NAD kinase
89 NCK2interactor60.7002.400SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
90 NDRG1suppressor70.4768.015Ndr (PF03096, IPR004142): Ndr family
91 NEDD8interactor210.57921.666ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
92 NPM1suppressor420.334230.320Nucleoplasmin (PF03066): Nucleoplasmin
SDA1 (PF05285, IPR007949): SDA1
NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
93 NPM3interactor50.7000.682Nucleoplasmin (PF03066): Nucleoplasmin
94 NTRK1oncoprotein620.192875.540I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
95 NUDT21protein found in more fusions170.44219.548NUDIX_2 (PF13869, IPR016706): Nucleotide hydrolase
96 NUDT3interactor30.6670.667NUDIX (PF00293, IPR000086): NUDIX domain
97 NUP85interactor70.5243.253Nucleopor_Nup85 (PF07575, IPR011502): Nup85 Nucleoporin
98 OBSL1interactor280.32883.590BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
99 OGFOD2interactor100NA
100 PABPC1oncoprotein300.42973.110RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain
YflT (PF11181, IPR025889): Heat induced stress protein YflT
101 PAN2interactor120.4096.060RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
102 PDCD5suppressor30.6670.667dsDNA_bind (PF01984, IPR002836): Double-stranded DNA-binding domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
103 PHACTR3interactor21.0000RPEL (PF02755, IPR004018, SM00707): RPEL repeat
104 PKN2interactor120.34520.638C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
105 PLEKHA4interactor100IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
SlyX (PF04102, IPR007236): SlyX
106 PLGRKTinteractor21.0000DUF2368 (PF10166, IPR019319): Uncharacterised conserved protein (DUF2368)
107 PLOD3protein found in more fusions100.5834.6152OG-FeII_Oxy (PF03171, IPR005123): 2OG-Fe(II) oxygenase superfamily
Anp1 (PF03452, IPR005109): Anp1
108 PRPF38Binteractor21.0000PRP38 (PF03371, IPR005037): PRP38 family
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
109 PSMD11interactor130.37219.827DUF247 (PF03140, IPR004158): Plant protein of unknown function
PCI (PF01399, IPR000717, SM00088): PCI domain
AAA_16 (PF13191): AAA ATPase domain
TPR_12 (PF13424): Tetratricopeptide repeat
110 PTK2protein found in more fusions80.6195.400FERM_M (PF00373, IPR019748): FERM central domain
Focal_AT (PF03623, IPR005189): Focal adhesion targeting region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
111 PTPN4interactor21.0000FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
112 PTPRSinteractor30.6670.080fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
Ig_3 (PF13927): Immunoglobulin domain
113 RAD52oncoprotein50.6670.271Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein
DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
114 RANGAP1protein found in more fusions90.5368.321RanGAP1_C (PF07834, IPR009109): RanGAP1 C-terminal domain
SDA1 (PF05285, IPR007949): SDA1
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
115 RBM6suppressor21.0000G-patch (PF01585, IPR000467, SM00443): G-patch domain
Pap_E4 (PF02711, IPR003861): E4 protein
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Inhibitor_I53 (PF11714, IPR021716): Thrombin inhibitor Madanin
Pentapeptide_4 (PF13599, IPR001646): Pentapeptide repeats (9 copies)
PcfK (PF14058, IPR025624): PcfK-like protein
116 RECQL5oncoprotein100DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
RecQ5 (PF06959, IPR010716): RecQ helicase protein-like 5 (RecQ5)
SRI (PF08236, IPR013257): SRI (Set2 Rpb1 interacting) domain
TFIIS_M (PF07500, IPR003618): Transcription factor S-II (TFIIS), central domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
TAtT (PF16811, IPR031823): TRAP transporter T-component
117 RGL2interactor100RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
118 RPL38interactor160.55822.275Ribosomal_L38e (PF01781, IPR002675): Ribosomal L38e protein family
119 RPL4P5interactor100NA
120 RPL5suppressor280.52439.213Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
121 RPL8interactor280.38683.918Ribosomal_L2 (PF00181, IPR022666): Ribosomal Proteins L2, RNA binding domain
Ribosomal_L2_C (PF03947, IPR022669): Ribosomal Proteins L2, C-terminal domain
122 RPS28interactor150.6106.615Ribosomal_S28e (PF01200, IPR000289): Ribosomal protein S28e
123 RPS6KB2interactor90.5003.010Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
124 SAT1protein found in more fusions40.6671.000Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
125 SHFM1interactor110.38218.406CLLAC (PF15675, IPR031379): CLLAC-motif containing domain
126 SIRT1suppressor80.4765.040DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
127 SIRT6suppressor40.8330.333SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
128 SKILsuppressor31.0000c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
DUF489 (PF04356, IPR007451): Protein of unknown function (DUF489)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
DUF2115 (PF09888, IPR019215): Uncharacterized protein conserved in archaea (DUF2115)
129 SLC33A1interactor21.0000Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
130 SMURF1interactor120.32711.411C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
131 SNAPINinteractor100Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
132 SNRPA1interactor140.37417.638LRR_9 (PF14580): Leucine-rich repeat
133 SNRPD2interactor210.46226.462LSM (PF01423, IPR001163): LSM domain
134 SNW1protein found in more fusions350.267241.503SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
135 SRSF9interactor130.4876.754RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
136 STAU1protein found in more fusions250.53632.757dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
137 STRIP1interactor31.0000ELM2 (PF01448, IPR000949): ELM2 domain
N1221 (PF07923, IPR012486): N1221-like protein
DUF3402 (PF11882, IPR021819): Domain of unknown function (DUF3402)
138 SUMO2interactor70.4006.817Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
139 TARDBPinteractor260.51343.912RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
140 TNNT1protein found in more fusions40.6670.667Troponin (PF00992, IPR001978): Troponin
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
141 TP53I3interactor100ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
HupF_HypC (PF01455, IPR001109): HupF/HypC family
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
142 TRAP1oncoprotein110.4913.402HSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
143 TRIB3interactor40.5001.533Pkinase (PF00069, IPR000719): Protein kinase domain
144 TRIM55interactor50.8330.667Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
NABP (PF07990, IPR012940): Nucleic acid binding protein NABP
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
145 TRIM63interactor70.4677.000DUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
KIP1 (PF07765, IPR011684): KIP1-like protein
RED_C (PF07807, IPR012492): RED-like protein C-terminal region
zf-HIT (PF04438, IPR007529): HIT zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
YceG_bac (PF14266, IPR025647): Putative component of 'biosynthetic module'
146 TUBB3interactor110.4917.197Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
147 UCHL5oncoprotein100.41715.855Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
148 VARSinteractor200.41638.351Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
149 VCAM1interactor320.268121.056C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
150 WDR33interactor40.6670.800Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
151 YWHAEoncoprotein280.354102.34714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
152 YWHAGprotein found in more fusions190.38640.84814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
153 ZBED8interactor21.0000Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
DUF4371 (PF14291, IPR025398): Domain of unknown function (DUF4371)
154 ZDHHC17protein found in more fusions50.6670.583zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)
155 ZNF24interactor31.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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