Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins EEF1D (from a repository: Sun Dec 4 09:23:44 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 104 The number (and %) of the onco-proteins 34 (32.69 %) The number (and %) of the tumor suppressors 15 (14.42 %) Total number of binary PPIs (saturation %) 746 (13.93 %) The number (and %) of affected PPIs 104 (13.94 %) The number of possible different fusions 27 PPI diameter 2 PPI radius 1 The average degree of PPI 13.423 Assortativity coefficient -0.2414 The network average Clustering coefficient 0.513 The number (and %) of a zero Clustering coefficients 3 (2.88 %) The number (and %) of a zero Betweenness Centrality 12 (11.54 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EEF1D	All fusions : BF513928; BF513932; BG955510;
Proteins found in more fusions	APP (see 4 fusions); LMNA (see 3 fusions); EEF1G (see 1 fusions); STAU1 (see 2 fusions); ELF3 (see 2 fusions); EEF1A1 (see 1 fusions); U2AF2 (see 2 fusions); NPM1 (see 1 fusions); CUL7 (see 2 fusions); PPME1 (see 1 fusions); HUWE1 (see 2 fusions); CUL1 (see 3 fusions); AHNAK (see 2 fusions); SQSTM1 (see 5 fusions); GRB2 (see 1 fusions); SIAH1 (see 4 fusions); EEF1D (see 3 fusions); MCM2 (see 1 fusions); APC (see 1 fusions); HSPB1 (see 4 fusions); FOS (see 4 fusions); CSNK2A1 (see 1 fusions); SIAH2 (see 1 fusions); HCFC1 (see 2 fusions); NTRK1/TPR (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EEF1D	parental protein	104	0.113	5792.909	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
2	ABTB1	interactor	2	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
3	ACLY	interactor	12	0.515	8.435	ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain CoA_binding (PF02629, IPR003781, SM00881): CoA binding domain Ligase_CoA (PF00549, IPR005811): CoA-ligase Citrate_bind (PF16114, IPR032263): ATP citrate lyase citrate-binding
4	ADRB2	interactor	10	0.639	2.833	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5	AHNAK	suppressor	15	0.451	22.777	DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37
6	AKAP8	interactor	7	0.476	5.950	AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95) Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
7	ANLN	oncoprotein	5	0.700	2.067	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
8	APC	suppressor	7	0.400	7.150	APC_15aa (PF05972, IPR009240): APC 15 residue motif APC_basic (PF05956, IPR009234): APC basic domain APC_r (PF05923): APC repeat Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) EB1_binding (PF05937, IPR009232): EB-1 Binding Domain FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) SAMP (PF05924, IPR009224): SAMP Motif Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4 Arm_APC_u3 (PF16629): Armadillo-associated region on APC APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6 APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
9	APP	protein found in more fusions	25	0.250	123.801	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
10	ARHGAP21	interactor	5	0.800	1.333	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain MAJIN (PF15077, IPR027816): Membrane-anchored junction protein PH_9 (PF15410): Pleckstrin homology domain
11	ASCC2	interactor	3	1.000	0	CUE (PF02845, IPR003892, SM00546): CUE domain BLOC1S3 (PF15753, IPR017245): Biogenesis of lysosome-related organelles complex 1 subunit 3
12	ATG7	interactor	4	0.667	0.451	ThiF (PF00899, IPR000594): ThiF family ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
13	BAG6	interactor	7	0.400	3.594	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
14	CAMSAP2	interactor	2	1.000	0	Bundlin (PF05307, IPR007971): Bundlin IncA (PF04156, IPR007285): IncA protein Presenilin (PF01080, IPR001108): Presenilin CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain FAM60A (PF15396, IPR026065): Protein Family FAM60A CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
15	CCT2	interactor	18	0.464	20.390	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
16	CCT6A	interactor	15	0.457	14.368	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
17	CD48	interactor	2	1.000	0	I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
18	CD81	interactor	11	0.667	3.983	Tetraspannin (PF00335, IPR018499): Tetraspanin family
19	CDK2	suppressor	28	0.291	111.256	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
20	CRMP1	interactor	6	0.800	1.333	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
21	CSNK2A1	oncoprotein	22	0.333	82.382	Pkinase (PF00069, IPR000719): Protein kinase domain
22	CUL1	suppressor	24	0.462	43.901	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
23	CUL2	suppressor	17	0.500	22.188	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
24	CUL5	suppressor	16	0.592	15.038	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25	CUL7	protein found in more fusions	32	0.256	125.507	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
26	DDX46	interactor	7	0.667	3.036	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain DEAD (PF00270, IPR011545): DEAD/DEAH box helicase DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) CdAMP_rec (PF06153, IPR010375): Cyclic-di-AMP receptor DDRGK (PF09756, IPR019153, SM01128): DDRGK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term FAM176 (PF14851): FAM176 family
27	ECH1	interactor	6	0.600	2.209	ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
28	EED	suppressor	21	0.311	50.437	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
29	EEF1A1	suppressor	31	0.432	91.199	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
30	EEF1A2	oncoprotein	13	0.436	19.571	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
31	EEF1B2	interactor	30	0.357	98.509	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
32	EEF1G	protein found in more fusions	29	0.307	139.085	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
33	ELF3	oncoprotein	3	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
34	EPRS	interactor	15	0.324	20.130	GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain ProRS-C_1 (PF09180, IPR016061, SM00946): Prolyl-tRNA synthetase, C-terminal tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
35	ERP27	interactor	1	0	0	Thioredoxin_6 (PF13848): Thioredoxin-like domain
36	FBXO6	interactor	19	0.386	27.475	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
37	FLNC	interactor	9	0.639	4.319	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Filamin (PF00630, IPR017868): Filamin/ABP280 repeat PapC_N (PF13954, IPR025885): PapC N-terminal domain
38	FN1	oncoprotein	31	0.277	113.473	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
39	FOS	oncoprotein	9	0.536	6.119	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
40	FOSL2	oncoprotein	4	0.667	1.286	bZIP_1 (PF00170, IPR004827): bZIP transcription factor
41	FOXB1	interactor	4	0.667	0.800	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
42	FOXG1	oncoprotein	4	0.667	1.167	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region SPX (PF03105, IPR004331): SPX domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
43	FOXI2	interactor	2	1.000	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
44	FOXK1	interactor	5	0.600	3.167	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
45	FOXL1	oncoprotein	2	1.000	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
46	FRA10AC1	interactor	1	0	0	SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region Fra10Ac1 (PF09725, IPR019129): Folate-sensitive fragile site protein Fra10Ac1 UBA2_C (PF16195, IPR032426): SUMO-activating enzyme subunit 2 C-terminus
47	GARS	interactor	8	0.536	2.650	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
48	GLI1	suppressor	2	1.000	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
49	GRB2	oncoprotein	14	0.615	7.809	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
50	GTF2F1	interactor	7	0.619	3.375	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
51	HCFC1	protein found in more fusions	7	0.667	2.460	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
52	HECW2	interactor	6	0.600	3.067	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
53	HEXDC	interactor	1	0	0	Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
54	HNRNPK	oncoprotein	30	0.367	84.133	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
55	HSPB1	oncoprotein	21	0.426	46.125	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
56	HUWE1	oncoprotein	25	0.337	87.360	BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414)
57	IGSF8	oncoprotein	12	0.515	9.265	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
58	ITGA4	interactor	25	0.428	44.508	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
59	JUN	oncoprotein	9	0.571	7.319	bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor
60	KTN1	oncoprotein	6	0.667	2.952	ETRAMP (PF09716, IPR006389): Malarial early transcribed membrane protein (ETRAMP) Fez1 (PF06818): Fez1 Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Fzo_mitofusin (PF04799, IPR006884): fzo-like conserved region HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper IncA (PF04156, IPR007285): IncA protein OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) PTPS (PF01242, IPR007115): 6-pyruvoyl tetrahydropterin synthase Spectrin (PF00435, IPR002017): Spectrin repeat TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) Fimbrial_PilY2 (PF14481, IPR029497): Type 4 fimbrial biogenesis protein PilY2 Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
61	LIMA1	suppressor	10	0.400	17.510	LIM (PF00412, IPR001781, SM00132): LIM domain ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
62	LMNA	protein found in more fusions	21	0.311	75.535	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
63	MAP1B	interactor	7	0.381	4.202	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) MAP1B_neuraxin (PF00414, IPR000102): Neuraxin and MAP1B repeat Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup Striatin (PF08232, IPR013258): Striatin family IHABP4_N (PF16174, IPR032381): Intracellular hyaluronan-binding protein 4 N-terminal
64	MATR3	interactor	15	0.527	12.608	DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAM60A (PF15396, IPR026065): Protein Family FAM60A
65	MAX	suppressor	4	0.667	0.667	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain SlyX (PF04102, IPR007236): SlyX
66	MCCC1	interactor	5	0.700	1.154	Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
67	MCM2	oncoprotein	37	0.349	179.430	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
68	NPM1	suppressor	39	0.343	208.037	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
69	NTRK1	oncoprotein	56	0.187	743.819	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
70	OARD1	interactor	3	0.667	0.667	3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Macro (PF01661, IPR002589, SM00506): Macro domain
71	PCBP1	oncoprotein	24	0.428	53.861	Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein KH_2 (PF07650, IPR004044): KH domain KH_1 (PF00013, IPR004088, SM00322): KH domain
72	PKM	oncoprotein	27	0.399	87.342	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
73	PKN2	interactor	9	0.393	9.287	C2 (PF00168, IPR000008, SM00239): C2 domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
74	POT1	interactor	7	0.467	5.019	POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
75	PPME1	protein found in more fusions	5	0.833	0.200	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
76	PSMD10	interactor	6	0.400	6.400	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies)
77	RAD21	oncoprotein	9	0.528	7.997	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
78	RAD52	oncoprotein	4	1.000	0	Rad52_Rad22 (PF04098, IPR007232): Rad52/22 family double-strand break repair protein DUF2335 (PF10097, IPR019284): Predicted membrane protein (DUF2335)
79	RELA	oncoprotein	12	0.400	23.159	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
80	RNF2	interactor	21	0.200	96.844	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
81	RPL15	interactor	15	0.638	7.620	Ribosomal_L15e (PF00827, IPR000439): Ribosomal L15
82	RPL18	interactor	20	0.484	19.368	Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
83	RTN4	suppressor	9	0.464	11.119	CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain Reticulon (PF02453, IPR003388): Reticulon Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
84	SF3A3	interactor	15	0.324	36.157	DUF3449 (PF11931, IPR024598): Domain of unknown function (DUF3449) SF3a60_bindingd (PF12108, IPR021966): Splicing factor SF3a60 binding domain Telomere_Sde2_2 (PF13297): Telomere stability C-terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal SF3A3 (PF16837, IPR031774): Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9
85	SIAH1	suppressor	7	0.467	4.783	Sina (PF03145, IPR018121): Seven in absentia protein family
86	SIAH2	oncoprotein	5	0.667	1.500	Sina (PF03145, IPR018121): Seven in absentia protein family zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
87	SLC33A1	interactor	3	0.667	0.500	Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
88	SMURF1	interactor	11	0.378	7.197	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
89	SQSTM1	oncoprotein	13	0.409	23.763	PB1 (PF00564, IPR000270, SM00666): PB1 domain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type UBA_5 (PF16577, IPR015940): UBA domain
90	SRRM2	interactor	16	0.458	17.595	cwf21 (PF08312, IPR013170, SM01115): cwf21 domain DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Pap_E4 (PF02711, IPR003861): E4 protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 CTD (PF12815, IPR024945, SM01104): Spt5 C-terminal nonapeptide repeat binding Spt4 DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
91	SRRT	interactor	11	0.491	11.462	ARS2 (PF04959, IPR007042): Arsenite-resistance protein 2 DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit Macoilin (PF09726, IPR019130): Transmembrane protein DUF3546 (PF12066, IPR021933): Domain of unknown function (DUF3546) DUF4187 (PF13821, IPR025239): Domain of unknown function (DUF4187)
92	STAU1	protein found in more fusions	23	0.455	32.107	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
93	STMN1	interactor	9	0.472	7.368	Stathmin (PF00836, IPR000956): Stathmin family
94	SUPT5H	interactor	10	0.489	7.064	KOW (PF00467, IPR005824, SM00739): KOW motif Ribonuc_P_40 (PF08584, IPR013893): Ribonuclease P 40kDa (Rpp40) subunit Spt5-NGN (PF03439, IPR005100): Early transcription elongation factor of RNA pol II, NGN section Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF3912 (PF13051, IPR025023): Protein of unknown function (DUF3912)
95	SYNPO	interactor	6	0.667	3.500	Calsarcin (PF05556, IPR008438): Calcineurin-binding protein (Calsarcin)
96	TERF1	interactor	11	0.400	15.537	TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
97	TINF2	interactor	7	0.467	5.786	TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
98	TPR	oncoprotein	14	0.527	16.385	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus ZapB (PF06005, IPR009252): Cell division protein ZapB Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 XhlA (PF10779, IPR019715): Haemolysin XhlA ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein DUF3373 (PF11853, IPR021803): Protein of unknown function (DUF3373) DUF4107 (PF13389, IPR025180): Protein of unknown function (DUF4107) JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II CREPT (PF16566, IPR032337): Cell-cycle alteration and expression-elevated protein in tumour DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
99	TPT1	interactor	4	0.500	0.611	TCTP (PF00838, IPR018105): Translationally controlled tumour protein
100	U2AF2	protein found in more fusions	25	0.460	45.161	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Transformer (PF06495, IPR010519): Fruit fly transformer protein
101	VARS	interactor	22	0.260	118.592	Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
102	VCAM1	interactor	21	0.381	35.195	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
103	VIM	suppressor	21	0.337	52.471	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
104	ZW10	interactor	7	0.429	6.774	Zw10 (PF06248, IPR009361): Centromere/kinetochore Zw10 DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)

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