Find Fusion Network

Visualization interactions

Powered by Cytoscape Web for: parental proteins EEF1A1 (from a repository: Tue Nov 29 22:06:58 2016)

Examples AFF1 MLL ACTN4 + MLLAFF1 + MLLALK + MSNALK + TFGALK + TPM3ALK + TPM4ASXL2 + KAT6AATF1 + FUSBCR + ABL1BCR + FGFR1CCND1 + TACSTD2CD74 + ROS1CDK6 + MLLCOL1A1 + PDGFBCREB3L2 + PPARGCREB3L2 + FUSCREBBP + KAT6ADAZAP1 + MEF2DELL + MLLEPS15 + MLLERG + EWSR1ERG + FUSERG + TMPRSS2ETV5 + TMPRSS2ETV6 + ABL1ETV6 + NTRK3ETV6 + PAX5EWSR1 + FLI1EWSR1 + WT1FOXO1 + PAX3FOXP1 + PAX5FRYL + MLLGAS7 + MLLGMPS + MLLGOLGA5 + RETHOOK3 + RETHOXC13 + NUP98HOXD13 + NUP98MECOM + RUNX1MKL1 + RBM15MLL + MLLT1MLL + MLLT4MLL + MLLT10MLL + PICALMMLLT10 + PICALMNCOA1 + PAX3NIN + PDGFRBNPM1 + RARANRG1 + ODZ4NTRK1 + TFGNUMA1 + RARANUP98 + PHF23PAX5 + ZNF521PBX1 + TCF3RET + TRIM27ROS1 + SLC34A2PML + RARAPRKAR1A + RARAPRKAR1A + RETRUNX1 + RUNX1T1RUNX1 + SH3D19	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
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Statistics and Network structure information

Statistic of PPI Value(s) The number of interactors (fusion and proteins) 370 The number (and %) of the onco-proteins 106 (28.65 %) The number (and %) of the tumor suppressors 53 (14.32 %) Total number of binary PPIs (saturation %) 6049 (8.86 %) The number (and %) of affected PPIs 370 (6.12 %) The number of possible different fusions 73 PPI diameter 2 PPI radius 1 The average degree of PPI 31.957 Assortativity coefficient -0.1767 The network average Clustering coefficient 0.476 The number (and %) of a zero Clustering coefficients 11 (2.97 %) The number (and %) of a zero Betweenness Centrality 43 (11.62 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: EEF1A1	All fusions
Proteins found in more fusions	GRK5 (see 4 fusions); ZDHHC17 (see 2 fusions); U2AF2 (see 2 fusions); ACTG1/ACTB (see 1 fusions); EP300 (see 1 fusions); HSPB1/OBSL1 (see 1 fusions); CUL4A (see 4 fusions); RPS24/RPS23 (see 1 fusions); RBBP8 (see 1 fusions); EEF1D (see 3 fusions); EEF1A1/RPL12 (see 1 fusions); RPS4X/AHSA1 (see 1 fusions); POLR2E (see 2 fusions); HSPB1 (see 4 fusions); POLR2A (see 2 fusions); RAC1/PKM (see 1 fusions); DDX17 (see 3 fusions); RPS19/RPS14 (see 1 fusions); TUBG1 (see 1 fusions); MME (see 1 fusions); TRIM25 (see 2 fusions); EEF1A1 (see 1 fusions); NTRK1/RPL7A (see 1 fusions); CBL (see 1 fusions); GSK3B (see 1 fusions); CUL3 (see 1 fusions); AHNAK (see 2 fusions); RAC1 (see 1 fusions); GAPDH/CDKN1A (see 1 fusions); IMMT (see 4 fusions); ACTG1 (see 4 fusions); COPS5 (see 1 fusions); ZBTB16 (see 3 fusions); TP53 (see 3 fusions); AP2M1 (see 3 fusions); FUS/PKM (see 1 fusions); ABCC1 (see 1 fusions); CRY2 (see 3 fusions); CASP2 (see 3 fusions); PCBP2 (see 3 fusions); RACK1 (see 3 fusions); FN1/RPL6 (see 1 fusions); EEF1G (see 1 fusions); SMAD4 (see 2 fusions); NPM1 (see 1 fusions); CUL1 (see 3 fusions); PCNA (see 1 fusions); RPA1 (see 1 fusions); SNW1 (see 1 fusions); HSP90AA1 (see 2 fusions); HNRNPUL1 (see 1 fusions); RANBP9 (see 2 fusions); CDC37 (see 2 fusions); CBS (see 1 fusions); GAPDH (see 2 fusions); RBMX (see 3 fusions); STAU1 (see 2 fusions); NUP214 (see 1 fusions); CUL7 (see 2 fusions); ARIH2 (see 2 fusions); ACTB (see 3 fusions); RACK1/FN1 (see 1 fusions); LRRK2 (see 1 fusions); PUF60 (see 2 fusions); PABPC1 (see 2 fusions); MAPK14 (see 1 fusions); HNRNPL (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); UBR5 (see 4 fusions); PFKM (see 1 fusions); TRIM29 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	EEF1A1	parental protein	370	0.082	71411.660	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
2	ABCC1	oncoprotein	6	0.800	0.205	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304) DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
3	ABCC2	interactor	4	0.500	1.056	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805) DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
4	ABTB2	oncoprotein	4	1.000	0	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
5	ACAT1	interactor	14	0.436	4.087	Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
6	ACTB	oncoprotein	69	0.166	721.892	Actin (PF00022, IPR004000, SM00268): Actin
7	ACTG1	protein found in more fusions	32	0.232	157.015	Actin (PF00022, IPR004000, SM00268): Actin
8	ADRB2	interactor	29	0.206	93.496	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
9	AGO3	interactor	8	0.786	0.606	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
10	AHNAK	suppressor	28	0.368	53.608	DUF945 (PF06097, IPR010352): Bacterial protein of unknown function (DUF945) ELFV_dehydrog_N (PF02812, IPR006097): Glu/Leu/Phe/Val dehydrogenase, dimerisation domain T2SSN (PF01203, IPR022792): Type II secretion system (T2SS), protein N PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) TT_ORF2a (PF08197, IPR013267): pORF2a truncated protein DUF2993 (PF11209, IPR021373): Protein of unknown function (DUF2993) DUF4097 (PF13349, IPR025164): Putative adhesin Ntox37 (PF15535, IPR029108): Bacterial toxin 37
11	AHSA1	protein found in more fusions	32	0.484	49.565	Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
12	AICDA	interactor	9	0.321	6.133	APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
13	ALKBH3	interactor	9	0.472	8.448	2OG-FeII_Oxy_2 (PF13532, IPR027450): 2OG-Fe(II) oxygenase superfamily
14	ALPL	suppressor	2	1.000	0	Alk_phosphatase (PF00245, IPR001952, SM00098): Alkaline phosphatase
15	AMFR	oncoprotein	11	0.444	12.158	CUE (PF02845, IPR003892, SM00546): CUE domain UbiA (PF01040, IPR000537): UbiA prenyltransferase family zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
16	ANKRD24	interactor	1	0	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD) CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1 Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein TSC22 (PF01166, IPR000580): TSC-22/dip/bun family TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 AIF-MLS (PF14962, IPR032773): Mitochondria Localisation Sequence Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion Leu_zip (PF15294): Leucine zipper
17	ANXA7	suppressor	14	0.319	17.536	Annexin (PF00191, IPR018502, SM00335): Annexin
18	AP2M1	protein found in more fusions	23	0.429	35.870	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
19	APLP1	interactor	10	0.222	22.534	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus Ints3 (PF10189, IPR019333): Integrator complex subunit 3 APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
20	ARIH2	protein found in more fusions	9	0.500	1.506	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) zinc_ribbon_12 (PF11331, IPR021480): Probable zinc-ribbon domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING PRAS (PF15798, IPR026682): Proline-rich AKT1 substrate 1
21	ARRB2	interactor	59	0.352	271.307	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
22	ATP5B	interactor	32	0.425	40.861	AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain NACHT (PF05729): NACHT domain
23	AURKA	oncoprotein	40	0.358	117.866	Pkinase (PF00069, IPR000719): Protein kinase domain MTBP_C (PF14920, IPR029418): MDM2-binding
24	AXIN1	suppressor	6	0.600	1.543	Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain DIX (PF00778, IPR001158, SM00021): DIX domain AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
25	BBS1	interactor	1	0	0	BBS1 (PF14779, IPR032728): Ciliary BBSome complex subunit 1 BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
26	BBS2	interactor	1	0	0	BBS2_N (PF14781, IPR029430): Ciliary BBSome complex subunit 2, N-terminal BBS2_C (PF14782, IPR029333): Ciliary BBSome complex subunit 2, C-terminal BBS2_Mid (PF14783, IPR029429): Ciliary BBSome complex subunit 2, middle region
27	BBS4	interactor	3	1.000	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat Mu-like_Pro (PF10123, IPR012106): Mu-like prophage I protein TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
28	BRMS1	suppressor	5	0.667	0.250	Dynactin_p62 (PF05502, IPR008603): Dynactin p62 family Sds3 (PF08598, IPR013907): Sds3-like
29	BTBD2	interactor	7	0.810	0.499	BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch BTB (PF00651, IPR013069, SM00225): BTB/POZ domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PHR (PF08005, IPR012983): PHR domain
30	CAD	oncoprotein	35	0.286	145.091	Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 (PF02787, IPR005480, SM01096): Carbamoyl-phosphate synthetase large chain, oligomerisation domain CPSase_sm_chain (PF00988, IPR002474, SM01097): Carbamoyl-phosphate synthase small chain, CPSase domain GATase (PF00117, IPR017926): Glutamine amidotransferase class-I MGS (PF02142, IPR011607, SM00851): MGS-like domain OTCace (PF00185, IPR006131): Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain OTCace_N (PF02729, IPR006132): Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain ATPgrasp_Ter (PF15632, IPR011226): ATP-grasp in the biosynthetic pathway with Ter operon
31	CAND1	interactor	122	0.318	1100.880	Adaptin_N (PF01602, IPR002553): Adaptin N terminal region DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981) HEAT (PF02985, IPR000357): HEAT repeat TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20) RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1 DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
32	CASP2	suppressor	5	0.500	2.133	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain
33	CBL	suppressor	21	0.453	34.687	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
34	CBS	protein found in more fusions	10	0.472	11.322	CBS (PF00571, IPR000644, SM00116): CBS domain DUF1414 (PF07208, IPR009857): Protein of unknown function (DUF1414) PALP (PF00291, IPR001926): Pyridoxal-phosphate dependent enzyme
35	CCAR2	suppressor	20	0.353	43.153	DREPP (PF05558, IPR008469): DREPP plasma membrane polypeptide IncA (PF04156, IPR007285): IncA protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 DBC1 (PF14443, IPR025954, SM01122): DBC1 S1-like (PF14444, IPR025223): S1-like
36	CCDC130	interactor	3	1.000	0	DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
37	CCDC8	interactor	78	0.275	496.478	Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal PNMA (PF14893, IPR026523): PNMA
38	CCL18	interactor	2	1.000	0	IL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
39	CD81	interactor	51	0.314	215.994	Tetraspannin (PF00335, IPR018499): Tetraspanin family
40	CDC25A	oncoprotein	9	0.528	3.866	M-inducer_phosp (PF06617, IPR000751): M-phase inducer phosphatase Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
41	CDC37	protein found in more fusions	31	0.347	81.541	CDC37_C (PF08564, IPR013873, SM01069): Cdc37 C terminal domain CDC37_M (PF08565, IPR013874, SM01070): Cdc37 Hsp90 binding domain CDC37_N (PF03234, IPR013855, SM01071): Cdc37 N terminal kinase binding Rho_Binding (PF08912, IPR015008): Rho Binding TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
42	CDK2	suppressor	99	0.260	1027.828	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
43	CDKN1A	suppressor	42	0.271	228.871	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
44	CEP250	interactor	53	0.485	116.914	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1 DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) EHN (PF06441, IPR010497): Epoxide hydrolase N terminus ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family IncA (PF04156, IPR007285): IncA protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain SlyX (PF04102, IPR007236): SlyX Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal TSC22 (PF01166, IPR000580): TSC-22/dip/bun family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570) DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472) Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
45	CKS2	oncoprotein	8	0.571	2.777	CKS (PF01111, IPR000789, SM01084): Cyclin-dependent kinase regulatory subunit
46	COPS5	protein found in more fusions	119	0.296	1229.633	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
47	COX17	interactor	2	1.000	0	COX17 (PF05051, IPR007745): Cytochrome C oxidase copper chaperone (COX17)
48	CRADD	interactor	2	1.000	0	CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Death (PF00531, IPR000488, SM00005): Death domain
49	CRCT1	interactor	2	1.000	0	NICE-1 (PF15845, IPR031698): Cysteine-rich C-terminal 1 family
50	CRK	oncoprotein	21	0.376	48.287	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
51	CRY1	interactor	27	0.277	48.060	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
52	CRY2	protein found in more fusions	29	0.299	49.758	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
53	CUL1	suppressor	116	0.312	998.855	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
54	CUL2	suppressor	85	0.338	458.781	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
55	CUL3	protein found in more fusions	152	0.212	2927.758	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
56	CUL4A	protein found in more fusions	49	0.395	160.852	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
57	CUL5	suppressor	86	0.361	473.975	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
58	CUL7	protein found in more fusions	99	0.236	779.773	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
59	DARS	interactor	26	0.440	29.948	tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N) tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
60	DCUN1D1	interactor	45	0.499	79.948	Cullin_binding (PF03556, IPR005176): Cullin binding UBA_4 (PF14555): UBA-like domain
61	DDX1	oncoprotein	41	0.441	107.669	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
62	DDX17	protein found in more fusions	45	0.331	93.085	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Ferritin (PF00210, IPR008331): Ferritin-like domain GRP (PF07172, IPR010800): Glycine rich protein family Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
63	DIABLO	suppressor	6	0.400	5.333	Smac_DIABLO (PF09057, IPR015142): Second Mitochondria-derived Activator of Caspases
64	DLEU1	suppressor	3	0.667	0.105	DD_K (PF12121, IPR022731): Dermaseptin
65	DUSP7	interactor	2	1.000	0	DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
66	DUT	interactor	15	0.410	31.492	dUTPase (PF00692, IPR008180): dUTPase
67	DYNLL1	interactor	14	0.449	17.848	Dynein_light (PF01221, IPR001372): Dynein light chain type 1
68	EEF1B2	interactor	34	0.356	82.887	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
69	EEF1D	protein found in more fusions	31	0.432	45.235	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
70	EEF1G	protein found in more fusions	49	0.249	358.591	EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein
71	EEF2	interactor	74	0.383	450.023	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
72	EFTUD2	interactor	41	0.321	114.029	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
73	EGFR	oncoprotein	68	0.193	687.492	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
74	EIF3F	suppressor	11	0.545	3.143	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
75	EIF4A1	interactor	34	0.367	79.400	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
76	EIF4A3	interactor	61	0.424	224.413	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
77	ENO2	interactor	15	0.495	15.933	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
78	ENO3	interactor	10	0.489	10.226	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
79	EP300	oncoprotein	37	0.229	215.021	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
80	ESRRB	suppressor	17	0.500	10.973	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
81	EXOSC4	interactor	12	0.473	10.698	RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1 RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
82	FAM98B	interactor	15	0.505	17.826	DUF2465 (PF10239, IPR018797): Protein of unknown function (DUF2465)
83	FAS	suppressor	4	0.667	0.400	Death (PF00531, IPR000488, SM00005): Death domain TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
84	FBL	interactor	57	0.497	131.441	Fibrillarin (PF01269, IPR000692): Fibrillarin
85	FBXO6	interactor	73	0.194	616.194	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
86	FN1	oncoprotein	121	0.228	1542.890	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
87	FUS	suppressor	71	0.384	298.377	Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
88	GADD45A	suppressor	13	0.485	14.888	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
89	GADD45G	suppressor	6	0.667	1.439	Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
90	GAPDH	oncoprotein	74	0.234	834.269	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
91	GART	interactor	13	0.449	12.230	AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain Formyl_trans_N (PF00551, IPR002376): Formyl transferase GARS_A (PF01071, IPR020561): Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_C (PF02843, IPR020560): Phosphoribosylglycinamide synthetase, C domain GARS_N (PF02844, IPR020562): Phosphoribosylglycinamide synthetase, N domain
92	GMPPB	interactor	3	0.667	1.000	Hexapep (PF00132, IPR001451): Bacterial transferase hexapeptide (six repeats) NTP_transferase (PF00483, IPR005835): Nucleotidyl transferase
93	GORASP2	interactor	8	0.286	10.458	GRASP55_65 (PF04495, IPR024958): GRASP55/65 PDZ-like domain
94	GPX7	interactor	3	0.667	0.667	GSHPx (PF00255, IPR000889): Glutathione peroxidase SCO1-SenC (PF02630, IPR003782): SCO1/SenC Acyl-CoA_dh_C (PF12806, IPR025878): Acetyl-CoA dehydrogenase C-terminal like
95	GRK5	protein found in more fusions	23	0.268	40.704	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
96	GSK3B	suppressor	18	0.368	30.321	Pkinase (PF00069, IPR000719): Protein kinase domain
97	GTF2I	interactor	24	0.250	88.488	GTF2I (PF02946, IPR004212): GTF2I-like repeat
98	H2AFX	suppressor	31	0.260	75.709	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
99	HIST1H2AD	interactor	16	0.750	3.268	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
100	HIST1H3E	interactor	23	0.375	33.436	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
101	HNRNPA1	interactor	97	0.301	808.979	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
102	HNRNPDL	interactor	33	0.422	58.719	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
103	HNRNPK	oncoprotein	76	0.288	509.774	ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain KH_1 (PF00013, IPR004088, SM00322): KH domain
104	HNRNPL	protein found in more fusions	42	0.406	106.910	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
105	HNRNPUL1	protein found in more fusions	27	0.502	28.682	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit SAP (PF02037, IPR003034, SM00513): SAP domain SPRY (PF00622, IPR003877, SM00449): SPRY domain AAA_33 (PF13671): AAA domain PRIMA1 (PF16101): Proline-rich membrane anchor 1
106	HSD17B10	interactor	23	0.383	40.636	adh_short (PF00106, IPR002198): short chain dehydrogenase
107	HSP90AA1	oncoprotein	92	0.268	1060.291	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
108	HSPA1A	interactor	62	0.263	397.011	HSP70 (PF00012, IPR013126): Hsp70 protein
109	HSPA2	interactor	19	0.491	21.519	HSP70 (PF00012, IPR013126): Hsp70 protein
110	HSPA8	oncoprotein	91	0.245	943.718	HSP70 (PF00012, IPR013126): Hsp70 protein
111	HSPA9	oncoprotein	70	0.229	574.447	HSP70 (PF00012, IPR013126): Hsp70 protein
112	HSPB1	oncoprotein	47	0.327	205.687	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
113	HSPB2	interactor	10	0.417	9.775	Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
114	HSPE1	interactor	15	0.324	31.323	Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
115	HTRA2	suppressor	9	0.321	9.205	Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32 PDZ_2 (PF13180, IPR001478): PDZ domain Trypsin_2 (PF13365): Trypsin-like peptidase domain
116	IKBKG	interactor	23	0.299	74.204	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
117	ILF2	interactor	75	0.466	207.341	DZF (PF07528, IPR006561, SM00572): DZF domain
118	ILF3	oncoprotein	92	0.385	734.659	dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain
119	IMMT	protein found in more fusions	23	0.160	71.843	Mitofilin (PF09731, IPR019133): Mitochondrial inner membrane protein
120	INPPL1	oncoprotein	17	0.493	17.636	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain
121	IQCB1	interactor	20	0.389	33.413	DUF1765 (PF08578, IPR013887): Protein of unknown function (DUF1765) IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif HJURP_C (PF12347, IPR022102): Holliday junction regulator protein family C-terminal repeat Condensin2nSMC (PF12422, IPR024741): Condensin II non structural maintenance of chromosomes subunit
122	ISG15	suppressor	25	0.230	65.813	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
123	ITGA4	interactor	93	0.261	754.962	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
124	ITGB1BP1	interactor	1	0	0	ICAP-1_inte_bdg (PF10480, IPR019517): Beta-1 integrin binding protein
125	ITSN1	interactor	7	0.400	3.656	C2 (PF00168, IPR000008, SM00239): C2 domain VIT1 (PF01988, IPR008217): VIT family DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915) SH3_9 (PF14604, IPR001452): Variant SH3 domain DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748) INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region PH_13 (PF16652, IPR001849): Pleckstrin homology domain
126	KCNE3	interactor	2	1.000	0	ISK_Channel (PF02060, IPR000369): Slow voltage-gated potassium channel
127	KIAA0368	interactor	23	0.372	63.970	HEAT (PF02985, IPR000357): HEAT repeat IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD) CLASP_N (PF12348, IPR024395): CLASP N terminal MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal Ecm29 (PF13001, IPR024372): Proteasome stabiliser HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
128	KIF1B	suppressor	3	0.667	1.000	FHA (PF00498, IPR000253, SM00240): FHA domain IncA (PF04156, IPR007285): IncA protein PH (PF00169, IPR001849, SM00233): PH domain Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain KIF1B (PF12423, IPR022140): Kinesin protein 1B MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal DUF3694 (PF12473, IPR022164): Kinesin protein Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
129	KMT5C	interactor	2	1.000	0	SET (PF00856, IPR001214, SM00317): SET domain
130	KRAS	oncoprotein	24	0.213	108.132	Ras (PF00071, IPR001806, SM00173): Ras family
131	LAMA4	interactor	3	1.000	0	DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883) ZapB (PF06005, IPR009252): Cell division protein ZapB Laminin_G_2 (PF02210, IPR001791): Laminin G domain Laminin_I (PF06008, IPR009254): Laminin Domain I Laminin_II (PF06009, IPR010307): Laminin Domain II Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein
132	LAMTOR1	interactor	3	0.667	1.000	LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
133	LAMTOR5	interactor	9	0.333	14.896	LAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
134	LGR4	interactor	20	0.246	29.244	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
135	LIG4	interactor	9	0.278	8.152	APG17 (PF04108, IPR007240): Autophagy protein Apg17 BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus DNA_ligase_IV (PF11411, IPR021536): DNA ligase IV RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
136	LRRK2	oncoprotein	19	0.386	22.927	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
137	LSM3	interactor	8	0.429	5.417	LSM (PF01423, IPR001163): LSM domain
138	MAD2L1BP	interactor	3	1.000	0	p31comet (PF06581, IPR009511): Mad1 and Cdc20-bound-Mad2 binding
139	MAGEA1	interactor	7	0.286	8.987	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
140	MAGOH	interactor	40	0.387	79.868	Mago_nashi (PF02792, IPR004023): Mago nashi protein
141	MAP3K14	interactor	6	0.800	0.480	Pkinase (PF00069, IPR000719): Protein kinase domain
142	MAPK14	oncoprotein	16	0.276	38.780	Pkinase (PF00069, IPR000719): Protein kinase domain
143	MAT1A	interactor	2	0	0	S-AdoMet_synt_C (PF02773, IPR022630): S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M (PF02772, IPR022629): S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N (PF00438, IPR022628): S-adenosylmethionine synthetase, N-terminal domain
144	MCM2	oncoprotein	116	0.280	1263.437	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
145	MCM5	oncoprotein	35	0.408	72.985	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
146	MDM2	oncoprotein	53	0.271	331.284	Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
147	MEX3C	interactor	6	0.467	1.345	KH_1 (PF00013, IPR004088, SM00322): KH domain zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
148	MGMT	interactor	16	0.375	25.788	DNA_binding_1 (PF01035, IPR014048): 6-O-methylguanine DNA methyltransferase, DNA binding domain Methyltransf_1N (PF02870, IPR008332): 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
149	MID1	oncoprotein	12	0.418	7.538	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain SPRY (PF00622, IPR003877, SM00449): SPRY domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
150	MLLT3	oncoprotein	2	1.000	0	Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Sox_N (PF12444, IPR022151): Sox developmental protein N terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal NKAP (PF15692): NF-kappa-B-activating protein BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
151	MME	suppressor	12	0.309	14.832	Peptidase_M13 (PF01431, IPR018497): Peptidase family M13 Peptidase_M13_N (PF05649, IPR008753): Peptidase family M13
152	MNAT1	oncoprotein	8	0.571	2.428	MAT1 (PF06391, IPR015877): CDK-activating kinase assembly factor MAT1 Mu-like_Com (PF10122, IPR019294): Mu-like prophage protein Com zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
153	MOV10	interactor	56	0.258	420.524	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
154	MRM1	interactor	3	0.667	0.053	SpoU_methylase (PF00588, IPR001537): SpoU rRNA Methylase family SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
155	MRPL14	interactor	5	0.700	0.987	Ribosomal_L14 (PF00238, IPR000218): Ribosomal protein L14p/L23e RTT107_BRCT_6 (PF16771, IPR031906): Regulator of Ty1 transposition protein 107 BRCT domain
156	MRPL42	interactor	3	1.000	0	MRP-S32 (PF10210, IPR019346): Mitochondrial 28S ribosomal protein S32
157	MRPS7	interactor	14	0.659	9.427	DUF454 (PF04304, IPR007401): Protein of unknown function (DUF454) Ribosomal_S7 (PF00177, IPR023798): Ribosomal protein S7p/S5e
158	MTRNR2L1	interactor	2	1.000	0	Humanin (PF15040, IPR028139): Humanin family
159	MYBBP1A	suppressor	37	0.556	69.279	DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
160	MYOC	interactor	8	0.714	0.827	IncA (PF04156, IPR007285): IncA protein OLF (PF02191, IPR003112, SM00284): Olfactomedin-like domain
161	MYSM1	interactor	2	1.000	0	SWIRM (PF04433, IPR007526): SWIRM domain JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
162	NABP2	interactor	5	0.600	0.722	tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
163	NAPRT	interactor	3	0.667	0.047	NAPRTase (PF04095, IPR007229): Nicotinate phosphoribosyltransferase (NAPRTase) family
164	NEDD8	interactor	56	0.430	134.668	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
165	NEU1	interactor	3	0.667	0.286	BNR_2 (PF13088, IPR011040): BNR repeat-like domain
166	NIFK	interactor	29	0.670	49.584	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) hNIFK_binding (PF12196, IPR021043): FHA Ki67 binding domain of hNIFK
167	NLGN3	interactor	2	1.000	0	COesterase (PF00135, IPR002018): Carboxylesterase family Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
168	NOP56	interactor	60	0.590	160.855	Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region Nop (PF01798, IPR002687): snoRNA binding domain, fibrillarin NOP5NT (PF08156, IPR012974): NOP5NT (NUC127) domain RNA_polI_A34 (PF08208, IPR013240): DNA-directed RNA polymerase I subunit RPA34.5 SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
169	NPM1	suppressor	107	0.371	796.587	Nucleoplasmin (PF03066): Nucleoplasmin SDA1 (PF05285, IPR007949): SDA1 NPM1-C (PF16276, IPR032569): Nucleophosmin C-terminal domain
170	NR4A1	suppressor	6	0.667	3.867	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
171	NRAS	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
172	NREP	interactor	1	0	0	DUF2719 (PF10891, IPR020122): Protein of unknown function (DUF2719) Alveol-reg_P311 (PF11092, IPR024417): Neuronal protein 3.1 (p311)
173	NTRK1	oncoprotein	149	0.173	3459.726	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
174	NUP214	oncoprotein	14	0.359	11.675	dCache_2 (PF08269, IPR004010, SM01049): Cache domain HisKA (PF00512, IPR003661, SM00388): His Kinase A (phospho-acceptor) domain MIP-T3 (PF10243): Microtubule-binding protein MIP-T3 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region Mustang (PF15682, IPR031394): Musculoskeletal, temporally activated-embryonic nuclear protein 1 NUP214 (PF16755): Nucleoporin or Nuclear pore complex subunit NUP214=Nup159
175	NXF1	interactor	63	0.177	718.597	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
176	OBSL1	protein found in more fusions	89	0.252	592.947	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
177	ORMDL3	interactor	1	0	0	ORMDL (PF04061, IPR007203): ORMDL family
178	PABPC1	oncoprotein	74	0.424	310.957	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
179	PABPC3	interactor	7	0.429	2.611	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain YflT (PF11181, IPR025889): Heat induced stress protein YflT
180	PABPC4	interactor	40	0.533	40.649	ApbA_C (PF08546, IPR013752): Ketopantoate reductase PanE/ApbA C terminal RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP (PF00658, IPR002004, SM00517): Poly-adenylate binding protein, unique domain HHV-5_US34A (PF17087, IPR031384): Herpesvirus US34A protein family
181	PAEP	suppressor	2	1.000	0	Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
182	PAFAH1B3	interactor	10	0.528	4.555	Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
183	PAPSS1	interactor	2	1.000	0	APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258 PUA_2 (PF14306, IPR025980): PUA-like domain
184	PARK2	suppressor	62	0.239	451.649	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
185