Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins EDC3 (from a repository: Mon Dec 5 04:19:47 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)28
The number (and %) of the onco-proteins9 (32.14 %)
The number (and %) of the tumor suppressors2 (7.14 %)
Total number of binary PPIs (saturation %)106 (28.04 %)
The number (and %) of affected PPIs28 (26.42 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI7.000
Assortativity coefficient-0.3103
The network average Clustering coefficient0.551
The number (and %) of a zero Clustering coefficients5 (17.86 %)
The number (and %) of a zero Betweenness Centrality8 (28.57 %)

ACTIVE INTERACTORS


List of the fusions

Proteins found in more fusions YWHAZ (see 1 fusions); EDC3 (see 1 fusions); YWHAG (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 EDC3parental protein280.202399.324FDF (PF09532, IPR019050, SM01199): FDF domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
LSM14 (PF12701, IPR025609): Scd6-like Sm domain
Edc3_linker (PF16598): Linker region of enhancer of mRNA-decapping protein 3
DUF5096 (PF17019, IPR031512): Domain of unknown function (DUF5096)
2 ANXA10interactor100Annexin (PF00191, IPR018502, SM00335): Annexin
3 BAG4interactor41.0000BAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
4 CARD9interactor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
5 CEP19interactor21.0000CEP19 (PF14933, IPR029412): CEP19-like protein
6 CLTConcoprotein50.8000.667Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
7 CRKLoncoprotein60.8670.800SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8 DCP1Ainteractor150.45732.571DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
9 DCP1Binteractor110.49117.805DCP1 (PF06058, IPR010334): Dcp1-like decapping family
mRNA_decap_C (PF16741, IPR031953): mRNA-decapping enzyme C-terminus
10 DCP2interactor90.55610.000DCP2 (PF05026, IPR007722, SM01125): Dcp2, box A domain
NUDIX (PF00293, IPR000086): NUDIX domain
11 DDX6oncoprotein110.52715.252DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 EDC4interactor120.59111.738DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF2756 (PF10956, IPR020158): Protein of unknown function (DUF2756)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
13 EFHC2interactor100DUF1126 (PF06565, IPR010554): Repeat of unknown function (DUF1126)
EF-hand_6 (PF13405, IPR002048): EF-hand domain
14 FAM96Binteractor30.6670.500DUF59 (PF01883, IPR002744): Domain of unknown function DUF59
15 KLK10suppressor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
16 NTRK1oncoprotein140.50023.186I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PIM1oncoprotein51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
18 PPP1R35interactor50.9000.286PPP1R35_C (PF15503, IPR029135): Protein phosphatase 1 regulatory subunit 35 C-terminus
19 STILoncoprotein30.6670.333STIL_N (PF15253, IPR026123): SCL-interrupting locus protein N-terminus
20 TERF2interactor200Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
TERF2_RBM (PF16772, IPR031902): Telomeric repeat-binding factor 2 Rap1-binding motif
21 UPF1interactor90.47213.971UPF1_Zn_bind (PF09416, IPR018999): RNA helicase (UPF2 interacting domain)
AAA_11 (PF13086): AAA domain
AAA_12 (PF13087): AAA domain
22 USP4oncoprotein60.6002.667UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
23 XPO1interactor110.54513.619CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
24 YWHABinteractor70.7142.41914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
25 YWHAGprotein found in more fusions70.8670.61914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
26 YWHAQinteractor90.5288.05214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
27 YWHAZprotein found in more fusions70.8670.61914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
28 ZFP36suppressor80.6075.571zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)

B a c k    t o    T o p ⇑