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Visible interactions: all affected independent (normal) nothing (blank)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)59
The number (and %) of the onco-proteins20 (33.90 %)
The number (and %) of the tumor suppressors5 (8.47 %)
Total number of binary PPIs (saturation %)223 (13.03 %)
The number (and %) of affected PPIs59 (26.46 %)
The number of possible different fusions17
PPI diameter2
PPI radius1
The average degree of PPI6.746
Assortativity coefficient-0.2708
The network average Clustering coefficient0.490
The number (and %) of a zero Clustering coefficients12 (20.34 %)
The number (and %) of a zero Betweenness Centrality18 (30.51 %)


List of the fusions

PPI for parental proteins: ECHS1 All fusions
: H39530;
Proteins found in more fusions CAMK2D (see 1 fusions); VCL (see 2 fusions); CUL7 (see 2 fusions); CTBP1 (see 2 fusions); AHCYL1 (see 3 fusions); ECHS1 (see 1 fusions); ABCC1 (see 1 fusions); GRB2 (see 1 fusions); SLC9A3R1 (see 2 fusions); TGM2 (see 4 fusions); GSS (see 1 fusions); TPD52L2 (see 2 fusions); ITPA (see 1 fusions); HERC1 (see 1 fusions); YWHAZ (see 1 fusions); UBA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 ECHS1parental protein590.0852433.879ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
2 ABCC1oncoprotein40.6671.000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
ABC_ATPase (PF09818, IPR019195): Predicted ATPase of the ABC class
DUF2304 (PF10066, IPR019277): Uncharacterized conserved protein (DUF2304)
DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
3 ABHD14Ainteractor60.8670.686Abhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
4 ADI1interactor30.6670.667ARD (PF03079, IPR004313): ARD/ARD' family
5 AHCYL1suppressor60.6001.917AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
6 AKR1A1interactor31.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
7 ALDOAinteractor80.42910.667Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
8 ATPAF2interactor100ATP12 (PF07542, IPR011419): ATP12 chaperone protein
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
9 BAG6interactor60.6002.556DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 CAMK2Doncoprotein200CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CAMK2Ginteractor100CaMKII_AD (PF08332, IPR013543): Calcium/calmodulin dependent protein kinase II association domain
Pkinase (PF00069, IPR000719): Protein kinase domain
12 CAPN1interactor110.50916.552Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
13 CBWD2interactor21.0000cobW (PF02492, IPR003495): CobW/HypB/UreG, nucleotide-binding domain
CobW_C (PF07683, IPR011629, SM00833): Cobalamin synthesis protein cobW C-terminal domain
14 CLDN12interactor100FixS (PF03597, IPR004714): Cytochrome oxidase maturation protein cbb3-type
15 CNDP2suppressor70.5245.700Peptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
16 COX4I1interactor30.6670.667COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
17 CTBP1protein found in more fusions31.00002-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
18 CUL7protein found in more fusions100.25015.383ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
19 CYP2E1interactor100p450 (PF00067, IPR001128): Cytochrome P450
20 DBTinteractor40.5002.6672-oxoacid_dh (PF00198, IPR001078): 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
E3_binding (PF02817, IPR004167): e3 binding domain
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
21 DCPSinteractor80.7502.871DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
22 DDA1interactor100DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
23 EPB41suppressor31.00004_1_CTD (PF05902, IPR008379): 4.1 protein C-terminal domain (CTD)
FA (PF08736, IPR014847): FERM adjacent (FA)
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
SAB (PF04382, IPR007477): SAB domain
24 GINS3interactor90.7503.438Sld5 (PF05916, IPR021151): GINS complex protein
25 GRB2oncoprotein80.5713.883SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
26 GSSprotein found in more fusions80.7142.533GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
27 HERC1protein found in more fusions200Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM)
Presenilin (PF01080, IPR001108): Presenilin
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SPRY (PF00622, IPR003877, SM00449): SPRY domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
28 HSPA9oncoprotein140.39638.410HSP70 (PF00012, IPR013126): Hsp70 protein
29 ISYNA1interactor50.6003.000NAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase
30 ITPAprotein found in more fusions60.6002.250Ham1p_like (PF01725, IPR002637): Ham1 family
31 MOV10interactor120.33330.650AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
32 NEDD1interactor21.0000NRBF2 (PF08961, IPR015056): Nuclear receptor-binding factor 2, autophagy regulator
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
FliM (PF02154, IPR001689): Flagellar motor switch protein FliM
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Mto2_bdg (PF12808, IPR024545): Micro-tubular organiser Mto1 C-term Mto2-binding region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
33 NTRK1oncoprotein290.201254.369I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 NXF1interactor110.33320.717NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
35 PCBP1oncoprotein50.6002.889Bac_chlorC (PF02043, IPR001470): Bacteriochlorophyll C binding protein
KH_2 (PF07650, IPR004044): KH domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
36 PFASinteractor140.49524.471AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
37 PPIBinteractor50.6002.222Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
38 PPM1Binteractor100PP2C (PF00481, IPR001932): Protein phosphatase 2C
PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain
39 PPP4R3Binteractor80.6795.367Diphtheria_T (PF02764, IPR022405): Diphtheria toxin, T domain
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
IGF2_C (PF08365, IPR013576): Insulin-like growth factor II E-peptide
WH1 (PF00568, IPR000697, SM00461): WH1 domain
40 RAB11FIP5interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
RBD-FIP (PF09457, IPR019018): FIP domain
41 RAP1Asuppressor31.0000Ras (PF00071, IPR001806, SM00173): Ras family
42 RAP1GDS1oncoprotein130.55118.457Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
43 SERPINA1oncoprotein100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
44 SLC9A3R1suppressor90.7502.833EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
45 SUMO3interactor40.5001.750Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
46 SYNCRIPinteractor50.6001.456RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
47 TALDO1interactor50.7002.333TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
48 TGM2protein found in more fusions80.7143.467Transglut_C (PF00927, IPR008958): Transglutaminase family, C-terminal ig like domain
Transglut_N (PF00868, IPR001102): Transglutaminase family
Transglut_core (PF01841, IPR002931, SM00460): Transglutaminase-like superfamily
49 TPD52L2protein found in more fusions60.6002.083TPD52 (PF04201, IPR007327): Tumour protein D52 family
50 UBA1protein found in more fusions50.6670.556ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
51 UBA5interactor200Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
ThiF (PF00899, IPR000594): ThiF family
52 UBE2V1interactor60.5335.167UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
53 UCHL5oncoprotein50.8330.400Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
54 USP14interactor90.44413.519UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
55 USP15oncoprotein70.6004.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
56 VCLoncoprotein110.6676.655Vinculin (PF01044, IPR006077): Vinculin family
57 YEATS4interactor100YEATS (PF03366, IPR005033): YEATS family
SOGA (PF11365, IPR027881): Protein SOGA
58 YWHAQinteractor140.36342.30814-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
59 YWHAZprotein found in more fusions140.38529.27214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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