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Visible interactions: all affected independent (normal) nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: parental proteins DZIP3 (from a repository: Fri Mar 22 13:58:37 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)50
The number (and %) of the onco-proteins14 (28.00 %)
The number (and %) of the tumor suppressors3 (6.00 %)
Total number of binary PPIs (saturation %)146 (11.92 %)
The number (and %) of affected PPIs50 (34.25 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI4.720
Assortativity coefficient-0.4040
The network average Clustering coefficient0.589
The number (and %) of a zero Clustering coefficients9 (18.00 %)
The number (and %) of a zero Betweenness Centrality25 (50.00 %)

ACTIVE INTERACTORS


List of the fusions

PPI for parental proteins: DZIP3 All fusions
Proteins found in more fusions UBE2R2 (see 1 fusions); TSG101 (see 2 fusions); UBE2D2 (see 2 fusions); UBE2H (see 4 fusions); ATXN1 (see 3 fusions); UBE2E1 (see 3 fusions); DZIP3 (see 1 fusions); UBE2E2 (see 1 fusions); HNRNPUL1 (see 1 fusions); UBE2N (see 1 fusions); GRIP1 (see 2 fusions); HDAC1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 DZIP3parental protein500.0591999.567DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
SlyX (PF04102, IPR007236): SlyX
zf-RING-like (PF08746, IPR014857): RING-like domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
2 AKTIPinteractor100UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
3 AP1M1interactor100Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
4 ARHGAP32oncoprotein30.6670.667PX (PF00787, IPR001683, SM00312): PX domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
RPEL (PF02755, IPR004018, SM00707): RPEL repeat
SH3_9 (PF14604, IPR001452): Variant SH3 domain
5 ATXN1protein found in more fusions90.32118.333AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
Spt20 (PF12090, IPR021950): Spt20 family
ATXN-1_C (PF12547, IPR020997): Capicua transcriptional repressor modulator
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
6 BECN1suppressor31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Ima1_N (PF09779, IPR018617): Ima1 N-terminal domain
BH3 (PF15285, IPR029318): Beclin-1 BH3 domain, Bcl-2-interacting
7 BIRC2oncoprotein100.38919.500BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
8 BIRC3oncoprotein90.5368.500BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
9 CARM1oncoprotein31.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PRMT5 (PF05185, IPR025799): PRMT5 arginine-N-methyltransferase
CBP_GIL (PF10995, IPR017745): GGDEF I-site like or GIL domain
CARM1 (PF11531, IPR020989): Coactivator-associated arginine methyltransferase 1 N terminal
10 CEP63interactor30.6671.000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
11 DAZ1interactor200DUF1970 (PF09301, IPR015380): Domain of unknown function (DUF1970)
Nucleoporin2 (PF04096, IPR007230): Nucleoporin autopeptidase
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
WRC (PF08879, IPR014977): WRC
DUF2582 (PF10771, IPR019707): Winged helix-turn-helix domain (DUF2582)
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
12 GRIP1protein found in more fusions50.8330.667PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
13 GTF2H2C_2interactor100C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain
Prim_Zn_Ribbon (PF08273, IPR013237, SM00778): Zinc-binding domain of primase-helicase
Ssl1 (PF04056, IPR007198): Ssl1-like
zf-HIT (PF04438, IPR007529): HIT zinc finger
UPF0547 (PF10571, IPR018886): Uncharacterised protein family UPF0547
zf-C2H2_4 (PF13894): C2H2-type zinc finger
14 HDAC1suppressor50.8330.667FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
15 HIST1H2ABinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
16 HIST2H2BEinteractor100Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
17 HNRNPFinteractor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Spot_14 (PF07084, IPR009786): Thyroid hormone-inducible hepatic protein Spot 14
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
18 HNRNPUL1protein found in more fusions60.5005.000Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
19 HOTAIRinteractor21.0000NA
20 MED4interactor30.6671.000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
21 NCOR1oncoprotein31.0000BES1_N (PF05687, IPR008540): BES1/BZR1 plant transcription factor, N-terminal
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Eapp_C (PF10238, IPR019370): E2F-associated phosphoprotein
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
GPS2_interact (PF15784, IPR031557): G-protein pathway suppressor 2-interacting domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
RBR (PF17208): RNA binding Region
22 NXF1interactor90.35717.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
23 PCGF3interactor31.0000GAGA (PF09237, IPR015318): GAGA factor
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
24 RAD18interactor41.0000PhoU_div (PF01865, IPR018445): Protein of unknown function DUF47
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
25 RBM4Binteractor21.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
26 RNF38interactor70.4007.333zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
27 TOLLIPinteractor40.6671.000C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
28 TRIM21interactor80.42910.500DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
29 TSG101suppressor70.5335.833APG6 (PF04111, IPR007243): Autophagy protein Apg6
Laminin_II (PF06009, IPR010307): Laminin Domain II
UEV (PF05743, IPR008883): UEV domain
Vps23_core (PF09454, IPR017916): Vps23 core domain
30 UBE2D1interactor70.6672.667UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
31 UBE2D2oncoprotein110.44419.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
32 UBE2D3interactor60.5004.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
33 UBE2D4interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
34 UBE2E1protein found in more fusions41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
35 UBE2E2protein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
36 UBE2E3interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
37 UBE2Hprotein found in more fusions50.5002.500UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
38 UBE2Iinteractor160.23875.233UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
39 UBE2Kinteractor60.6004.333UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
40 UBE2Nprotein found in more fusions60.7001.733UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
41 UBE2R2protein found in more fusions31.0000NOA36 (PF06524, IPR010531): NOA36 protein
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
42 UBE2Uinteractor100UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
efb-c (PF12199, IPR021033): Extracellular fibrinogen binding protein C terminal
TMEM154 (PF15102, IPR028064): TMEM154 protein family
43 UBE2V1interactor70.6195.567UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
44 UBE2V2interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
45 UBE2Winteractor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
46 UBE2Zinteractor30.6671.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
47 UBR3interactor30.6671.000zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
CRAL_TRIO (PF00650, IPR001251, SM00516): CRAL/TRIO domain
48 ZCCHC10interactor21.0000Macoilin (PF09726, IPR019130): Transmembrane protein
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
zf-CCHC_3 (PF13917): Zinc knuckle
49 ZNF24interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
50 ZNF765interactor100HNH (PF01844, IPR002711): HNH endonuclease
KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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